PPP1CA

General Information

Gene Name       : PPP1CA
Gene ID             : ENSG00000172531.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PPP1CA)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PPP1CAENSG00000172531.1480.74137.79109.26ENCSR000AEF
HepG2PPP1CAENSG00000172531.14136.8294.18115.50ENCSR985KAT
K562PPP1CAENSG00000172531.14183.07138.16160.62ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
PPP1CA293TshRNABG293LV05-9,BG293LV05-10BG293LV05-1,BG293LV05-2NotSatisfiedENCORE2
PPP1CA293TshRNAPPP1CA-BG293LV05-11,PPP1CA-BG293LV05-12NT-BG293LV05-1,NT-BG293LV05-2,SubmittingENCORE2
PPP1CA293TshRNAPPP1CA-BG293LV06-57,PPP1CA-BG293LV06-58NT-BG293LV06-1,NT-BG293LV06-2,SequencedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PPP1CA is not avaliable on ENCORE database.



Proteins bound to RNA
  • PPP1CA RNA is bound by 23 proteins.  







eCLIP assay for PPP1CA is not avaliable on ENCORE database.





23 proteins are bound to PPP1CA RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr116716581167165860-3'-UTR,intron-Distal,intron-Proximal3.5943611.31612HepG2SUB1
chr116716586967165961-3'-UTR,intron-Distal,intron-Proximal4.0548916.07524K562PUM2
chr116716574367165784-3'-UTR,intron-Distal6.25122400.00000K562PABPC4
chr116716580967165860-3'-UTR,intron-Distal,intron-Proximal6.00146400.00000K562PABPC4
chr116716599467166062-3'-UTR,CDS,intron-Distal,intron-Proximal3.448927.82548HepG2LARP4
chr116716569867165730-3'-UTR,intron-Distal5.7727221.03703K562PABPC4
chr116716582367165853-3'-UTR,intron-Distal,intron-Proximal4.2170245.02841K562TIA1
chr116716578567165862-3'-UTR,intron-Distal,intron-Proximal4.3455910.75303HepG2TIAL1
chr116716579367165823-3'-UTR,intron-Distal,intron-Proximal4.0487551.52850K562TIA1
chr116716568467165727-3'-UTR,intron-Distal3.413853.66308K562UPF1
chr116716578467165809-3'-UTR,intron-Distal,intron-Proximal5.29781400.00000K562PABPC4
chr116716576267165860-3'-UTR,intron-Distal,intron-Proximal4.015753.84801HepG2TIA1
chr116716575767165860-3'-UTR,intron-Distal,intron-Proximal4.1538620.22128K562DDX6
chr116716575867165861-3'-UTR,intron-Distal,intron-Proximal3.9557125.17124HepG2DDX55
chr116716596467166083-3'-UTR,CDS,intron-Distal,intron-Proximal3.336458.84609K562IGF2BP2
chr116716575267165863-3'-UTR,intron-Distal,intron-Proximal4.9527314.84455HepG2UPF1
chr116716572967165793-3'-UTR,intron-Distal3.2013629.31539K562TIA1
chr116716570667165729-3'-UTR,intron-Distal3.919934.08867HepG2LARP4
chr116716579667165861-3'-UTR,intron-Distal,intron-Proximal4.1970930.16580HepG2LARP4
chr116716568267165749-3'-UTR,intron-Distal3.384818.44052K562IGF2BP2
chr116716574767165785-3'-UTR,intron-Distal4.271968.81208HepG2LARP4
chr116716569267165752-3'-UTR,intron-Distal4.532445.35992HepG2UPF1
chr116716578167165861-3'-UTR,intron-Distal,intron-Proximal3.6217033.94661K562DDX55
chr116716573067165743-3'-UTR,intron-Distal6.4784017.39935K562PABPC4
chr116716577467165863-3'-UTR,intron-Distal,intron-Proximal3.313683.40391K562XRCC6
chr116716922867169296-5'-UTR,CDS,intron-Distal,intron-Proximal3.032393.70975K562UCHL5
chr116716923367169310-5'-UTR,CDS,intron-Distal,intron-Proximal5.1579839.05746K562DDX3X
chr116716924167169327-5'-UTR,CDS,intron-Distal,intron-Proximal5.3297232.02124HepG2DDX3X
chr116716824367168315-CDS,intron-Distal,intron-Proximal3.907845.68852HepG2RPS3
