PLCB3

General Information

Gene Name       : PLCB3
Gene ID             : ENSG00000149782.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PLCB3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PLCB3ENSG00000149782.110.682.451.57ENCSR000AEF
HepG2PLCB3ENSG00000149782.1114.295.279.78ENCSR985KAT
K562PLCB3ENSG00000149782.1117.2510.7914.02ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PLCB3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PLCB3 RNA is bound by 21 proteins.  







eCLIP assay for PLCB3 is not avaliable on ENCORE database.





21 proteins are bound to PLCB3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr116403514264035195+3'-UTR,intron-Distal4.298094.75108HepG2PABPN1
chr116403519664035270+3'-UTR,intron-Distal3.435515.41979HepG2DDX55
chr116403520564035273+3'-UTR,intron-Distal3.6359212.88800K562DDX6
chr116403519564035272+3'-UTR,intron-Distal3.778864.78537HepG2PABPN1
chr116403519564035265+3'-UTR,intron-Distal3.464939.41693K562DDX55
chr116403514264035158+3'-UTR,intron-Distal3.171325.53289HepG2DDX55
chr116403514264035191+3'-UTR,intron-Distal3.4367917.31145K562DDX55
chr116403519364035280+3'-UTR,intron-Distal3.017374.14144HepG2LSM11
chr116403521364035277+3'-UTR,intron-Distal4.7084713.70377K562PABPC4
chr116401901064019136+5'-UTR,CDS4.919956.75419HepG2DDX3X
chr116402248364022503+CDS4.205183.20743HepG2PPIG
chr116402193164021964+CDS,intron-Distal3.636025.69590K562DDX24
chr116402653764026567+CDS3.239354.92880K562ZNF622
chr116403384464033874+CDS3.617364.40383K562UCHL5
chr116403027064030321+CDS,intron-Proximal5.217266.69228HepG2PRPF8
chr116403149264031537+CDS,intron-Proximal3.244576.67395K562DDX24
chr116402894364028966+CDS3.622015.14149K562DDX24
chr116401913464019201+CDS4.763673.28019K562DDX3X
chr116402181064021905+CDS,intron-Distal,intron-Proximal4.258173.79177K562SMNDC1
chr116402422064024237+CDS,intron-Proximal3.932866.64581K562YBX3
chr116403400464034023+CDS3.676893.86355HepG2PPIG
chr116402671564026758+CDS,intron-Proximal5.416117.81430K562AQR
chr116402744964027521+CDS,intron-Proximal3.850916.26407K562SF3B4
chr116402223564022290+CDS,intron-Distal,intron-Proximal4.742726.92541HepG2PPIG
chr116403126564031315+CDS,intron-Proximal3.515075.13777HepG2PRPF8
chr116402222064022242+CDS,intron-Distal3.670597.13692K562ZNF622
chr116403153964031571+CDS3.170594.62864K562ZNF622
chr116402763464027682+CDS3.916745.08388K562UCHL5
chr116402614464026203+CDS,intron-Proximal3.783793.14999HepG2GRWD1
chr116402594364025977+CDS,intron-Proximal3.942546.64581K562YBX3
chr116402893864028968+CDS3.663696.44455K562ZNF622
chr116403158364031599+CDS,intron-Proximal3.967663.04871K562AQR
chr116403465664034677+CDS,intron-Proximal4.545373.79199HepG2PPIG
chr116402419164024220+CDS4.493335.43239K562YBX3
chr116402905364029072+CDS4.031835.96588K562ZNF622
chr116402954664029590+CDS,intron-Proximal4.206366.01372K562AQR
chr116402192564021954+CDS,intron-Distal3.854963.32039HepG2PPIG
chr116402222764022282+CDS,intron-Distal4.047586.80284K562DDX24
chr116402659664026648+CDS3.365344.89070K562UCHL5
chr116401965064019782+intron-Distal3.711384.25794K562HNRNPK
chr116402007864020157+intron-Distal4.542854.86913K562XRN2
chr116402180564021870+intron-Distal,intron-Proximal4.260024.37414K562RBFOX2
chr116401986364019996+intron-Distal4.809586.49770K562HNRNPK
chr116402029264020343+intron-Distal3.646343.57928K562GTF2F1
chr116402308864023132+intron-Proximal4.7138810.26000K562SSB
chr116402980064029851+intron-Proximal4.060864.98250K562AQR
chr116403159964031627+intron-Proximal5.038673.62536K562AQR
chr116403028064030324+intron-Proximal4.234654.21433K562PRPF8
chr116402914264029228+intron-Proximal5.498108.03507K562AQR
chr116402252764022575+intron-Proximal4.739114.48002K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PLCB3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PLCB3 is not available on ENCORE database.

