SPIRE1

General Information

Gene Name       : SPIRE1
Gene ID             : ENSG00000134278.15
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SPIRE1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SPIRE1ENSG00000134278.154.615.174.89ENCSR000AEF
HepG2SPIRE1ENSG00000134278.159.458.438.94ENCSR985KAT
K562SPIRE1ENSG00000134278.158.889.129.00ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SPIRE1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SPIRE1 RNA is bound by 15 proteins.  







eCLIP assay for SPIRE1 is not avaliable on ENCORE database.





15 proteins are bound to SPIRE1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr181244913512449234-3'-UTR,intron-Distal4.161854.95438K562YBX3
chr181265787512657938-5'-UTR,intron-Distal,intron-Proximal4.267184.38106HepG2PPIG
chr181253537512535489-CDS,intron-Distal,intron-Proximal3.881263.92684K562KHSRP
chr181247983312479933-CDS,intron-Distal,intron-Proximal3.455413.91876HepG2U2AF2
chr181246331412463412-CDS,intron-Distal,intron-Proximal4.379544.75655HepG2PRPF8
chr181253552612535616-CDS,intron-Distal,intron-Proximal3.006213.01994K562BUD13
chr181247877412478832-intron-Distal3.944227.55718K562HNRNPL
chr181247822812478306-intron-Distal4.567408.18013HepG2HNRNPL
chr181247817612478228-intron-Distal4.809206.36545HepG2HNRNPL
chr181248168612481744-intron-Distal5.388538.16423HepG2U2AF2
chr181247831712478364-intron-Distal3.527723.65621HepG2HNRNPL
chr181249139412491485-intron-Distal4.001244.31512K562KHSRP
chr181248149712481583-intron-Distal5.0200511.62651HepG2U2AF2
chr181265560312655696-intron-Distal4.304824.48623K562EXOSC5
chr181247876812478812-intron-Distal5.7948013.38324K562AGGF1
chr181247838412478406-intron-Distal5.043697.12139K562AGGF1
chr181259357912593674-intron-Distal4.525415.30668HepG2RBFOX2
chr181265312712653257-intron-Distal,intron-Proximal4.394364.28571K562HNRNPM
chr181247819012478302-intron-Distal6.0573848.30814K562AGGF1
chr181260633212606396-intron-Distal4.536755.04769HepG2PTBP1
chr181260633612606402-intron-Distal5.082345.89856K562PTBP1
chr181247818012478228-intron-Distal5.2159011.16731K562HNRNPL
chr181264043112640511-intron-Distal4.680545.18111K562CSTF2T
chr181247824012478317-intron-Distal4.152383.77360K562GTF2F1
chr181247799512478092-intron-Distal4.767236.58335HepG2QKI
chr181247883212478896-intron-Distal5.4672912.49233K562HNRNPL
chr181247822712478284-intron-Distal4.579875.38480HepG2AGGF1
chr181247846012478499-intron-Distal4.2508010.16849K562AGGF1
chr181247822812478314-intron-Distal6.2125722.39437K562HNRNPL
chr181261622612616301-intron-Distal4.796764.40618K562PTBP1
chr181247883312478891-intron-Distal4.8334017.58670K562AGGF1
chr181248149112481572-intron-Distal4.024605.39628K562PTBP1
chr181247831412478361-intron-Distal3.200846.25504K562HNRNPL
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SPIRE1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SPIRE1 is not available on ENCORE database.

  • 96 RBPs can affect the levels of SPIRE1.  








The Knockdown/knockout RNA-Seq assay for SPIRE1 is not available on ENCORE database.