chr116716820467168229-CDS,intron-Distal,intron-Proximal3.5242910.70078K562YBX3
chr116716922467169233-CDS,intron-Distal4.764657.17614K562YBX3
chr116716918967169205-CDS,intron-Distal3.276596.92749HepG2PRPF8
chr116716816067168331-CDS,intron-Distal,intron-Proximal3.096786.23329K562METAP2
chr116716712467167136-CDS,intron-Distal,intron-Proximal3.433246.74819K562YBX3
chr116716642567166489-CDS,intron-Distal,intron-Proximal4.545155.50717HepG2G3BP1
chr116716704967167118-CDS,intron-Distal,intron-Proximal4.1413917.20665K562YBX3
chr116716864267168671-CDS,intron-Distal,intron-Proximal3.9260918.63496K562DDX3X
chr116716658667166635-CDS,intron-Distal,intron-Proximal3.284423.97184HepG2G3BP1
chr116716636967166417-CDS,intron-Distal,intron-Proximal4.438587.13970HepG2PRPF8
chr116716604867166083-CDS,intron-Distal,intron-Proximal3.119575.56979K562YBX3
chr116716853867168544-CDS,intron-Distal,intron-Proximal4.082036.64581K562YBX3
chr116716611967166198-CDS,intron-Distal,intron-Proximal4.6976511.05644K562PRPF8
chr116716854467168583-CDS,intron-Distal4.7485411.17637K562YBX3
chr116716919867169224-CDS,intron-Distal4.1795611.47083K562YBX3
chr116716615367166214-CDS,intron-Distal,intron-Proximal5.2099420.81882HepG2PRPF8
chr116716865767168670-CDS,intron-Distal4.284408.79526K562YBX3
chr116716837067168390-CDS,intron-Distal3.376017.04063K562YBX3
chr116716630667166384-CDS,intron-Distal,intron-Proximal3.091263.13970HepG2SF3B4
chr116716817667168190-CDS,intron-Distal,intron-Proximal5.2914120.24766K562YBX3
chr116716860767168631-CDS,intron-Distal3.6714610.24124K562DDX3X
chr116716661767166692-CDS,intron-Distal,intron-Proximal4.772785.32906HepG2AQR
chr116716659967166654-CDS,intron-Distal,intron-Proximal4.319795.97994K562AQR
chr116716831867168370-CDS,intron-Distal,intron-Proximal3.058979.49655K562YBX3
chr116716915967169200-CDS,intron-Distal,intron-Proximal5.4447610.58731HepG2AQR
chr116716701167167033-CDS,intron-Distal,intron-Proximal3.176733.07246K562AQR
chr116716919767169233-CDS,intron-Distal4.2112224.68994K562DDX3X
chr116716643767166479-CDS,intron-Distal3.743863.05875K562RBM15
chr116716651367166565-CDS,intron-Distal3.706354.69290HepG2RPS3
chr116716815967168176-CDS,intron-Distal,intron-Proximal4.7681023.44458K562YBX3
chr116716819167168204-CDS,intron-Distal4.4298415.54756K562YBX3
chr116716866067168671-CDS,intron-Distal,intron-Proximal4.672956.16046K562LIN28B
chr116716661367166634-CDS,intron-Distal3.632568.67507K562YBX3
chr116716661567166697-CDS,intron-Distal,intron-Proximal4.911834.22343HepG2XPO5
chr116716827567168318-CDS,intron-Distal,intron-Proximal3.0565614.64966K562YBX3
chr116716919867169236-CDS,intron-Distal4.676295.91381K562LIN28B
chr116716915567169171-intron-Distal,intron-Proximal4.333656.80869K562AQR
chr116716692067167011-intron-Distal,intron-Proximal3.725104.38107K562AQR
chr116716919067169198-intron-Distal4.391968.29266K562AQR
chr116716915267169189-intron-Distal,intron-Proximal3.285896.92749HepG2PRPF8
chr116716798567168047-intron-Distal3.780315.97302HepG2XPO5
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PPP1CA is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PPP1CA is not available on ENCORE database.

  • 87 RBPs can affect the levels of PPP1CA.  








The Knockdown/knockout RNA-Seq assay for PPP1CA is not available on ENCORE database.





