APH1A

General Information

Gene Name       : APH1A
Gene ID             : ENSG00000117362.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: APH1A)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878APH1AENSG00000117362.1252.3772.0062.19ENCSR000AEF
HepG2APH1AENSG00000117362.1280.0574.0677.06ENCSR985KAT
K562APH1AENSG00000117362.1267.5856.8362.20ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for APH1A is not avaliable on ENCORE database.



Proteins bound to RNA
  • APH1A RNA is bound by 23 proteins.  







eCLIP assay for APH1A is not avaliable on ENCORE database.





23 proteins are bound to APH1A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1150238423150238478-3'-UTR,intron-Distal4.760785.18898HepG2LARP4
chr1150237844150237920-3'-UTR,intron-Distal6.1805920.58312HepG2UPF1
chr1150238106150238216-3'-UTR,intron-Distal4.9536328.15802HepG2UPF1
chr1150238216150238260-3'-UTR,intron-Distal4.308704.02104HepG2TIA1
chr1150238770150238816-3'-UTR,intron-Distal3.258023.15019HepG2IGF2BP1
chr1150238841150238902-3'-UTR,intron-Distal,intron-Proximal4.269036.61524HepG2UPF1
chr1150238139150238188-3'-UTR,intron-Distal3.525834.41542HepG2FAM120A
chr1150238423150238509-3'-UTR,intron-Distal3.518788.67784K562UPF1
chr1150237836150237910-3'-UTR,intron-Distal4.6550823.28992K562FAM120A
chr1150237835150237904-3'-UTR,intron-Distal4.6054623.39108K562PABPC4
chr1150238771150238839-3'-UTR,intron-Distal,intron-Proximal3.961733.08588HepG2IGF2BP3
chr1150237831150237916-3'-UTR,intron-Distal3.132415.33855HepG2FUBP3
chr1150237840150237893-3'-UTR,intron-Distal5.4528610.99341HepG2DDX6
chr1150237841150237908-3'-UTR,intron-Distal3.901946.74096K562ZC3H11A
chr1150238432150238491-3'-UTR,intron-Distal5.338769.71345HepG2AKAP1
chr1150237837150237862-3'-UTR,intron-Distal4.840885.48435HepG2TIA1
chr1150237835150237919-3'-UTR,intron-Distal4.379174.41043K562APOBEC3C
chr1150237844150237924-3'-UTR,intron-Distal3.425684.52939HepG2PRPF4
chr1150237841150237890-3'-UTR,intron-Distal3.6220110.41769HepG2LARP4
chr1150237837150237887-3'-UTR,intron-Distal4.3758119.26949K562TIA1
chr1150238565150238669-3'-UTR,CDS,intron-Distal,intron-Proximal3.7363511.17775HepG2AKAP1
chr1150238584150238664-3'-UTR,CDS,intron-Distal,intron-Proximal3.062356.16228K562UPF1
chr1150238756150238787-3'-UTR,intron-Distal3.536414.26467K562UPF1
chr1150238566150238671-3'-UTR,CDS,intron-Distal,intron-Proximal3.958025.75237K562PCBP1
chr1150237845150237924-3'-UTR,intron-Distal3.201783.46181K562DDX55
chr1150237835150237912-3'-UTR,intron-Distal6.4407235.53447K562UPF1
chr1150238707150238754-3'-UTR,intron-Distal,intron-Proximal3.381764.69164HepG2IGF2BP1
chr1150238156150238228-3'-UTR,intron-Distal3.053597.47822K562UPF1
chr1150238733150238775-3'-UTR,intron-Distal,intron-Proximal5.108449.25213HepG2UPF1
chr1150238484150238563-3'-UTR,CDS,intron-Distal5.1511817.89174HepG2UPF1
chr1150238717150238828-3'-UTR,intron-Distal,intron-Proximal4.7301212.77891HepG2AKAP1
