TMEM106B

General Information

Gene Name       : TMEM106B
Gene ID             : ENSG00000106460.18
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM106B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM106BENSG00000106460.188.857.308.07ENCSR000AEF
HepG2TMEM106BENSG00000106460.188.0314.3411.18ENCSR985KAT
K562TMEM106BENSG00000106460.1811.4013.8012.60ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM106B is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM106B RNA is bound by 7 proteins.  







eCLIP assay for TMEM106B is not avaliable on ENCORE database.





7 proteins are bound to TMEM106B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr71227173912271780+3'-UTR4.316594.65489K562IGF2BP1
chr71227229212272475+3'-UTR5.032217.05886K562IGF2BP1
chr71227221812272260+3'-UTR4.094973.74511K562IGF2BP1
chr71227459512274651+3'-UTR4.717704.90799K562UPF1
chr71227443612274480+3'-UTR4.636044.46951K562FAM120A
chr71227466212274723+3'-UTR3.862373.53569K562LIN28B
chr71227189212271946+3'-UTR3.858773.25872K562IGF2BP1
chr71225094712250976+5'-UTR3.992633.25175K562YBX3
chr71225094812251053+5'-UTR,intron-Proximal3.126693.30188K562DDX3X
chr71225094712251101+5'-UTR,intron-Proximal3.7788811.34202HepG2DDX3X
chr71225097612251022+5'-UTR3.536098.62113K562YBX3
chr71227151812271561+CDS3.898013.86978K562YBX3
chr71225446212254511+CDS3.487995.12963K562DDX3X
chr71225460812254656+CDS,intron-Proximal4.161853.43253K562YBX3
chr71226703912267161+intron-Distal4.560456.11322HepG2HNRNPL
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM106B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM106B is not available on ENCORE database.

  • 105 RBPs can affect the levels of TMEM106B.  








The Knockdown/knockout RNA-Seq assay for TMEM106B is not available on ENCORE database.





