TMEM258

General Information

Gene Name       : TMEM258
Gene ID             : ENSG00000134825.15
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: TMEM258)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM258ENSG00000134825.15105.57132.29118.93ENCSR000AEF
HepG2TMEM258ENSG00000134825.15150.81121.59136.20ENCSR985KAT
K562TMEM258ENSG00000134825.15184.86143.59164.23ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM258 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM258 RNA is bound by 15 proteins.  







eCLIP assay for TMEM258 is not avaliable on ENCORE database.





15 proteins are bound to TMEM258 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr116155725661557306-3'-UTR,CDS,intron-Distal,intron-Proximal3.152723.40391K562XRCC6
chr116155661361556664-3'-UTR,intron-Distal5.625928.71274HepG2SUB1
chr116155726161557277-3'-UTR,CDS,intron-Distal3.4497026.98911K562PUM2
chr116155725661557313-3'-UTR,CDS,intron-Distal,intron-Proximal3.306117.30056K562LARP4
chr116155660561556653-3'-UTR,intron-Distal3.8919740.91750K562TIA1
chr116155725561557273-3'-UTR,CDS,intron-Distal,intron-Proximal6.8751828.59120HepG2LARP4
chr116155661361556658-3'-UTR,intron-Distal4.777059.02755K562LARP4
chr116155660861556661-3'-UTR,intron-Distal6.2559174.39972K562PUM2
chr116155801861558075-3'-UTR,CDS,intron-Distal,intron-Proximal3.498717.14562K562DROSHA
chr116155668661556707-3'-UTR,intron-Distal4.3710117.81675K562PABPC4
chr116155666161556709-3'-UTR,intron-Distal4.7108649.26235K562PUM2
chr116155661361556661-3'-UTR,intron-Distal6.5237322.37888HepG2LARP4
chr116155725561557266-3'-UTR,intron-Distal,intron-Proximal4.5660941.05276K562PABPC4
chr116155731461557358-3'-UTR,CDS,intron-Distal5.31066400.00000K562PABPC4
chr116155726661557314-3'-UTR,CDS,intron-Distal4.7280665.16088K562PABPC4
chr116155802661558077-3'-UTR,CDS,intron-Distal,intron-Proximal4.594077.17420HepG2DDX55
chr116155667261556708-3'-UTR,intron-Distal4.3764711.93232HepG2LARP4
chr116155725561557332-3'-UTR,CDS,intron-Distal,intron-Proximal3.586567.46398K562RPS3
chr116155735961557382-3'-UTR,CDS,intron-Distal3.5035243.39757K562YBX3
chr116155655461556607-3'-UTR,intron-Distal,intron-Proximal,polyA_site3.760603.19526HepG2CSTF2T
chr116155661361556662-3'-UTR,intron-Distal3.519276.68564K562APOBEC3C
chr116155738261557389-3'-UTR,CDS,intron-Distal3.3301033.01451K562YBX3
chr116155738961557394-3'-UTR,CDS,intron-Distal,intron-Proximal3.2448732.24789K562YBX3
chr116155733961557358-3'-UTR,CDS,intron-Distal3.0403625.31173K562YBX3
chr116155661461556665-3'-UTR,intron-Distal4.9138747.89630K562PABPC4
chr116155725561557261-3'-UTR,intron-Distal,intron-Proximal3.4573822.06932K562PUM2
chr116155666161556700-3'-UTR,intron-Distal3.239854.49055K562YBX3
chr116155803061558070-3'-UTR,CDS,intron-Distal4.5005562.71568K562DDX3X
chr116155804161558094-3'-UTR,CDS,intron-Distal,intron-Proximal3.188275.28960K562AQR
chr116155661461556657-3'-UTR,intron-Distal4.236375.68843K562DDX6
chr116155806261558075-3'-UTR,CDS,intron-Distal,intron-Proximal3.337763.95084K562PABPC4
chr116155724761557349-3'-UTR,CDS,intron-Distal,intron-Proximal5.1806115.85130HepG2DDX55
chr116155727361557367-3'-UTR,CDS,intron-Distal5.3566152.49956HepG2LARP4
chr116155726061557333-3'-UTR,CDS,intron-Distal3.481726.67587HepG2DDX3X
chr116156002761560043-5'-UTR,CDS,intron-Distal4.223733.09880K562DROSHA
chr116156002761560032-5'-UTR,CDS,intron-Distal4.6720232.22215K562DDX3X
chr116155998761560011-5'-UTR,intron-Distal4.727278.52787K562AQR
chr116156002961560072-5'-UTR,CDS,intron-Distal,intron-Proximal4.076534.38588HepG2DDX3X
chr116156003261560073-5'-UTR,intron-Distal,intron-Proximal4.3955040.03861K562DDX3X
chr116155799961558030-CDS,intron-Distal3.8747744.37840K562DDX3X
chr116155796361558008-CDS,intron-Distal,intron-Proximal3.7912216.61815HepG2LARP4
chr116155800861558053-CDS,intron-Distal4.2237715.34321HepG2LARP4
chr116155796461557969-CDS,intron-Distal,intron-Proximal3.4582533.70121K562YBX3
chr116155796361557999-CDS,intron-Distal,intron-Proximal3.0528528.07418K562DDX3X
chr116155796961557991-CDS,intron-Distal3.2093238.81505K562YBX3
chr116155799861558062-CDS,intron-Distal4.4629060.55253K562PABPC4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM258 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM258 is not available on ENCORE database.