chr1150238110150238139-3'-UTR,intron-Distal3.454243.06661HepG2FAM120A
chr1150238560150238618-3'-UTR,CDS,intron-Distal3.5662910.16725HepG2PCBP2
chr1150238868150238912-3'-UTR,intron-Distal,intron-Proximal3.688835.63973HepG2AKAP1
chr1150238041150238074-3'-UTR,intron-Distal4.010185.48330K562UPF1
chr1150238479150238549-3'-UTR,CDS,intron-Distal3.175153.88579K562IGF2BP2
chr1150237862150237882-3'-UTR,intron-Distal4.913095.89618HepG2TIA1
chr1150237841150237927-3'-UTR,intron-Distal3.441657.55525K562GTF2F1
chr1150238121150238209-3'-UTR,intron-Distal3.609136.73008HepG2AKAP1
chr1150237846150237881-3'-UTR,intron-Distal4.687594.98572HepG2TIAL1
chr1150238563150238658-3'-UTR,CDS,intron-Distal,intron-Proximal4.2467915.79680HepG2UPF1
chr1150237834150237913-3'-UTR,intron-Distal4.2426718.92405K562DDX6
chr1150238491150238560-3'-UTR,CDS,intron-Distal4.183846.16190HepG2AKAP1
chr1150238003150238098-3'-UTR,intron-Distal5.0575025.15180HepG2UPF1
chr1150238421150238484-3'-UTR,intron-Distal3.919089.25614HepG2UPF1
chr1150238003150238088-3'-UTR,intron-Distal5.9854418.04243HepG2AKAP1
chr1150238718150238767-3'-UTR,intron-Distal,intron-Proximal3.414495.54091HepG2LARP4
chr1150237890150237924-3'-UTR,intron-Distal3.313875.00851HepG2LARP4
chr1150237838150237928-3'-UTR,intron-Distal5.6942115.10302K562CPEB4
chr1150241147150241252-5'-UTR,CDS,intron-Distal,intron-Proximal4.807514.65678K562METAP2
chr1150241184150241252-5'-UTR,CDS,intron-Distal,intron-Proximal3.810225.97131K562DDX3X
chr1150241201150241351-5'-UTR,CDS,intron-Distal,intron-Proximal3.764787.57637K562PCBP1
chr1150241252150241331-5'-UTR,intron-Distal,intron-Proximal5.3303918.09658K562DDX3X
chr1150241186150241256-5'-UTR,CDS,intron-Distal,intron-Proximal4.9346446.44692HepG2DDX3X
chr1150241331150241381-5'-UTR,intron-Distal3.926418.12116K562DDX3X
chr1150241259150241372-5'-UTR,intron-Distal,intron-Proximal6.08538400.00000HepG2DDX3X
chr1150241149150241184-CDS,intron-Distal3.252663.24636K562DDX3X
chr1150241145150241186-CDS,intron-Distal4.3201111.34202HepG2DDX3X
chr1150238952150239014-CDS,intron-Distal,intron-Proximal3.487338.67981K562YBX3
chr1150240472150240526-CDS,intron-Distal,intron-Proximal4.7113448.44668HepG2DDX3X
chr1150239515150239529-CDS,intron-Distal3.936754.82666HepG2DDX3X
chr1150240421150240452-CDS,intron-Distal,intron-Proximal4.202827.93174K562YBX3
chr1150239786150239821-CDS,intron-Distal3.266234.25624HepG2DDX3X
chr1150240433150240472-CDS,intron-Distal,intron-Proximal4.9073013.85526HepG2DDX3X
chr1150241097150241145-CDS,intron-Distal4.4513218.70677HepG2DDX3X
chr1150240452150240473-CDS,intron-Distal,intron-Proximal3.202036.82055K562YBX3
chr1150240374150240417-CDS,intron-Distal,intron-Proximal4.861228.20930HepG2DDX3X
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for APH1A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for APH1A is not available on ENCORE database.

  • 104 RBPs can affect the levels of APH1A.  








The Knockdown/knockout RNA-Seq assay for APH1A is not available on ENCORE database.





