MEGF8

General Information

Gene Name       : MEGF8
Gene ID             : ENSG00000105429.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MEGF8)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MEGF8ENSG00000105429.122.082.912.50ENCSR000AEF
HepG2MEGF8ENSG00000105429.129.665.847.75ENCSR985KAT
K562MEGF8ENSG00000105429.123.352.643.00ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MEGF8 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MEGF8 RNA is bound by 15 proteins.  







eCLIP assay for MEGF8 is not avaliable on ENCORE database.





15 proteins are bound to MEGF8 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr194288035942880477+3'-UTR,CDS,intron-Distal4.3965310.16433HepG2UPF1
chr194288008942880195+3'-UTR,CDS,intron-Distal3.869823.51767HepG2GRSF1
chr194288084942880915+3'-UTR,CDS,intron-Distal3.417584.98031HepG2PRPF4
chr194288157542881646+3'-UTR,intron-Distal4.634144.56348K562UPF1
chr194288197042882079+3'-UTR,intron-Distal4.913306.52213HepG2UPF1
chr194288202442882134+3'-UTR,intron-Distal4.708866.84064HepG2GRSF1
chr194288232342882373+3'-UTR,intron-Distal4.378663.31330K562UPF1
chr194288209342882150+3'-UTR,intron-Distal3.413853.66308K562UPF1
chr194288231442882391+3'-UTR,intron-Distal4.749266.23064HepG2UPF1
chr194288057442880679+3'-UTR,CDS,intron-Distal3.551056.60798HepG2UPF1
chr194282995242830013+5'-UTR4.582379.31832HepG2DDX3X
chr194282982142829922+5'-UTR4.1609520.34347HepG2DDX3X
chr194282981342829921+5'-UTR3.031883.84340HepG2NCBP2
chr194285566242855707+CDS3.419603.05161HepG2PPIG
chr194283043242830501+CDS4.191533.92497HepG2UPF1
chr194284868942848733+CDS3.551123.86355HepG2PPIG
chr194286728742867382+CDS,intron-Distal3.667967.33240HepG2PCBP2
chr194284006442840130+CDS,intron-Proximal4.270095.99890HepG2U2AF2
chr194283991742840104+CDS,intron-Distal,intron-Proximal4.5889721.16497K562PTBP1
chr194285582842855902+CDS3.324265.60389HepG2PPIG
chr194283990142840102+CDS,intron-Distal,intron-Proximal3.9073318.46292HepG2PTBP1
chr194286107242861136+CDS,intron-Proximal4.876846.04125HepG2LIN28B
chr194283919842839281+CDS3.232055.54641HepG2PPIG
chr194285558042855629+CDS,intron-Proximal3.005163.47879HepG2PPIG
chr194286057042860646+CDS,intron-Proximal4.5355110.42975HepG2PRPF8
chr194286155542861648+CDS,intron-Proximal3.661674.39727HepG2LIN28B
chr194284130342841359+CDS,intron-Proximal3.201974.40420HepG2PPIG
chr194286060442860669+CDS,intron-Proximal4.082404.89208K562AQR
chr194286055042860602+CDS3.430964.77136HepG2PPIG
chr194285403842854192+intron-Distal5.6121010.65318HepG2PCBP2
chr194283903242839117+intron-Distal,intron-Proximal4.9138313.94191HepG2PTBP1
chr194284838742848473+intron-Distal4.8179015.33490HepG2HNRNPK
chr194284778342847965+intron-Distal,intron-Proximal5.537539.60578HepG2AQR
chr194283855142838710+intron-Distal4.646547.31982HepG2DDX59
chr194283890142838981+intron-Distal4.020538.52957HepG2PTBP1
chr194283968042839760+intron-Distal4.814579.03914K562PTBP1
chr194285612042856209+intron-Distal3.425195.19856HepG2PTBP1
chr194283979842839882+intron-Distal3.879599.24535HepG2PTBP1
chr194283969642839766+intron-Distal4.3994311.64729HepG2PTBP1
chr194283849042838613+intron-Distal5.060439.27360HepG2HNRNPK
chr194285614142856230+intron-Distal4.342607.33269K562PTBP1
chr194284841042848488+intron-Distal4.846454.91906HepG2DDX59
chr194286748842867543+intron-Distal,intron-Proximal4.683405.96444HepG2PCBP2
chr194285702442857079+intron-Proximal4.367473.95187HepG2AQR
chr194283908842839169+intron-Proximal5.461847.41017K562PTBP1
chr194286317542863245+intron-Proximal3.980333.31322HepG2SF3B4
chr194283911742839180+intron-Proximal4.9721011.90381HepG2PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MEGF8 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MEGF8 is not available on ENCORE database.