  • 98 RBPs can affect the levels of TMEM258.  








The Knockdown/knockout RNA-Seq assay for TMEM258 is not available on ENCORE database.





98 RBPs can affect the gene expression of TMEM258 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM258ENSG00000134825.9330.03620507.70570-0.621404.542903.30450HepG2ADAR
TMEM258ENSG00000134825.9725.447901143.03020-0.6559011.169309.94680HepG2AUH
TMEM258ENSG00000134825.9293.10080179.806100.704903.805503.01170HepG2CPSF6
TMEM258ENSG00000134825.9504.79090988.60170-0.9697019.3618017.97220HepG2CELF1
TMEM258ENSG00000134825.9468.62110714.36440-0.608205.543404.61790HepG2DDX21
TMEM258ENSG00000134825.9450.87570657.92060-0.545203.279402.06360HepG2AGO1
TMEM258ENSG00000134825.9475.31670674.67740-0.505304.360703.03820HepG2EIF3G
TMEM258ENSG00000134825.9766.746501048.69900-0.451805.638104.51540HepG2EIF4G1
TMEM258ENSG00000134825.9836.653801312.32570-0.6494012.4045011.28050HepG2ETF1
TMEM258ENSG00000134825.9797.44010976.89870-0.292802.500301.60600HepG2HNRNPA2B1
TMEM258ENSG00000134825.9276.49070194.513000.507302.131301.57130HepG2HNRNPLL
TMEM258ENSG00000134825.9423.21320570.31710-0.430403.831603.12860HepG2HNRNPU
TMEM258ENSG00000134825.9713.674701021.91290-0.517904.126603.31650HepG2IGF2BP2
TMEM258ENSG00000134825.9465.60960582.56360-0.323302.121101.46960HepG2ILF2
TMEM258ENSG00000134825.9661.434001027.97900-0.636104.569403.25070HepG2KHSRP
TMEM258ENSG00000134825.9746.934201084.37910-0.537804.353603.53370HepG2MAGOH
TMEM258ENSG00000134825.9628.838301090.39750-0.794107.750506.73630HepG2MATR3
TMEM258ENSG00000134825.9721.703001116.04120-0.628905.692804.79970HepG2NCBP2
TMEM258ENSG00000134825.9852.926701054.01710-0.305402.518101.79240HepG2NOL12
TMEM258ENSG00000134825.9385.62610650.19340-0.753702.814201.71240HepG2NONO
TMEM258ENSG00000134825.9628.41330993.71790-0.661106.077905.01960HepG2PABPC4
TMEM258ENSG00000134825.9443.72770564.54170-0.347402.582401.76120HepG2PARN
TMEM258ENSG00000134825.9652.31280939.75050-0.526707.123906.22430HepG2PCBP1
TMEM258ENSG00000134825.9406.84550694.05150-0.770605.209603.81360HepG2PCBP2
TMEM258ENSG00000134825.9247.39740508.68090-1.0399014.1157012.52190HepG2PPIL4
TMEM258ENSG00000134825.9488.65470729.59750-0.578303.168501.87160HepG2PRPF6
TMEM258ENSG00000134825.9562.62020956.24840-0.7652012.6609011.65980HepG2PTBP1
TMEM258ENSG00000134825.9642.216601006.16370-0.647707.402006.48860HepG2PUF60
TMEM258ENSG00000134825.9829.296401067.31240-0.364003.176002.45690HepG2PUM2
TMEM258ENSG00000134825.9505.47680644.40740-0.350302.040701.49320HepG2PUS1
TMEM258ENSG00000134825.9630.954501035.60420-0.7149010.366709.26710HepG2QKI
TMEM258ENSG00000134825.9407.47810669.70350-0.716803.552502.75630HepG2RAVER1
TMEM258ENSG00000134825.9638.15890939.89110-0.558605.781804.83930HepG2RBM25
TMEM258ENSG00000134825.9775.101601064.19840-0.457305.552704.82880HepG2NELFE
TMEM258ENSG00000134825.9695.19440991.18190-0.511706.656805.76020HepG2RECQL
