GSK3A

General Information

Gene Name       : GSK3A
Gene ID             : ENSG00000105723.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: GSK3A)


Antibody Validation


Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878GSK3AENSG00000105723.1122.1932.6127.40ENCSR000AEF
HepG2GSK3AENSG00000105723.1135.0734.7434.91ENCSR985KAT
K562GSK3AENSG00000105723.1165.0261.0363.02ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq GSK3A-BGKcLV13-K562ENCSR610HJOGSK3AK562ReleasedENCSR712CQC   CRISPRKD% = 73.2,71.9
knockdown followed by RNA-seq GSK3A-BGHcLV14-HepG2ENCSR300RMYGSK3AHepG2ReleasedENCSR750CPT   CRISPRKD% = 60.6,65.3






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
GSK3AENCAB957NOPMA3-038RF227934Released, ENCODE4BGHcLV14-41, Released, ENCODE4BGKcLV13-41, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
GSK3AK562CRISPRENCSR610HJOENCSR712CQCGSK3A-BGKcLV13-41,GSK3A-BGKcLV13-42NT-BGKcLV13-1,NT-BGKcLV13-273.2,71.9ReleasedENCODE4
GSK3AK562CRISPRBGKcLV13-43,BGKcLV13-44BGKcLV13-1,BGKcLV13-213.6,5.3NotSatisfiedENCODE4
GSK3AHepG2CRISPRENCSR300RMYENCSR750CPTGSK3A-BGHcLV14-41,GSK3A-BGHcLV14-42NT-BGHcLV14-1,NT-BGHcLV14-260.6,65.3ReleasedENCODE4
GSK3AHepG2CRISPRBGHcLV14-43,BGHcLV14-44BGHcLV14-1,BGHcLV14-247.9,49.4NotSatisfiedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
GSK3AProduct_ID: MA3-038
Lot_ID: RF227934
Source: Thermo Fisher
Target Name: GSK3A-human
GSK3alpha-HEPG2-CRISPR-MA3-038.png<br>Caption: Western blot following CRISPR against GSK3A in HepG2 whole cell lysate using GSK3A specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against GSK3A. GSK3A protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
ThermoFisher_MA3-038_RF227934_GSK3.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the GSK3 specific antibody, MA3-038. Lanes 1 and 3 are 2.5% of five million whole cell lysate input. Lanes 2 and 4 are 50% of IP enrichment from five million whole cell lysate using normal IgG antibody and the GSK3-specific antibody, MA3-038. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
GSK3alpha-K562-CRISPR-MA3-038.png<br>Caption: Western blot following CRISPR against GSK3A in K562 whole cell lysate using GSK3A specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against GSK3A. GSK3A protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for GSK3A is not avaliable on ENCORE database.



Proteins bound to RNA

  • GSK3A RNA is bound by 24 proteins.  







eCLIP assay for GSK3A is not avaliable on ENCORE database.