  • 104 RBPs can affect the levels of MEGF8.  








The Knockdown/knockout RNA-Seq assay for MEGF8 is not available on ENCORE database.





104 RBPs can affect the gene expression of MEGF8 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MEGF8ENSG00000105429.82196.900201703.090000.367202.789701.84410HepG2ABCF1
MEGF8ENSG00000105429.82623.349902077.846700.336202.798902.10930HepG2AUH
MEGF8ENSG00000105429.81422.181101000.019600.508005.155404.36970HepG2BOP1
MEGF8ENSG00000105429.81294.942701745.14830-0.430501.980501.31920HepG2CIRBP
MEGF8ENSG00000105429.81400.29320918.049300.609006.491805.47080HepG2CPSF6
MEGF8ENSG00000105429.8985.56060544.845500.855009.829408.00390HepG2CSTF2
MEGF8ENSG00000105429.8711.792301009.50900-0.504102.832001.45540HepG2CSTF2T
MEGF8ENSG00000105429.81575.582901178.489200.418808.010906.84760HepG2DAZAP1
MEGF8ENSG00000105429.81978.287701704.236400.215002.705001.88010HepG2DDX19B
MEGF8ENSG00000105429.8832.857401086.28770-0.383302.985702.28410HepG2DDX21
MEGF8ENSG00000105429.82671.343702126.374600.329101.843601.32170HepG2DDX3X
MEGF8ENSG00000105429.81303.603301857.42710-0.510802.608301.34670HepG2DDX47
MEGF8ENSG00000105429.82641.837201827.401000.531602.056701.51740HepG2DDX6
MEGF8ENSG00000105429.81013.93280744.055000.446404.062503.22300HepG2DNAJC21
MEGF8ENSG00000105429.81027.83330737.623500.478503.940503.18970HepG2DNAJC2
MEGF8ENSG00000105429.83047.131401755.929700.795104.695803.93480HepG2EIF2S1
MEGF8ENSG00000105429.8934.360201162.76160-0.315502.785901.94560HepG2EIF4G1
MEGF8ENSG00000105429.81985.646401113.831500.8340013.4674011.76280HepG2EIF4G2
MEGF8ENSG00000105429.83149.720702385.792800.400705.406004.61410HepG2ETF1
MEGF8ENSG00000105429.82003.41380919.671101.123203.671102.49560HepG2FTO
MEGF8ENSG00000105429.82949.792901816.339400.699508.198907.08540HepG2G3BP1
MEGF8ENSG00000105429.81263.81480835.600200.596802.371101.72380HepG2HNRNPC
MEGF8ENSG00000105429.81503.112401152.949300.382505.024104.09400HepG2HNRNPF
MEGF8ENSG00000105429.81294.537701073.474800.270003.351802.61640HepG2HNRNPL
MEGF8ENSG00000105429.8866.733901186.39400-0.452904.699603.49660HepG2HNRNPM
MEGF8ENSG00000105429.81427.599901135.320700.330402.551501.85610HepG2IGF2BP1
MEGF8ENSG00000105429.81194.48530847.883600.494405.985604.94650HepG2ILF2
MEGF8ENSG00000105429.82441.186001707.975500.515203.933602.93920HepG2LARP4
MEGF8ENSG00000105429.81238.621401959.35680-0.661602.944902.26900HepG2MAGOH
MEGF8ENSG00000105429.8918.137101391.62150-0.600007.819706.52330HepG2MSI2
MEGF8ENSG00000105429.81421.108101012.957200.488302.707001.75040HepG2MTPAP
MEGF8ENSG00000105429.81753.689601168.594300.585507.417006.18410HepG2NOL12
MEGF8ENSG00000105429.81104.47660880.606400.326702.142001.48090HepG2NSUN2
MEGF8ENSG00000105429.81486.112701849.61210-0.315702.362001.79160HepG2PCBP1
MEGF8ENSG00000105429.81491.327201882.13280-0.335803.914403.28850HepG2PTBP1
MEGF8ENSG00000105429.81827.472501115.560800.7120011.4971010.39390HepG2PUF60
MEGF8ENSG00000105429.82185.266301184.258300.8837037.4114035.74030HepG2PUM1
MEGF8ENSG00000105429.81432.242201183.367600.275302.493701.85640HepG2PUM2
MEGF8ENSG00000105429.81113.533001876.95670-0.7533022.2743020.83360HepG2PUS1
MEGF8ENSG00000105429.8456.869101054.88820-1.207207.639906.50190HepG2RAVER1
MEGF8ENSG00000105429.8843.510701994.05070-1.2412037.5074036.02680HepG2RBM22