  • 92 RBPs can affect the levels of PLCB3.  








The Knockdown/knockout RNA-Seq assay for PLCB3 is not available on ENCORE database.





92 RBPs can affect the gene expression of PLCB3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PLCB3ENSG00000149782.7449.99570642.33800-0.513405.761504.94640HepG2ACO1
PLCB3ENSG00000149782.7523.13990645.36110-0.302902.295701.59030HepG2AKAP8L
PLCB3ENSG00000149782.7304.18520666.84250-1.1324014.6932013.46610HepG2BOP1
PLCB3ENSG00000149782.7254.79300569.49350-1.1604015.1165013.56670HepG2CALR
PLCB3ENSG00000149782.7371.19730642.20470-0.7908012.2767011.07770HepG2CKAP4
PLCB3ENSG00000149782.7348.46590612.18230-0.812907.550306.46000HepG2CPSF6
PLCB3ENSG00000149782.7706.01270493.542600.516404.236303.47190HepG2CELF1
PLCB3ENSG00000149782.7447.20850594.07350-0.409703.980203.00210HepG2DDX19B
PLCB3ENSG00000149782.7530.63210365.654000.537103.910903.11870HepG2DDX21
PLCB3ENSG00000149782.7146.90630358.29160-1.286206.380504.99810HepG2DDX24
PLCB3ENSG00000149782.7290.80040454.93640-0.645604.022103.27960HepG2DDX3X
PLCB3ENSG00000149782.7419.87830695.18310-0.727403.758702.62530HepG2DDX59
PLCB3ENSG00000149782.7399.12600614.54500-0.622706.828105.85420HepG2DKC1
PLCB3ENSG00000149782.7163.55230337.11130-1.043504.108402.74520HepG2AGO1
PLCB3ENSG00000149782.7502.32050375.682800.419002.149001.61920HepG2EIF2S1
PLCB3ENSG00000149782.7223.01900347.49250-0.639802.379101.53570HepG2EIF3D
PLCB3ENSG00000149782.7256.94470404.26520-0.653803.135302.40610HepG2EIF4B
PLCB3ENSG00000149782.7386.69610523.53540-0.437103.090702.21520HepG2EIF4G1
PLCB3ENSG00000149782.7599.64480856.94380-0.515106.409005.55600HepG2ETF1
PLCB3ENSG00000149782.7431.58550627.68460-0.540404.629303.55390HepG2EWSR1
PLCB3ENSG00000149782.7794.95500418.969100.923909.928108.69140HepG2FXR1
PLCB3ENSG00000149782.7300.96090693.91410-1.2052013.6209012.30560HepG2GPKOW
PLCB3ENSG00000149782.7475.21200613.25270-0.367903.218402.16670HepG2HDGF
PLCB3ENSG00000149782.7653.57900483.287600.435404.780703.91180HepG2HNRNPL
PLCB3ENSG00000149782.7355.53160662.21880-0.897308.864707.80820HepG2HNRNPLL
PLCB3ENSG00000149782.7450.61040587.18140-0.381903.458102.31760HepG2KIF1C
PLCB3ENSG00000149782.7778.746201081.65050-0.474002.999002.13200HepG2LARP4
PLCB3ENSG00000149782.7468.39460675.46940-0.528202.455701.54680HepG2MTPAP
PLCB3ENSG00000149782.7408.72550587.21430-0.522803.380202.55300HepG2NSUN2
PLCB3ENSG00000149782.7279.55700384.08040-0.458302.233001.57930HepG2PABPC4
PLCB3ENSG00000149782.7265.74170344.36250-0.373902.058701.31880HepG2PARN
PLCB3ENSG00000149782.7286.10170400.21910-0.484303.369502.71410HepG2PCBP1
PLCB3ENSG00000149782.7406.82590310.302400.390602.213801.54720HepG2PPIL4
PLCB3ENSG00000149782.7153.38870302.18820-0.978305.446804.35410HepG2PRPF8