87 RBPs can affect the gene expression of PPP1CA :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PPP1CAENSG00000172531.103431.236302760.790200.313501.941401.48670HepG2AKAP1
PPP1CAENSG00000172531.101676.854102284.20600-0.445903.968503.03490HepG2ASCC1
PPP1CAENSG00000172531.102027.864901522.371700.413502.253101.41230HepG2BCCIP
PPP1CAENSG00000172531.101674.890602029.55980-0.277102.063301.54090HepG2BOP1
PPP1CAENSG00000172531.102023.878901091.968000.890107.446506.20060HepG2CNOT7
PPP1CAENSG00000172531.101140.881201863.26660-0.707709.294008.10750HepG2CPSF6
PPP1CAENSG00000172531.102672.672202358.159800.180501.919901.36550HepG2CELF1
PPP1CAENSG00000172531.101584.399201285.674000.301303.179201.94300HepG2DDX1
PPP1CAENSG00000172531.101156.083901526.58500-0.401103.672802.90000HepG2DDX21
PPP1CAENSG00000172531.101009.851901494.77230-0.565807.347005.87000HepG2DDX24
PPP1CAENSG00000172531.101021.641201400.34400-0.454902.990301.65380HepG2DDX27
PPP1CAENSG00000172531.101677.388302272.16290-0.437802.481501.89460HepG2DDX6
PPP1CAENSG00000172531.101689.651101957.72740-0.212502.255201.63340HepG2DKC1
PPP1CAENSG00000172531.101739.376902412.96690-0.472203.883303.13050HepG2EIF4A3
PPP1CAENSG00000172531.101760.143302349.89950-0.416902.498001.84240HepG2EIF4B
PPP1CAENSG00000172531.101957.172802501.49690-0.354005.332304.23300HepG2EIF4G1
PPP1CAENSG00000172531.101967.861402396.23820-0.284102.044701.33710HepG2EIF4G2
PPP1CAENSG00000172531.101750.336102235.89300-0.353203.193502.02280HepG2ESF1
PPP1CAENSG00000172531.102777.954103295.50780-0.246503.741703.05990HepG2ETF1
PPP1CAENSG00000172531.101143.461001455.24930-0.347903.017801.82640HepG2FASTKD2
PPP1CAENSG00000172531.101413.715001722.38530-0.284902.286001.56590HepG2FUBP3
PPP1CAENSG00000172531.101666.294702112.21290-0.342102.282801.69860HepG2GPKOW
PPP1CAENSG00000172531.101886.377802330.18880-0.304804.035202.93970HepG2HNRNPA2B1
PPP1CAENSG00000172531.101020.381201415.71470-0.472404.606503.72670HepG2HNRNPC
PPP1CAENSG00000172531.101081.681202015.71870-0.8980013.8561012.59410HepG2HNRNPLL
PPP1CAENSG00000172531.101634.051101436.536600.185802.036801.39650HepG2ILF2
PPP1CAENSG00000172531.101651.035502309.51640-0.484203.508102.36130HepG2KHSRP
PPP1CAENSG00000172531.101655.618102436.28890-0.557305.757504.82200HepG2MAGOH
PPP1CAENSG00000172531.101102.219701787.28020-0.697409.345108.03050HepG2NSUN2
PPP1CAENSG00000172531.101393.24030998.248700.480902.251201.46490HepG2PABPC1
PPP1CAENSG00000172531.101451.941902232.46700-0.620706.765905.64490HepG2PABPC4
PPP1CAENSG00000172531.101687.881702369.49870-0.4894010.455009.39700HepG2PCBP1
PPP1CAENSG00000172531.101646.656902051.53840-0.317204.349103.40380HepG2PRPF4
PPP1CAENSG00000172531.101869.034002411.00890-0.367306.250705.49330HepG2PTBP1
PPP1CAENSG00000172531.101842.631002084.26580-0.177801.923901.39070HepG2PUS1
PPP1CAENSG00000172531.101973.297202611.27740-0.404105.884405.02150HepG2QKI
PPP1CAENSG00000172531.101578.982102754.41630-0.8028021.9919020.81310HepG2RBM22
PPP1CAENSG00000172531.101587.434502369.86610-0.578106.490205.49750HepG2RBM25
PPP1CAENSG00000172531.102135.312302683.25850-0.329505.347304.63510HepG2NELFE
PPP1CAENSG00000172531.101894.554702499.02330-0.399507.368906.43520HepG2RECQL
PPP1CAENSG00000172531.101448.228701252.398900.209502.171901.58880HepG2SAFB2
PPP1CAENSG00000172531.101764.677702510.25160-0.5084011.2912010.22110HepG2SF3B4
PPP1CAENSG00000172531.101534.466602219.99300-0.532803.324702.46460HepG2SNRNP70
PPP1CAENSG00000172531.101836.137203110.97930-0.7607027.7417026.58560HepG2SRFBP1
PPP1CAENSG00000172531.101979.580002620.12650-0.404408.049407.33970HepG2SRSF1
PPP1CAENSG00000172531.101728.747602131.58430-0.302204.653503.97210HepG2SRSF9
PPP1CAENSG00000172531.102248.863402701.00980-0.264304.006303.41370HepG2SSB
PPP1CAENSG00000172531.101136.110301489.99010-0.391202.477701.83340HepG2SUPV3L1
PPP1CAENSG00000172531.101295.718702354.98110-0.8620023.4952022.08400HepG2TAF15