104 RBPs can affect the gene expression of APH1A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
APH1AENSG00000117362.81053.376301829.33910-0.796305.525103.17770HepG2AARS
APH1AENSG00000117362.81302.553601615.22090-0.310402.391401.39130HepG2AATF
APH1AENSG00000117362.81785.065802161.70290-0.276204.051203.34150HepG2ACO1
APH1AENSG00000117362.82495.049903966.98030-0.669007.269906.45220HepG2AKAP1
APH1AENSG00000117362.82552.586103430.16260-0.426309.088407.96410HepG2AUH
APH1AENSG00000117362.8972.306601621.51990-0.737905.779104.53250HepG2BCLAF1
APH1AENSG00000117362.81839.662102161.17300-0.232403.284102.57010HepG2CKAP4
APH1AENSG00000117362.81309.882401587.21770-0.277102.681801.68080HepG2YBX3
APH1AENSG00000117362.82128.430202532.27940-0.250602.889502.23550HepG2CELF1
APH1AENSG00000117362.83498.503702722.754500.361608.807407.59950HepG2DAZAP1
APH1AENSG00000117362.82593.257601999.237900.375207.806806.52610HepG2DDX19B
APH1AENSG00000117362.8680.116101589.40760-1.2246035.7028032.55150HepG2DDX1
APH1AENSG00000117362.82710.780403800.01630-0.487304.765703.96220HepG2DDX3X
APH1AENSG00000117362.82575.873803264.41210-0.341802.259001.69540HepG2DDX6
APH1AENSG00000117362.82651.208002068.148300.358205.992205.06820HepG2DKC1
APH1AENSG00000117362.81647.584503138.03990-0.9295015.0886013.77480HepG2EIF2S1
APH1AENSG00000117362.81347.997201730.63660-0.360503.059801.82490HepG2EIF2S2
APH1AENSG00000117362.8914.663701393.65310-0.607605.895404.60990HepG2EIF3D
APH1AENSG00000117362.82011.349903376.54390-0.747407.060205.98900HepG2EIF4B
APH1AENSG00000117362.81936.307802686.22270-0.472309.655608.27380HepG2EIF4G1
APH1AENSG00000117362.81153.422902267.46460-0.9752021.2547019.18520HepG2FUBP3
APH1AENSG00000117362.82310.163103245.82260-0.490604.493503.65360HepG2G3BP1
APH1AENSG00000117362.81127.344501954.08360-0.7936010.888208.83310HepG2GNB2L1
APH1AENSG00000117362.81214.221801791.52050-0.561203.000001.55550HepG2HLTF
APH1AENSG00000117362.82337.321803286.90280-0.491905.733304.75610HepG2HNRNPK
APH1AENSG00000117362.81401.234503299.27530-1.2355026.1265024.30920HepG2IGF2BP2
APH1AENSG00000117362.81909.166403096.35840-0.697602.431501.51760HepG2IGF2BP3
APH1AENSG00000117362.82115.529103318.56790-0.649505.866704.35770HepG2KHSRP
APH1AENSG00000117362.82305.581403500.30690-0.602406.869905.85040HepG2MAGOH
APH1AENSG00000117362.82811.903903519.86950-0.324002.159101.59800HepG2MATR3
APH1AENSG00000117362.82048.751403602.75920-0.8144011.5046010.25570HepG2NCBP2
APH1AENSG00000117362.81021.638301685.93770-0.722704.677903.23380HepG2NONO
APH1AENSG00000117362.81097.341501517.41680-0.467602.182801.40870HepG2PABPC1
APH1AENSG00000117362.82285.466503208.38640-0.489404.671303.74360HepG2PABPC4
APH1AENSG00000117362.81656.315903314.39600-1.0008032.1165030.44090HepG2PCBP1
APH1AENSG00000117362.81263.925901767.24540-0.483602.812501.76440HepG2PCBP2
APH1AENSG00000117362.81116.979001414.98190-0.341202.123501.41180HepG2PRPF8
APH1AENSG00000117362.82139.494603372.38270-0.6565016.4170015.29860HepG2PTBP1
APH1AENSG00000117362.81633.621503652.67030-1.1609039.8311037.95700HepG2QKI
APH1AENSG00000117362.8863.427401704.93710-0.981607.643206.50490HepG2RAVER1