24 proteins are bound to GSK3A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr194273455242734609-3'-UTR,intron-Distal,intron-Proximal3.102486.68509K562CSTF2T
chr194273440742734512-3'-UTR,intron-Distal4.9092523.35545HepG2PCBP2
chr194273444142734497-3'-UTR,intron-Distal4.026475.75263HepG2LARP4
chr194273439742734531-3'-UTR,intron-Distal3.9603422.52307K562IGF2BP2
chr194273441842734542-3'-UTR,intron-Distal5.235048.54443K562HNRNPK
chr194273455842734656-3'-UTR,intron-Distal,intron-Proximal3.182007.96098K562ILF3
chr194273458242734654-3'-UTR,intron-Distal,intron-Proximal3.232484.28097K562DDX55
chr194273456042734647-3'-UTR,intron-Distal,intron-Proximal4.4476213.88138HepG2DDX59
chr194273449742734548-3'-UTR,intron-Distal4.617903.72779HepG2LARP4
chr194273441542734545-3'-UTR,intron-Distal3.310945.92186HepG2UPF1
chr194273487142734922-3'-UTR,intron-Distal3.293129.28412K562YBX3
chr194273441442734522-3'-UTR,intron-Distal3.036324.21858HepG2HNRNPK
chr194273460942734655-3'-UTR,intron-Distal,intron-Proximal4.8385175.51020K562PUM2
chr194273449842734549-3'-UTR,intron-Distal4.964179.20373HepG2DDX59
chr194273442942734528-3'-UTR,intron-Distal6.2942310.35815K562PCBP1
chr194273440542734467-3'-UTR,intron-Distal3.5507814.09174K562PUM2
chr194273455742734658-3'-UTR,intron-Distal,intron-Proximal5.151899.13275K562HNRNPK
chr194273456842734622-3'-UTR,intron-Distal,intron-Proximal7.1756726.05281HepG2PCBP2
chr194273481042734883-3'-UTR,intron-Distal,intron-Proximal3.254524.05280K562CSTF2T
chr194273449542734547-3'-UTR,intron-Distal3.140275.60676K562DDX55
chr194273455942734609-3'-UTR,intron-Distal,intron-Proximal5.06895400.00000K562PUM2
chr194273462242734673-3'-UTR,intron-Distal,intron-Proximal6.4182728.03605HepG2PCBP2
chr194273457142734636-3'-UTR,intron-Distal,intron-Proximal4.949595.50941K562PUM1
chr194273436042734418-3'-UTR,intron-Distal,intron-Proximal3.450683.07801K562UPF1
chr194273487142734965-3'-UTR,CDS,intron-Distal3.467645.41581K562IGF2BP2
chr194274663942746700-5'-UTR,intron-Distal5.502944.56463K562GEMIN5
chr194274653142746725-5'-UTR,CDS,intron-Distal4.6722035.70954HepG2DDX3X
chr194273743742737444-CDS,intron-Distal,intron-Proximal3.075724.24993HepG2PPIG
chr194274077142740786-CDS,intron-Distal3.923056.64581K562YBX3
chr194273744442737494-CDS,intron-Distal,intron-Proximal3.591936.20926HepG2PPIG
chr194273620742736270-CDS,intron-Distal,intron-Proximal3.725915.39224HepG2IGF2BP1