TMEM258ENSG00000134825.9445.29390657.98490-0.563302.949001.97590HepG2RPS10
TMEM258ENSG00000134825.9211.96100362.82360-0.775505.778104.92760HepG2RPS19
TMEM258ENSG00000134825.9534.09420688.41210-0.366202.325501.58820HepG2RPS2
TMEM258ENSG00000134825.9384.34700630.90750-0.715004.792303.73960HepG2RPS3A
TMEM258ENSG00000134825.9618.27960995.54730-0.6872011.0794010.01680HepG2SF3B4
TMEM258ENSG00000134825.9397.41200592.32270-0.575706.724505.79000HepG2SMN1
TMEM258ENSG00000134825.9732.081101039.14840-0.505306.834506.17230HepG2SRSF1
TMEM258ENSG00000134825.9648.55350993.45710-0.615209.319008.26100HepG2SRSF5
TMEM258ENSG00000134825.9471.43530845.41330-0.8426015.6009014.48110HepG2SRSF9
TMEM258ENSG00000134825.9352.62330548.85510-0.638304.141702.77090HepG2STIP1
TMEM258ENSG00000134825.9434.58720625.87370-0.526202.424101.30190HepG2SUB1
TMEM258ENSG00000134825.9792.703301129.81990-0.511208.017307.05060HepG2SUCLG1
TMEM258ENSG00000134825.9746.53020934.06180-0.323302.792802.23020HepG2TAF15
TMEM258ENSG00000134825.9595.87450858.23870-0.526405.482504.31730HepG2TIA1
TMEM258ENSG00000134825.9293.87030554.24560-0.9153011.0328010.14870HepG2TIAL1
TMEM258ENSG00000134825.9444.28090672.56750-0.598203.318101.71990HepG2TRA2A
TMEM258ENSG00000134825.9373.36970559.11860-0.582502.702702.14340HepG2TRIM56
TMEM258ENSG00000134825.9720.16910983.00250-0.448904.054802.97310HepG2TUFM
TMEM258ENSG00000134825.9226.49940390.05840-0.784204.301103.52680HepG2U2AF1
TMEM258ENSG00000134825.9270.54780374.18520-0.467903.309402.55660HepG2UPF1
TMEM258ENSG00000134825.9347.60880658.67940-0.922106.813804.86390HepG2XRCC5
TMEM258ENSG00000134825.9458.00290736.56710-0.685504.508903.16970HepG2XRCC6
TMEM258ENSG00000134825.91003.64850694.121600.531904.727003.78830HepG2XRN2
TMEM258ENSG00000134825.9345.84560669.21960-0.952408.123405.80460HepG2ZRANB2
TMEM258ENSG00000134825.92175.725901349.599100.6889018.1532016.82180K562AGGF1
TMEM258ENSG00000134825.92057.937801483.014300.472605.449003.95990K562AKAP8
TMEM258ENSG00000134825.92264.025401404.321300.688907.712706.57230K562AKAP8L
TMEM258ENSG00000134825.91776.354001473.475200.269602.778501.86330K562ATP5C1
TMEM258ENSG00000134825.9612.19420429.715100.510503.383002.41810K562BOP1
TMEM258ENSG00000134825.9607.54990456.906000.411002.883202.08440K562CPSF6
TMEM258ENSG00000134825.9667.183201078.57820-0.6930012.2146010.95170K562DDX47
TMEM258ENSG00000134825.9452.32860647.86550-0.518303.736602.14950K562DHX30
TMEM258ENSG00000134825.9439.17080622.33860-0.502903.643502.08900K562DNAJC21
TMEM258ENSG00000134825.9292.10350588.67650-1.011007.013205.36330K562EIF3A
TMEM258ENSG00000134825.9985.16590607.222900.698002.501401.69620K562FIP1L1
TMEM258ENSG00000134825.91142.417401512.85740-0.405205.209404.41630K562FXR1
TMEM258ENSG00000134825.9734.286001463.84350-0.9953011.156609.54510K562G3BP2
TMEM258ENSG00000134825.9639.10660436.229200.550904.364703.37310K562GPKOW