105 RBPs can affect the gene expression of TMEM106B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM106BENSG00000106460.14868.35800605.357100.520403.080001.95500HepG2AATF
TMEM106BENSG00000106460.14598.29340767.92220-0.360102.234701.33870HepG2ADAR
TMEM106BENSG00000106460.141580.273102030.73300-0.361801.986701.52660HepG2AKAP1
TMEM106BENSG00000106460.141100.91990887.094800.311403.218602.39870HepG2AKAP8L
TMEM106BENSG00000106460.141831.085001326.692400.464803.562902.80060HepG2AUH
TMEM106BENSG00000106460.14518.33590803.56230-0.632504.250203.08640HepG2BCCIP
TMEM106BENSG00000106460.141020.37290698.264900.547204.360603.25600HepG2BCLAF1
TMEM106BENSG00000106460.141246.10090929.772500.422402.740702.14510HepG2BOP1
TMEM106BENSG00000106460.141485.01280761.173800.9641019.9176018.19760HepG2CALR
TMEM106BENSG00000106460.141073.37830853.618600.330401.924901.34030HepG2CPSF6
TMEM106BENSG00000106460.14630.65250787.48870-0.320402.585101.60430HepG2YBX3
TMEM106BENSG00000106460.14885.19280619.885000.513903.082301.62380HepG2CSTF2T
TMEM106BENSG00000106460.141379.86720988.388900.481304.467003.68520HepG2CELF1
TMEM106BENSG00000106460.14867.627201062.86040-0.292803.483102.66870HepG2DAZAP1
TMEM106BENSG00000106460.14855.00660667.728500.356602.465201.82110HepG2DDX21
TMEM106BENSG00000106460.141058.72620653.559600.695809.122507.49610HepG2DDX24
TMEM106BENSG00000106460.141381.80160969.334400.511402.292801.40560HepG2DDX59
TMEM106BENSG00000106460.141200.84900835.686400.522904.899303.57890HepG2DDX5
TMEM106BENSG00000106460.14914.658401670.80090-0.869207.552606.57720HepG2DDX6
TMEM106BENSG00000106460.141236.84090844.708500.550004.182403.38390HepG2DKC1
TMEM106BENSG00000106460.141337.116101775.62060-0.409202.329901.74130HepG2EIF4A3
TMEM106BENSG00000106460.141111.168601728.46640-0.637403.802403.00090HepG2EIF4B
TMEM106BENSG00000106460.141003.28110794.571300.336402.433101.40720HepG2ESF1
TMEM106BENSG00000106460.142221.412801523.080100.544408.375007.42660HepG2ETF1
TMEM106BENSG00000106460.14866.37870636.392900.445003.742902.44190HepG2FASTKD2
TMEM106BENSG00000106460.141432.27570926.085300.629005.567004.51210HepG2FIP1L1
TMEM106BENSG00000106460.14775.915901790.97290-1.2068012.1131010.77090HepG2FXR1
TMEM106BENSG00000106460.141200.292501661.68130-0.469303.004502.31250HepG2G3BP1
TMEM106BENSG00000106460.141530.17960983.477300.637603.623902.01300HepG2HLTF
TMEM106BENSG00000106460.141244.45160976.751100.349303.800602.73240HepG2HNRNPA2B1
TMEM106BENSG00000106460.14683.463901681.92260-1.2992014.8022013.31030HepG2HNRNPK
TMEM106BENSG00000106460.14792.15800968.21470-0.289503.198002.47720HepG2HNRNPL
TMEM106BENSG00000106460.141524.70190923.526700.723208.911907.85280HepG2HNRNPLL
TMEM106BENSG00000106460.14496.00770639.08350-0.365602.145001.30750HepG2HNRNPM
TMEM106BENSG00000106460.14675.63100862.61210-0.352503.485802.81360HepG2HNRNPU
TMEM106BENSG00000106460.141239.129601689.16640-0.447002.615201.95690HepG2IGF2BP2
TMEM106BENSG00000106460.141179.431901791.59560-0.603204.592803.75340HepG2MAGOH
TMEM106BENSG00000106460.141110.886301801.71310-0.697704.933504.11160HepG2MATR3
TMEM106BENSG00000106460.14982.98720749.710400.390703.429102.52980HepG2MSI2
TMEM106BENSG00000106460.14876.703901844.22680-1.0729010.086008.92110HepG2NCBP2
TMEM106BENSG00000106460.14453.44250725.38870-0.677802.995301.85350HepG2NONO
TMEM106BENSG00000106460.141088.79390853.847500.350603.858502.87700HepG2PARN
TMEM106BENSG00000106460.141177.403401490.04870-0.339804.440203.70160HepG2PCBP1
TMEM106BENSG00000106460.14581.11630769.38230-0.404903.703402.86250HepG2PPIL4