chr194274086542740916-CDS,intron-Distal,intron-Proximal3.852725.93727K562SF3B4
chr194274426642744304-CDS,intron-Distal,intron-Proximal3.309517.99874HepG2BUD13
chr194274071642740763-CDS,intron-Distal,intron-Proximal4.625616.81564HepG2PRPF8
chr194274404942744113-CDS,intron-Distal,intron-Proximal5.065467.02967HepG2PRPF8
chr194273626542736302-CDS,intron-Distal,intron-Proximal3.415106.75003K562IGF2BP2
chr194273623742736302-CDS,intron-Distal,intron-Proximal5.007784.55547K562PCBP1
chr194274621142746340-CDS,intron-Distal4.221836.48405K562AQR
chr194273857542738655-CDS,intron-Distal,intron-Proximal5.908919.06724K562EFTUD2
chr194273496042735017-CDS,intron-Distal3.345608.88089K562YBX3
chr194274105842741163-CDS,intron-Distal,intron-Proximal3.990946.08476K562GPKOW
chr194273733042737390-CDS,intron-Distal,intron-Proximal4.159486.39986K562SF3B4
chr194274075642740771-CDS,intron-Distal,intron-Proximal4.078297.46470K562YBX3
chr194273851442738597-CDS,intron-Distal3.906223.29371HepG2IGF2BP1
chr194274100942741042-CDS,intron-Distal,intron-Proximal3.116453.71253K562LIN28B
chr194274645742746531-CDS,intron-Distal4.309969.66125HepG2DDX3X
chr194273721542737265-CDS,intron-Distal,intron-Proximal3.560863.94787K562AQR
chr194273620942736302-CDS,intron-Distal,intron-Proximal3.482299.50792K562DDX55
chr194274084142740868-CDS,intron-Distal3.940433.47885K562LIN28B
chr194273496542735017-CDS,intron-Distal4.049836.76074K562IGF2BP2
chr194273730942737358-CDS,intron-Distal,intron-Proximal3.268754.51003HepG2PPIG
chr194274637042746457-CDS,intron-Distal4.356529.66125HepG2DDX3X
chr194273732842737394-CDS,intron-Distal,intron-Proximal5.5042510.59102K562EFTUD2
chr194273620842736265-CDS,intron-Distal,intron-Proximal4.3718813.42856K562IGF2BP2
chr194273684042736885-intron-Distal,intron-Proximal3.919425.16342K562SF3B4
chr194274087042740919-intron-Distal,intron-Proximal4.961814.83371K562EFTUD2
chr194273840642738466-intron-Distal,intron-Proximal4.497356.46853K562EFTUD2
chr194273753642737584-intron-Distal,intron-Proximal5.2653613.53654K562SF3B4
chr194274391942744050-intron-Distal,intron-Proximal5.9938710.29365K562EFTUD2
chr194273691042736955-intron-Distal,intron-Proximal3.872203.28461K562BUD13
chr194274040542740452-intron-Distal4.997354.24111K562EFTUD2
chr194274400842744102-intron-Distal,intron-Proximal4.736505.70555K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for GSK3A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for GSK3A is not available on ENCORE database.