APH1AENSG00000117362.81959.909803291.74340-0.7481020.4560019.31400HepG2RBM22
APH1AENSG00000117362.81798.115403314.92100-0.8825020.9417019.19430HepG2RBM25
APH1AENSG00000117362.81505.527301874.90970-0.316602.334701.36390HepG2RCC2
APH1AENSG00000117362.82841.948803753.25380-0.401307.268806.46370HepG2NELFE
APH1AENSG00000117362.82895.866603495.43610-0.271504.433303.67630HepG2RECQL
APH1AENSG00000117362.81679.914802156.97840-0.360603.234802.50500HepG2RPLP0
APH1AENSG00000117362.81194.869801675.67280-0.487902.758801.81680HepG2RPS10
APH1AENSG00000117362.8946.741901356.22850-0.518606.035005.16840HepG2RPS19
APH1AENSG00000117362.81659.216502129.30590-0.359903.290602.41810HepG2RPS2
APH1AENSG00000117362.8845.494701399.63560-0.727205.229704.18160HepG2RRP9
APH1AENSG00000117362.82172.117801548.280800.4883011.3151010.15120HepG2SAFB2
APH1AENSG00000117362.8464.00950929.05240-1.001608.703707.51980HepG2SF3B1
APH1AENSG00000117362.81791.640003511.33520-0.9707031.4589029.85540HepG2SF3B4
APH1AENSG00000117362.81413.209401805.54030-0.353506.433605.51790HepG2SMN1
APH1AENSG00000117362.8771.276301033.75440-0.422602.038301.37250HepG2SNRNP70
APH1AENSG00000117362.82817.234803717.86470-0.4002010.056709.26320HepG2SRFBP1
APH1AENSG00000117362.82389.356403664.97190-0.6172016.2780015.33400HepG2SRSF1
APH1AENSG00000117362.82177.716002544.72620-0.224702.644702.02950HepG2SRSF5
APH1AENSG00000117362.82157.161202981.56210-0.4669010.941709.97230HepG2SRSF9
APH1AENSG00000117362.82562.012802894.03250-0.175802.224401.65570HepG2SUCLG1
APH1AENSG00000117362.81178.156601555.34550-0.400703.810902.71940HepG2SUPT6H
APH1AENSG00000117362.82827.325003293.93710-0.220402.532901.99350HepG2TAF15
APH1AENSG00000117362.82367.276903026.97930-0.354704.374403.33200HepG2TIA1
APH1AENSG00000117362.81962.631401689.301200.216301.787001.36700HepG2TIAL1
APH1AENSG00000117362.81335.019701704.47020-0.352505.043604.32790HepG2TRIM56
APH1AENSG00000117362.81281.142101970.75910-0.621305.557504.68310HepG2U2AF1
APH1AENSG00000117362.8490.057401078.95740-1.138609.524508.11860HepG2UCHL5
APH1AENSG00000117362.81469.425302037.04860-0.4712011.4310010.50620HepG2ZNF622
APH1AENSG00000117362.8800.260001065.04150-0.412403.341702.02840K562AARS
APH1AENSG00000117362.81267.369401562.04180-0.301602.120901.54550K562AKAP8L
APH1AENSG00000117362.81100.240501446.91980-0.395205.832704.42280K562BCLAF1
APH1AENSG00000117362.8870.119601097.70430-0.335202.943101.85270K562CSTF2
APH1AENSG00000117362.82396.597903329.56610-0.474307.746606.13960K562CELF1
APH1AENSG00000117362.8645.941801023.17030-0.663603.903201.66330K562DDX1
APH1AENSG00000117362.8795.846301086.97510-0.449803.514101.99270K562DHX30
APH1AENSG00000117362.8787.306301044.10190-0.407303.128801.69960K562DNAJC21
APH1AENSG00000117362.8941.202401295.48320-0.460902.860001.55760K562EEF2
APH1AENSG00000117362.8797.022601031.61630-0.372203.253501.51240K562FASTKD2
APH1AENSG00000117362.81565.832501282.174500.288202.132501.38420K562FIP1L1
APH1AENSG00000117362.8629.481501011.62520-0.684406.556204.68980K562FKBP4
APH1AENSG00000117362.8486.84210663.95840-0.447602.678101.77830K562FTO
APH1AENSG00000117362.81453.849501069.001900.443503.969803.26450K562FXR1