TMEM106BENSG00000106460.14855.07640609.552900.488203.634902.72350HepG2PRPF8
TMEM106BENSG00000106460.14761.377001516.15530-0.9937027.8246026.44130HepG2PTBP1
TMEM106BENSG00000106460.141431.713501067.919100.422807.207006.34280HepG2PUM1
TMEM106BENSG00000106460.141331.411201067.159200.319102.610301.95790HepG2PUM2
TMEM106BENSG00000106460.14399.88980899.29640-1.1692029.4794027.85560HepG2PUS1
TMEM106BENSG00000106460.141527.59750937.984400.703504.243403.37990HepG2RAVER1
TMEM106BENSG00000106460.142134.653201273.042400.7456017.9892016.90110HepG2RBM22
TMEM106BENSG00000106460.141197.794501687.35600-0.494408.398607.54840HepG2NELFE
TMEM106BENSG00000106460.141146.927801571.50510-0.454407.318906.38770HepG2RECQL
TMEM106BENSG00000106460.142107.14050921.185001.1936013.6076011.68790HepG2RPS10
TMEM106BENSG00000106460.14917.28350602.983000.605204.807203.80370HepG2RRP9
TMEM106BENSG00000106460.14576.28390768.19850-0.414704.497703.70940HepG2SAFB2
TMEM106BENSG00000106460.141207.026901578.55820-0.387105.587004.79700HepG2SF3B4
TMEM106BENSG00000106460.14750.88100895.85660-0.254702.420001.81290HepG2SMN1
TMEM106BENSG00000106460.141509.815901017.150400.569703.550502.66080HepG2SNRNP70
TMEM106BENSG00000106460.142592.724901437.906200.8504023.1712022.09000HepG2SRFBP1
TMEM106BENSG00000106460.141370.15220993.275000.464006.752705.83220HepG2SRSF5
TMEM106BENSG00000106460.141108.497701340.43910-0.274103.202102.61740HepG2SRSF9
TMEM106BENSG00000106460.141529.535201248.533300.292802.004001.54970HepG2SSB
TMEM106BENSG00000106460.14774.214401093.98040-0.498802.965301.82220HepG2STIP1
TMEM106BENSG00000106460.141450.250701129.660600.360305.014404.21950HepG2SUCLG1
TMEM106BENSG00000106460.14855.18500625.506500.451104.254103.09960HepG2SUPT6H
TMEM106BENSG00000106460.141551.28700899.885500.7856011.3380010.02000HepG2TARDBP
TMEM106BENSG00000106460.14631.41900845.67990-0.421502.648602.09380HepG2TRIM56
TMEM106BENSG00000106460.141062.14280792.318300.422703.309202.62720HepG2U2AF1
TMEM106BENSG00000106460.14320.57780464.63450-0.535403.161302.35170HepG2UCHL5
TMEM106BENSG00000106460.14370.21800720.27340-0.960204.937303.57160HepG2UPF2
TMEM106BENSG00000106460.141446.01540922.176400.648904.588502.95130HepG2XRCC5
TMEM106BENSG00000106460.14350.39370774.23310-1.1438013.4121011.83500HepG2XRN2
TMEM106BENSG00000106460.14813.02070586.255400.471705.997005.06850HepG2ZC3H8
TMEM106BENSG00000106460.141599.82220973.171600.7170020.6818019.52810HepG2ZNF622
TMEM106BENSG00000106460.141196.641601485.00110-0.311503.648203.01290K562AGGF1
TMEM106BENSG00000106460.14685.60200948.68020-0.468604.965502.89550K562AKAP1
TMEM106BENSG00000106460.141063.506701545.20270-0.539006.107805.11180K562AKAP8L
TMEM106BENSG00000106460.14829.701401313.00290-0.662208.050907.13740K562AQR
TMEM106BENSG00000106460.14269.99770382.90440-0.504002.769001.71610K562CCAR1
TMEM106BENSG00000106460.14993.026301355.58640-0.449004.224602.83650K562CPEB4
TMEM106BENSG00000106460.14535.58870781.76530-0.545605.264504.19040K562CPSF6
TMEM106BENSG00000106460.142423.582401999.529000.277402.849301.86170K562CELF1
TMEM106BENSG00000106460.14670.33040961.30850-0.520105.273003.77320K562DDX3X
TMEM106BENSG00000106460.14484.35680735.39140-0.602404.570902.41030K562DDX51
TMEM106BENSG00000106460.14784.33790974.65700-0.313402.657501.38720K562DDX6
TMEM106BENSG00000106460.14489.81180680.82920-0.475103.289302.28890K562EFTUD2
TMEM106BENSG00000106460.14703.04990876.93480-0.318802.798601.99770K562EIF3G
TMEM106BENSG00000106460.14705.358401004.35800-0.509804.763403.68650K562EIF4A3