96 RBPs can affect the gene expression of SPIRE1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SPIRE1ENSG00000134278.10480.06370357.437000.425402.382601.38440HepG2AATF
SPIRE1ENSG00000134278.10726.17340471.981300.621508.616907.66570HepG2ACO1
SPIRE1ENSG00000134278.101277.29580596.170001.0992013.6634012.57340HepG2AKAP1
SPIRE1ENSG00000134278.10907.69630561.443200.693006.052004.54320HepG2AKAP8
SPIRE1ENSG00000134278.10731.57010474.178200.625508.178106.94460HepG2AKAP8L
SPIRE1ENSG00000134278.101062.49200701.581800.598706.675705.68130HepG2AUH
SPIRE1ENSG00000134278.10314.35690480.11840-0.611003.522702.46720HepG2BCCIP
SPIRE1ENSG00000134278.10213.63700417.16940-0.965507.361205.97610HepG2BCLAF1
SPIRE1ENSG00000134278.10788.29610561.958100.488204.575903.61350HepG2CALR
SPIRE1ENSG00000134278.10897.54940548.430500.710604.322703.36170HepG2CNOT7
SPIRE1ENSG00000134278.10302.09880466.36700-0.626405.326003.91400HepG2YBX3
SPIRE1ENSG00000134278.10876.79520604.207200.537106.477905.57310HepG2CELF1
SPIRE1ENSG00000134278.10184.02580357.58110-0.958407.593105.47270HepG2DDX28
SPIRE1ENSG00000134278.101180.79230571.132001.0478014.1282012.82330HepG2DDX3X
SPIRE1ENSG00000134278.101237.17640691.679000.838805.498504.13530HepG2DDX59
SPIRE1ENSG00000134278.101736.85620490.505301.8240037.9046036.00940HepG2DDX6
SPIRE1ENSG00000134278.10332.34210441.67750-0.410302.309601.41510HepG2DHX30
SPIRE1ENSG00000134278.10325.16280453.89580-0.481204.323403.54110HepG2DNAJC2
SPIRE1ENSG00000134278.10678.78670471.642800.525203.532002.86640HepG2EIF2S1
SPIRE1ENSG00000134278.10646.75360463.639800.480103.904802.51940HepG2EIF2S2
SPIRE1ENSG00000134278.10520.93480347.594900.583603.574402.55460HepG2EIF3D
SPIRE1ENSG00000134278.10371.70580521.27300-0.487902.583301.96470HepG2EIF4A3
SPIRE1ENSG00000134278.10992.73990507.432600.968105.556604.60430HepG2EIF4B
SPIRE1ENSG00000134278.101529.52870805.483000.9251025.0373023.53930HepG2ETF1
SPIRE1ENSG00000134278.10690.21990461.188000.581602.231301.48200HepG2EWSR1
SPIRE1ENSG00000134278.10998.56590617.118400.694205.710504.64330HepG2FIP1L1
SPIRE1ENSG00000134278.10643.81250487.825300.400202.238001.63650HepG2G3BP1
SPIRE1ENSG00000134278.10231.89010378.10500-0.705303.830001.61050HepG2GRWD1
SPIRE1ENSG00000134278.10714.19610462.320000.627305.518004.64900HepG2HNRNPA1
SPIRE1ENSG00000134278.10220.58480514.24780-1.2211013.6761012.24610HepG2HNRNPC
SPIRE1ENSG00000134278.10382.65610659.00090-0.784203.523702.82320HepG2HNRNPLL
SPIRE1ENSG00000134278.10547.54370425.811400.362702.223101.37020HepG2HNRNPM
SPIRE1ENSG00000134278.10344.89340510.84770-0.566705.638804.79930HepG2HNRNPU
SPIRE1ENSG00000134278.10908.14680611.428900.570603.865702.40840HepG2HSPD1
SPIRE1ENSG00000134278.10850.84730495.893400.778807.866106.78780HepG2IGF2BP2
SPIRE1ENSG00000134278.10837.16380465.255300.847403.195902.13510HepG2IGF2BP3
SPIRE1ENSG00000134278.10383.61860521.81370-0.443904.222003.33520HepG2ILF2
SPIRE1ENSG00000134278.101297.88140853.885800.603904.550803.47650HepG2LARP4
SPIRE1ENSG00000134278.10796.28200499.496900.672707.170205.92660HepG2MSI2
SPIRE1ENSG00000134278.10437.99880671.91910-0.617402.579001.64770HepG2MTPAP
SPIRE1ENSG00000134278.10861.01230541.417100.669205.702404.80810HepG2NCBP2
SPIRE1ENSG00000134278.10829.20440579.367800.517102.968601.48450HepG2NKRF
SPIRE1ENSG00000134278.101088.52060501.237801.118709.102807.45040HepG2PABPC1
SPIRE1ENSG00000134278.10680.20410482.263300.496002.425801.74620HepG2PABPC4
SPIRE1ENSG00000134278.10757.11820455.970900.731508.764107.78280HepG2PCBP1
SPIRE1ENSG00000134278.10739.57410533.096500.472202.331101.37500HepG2PCBP2
SPIRE1ENSG00000134278.10354.01790455.63500-0.364102.335301.65240HepG2PPIL4
SPIRE1ENSG00000134278.10530.10760364.115600.541803.172302.31330HepG2PRPF8
SPIRE1ENSG00000134278.10691.90890463.918900.576604.330503.67920HepG2PTBP1
SPIRE1ENSG00000134278.10414.56440614.99580-0.569004.830504.06990HepG2PUF60
SPIRE1ENSG00000134278.10396.67180652.82490-0.7188011.0752010.05550HepG2PUM1
SPIRE1ENSG00000134278.10680.42570502.539000.437103.126002.46880HepG2QKI
SPIRE1ENSG00000134278.101186.67900514.513201.2055010.249908.95550HepG2RAVER1
SPIRE1ENSG00000134278.10819.01960615.753900.411403.512402.55640HepG2RBM15
SPIRE1ENSG00000134278.10930.51900673.240300.466805.048004.40120HepG2RBM22