MEGF8ENSG00000105429.81226.714501849.88150-0.592604.326003.49790HepG2RBM25
MEGF8ENSG00000105429.81553.921001025.446300.599605.215203.83530HepG2RBM27
MEGF8ENSG00000105429.81410.80620945.647400.577004.885003.83970HepG2RPS2
MEGF8ENSG00000105429.81383.77420906.375500.610304.499703.48100HepG2RPS3A
MEGF8ENSG00000105429.81182.20110853.500100.469903.004801.64200HepG2SART3
MEGF8ENSG00000105429.81731.95240696.374001.314405.043003.10070HepG2SF1
MEGF8ENSG00000105429.81520.467602037.71310-0.422402.750602.07810HepG2SF3A3
MEGF8ENSG00000105429.81860.398801069.733600.7983026.7996025.05400HepG2SLBP
MEGF8ENSG00000105429.81530.165901077.803100.505503.385502.31330HepG2SMNDC1
MEGF8ENSG00000105429.81206.49890623.222600.952903.104901.69610HepG2SNRNP200
MEGF8ENSG00000105429.8883.700802045.24380-1.2106047.6733046.23610HepG2SRSF1
MEGF8ENSG00000105429.81990.695701101.503200.8537026.3602024.70440HepG2SRSF5
MEGF8ENSG00000105429.81458.462001663.96740-0.190201.792401.33100HepG2SRSF9
MEGF8ENSG00000105429.81638.260301252.670300.387106.874605.97110HepG2SUCLG1
MEGF8ENSG00000105429.81525.844201161.060300.394103.735102.65560HepG2SUPT6H
MEGF8ENSG00000105429.8950.826801838.51430-0.9513024.9654023.50860HepG2TAF15
MEGF8ENSG00000105429.81609.54480968.119600.733309.937808.68830HepG2TARDBP
MEGF8ENSG00000105429.81296.94390806.397600.685508.889408.08500HepG2TIAL1
MEGF8ENSG00000105429.81793.57520813.791701.1400038.1724036.37740HepG2TRIM56
MEGF8ENSG00000105429.81918.961101089.923000.816008.908707.17980HepG2TUFM
MEGF8ENSG00000105429.8743.277301470.97220-0.9848015.0039013.49310HepG2U2AF1
MEGF8ENSG00000105429.8382.11940510.08190-0.416702.430501.71900HepG2UCHL5
MEGF8ENSG00000105429.82105.197601807.146300.220102.623701.94020HepG2UPF1
MEGF8ENSG00000105429.8802.480301744.71910-1.1205024.3810022.86780HepG2UTP3
MEGF8ENSG00000105429.8797.923601237.92590-0.6336013.0374011.75680HepG2ZC3H8
MEGF8ENSG00000105429.81593.907601987.50610-0.318403.488702.89460HepG2ZNF622
MEGF8ENSG00000105429.8627.31470794.79920-0.341403.143402.54460K562AGGF1
MEGF8ENSG00000105429.8686.94670873.28640-0.346302.553101.61520K562AKAP8
MEGF8ENSG00000105429.8601.70300827.00540-0.458803.856303.08330K562AKAP8L
MEGF8ENSG00000105429.81198.67070937.025200.355202.785501.54240K562APOBEC3C
MEGF8ENSG00000105429.8371.88250882.21870-1.2463017.3632016.05680K562AQR
MEGF8ENSG00000105429.8632.08370867.69160-0.457104.971203.70910K562ATP5C1
MEGF8ENSG00000105429.8584.39530428.698000.446903.521701.99700K562BCCIP
MEGF8ENSG00000105429.8528.55030414.276600.351302.379601.49110K562BCLAF1
MEGF8ENSG00000105429.8450.21480628.74340-0.481903.950602.12950K562CEBPZ
MEGF8ENSG00000105429.81119.38620840.075900.414004.581503.13100K562CPEB4
MEGF8ENSG00000105429.8411.71890314.290600.389502.256301.32090K562CSTF2
MEGF8ENSG00000105429.8890.004901306.04380-0.553307.792706.18170K562CELF1
MEGF8ENSG00000105429.8607.49580414.075700.552904.718303.30360K562DDX3X
MEGF8ENSG00000105429.8670.33020890.03710-0.409004.405803.26400K562DKC1
MEGF8ENSG00000105429.8844.75170681.997000.308702.431601.74970K562EIF2S2
MEGF8ENSG00000105429.8578.87420405.488800.513502.310901.40090K562EIF3A
MEGF8ENSG00000105429.8646.05090411.973700.649004.400103.05880K562EIF3D
MEGF8ENSG00000105429.8374.44870275.566500.442302.497501.74080K562EIF3G
MEGF8ENSG00000105429.81505.257801061.973100.503206.745905.30070K562EIF4G2