PLCB3ENSG00000149782.7387.40900502.26210-0.374601.956501.44320HepG2PUF60
PLCB3ENSG00000149782.7314.73490441.02610-0.486703.117302.46090HepG2QKI
PLCB3ENSG00000149782.7136.80350317.95900-1.216703.947503.11050HepG2RAVER1
PLCB3ENSG00000149782.7214.97100716.24120-1.7363037.7736036.28780HepG2RBM22
PLCB3ENSG00000149782.7279.97450400.27690-0.515703.097402.38820HepG2RBM25
PLCB3ENSG00000149782.7288.31340423.80390-0.555802.919201.89800HepG2RBM27
PLCB3ENSG00000149782.7694.52140453.222800.615706.950506.16140HepG2NELFE
PLCB3ENSG00000149782.7298.33230643.07350-1.1081014.0692012.75220HepG2RPLP0
PLCB3ENSG00000149782.7177.79250298.90550-0.749503.601102.71920HepG2RRP9
PLCB3ENSG00000149782.7528.02960309.822700.769109.666108.57590HepG2SAFB2
PLCB3ENSG00000149782.7368.88510817.28680-1.1477011.9581010.49770HepG2SF3A3
PLCB3ENSG00000149782.7358.94180655.44140-0.868709.009607.80640HepG2SF3B1
PLCB3ENSG00000149782.7469.00650361.303100.376302.746202.10390HepG2SMN1
PLCB3ENSG00000149782.7337.16530729.30230-1.113109.113707.70240HepG2SNRNP70
PLCB3ENSG00000149782.7425.55730808.95870-0.9267017.0819016.11500HepG2SRFBP1
PLCB3ENSG00000149782.7457.51420586.48790-0.358302.812702.11070HepG2SRSF7
PLCB3ENSG00000149782.7286.56040360.05140-0.329401.776101.31660HepG2SRSF9
PLCB3ENSG00000149782.7573.24890702.35130-0.293002.317501.83880HepG2SSB
PLCB3ENSG00000149782.7794.14960563.998000.493603.182802.52510HepG2SUCLG1
PLCB3ENSG00000149782.7320.52560571.16180-0.833508.451806.87250HepG2SUPT6H
PLCB3ENSG00000149782.7250.17690397.82480-0.669205.111404.38800HepG2TAF15
PLCB3ENSG00000149782.7345.49870645.57030-0.901909.495808.26790HepG2TARDBP
PLCB3ENSG00000149782.7448.77060341.076600.395802.902402.32820HepG2TRIM56
PLCB3ENSG00000149782.7272.14730723.53020-1.4107020.2184018.47000HepG2U2AF1
PLCB3ENSG00000149782.7311.66480616.22020-0.983502.772501.78240HepG2U2AF2
PLCB3ENSG00000149782.7576.67440724.80980-0.329802.911102.19760HepG2UPF1
PLCB3ENSG00000149782.7453.44940699.77330-0.625907.600606.68770HepG2UTP3
PLCB3ENSG00000149782.7330.80910452.59630-0.452203.499202.75790HepG2ZC3H8
PLCB3ENSG00000149782.7584.71500797.15010-0.447105.643504.93420HepG2ZNF622
PLCB3ENSG00000149782.71920.566701430.398100.425006.305805.50190K562AGGF1
PLCB3ENSG00000149782.71808.641301488.409000.281002.281501.68690K562AKAP8L
PLCB3ENSG00000149782.71078.613301595.71120-0.565006.044205.23410K562AQR
PLCB3ENSG00000149782.72443.045101931.896900.338604.576303.12730K562CPEB4
PLCB3ENSG00000149782.7815.63880645.787600.336802.740901.68920K562CSTF2
PLCB3ENSG00000149782.71886.524801580.381200.255402.854701.62340K562DDX21
PLCB3ENSG00000149782.71106.38740906.385600.287602.543901.30470K562DDX6
PLCB3ENSG00000149782.71076.297401325.32820-0.300303.089802.33680K562EIF2S2