SPIRE1ENSG00000134278.10584.71160456.047400.358402.031401.44810HepG2RBM25
SPIRE1ENSG00000134278.101371.56540751.770100.867405.813504.87490HepG2RPLP0
SPIRE1ENSG00000134278.10484.08050338.248500.517103.522502.83740HepG2RPS19
SPIRE1ENSG00000134278.10660.35290443.737600.573404.666003.64220HepG2RPS2
SPIRE1ENSG00000134278.10654.27860452.931400.530504.098502.77770HepG2RPS5
SPIRE1ENSG00000134278.10691.79750360.181400.941508.451707.17670HepG2RRP9
SPIRE1ENSG00000134278.10318.62400454.93120-0.513804.383403.60540HepG2SAFB2
SPIRE1ENSG00000134278.10912.85850535.826000.768505.891904.88360HepG2SF3A3
SPIRE1ENSG00000134278.10661.47570483.086400.453303.453902.80250HepG2SF3B4
SPIRE1ENSG00000134278.10488.15630589.64340-0.272502.021701.40450HepG2SLBP
SPIRE1ENSG00000134278.102247.45130760.410101.5633083.5760081.81210HepG2SRFBP1
SPIRE1ENSG00000134278.10750.53350504.202100.573805.656705.04040HepG2SRSF1
SPIRE1ENSG00000134278.10392.15020607.19440-0.630807.287606.33780HepG2SRSF5
SPIRE1ENSG00000134278.101151.16110410.164701.4887042.5166040.86040HepG2SRSF9
SPIRE1ENSG00000134278.10474.66560660.23330-0.476104.761504.12480HepG2SSB
SPIRE1ENSG00000134278.10718.41410478.951400.584803.858502.53850HepG2STIP1
SPIRE1ENSG00000134278.10720.71630480.807800.583903.021801.76230HepG2SUB1
SPIRE1ENSG00000134278.10648.95660453.098000.518203.164302.57040HepG2TAF15
SPIRE1ENSG00000134278.10548.55890416.439900.397402.532101.73000HepG2TIA1
SPIRE1ENSG00000134278.10277.47920500.82190-0.8519010.926509.91640HepG2TRIM56
SPIRE1ENSG00000134278.10994.43190527.928400.9134011.234109.94600HepG2U2AF1
SPIRE1ENSG00000134278.101101.07180589.050300.902302.593001.63930HepG2U2AF2
SPIRE1ENSG00000134278.10866.72930635.906700.446702.420201.64140HepG2UBE2L3
SPIRE1ENSG00000134278.10334.19600462.58520-0.469002.481401.79140HepG2XRN2
SPIRE1ENSG00000134278.10865.89180522.624200.7283013.7794012.79240HepG2ZNF622
SPIRE1ENSG00000134278.10615.31870882.98660-0.521106.485205.66870K562AGGF1
SPIRE1ENSG00000134278.10624.61780918.77320-0.556705.425104.49280K562AKAP8L
SPIRE1ENSG00000134278.10656.913001012.46190-0.624106.353805.52530K562AQR
SPIRE1ENSG00000134278.10646.61800963.98700-0.576107.641106.00500K562ATP5C1
SPIRE1ENSG00000134278.10345.11040509.56540-0.562203.862102.71560K562BCLAF1
SPIRE1ENSG00000134278.101220.51970993.762100.296403.018102.34090K562DDX47
SPIRE1ENSG00000134278.10584.06290770.51140-0.399702.799601.94580K562FIP1L1
SPIRE1ENSG00000134278.10398.00970610.87220-0.618104.914303.85920K562GPKOW
SPIRE1ENSG00000134278.10697.67090906.19760-0.377302.885202.11560K562GRSF1
SPIRE1ENSG00000134278.10274.83480454.82290-0.726705.836502.99580K562GRWD1
SPIRE1ENSG00000134278.10158.18870523.23980-1.7258025.8139024.07360K562HNRNPC
SPIRE1ENSG00000134278.10463.20950633.73530-0.452202.635701.72910K562HNRNPM
SPIRE1ENSG00000134278.10756.61130975.09850-0.366002.724801.90650K562KIF1C
SPIRE1ENSG00000134278.10453.03540647.73110-0.515804.459203.26150K562MATR3
SPIRE1ENSG00000134278.10336.38850639.19480-0.926104.491103.14690K562PABPN1
SPIRE1ENSG00000134278.10673.05350874.65210-0.378002.644301.84610K562PPIG
SPIRE1ENSG00000134278.10284.04890500.87550-0.818306.443005.29890K562PRPF8
SPIRE1ENSG00000134278.10291.28220469.14980-0.687604.959903.70140K562PSIP1
SPIRE1ENSG00000134278.101020.466101333.78640-0.386302.939802.09850K562PUF60
SPIRE1ENSG00000134278.101014.509701418.43860-0.483505.552303.99930K562PUM1
SPIRE1ENSG00000134278.101127.752501390.04680-0.301702.185701.33100K562PUM2
SPIRE1ENSG00000134278.10484.93920911.27400-0.9101011.7064010.63770K562PUS1
SPIRE1ENSG00000134278.10679.51820887.81380-0.385703.549302.89150K562RBM15
SPIRE1ENSG00000134278.10422.52210604.71610-0.517203.963602.94080K562RBM22
SPIRE1ENSG00000134278.10536.25780378.823600.501302.874101.85160K562RPS3
SPIRE1ENSG00000134278.10493.78600618.13430-0.324001.963401.35490K562SRSF1
SPIRE1ENSG00000134278.10444.93930583.73530-0.391702.423901.45120K562SRSF5
SPIRE1ENSG00000134278.10318.67580451.23750-0.501802.756301.82200K562TIAL1
SPIRE1ENSG00000134278.10282.20660479.43790-0.764606.267904.71010K562TRIM56
SPIRE1ENSG00000134278.10898.932401140.52390-0.343402.638201.79830K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SPIRE1 is not available on ENCORE database.