TMEM106BENSG00000106460.14674.62830904.50550-0.423004.208102.73280K562EIF4B
TMEM106BENSG00000106460.14684.35200876.71980-0.357402.864701.54780K562EWSR1
TMEM106BENSG00000106460.14655.63210874.57830-0.415703.116802.21310K562FIP1L1
TMEM106BENSG00000106460.14907.40180697.205200.380102.368901.33730K562FKBP4
TMEM106BENSG00000106460.14560.62600795.49420-0.504803.848402.83300K562FMR1
TMEM106BENSG00000106460.14705.442201044.49480-0.566207.694006.75220K562FXR1
TMEM106BENSG00000106460.141782.977101051.590500.761606.139404.99770K562G3BP2
TMEM106BENSG00000106460.14726.491001083.10440-0.576204.602303.62870K562GRSF1
TMEM106BENSG00000106460.14381.06060802.83300-1.0751015.8462014.49980K562HNRNPC
TMEM106BENSG00000106460.14439.47000716.98800-0.706207.218705.29750K562HNRNPF
TMEM106BENSG00000106460.14954.597601238.97760-0.376202.606701.41140K562HNRNPK
TMEM106BENSG00000106460.14836.043901267.45230-0.600307.024405.25960K562HNRNPL
TMEM106BENSG00000106460.14502.08300719.35330-0.518803.446502.39760K562HNRNPM
TMEM106BENSG00000106460.14935.673301239.72730-0.405902.519501.55520K562IGF2BP2
TMEM106BENSG00000106460.14606.89300814.37680-0.424302.860001.37990K562LIN28B
TMEM106BENSG00000106460.14871.955001303.54880-0.580104.500903.42170K562MAGOH
TMEM106BENSG00000106460.141507.040801837.07040-0.285702.520401.65960K562MBNL1
TMEM106BENSG00000106460.14582.11790728.54810-0.323702.151001.37860K562METAP2
TMEM106BENSG00000106460.14662.86050874.09970-0.399104.366603.37120K562MTPAP
TMEM106BENSG00000106460.14681.756601159.95320-0.766707.429405.79410K562PCBP2
TMEM106BENSG00000106460.14670.02670992.81960-0.567305.557204.32740K562PPIG
TMEM106BENSG00000106460.14458.25190662.52600-0.531803.737602.86560K562PRPF8
TMEM106BENSG00000106460.14531.59680719.83980-0.437302.840901.92140K562PSIP1
TMEM106BENSG00000106460.14406.252201266.43120-1.6403020.4337018.70300K562PTBP1
TMEM106BENSG00000106460.14439.294801532.47620-1.8026045.5192043.23930K562PUS1
TMEM106BENSG00000106460.141187.952401493.11820-0.329903.404002.75720K562RBM15
TMEM106BENSG00000106460.14692.128801214.70810-0.811506.420405.07010K562RBM22
TMEM106BENSG00000106460.14942.444301278.20370-0.439602.543401.50030K562NELFE
TMEM106BENSG00000106460.14579.60470798.57800-0.462402.965701.92610K562RPS3
TMEM106BENSG00000106460.14843.703601093.99010-0.374803.481002.51750K562SF3B4
TMEM106BENSG00000106460.14453.86220622.65600-0.456203.179302.06160K562SRFBP1
TMEM106BENSG00000106460.14459.86820981.80920-1.0942027.4375025.05720K562SRPK2
TMEM106BENSG00000106460.14799.117901241.45250-0.635505.654904.65060K562SRSF1
TMEM106BENSG00000106460.14520.60570771.00410-0.566505.117003.60950K562SRSF4
TMEM106BENSG00000106460.14862.716601256.58670-0.542604.234803.35320K562TARDBP
TMEM106BENSG00000106460.14915.994801212.07880-0.404102.935402.08970K562TIA1
TMEM106BENSG00000106460.14522.46960692.35620-0.406202.378201.51550K562TIAL1
TMEM106BENSG00000106460.14555.06400735.62430-0.406302.918701.94260K562TRIM56
TMEM106BENSG00000106460.14842.330501029.81840-0.289902.954602.21150K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM106B is not available on ENCORE database.





2 RBPs can affect the splicing of TMEM106B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM106BENSG00000106460.14chr7+122706871227074112270014122700641227146212272715-0.087000.005260.07548excludedK562U2AF2
SETMEM106BENSG00000106460.14chr7+1225382612254020122509251225105112254434122546530.192000.002480.07930includedK562PTBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM106B is not avaliable on ENCORE database.