PPP1CAENSG00000172531.101550.526102164.00310-0.480906.679405.38410HepG2TIA1
PPP1CAENSG00000172531.101627.133401378.758200.238902.607902.05690HepG2TRIM56
PPP1CAENSG00000172531.101199.259801466.73680-0.290501.954401.33740HepG2XRN2
PPP1CAENSG00000172531.101173.567302024.56110-0.7867026.0769024.39650HepG2ZC3H8
PPP1CAENSG00000172531.102739.177702158.857000.343407.643306.85110HepG2ZNF622
PPP1CAENSG00000172531.103749.339402989.721300.326505.886405.10790K562AGGF1
PPP1CAENSG00000172531.103729.465203110.921700.261502.162101.58180K562AKAP8L
PPP1CAENSG00000172531.102486.734103622.76240-0.542805.524604.74440K562AQR
PPP1CAENSG00000172531.101561.529702173.75680-0.477203.207902.26680K562BOP1
PPP1CAENSG00000172531.101838.838302311.40420-0.330002.993102.17740K562CPSF6
PPP1CAENSG00000172531.104434.520205476.95710-0.304603.817702.66290K562CELF1
PPP1CAENSG00000172531.104167.168603205.117100.378605.607804.63690K562EIF2S2
PPP1CAENSG00000172531.101473.191101108.307900.410504.867903.82780K562EIF3G
PPP1CAENSG00000172531.101414.546801729.02050-0.289602.250101.50780K562EIF4A3
PPP1CAENSG00000172531.103818.791904454.31540-0.222102.792101.85030K562EIF4G2
PPP1CAENSG00000172531.103551.641502456.471500.531807.058005.64520K562FIP1L1
PPP1CAENSG00000172531.102316.097201798.101700.365105.292604.49260K562FXR1
PPP1CAENSG00000172531.10372.713701024.63900-1.4590012.3022010.58890K562G3BP2
PPP1CAENSG00000172531.102331.139202922.86140-0.326304.264802.85590K562GLRX3
PPP1CAENSG00000172531.102429.665203097.56960-0.350402.541601.51140K562HNRNPA1
PPP1CAENSG00000172531.101464.208202040.77840-0.479005.878705.03980K562HNRNPC
PPP1CAENSG00000172531.102614.283802020.602400.371502.809801.87270K562HNRNPM
PPP1CAENSG00000172531.104413.757803330.286200.406304.491703.48370K562HSPD1
PPP1CAENSG00000172531.102080.640201550.355600.424302.394901.46060K562IGF2BP2
PPP1CAENSG00000172531.101976.938601576.531700.326402.801601.60070K562IGF2BP3
PPP1CAENSG00000172531.101307.208801884.24200-0.527503.855602.73960K562KRR1
PPP1CAENSG00000172531.101974.774001624.948300.281202.439701.57880K562MATR3
PPP1CAENSG00000172531.102330.351203073.03900-0.399108.189306.86800K562MTPAP
PPP1CAENSG00000172531.102620.811803414.24600-0.3816010.655009.32000K562NSUN2
PPP1CAENSG00000172531.102485.631203758.34210-0.596506.722605.42490K562PCBP3
PPP1CAENSG00000172531.102068.938402882.77250-0.478607.011705.74530K562POLR2G
PPP1CAENSG00000172531.104003.829302788.753400.521706.620605.25560K562PPIG
PPP1CAENSG00000172531.102283.719501864.452300.292502.130501.46900K562PRPF8
PPP1CAENSG00000172531.102369.889401582.163100.582809.309008.13920K562PTBP1
PPP1CAENSG00000172531.103913.240003085.315600.342801.830101.36980K562PUS1
PPP1CAENSG00000172531.103811.545103006.063500.342404.913904.14420K562RBM15
PPP1CAENSG00000172531.101977.132401478.778100.418903.634701.97180K562RBM34
PPP1CAENSG00000172531.101718.290301144.912600.585603.007901.95950K562RPS3
PPP1CAENSG00000172531.101511.311501906.30390-0.335002.581301.36580K562SLBP
PPP1CAENSG00000172531.102758.693803451.89490-0.323406.453405.09480K562SRPK2
PPP1CAENSG00000172531.101385.358501105.136800.325902.644801.62150K562SRSF4
PPP1CAENSG00000172531.102590.177503222.87020-0.315302.629901.31170K562SSRP1
PPP1CAENSG00000172531.101432.659301804.90370-0.333202.235001.32730K562SUPV3L1
PPP1CAENSG00000172531.102343.659101569.637400.578204.587903.67100K562TARDBP
PPP1CAENSG00000172531.102090.825101514.153800.465505.366604.17060K562TIA1
PPP1CAENSG00000172531.102022.378501486.387400.444103.251202.05030K562TRA2A
PPP1CAENSG00000172531.10727.655701025.14670-0.494503.594202.67730K562U2AF2
PPP1CAENSG00000172531.103072.562403620.21140-0.236603.466402.66790K562UPF1
PPP1CAENSG00000172531.102460.349603097.67770-0.332303.530702.54370K562WDR3
PPP1CAENSG00000172531.103145.281004081.52970-0.375903.830602.78470K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PPP1CA is not available on ENCORE database.