PLCB3ENSG00000149782.7564.98980395.942900.512804.312603.33010K562EIF3G
PLCB3ENSG00000149782.7538.65750875.55610-0.700806.510404.64890K562FKBP4
PLCB3ENSG00000149782.7112.37160346.62720-1.6251014.5788012.66300K562G3BP2
PLCB3ENSG00000149782.71313.604501774.52690-0.433905.954804.31960K562GLRX3
PLCB3ENSG00000149782.71412.753201766.05800-0.322002.689801.94300K562GRSF1
PLCB3ENSG00000149782.7785.481201008.35950-0.360402.797602.19790K562HNRNPC
PLCB3ENSG00000149782.7391.23550618.36160-0.660402.913701.64570K562HNRNPK
PLCB3ENSG00000149782.71284.153601631.84730-0.345702.773201.97740K562HSPD1
PLCB3ENSG00000149782.71093.88910619.841600.819404.821103.30730K562IGF2BP2
PLCB3ENSG00000149782.7915.27330630.228900.538203.445002.07560K562IGF2BP3
PLCB3ENSG00000149782.72112.987801769.470500.255902.301201.48500K562MBNL1
PLCB3ENSG00000149782.71410.338501865.70650-0.403706.510105.31810K562MTPAP
PLCB3ENSG00000149782.7444.47140735.96900-0.727602.172801.50430K562PRPF8
PLCB3ENSG00000149782.71138.36570904.109200.332302.251901.44360K562PSIP1
PLCB3ENSG00000149782.71882.032502448.51130-0.379603.856102.89760K562PUF60
PLCB3ENSG00000149782.71999.163302604.66660-0.381705.216603.71670K562PUM1
PLCB3ENSG00000149782.72216.924302551.76090-0.202902.149301.30130K562PUM2
PLCB3ENSG00000149782.71728.709501438.215000.265302.702302.11460K562RBM15
PLCB3ENSG00000149782.7806.08830591.040300.447602.841901.44480K562RBM34
PLCB3ENSG00000149782.72196.163201434.426800.614402.655601.38930K562SFPQ
PLCB3ENSG00000149782.71015.64270636.089000.675007.861105.95810K562SRSF4
PLCB3ENSG00000149782.71010.245601223.65970-0.276502.176201.44710K562SYNCRIP
PLCB3ENSG00000149782.7197.36890340.24280-0.785703.396801.71280K562TAF15
PLCB3ENSG00000149782.71053.11210627.353800.747204.210303.33190K562TARDBP
PLCB3ENSG00000149782.7930.13700605.190400.620005.262304.08160K562TIA1
PLCB3ENSG00000149782.7907.38240594.203200.610704.633603.15470K562TRA2A
PLCB3ENSG00000149782.7221.46890346.88860-0.647404.663903.62670K562U2AF2
PLCB3ENSG00000149782.71493.021501880.64410-0.333003.160502.22860K562WDR3
PLCB3ENSG00000149782.71589.566601955.76610-0.299104.385403.33670K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PLCB3 is not available on ENCORE database.





3 RBPs can affect the splicing of PLCB3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPLCB3ENSG00000149782.7chr11+640339666403402464033786640338766403465664034743-0.117000.000000.00020excludedK562WDR3
SEPLCB3ENSG00000149782.7chr11+640314926403158464031162640312676403242264032576-0.224000.000000.00018excludedHepG2U2AF1
RIPLCB3ENSG00000149782.7chr11+6403103364031267640310336403106964031162640312670.169000.000000.00000includedK562UTP18

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PLCB3 is not avaliable on ENCORE database.