APH1AENSG00000117362.8447.12760730.69080-0.708605.133704.10340K562G3BP2
APH1AENSG00000117362.81069.337701491.29380-0.479806.707204.97830K562GLRX3
APH1AENSG00000117362.81654.341002036.37970-0.299702.763601.69180K562HNRNPA1
APH1AENSG00000117362.8997.062501341.44570-0.428003.818201.60230K562HNRNPH1
APH1AENSG00000117362.81431.906201054.682500.441003.055102.07140K562HNRNPM
APH1AENSG00000117362.82373.179601738.250400.449104.756903.72090K562HSPD1
APH1AENSG00000117362.8640.924101014.41740-0.662406.491304.23650K562ILF3
APH1AENSG00000117362.81228.076101657.86860-0.432904.647903.53110K562KIF1C
APH1AENSG00000117362.8394.41590627.62660-0.670202.849201.89840K562KRR1
APH1AENSG00000117362.82167.555902886.15590-0.413104.319102.91080K562MSI2
APH1AENSG00000117362.81179.237301567.90340-0.411006.393305.21080K562MTPAP
APH1AENSG00000117362.8991.409301301.75660-0.392902.309901.52100K562NAA15
APH1AENSG00000117362.81332.190501742.06790-0.387007.607006.45430K562NSUN2
APH1AENSG00000117362.8855.689801143.47480-0.418302.247701.37050K562PCBP2
APH1AENSG00000117362.81184.406901621.64770-0.453303.654902.69630K562PCBP3
APH1AENSG00000117362.8959.776901243.84880-0.374003.496702.58970K562POLR2G
APH1AENSG00000117362.81803.261301455.630800.308902.419201.65500K562PPIG
APH1AENSG00000117362.81482.554701718.99660-0.213502.100801.38380K562SF3A3
APH1AENSG00000117362.8406.04510699.05620-0.783806.511604.98580K562SF3B1
APH1AENSG00000117362.8748.272601069.41140-0.515204.677902.99860K562SLBP
APH1AENSG00000117362.81151.271001394.13290-0.276102.658801.51780K562SRSF7
APH1AENSG00000117362.81069.346101538.50230-0.524804.672902.97070K562STAU1
APH1AENSG00000117362.8843.564501179.42300-0.483503.567202.39840K562SUPV3L1
APH1AENSG00000117362.81534.985101247.627000.298902.711401.90150K562SYNCRIP
APH1AENSG00000117362.8451.38680731.49100-0.696508.223506.82480K562U2AF2
APH1AENSG00000117362.8846.296001248.23940-0.560705.265003.81990K562UCHL5
APH1AENSG00000117362.81179.891801580.54840-0.421804.512003.38080K562WDR3
APH1AENSG00000117362.81313.815501643.59900-0.323104.698803.62070K562WDR43
APH1AENSG00000117362.81984.450002725.28620-0.457703.202102.26600K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for APH1A is not available on ENCORE database.





5 RBPs can affect the splicing of APH1A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEAPH1AENSG00000117362.8chr1-150240356150240527150240115150240189150241097150241703-0.238000.000000.00002excludedHepG2U2AF1
SEAPH1AENSG00000117362.8chr1-150239755150239803150239496150239602150240115150240166-0.144000.000820.06190excludedK562SUPV3L1
SEAPH1AENSG00000117362.8chr1-150240115150240189150239755150239878150240356150240527-0.054000.001530.04258excludedHepG2SF3A3
SEAPH1AENSG00000117362.8chr1-150240115150240189150239755150239878150241097150241423-0.075000.000010.00081excludedHepG2PCBP1
A3SSAPH1AENSG00000117362.8chr1-1502403561502406031502403561502405271502410971502417030.127000.000000.00000longerK562AQR
A3SSAPH1AENSG00000117362.8chr1-1502401151502402451502401151502401891502403561502403910.065000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for APH1A is not avaliable on ENCORE database.