MEGF8ENSG00000105429.867.65460140.96950-1.059104.209403.29570K562G3BP2
MEGF8ENSG00000105429.8618.16220385.849400.679805.116103.15770K562GEMIN5
MEGF8ENSG00000105429.8312.49850575.82330-0.881802.615001.44160K562HNRNPA2B1
MEGF8ENSG00000105429.8759.12130342.712101.1472016.8193015.42590K562HNRNPC
MEGF8ENSG00000105429.8626.68960785.62180-0.326102.243601.30240K562HNRNPL
MEGF8ENSG00000105429.8202.44710401.41410-0.987507.389505.75420K562HNRNPM
MEGF8ENSG00000105429.8533.44460877.72650-0.718408.522306.86560K562KIF1C
MEGF8ENSG00000105429.8417.48650320.585900.380902.152701.40650K562MAGOH
MEGF8ENSG00000105429.8541.23610840.14590-0.634406.428104.51390K562MAK16
MEGF8ENSG00000105429.8487.14430319.904000.606605.026003.73610K562MATR3
MEGF8ENSG00000105429.8865.333501131.91410-0.387402.993101.81620K562MSI2
MEGF8ENSG00000105429.8309.94850689.19240-1.1529010.976208.77340K562NAA15
MEGF8ENSG00000105429.8728.28890923.71650-0.342902.316501.62780K562NSUN2
MEGF8ENSG00000105429.8999.05300638.373200.646102.693701.87400K562PCBP3
MEGF8ENSG00000105429.8852.32210489.649600.7995011.087209.53760K562POLR2G
MEGF8ENSG00000105429.8218.65100374.50810-0.776405.195004.16840K562PRPF8
MEGF8ENSG00000105429.8452.77200311.484800.539504.068603.27840K562PTBP1
MEGF8ENSG00000105429.8481.41650820.29940-0.768907.441506.59710K562PUS1
MEGF8ENSG00000105429.8422.08210799.14470-0.9209014.3755013.01480K562RBM15
MEGF8ENSG00000105429.8199.41210298.56340-0.582303.306902.38220K562RBM22
MEGF8ENSG00000105429.878.58200133.81410-0.768002.635601.34170K562RBM25
MEGF8ENSG00000105429.8503.96270291.129100.791606.684004.33220K562RBM34
MEGF8ENSG00000105429.8550.23820314.216700.808207.509205.62940K562NELFE
MEGF8ENSG00000105429.8481.49450186.111701.3713013.3112011.01180K562RPS3
MEGF8ENSG00000105429.8257.79540529.27840-1.037803.113401.78180K562SNRNP200
MEGF8ENSG00000105429.8326.59860179.672300.862105.715904.09750K562SRSF4
MEGF8ENSG00000105429.8470.87820644.90410-0.453704.212002.74710K562SRSF7
MEGF8ENSG00000105429.8477.81970309.016500.628703.741802.91400K562TARDBP
MEGF8ENSG00000105429.8559.18710298.094500.9075010.415208.70700K562TIA1
MEGF8ENSG00000105429.8405.65350292.638200.471002.645101.58000K562TRA2A
MEGF8ENSG00000105429.869.36780136.75580-0.979303.739102.42670K562U2AF1
MEGF8ENSG00000105429.869.81610141.20280-1.016104.733103.68760K562U2AF2
MEGF8ENSG00000105429.8481.52320831.55960-0.788204.099902.42490K562UTP18
MEGF8ENSG00000105429.8607.34720838.06570-0.464502.389201.57370K562WDR3
MEGF8ENSG00000105429.8769.94130993.90590-0.368402.886702.00160K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MEGF8 is not available on ENCORE database.





4 RBPs can affect the splicing of MEGF8 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMEGF8ENSG00000105429.8chr19+4287550142875634428748524287498342879658428829210.285000.000230.00801includedHepG2HNRNPK
SEMEGF8ENSG00000105429.8chr19+428629384286310642862295428624594286324942863394-0.220000.000010.00227excludedHepG2IGF2BP3
SEMEGF8ENSG00000105429.8chr19+428629384286310642862295428624594286324942863394-0.357000.000420.03488excludedHepG2TIAL1
MXEMEGF8ENSG00000105429.8chr19+42852423428526244285365042853851428488214284898542854299428545360.351000.015210.075741includedHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MEGF8 is not avaliable on ENCORE database.