TMEM258ENSG00000134825.92258.846101626.571500.473705.742704.64920K562GRSF1
TMEM258ENSG00000134825.91106.99090573.222800.949402.799001.57050K562HNRNPA2B1
TMEM258ENSG00000134825.9525.62020698.32330-0.409902.937902.32520K562HNRNPC
TMEM258ENSG00000134825.9846.044101114.90010-0.398103.727901.53720K562HNRNPH1
TMEM258ENSG00000134825.91240.71610974.701500.348002.951001.85640K562HNRNPL
TMEM258ENSG00000134825.91426.137001731.48350-0.279902.889901.97630K562HNRNPU
TMEM258ENSG00000134825.91856.580901490.328200.316902.561201.77110K562KIF1C
TMEM258ENSG00000134825.91803.829101426.617000.338403.051401.91090K562MAK16
TMEM258ENSG00000134825.91629.762801170.230900.477803.220702.25410K562NAA15
TMEM258ENSG00000134825.91352.60990501.077001.432509.001606.85690K562PABPN1
TMEM258ENSG00000134825.9918.013701347.74300-0.554004.918503.80950K562PCBP3
TMEM258ENSG00000134825.9679.308701033.76690-0.605807.200405.92100K562POLR2G
TMEM258ENSG00000134825.91258.22550689.514100.867603.141102.25950K562PPIG
TMEM258ENSG00000134825.91417.02510595.399801.250803.753301.96510K562PPP1R8
TMEM258ENSG00000134825.9841.09410626.151500.425702.929501.99350K562PSIP1
TMEM258ENSG00000134825.91240.033801617.86020-0.383702.614701.96630K562PTBP1
TMEM258ENSG00000134825.92076.124801392.685900.575907.010706.19190K562PUS1
TMEM258ENSG00000134825.91888.066801356.975400.476404.721803.96700K562RBM15
TMEM258ENSG00000134825.9732.48160571.434000.358102.360601.44920K562RCC2
TMEM258ENSG00000134825.91207.914701632.07500-0.434202.663201.59400K562NELFE
TMEM258ENSG00000134825.9840.748901157.26370-0.461003.030302.17480K562RPS19
TMEM258ENSG00000134825.9602.80100859.39640-0.511603.499502.36180K562RPS3
TMEM258ENSG00000134825.9602.02810921.10480-0.613506.520404.86580K562SAFB
TMEM258ENSG00000134825.9634.00040952.31840-0.587005.629803.56610K562SDAD1
TMEM258ENSG00000134825.91170.46430458.057201.353407.292205.02630K562SF1
TMEM258ENSG00000134825.9757.41210541.688500.483503.759602.51070K562SRFBP1
TMEM258ENSG00000134825.91254.954601586.15700-0.337901.982201.37160K562SRSF1
TMEM258ENSG00000134825.9769.119901176.67900-0.613408.853306.19990K562SRSF9
TMEM258ENSG00000134825.91306.36520629.389901.053404.770302.71840K562SUPT6H
TMEM258ENSG00000134825.9832.950801036.89230-0.316002.494501.71690K562SYNCRIP
TMEM258ENSG00000134825.91964.222901605.047400.291201.898501.30480K562TARDBP
TMEM258ENSG00000134825.9645.14850979.83060-0.602904.724602.35800K562TRNAU1AP
TMEM258ENSG00000134825.91313.41280619.210401.084703.761601.79400K562YTHDC2
TMEM258ENSG00000134825.9754.201001102.53080-0.547806.558903.86060K562ZNF800
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM258 is not available on ENCORE database.





1 RBPs can affect the splicing of TMEM258 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSTMEM258ENSG00000134825.9chr11-6155789461558124615578946155807461560027615600520.059000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM258 is not avaliable on ENCORE database.