  • 81 RBPs can affect the levels of GSK3A.  








The Knockdown/knockout RNA-Seq assay for GSK3A is not available on ENCORE database.





81 RBPs can affect the gene expression of GSK3A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
GSK3AENSG00000105723.71221.89840987.134000.307702.201101.64600HepG2ACO1
GSK3AENSG00000105723.71655.394701258.431100.395402.499201.99110HepG2AKAP1
GSK3AENSG00000105723.7974.255001194.18270-0.293702.317301.60660HepG2CALR
GSK3AENSG00000105723.7977.76900664.347800.557502.966902.17210HepG2CNOT7
GSK3AENSG00000105723.71000.053201439.85250-0.525806.124704.52450HepG2CPSF7
GSK3AENSG00000105723.7427.72180636.34480-0.573103.318401.78390HepG2CSTF2T
GSK3AENSG00000105723.71135.71560912.848400.315102.061201.33230HepG2DDX19B
GSK3AENSG00000105723.7847.309101099.84140-0.376302.256901.67780HepG2EIF4A3
GSK3AENSG00000105723.7889.954301237.17170-0.475206.378405.19940HepG2EIF4G1
GSK3AENSG00000105723.71382.866001869.13180-0.434703.296802.60390HepG2GPKOW
GSK3AENSG00000105723.7955.533201152.44490-0.270302.356201.48560HepG2HNRNPA2B1
GSK3AENSG00000105723.7711.633101043.11550-0.551704.940804.02870HepG2HNRNPK
GSK3AENSG00000105723.7684.151201142.18550-0.7394016.2999014.78350HepG2HNRNPL
GSK3AENSG00000105723.71393.907401783.73870-0.355802.652602.03410HepG2HNRNPLL
GSK3AENSG00000105723.72373.908601821.671200.381902.339301.57990HepG2LARP4
GSK3AENSG00000105723.7951.568901243.38830-0.385903.902102.99680HepG2NOL12
GSK3AENSG00000105723.7327.52080607.31170-0.890905.364804.09800HepG2PABPC1
GSK3AENSG00000105723.7514.248401017.57200-0.9846012.3077010.81580HepG2PABPC4
GSK3AENSG00000105723.71615.686701260.046700.358606.461805.63490HepG2PUM1
GSK3AENSG00000105723.7978.90240695.844000.492302.133001.50800HepG2RAVER1
GSK3AENSG00000105723.71443.03780640.976001.170703.923301.73290HepG2RBM17
GSK3AENSG00000105723.71108.966401490.53200-0.426603.960403.16690HepG2RPLP0
GSK3AENSG00000105723.7879.28390644.611400.447803.752503.04710HepG2RPS19
GSK3AENSG00000105723.71234.04270619.717700.993603.077501.63080HepG2SF1
GSK3AENSG00000105723.72468.289401539.828000.680605.924204.91340HepG2SF3A3
GSK3AENSG00000105723.7973.085301138.18800-0.226101.999401.38510HepG2SLBP
GSK3AENSG00000105723.71289.24030553.201901.220504.836002.98270HepG2SNRNP200
GSK3AENSG00000105723.71975.109001473.852400.422207.325206.61640HepG2SRFBP1
GSK3AENSG00000105723.7678.16140928.29400-0.453003.629603.01630HepG2SRSF9
GSK3AENSG00000105723.71100.648801279.58840-0.217302.107601.64400HepG2SSB
GSK3AENSG00000105723.7367.18400540.52700-0.557903.103002.04920HepG2TFIP11
GSK3AENSG00000105723.7661.59110942.47170-0.510504.242203.21580HepG2TIA1
GSK3AENSG00000105723.7756.27500903.39760-0.256502.181201.66860HepG2TRIM56
GSK3AENSG00000105723.71588.56290644.357001.301705.012303.65720HepG2U2AF2
GSK3AENSG00000105723.7907.882901365.59330-0.5889011.4486010.20490HepG2UPF1
GSK3AENSG00000105723.72642.175101554.159000.7655024.3558022.78700K562AGGF1
GSK3AENSG00000105723.71005.39190809.810300.312002.883701.34570K562AKAP1
GSK3AENSG00000105723.72145.195001707.834000.328802.988401.95540K562AKAP8
GSK3AENSG00000105723.72587.303401617.184700.677907.065205.98080K562AKAP8L
GSK3AENSG00000105723.73309.634201912.309300.7913013.7266012.56150K562AQR
GSK3AENSG00000105723.72023.329101696.838500.253802.645201.75220K562ATP5C1
GSK3AENSG00000105723.71901.518102447.17520-0.364003.117202.18950K562BOP1
GSK3AENSG00000105723.71636.230501202.776800.443904.051202.72740K562CCAR1
GSK3AENSG00000105723.72503.385602982.41550-0.252602.526001.59420K562CELF1
GSK3AENSG00000105723.72367.182801823.454900.376402.957801.43810K562DDX19B
GSK3AENSG00000105723.71028.50840820.496200.325902.548101.54970K562DDX3X
GSK3AENSG00000105723.71801.905901346.534700.420203.640802.08330K562DHX30
GSK3AENSG00000105723.72332.411301740.132300.422503.991702.91380K562DKC1
GSK3AENSG00000105723.71495.968301102.308200.440503.713102.64340K562EFTUD2
GSK3AENSG00000105723.71984.494901223.420800.697802.207401.32130K562EIF3A