14 RBPs can affect the splicing of PPP1CA :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPPP1CAENSG00000172531.10chr11-671685386716870367168159671683906716919867169264-0.073000.000130.00380excludedK562SRSF1
SEPPP1CAENSG00000172531.10chr11-6716853867168703671681596716839067169198671692640.079000.000000.00018includedHepG2AKAP1
SEPPP1CAENSG00000172531.10chr11-671685386716870367168174671683906716919867169264-0.080000.000040.00711excludedHepG2SRSF7
SEPPP1CAENSG00000172531.10chr11-671685386716870367168159671683906716919867169264-0.142000.000110.02993excludedHepG2UCHL5
SEPPP1CAENSG00000172531.10chr11-671685386716870367168159671683906716919867169264-0.079000.000050.00686excludedK562SUPV3L1
SEPPP1CAENSG00000172531.10chr11-671685386716870367168159671683906716919867169264-0.069000.000030.01003excludedK562NSUN2
SEPPP1CAENSG00000172531.10chr11-6716853867168670671681596716839067169198671692590.056000.000000.00075includedHepG2SFPQ
SEPPP1CAENSG00000172531.10chr11-671685386716870367168159671683906716919867169264-0.063000.000140.02957excludedK562UPF1
SEPPP1CAENSG00000172531.10chr11-6716853867168703671681596716839067169198671692640.081000.000960.08427includedHepG2TAF15
SEPPP1CAENSG00000172531.10chr11-671685386716870367168159671683906716919867169264-0.056000.000080.01727excludedK562ZC3H8
SEPPP1CAENSG00000172531.10chr11-671685386716870367168174671683906716919867169264-0.069000.000010.03619excludedK562CPEB4
RIPPP1CAENSG00000172531.10chr11-6716619267166634671661926716632767166410671666340.089000.000000.00000includedK562AQR
MXEPPP1CAENSG00000172531.10chr11-6716703167167136671681596716839067166410671666346716853867168670-0.089000.000570.042852includedHepG2NOL12
MXEPPP1CAENSG00000172531.10chr11-67166410671666346716703167167136671661926716632767168159671683900.111000.000380.045621includedK562FMR1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PPP1CA is not avaliable on ENCORE database.