7 RBPs can affect the splicing of SPIRE1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESPIRE1ENSG00000134278.10chr18-124597531245992712454344124544821246334912463492-0.264000.000620.04160excludedHepG2RBM22
SESPIRE1ENSG00000134278.10chr18-124522531245239012449666124498951245248312452511-0.272000.005940.08659excludedHepG2U2AF1
SESPIRE1ENSG00000134278.10chr18-124597531245992712454344124544821246334912463492-0.299000.000450.00716excludedHepG2U2AF2
SESPIRE1ENSG00000134278.10chr18-124597531245992712454344124544821246334912463492-0.391000.000550.04239excludedHepG2HNRNPL
SESPIRE1ENSG00000134278.10chr18-1248595712485999124796971247987012493070124932000.398000.000160.01040includedHepG2SF3B4
A3SSSPIRE1ENSG00000134278.10chr18-1245975312459987124597531245992712463349124634920.159000.019630.09387longerK562AQR
MXESPIRE1ENSG00000134278.10chr18-1250647512506640125124521251253012496014124961011253547412535600-0.176000.003400.042282includedK562DROSHA
MXESPIRE1ENSG00000134278.10chr18-1249601412496101125124521251253012493070124932001253547412535600-0.157000.004470.027852includedHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SPIRE1 is not avaliable on ENCORE database.