GSK3AENSG00000105723.7977.65790549.846500.8302013.8116011.99560K562EIF3G
GSK3AENSG00000105723.7988.98160771.921300.357403.387502.08610K562EIF4B
GSK3AENSG00000105723.71060.89770748.223100.503605.592903.63010K562EWSR1
GSK3AENSG00000105723.71037.87420808.668600.359903.390201.39590K562FUBP3
GSK3AENSG00000105723.71579.36860891.437100.8250018.7769017.31080K562FXR1
GSK3AENSG00000105723.71020.62970795.578200.359302.821401.37360K562G3BP1
GSK3AENSG00000105723.7191.65470521.26400-1.443509.940608.44190K562G3BP2
GSK3AENSG00000105723.72068.017202484.40510-0.264702.127801.42810K562GPKOW
GSK3AENSG00000105723.72527.988801298.265100.961304.833803.07840K562HNRNPA2B1
GSK3AENSG00000105723.71202.734101530.60980-0.347802.800302.20010K562HNRNPC
GSK3AENSG00000105723.71114.03450832.385300.420402.581101.60040K562IGF2BP2
GSK3AENSG00000105723.72437.184301716.195700.505907.041105.57970K562KIF1C
GSK3AENSG00000105723.71906.293601481.569900.363503.017501.55760K562LARP7
GSK3AENSG00000105723.71084.24470874.536300.310002.437301.64550K562MAGOH
GSK3AENSG00000105723.72174.289701642.855200.404203.000201.86980K562MAK16
GSK3AENSG00000105723.71109.38410872.721400.346102.857001.91910K562MATR3
GSK3AENSG00000105723.72819.069201922.578400.552108.349506.59220K562MBNL1
GSK3AENSG00000105723.71789.047802058.31620-0.202302.199601.47500K562MTPAP
GSK3AENSG00000105723.72378.087901347.591900.819307.548105.81390K562NAA15
GSK3AENSG00000105723.72025.213001135.004700.835303.142302.06720K562PABPN1
GSK3AENSG00000105723.71098.37920854.983100.361303.200901.74620K562PCBP1
GSK3AENSG00000105723.71124.32880778.071900.531005.478804.09290K562PCBP2
GSK3AENSG00000105723.71631.801901072.675900.605206.587505.42840K562PRPF8
GSK3AENSG00000105723.71302.70700849.686900.616408.558407.43240K562PTBP1
GSK3AENSG00000105723.73885.415201603.718901.276509.363508.41350K562PUS1
GSK3AENSG00000105723.72938.992701562.652600.9112011.6229010.41850K562RBM15
GSK3AENSG00000105723.71061.30940814.601900.381602.996102.11840K562RBM22
GSK3AENSG00000105723.71576.559901251.756900.332703.278102.19690K562RCC2
GSK3AENSG00000105723.72289.623701670.511900.454704.963803.51130K562SAFB
GSK3AENSG00000105723.72099.668801037.639601.016804.812003.08000K562SF1
GSK3AENSG00000105723.7851.54790541.671700.652608.042606.54100K562SF3B4
GSK3AENSG00000105723.72230.429001264.485700.818703.246601.79410K562SFPQ
GSK3AENSG00000105723.73141.017101192.211801.397509.996007.18680K562SNRNP200
GSK3AENSG00000105723.71543.861901186.661400.379503.389202.22550K562SRFBP1
GSK3AENSG00000105723.71449.94510833.006500.7995013.4140011.85900K562SRSF1
GSK3AENSG00000105723.72445.031501880.252600.378803.058602.19230K562SYNCRIP
GSK3AENSG00000105723.71237.41120842.992100.553605.468204.45630K562TARDBP
GSK3AENSG00000105723.71055.59300813.178100.376303.262702.36350K562TIA1
GSK3AENSG00000105723.71032.78690798.123000.371802.693701.61880K562TRA2A
GSK3AENSG00000105723.71970.985002425.02590-0.299104.762303.84610K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for GSK3A is not available on ENCORE database.





1 RBPs can affect the splicing of GSK3A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSGSK3AENSG00000105723.7chr19-4273620842736405427362084273630142736647427368340.252000.000000.00000longerK562AQR
A3SSGSK3AENSG00000105723.7chr19-4273664742736879427366474273683442737261427373570.088000.000000.00000longerK562AQR
A3SSGSK3AENSG00000105723.7chr19-4273869942738946427386994273883042740757427408980.052000.000000.00000longerK562AQR
A3SSGSK3AENSG00000105723.7chr19-4273743742737594427374374273753542738504427386110.127000.000000.00000longerK562AQR
A3SSGSK3AENSG00000105723.7chr19-4274410642744322427441064274429442746334427467770.136000.000000.00000longerK562AQR
MXEGSK3AENSG00000105723.7chr19-42738504427386114273869942738855427374374273753542740757427408680.083000.000000.000001includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for GSK3A is not avaliable on ENCORE database.