FAM53B

General Information

Gene Name       : FAM53B
Gene ID             : ENSG00000189319.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: FAM53B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FAM53BENSG00000189319.131.704.433.06ENCSR000AEF
HepG2FAM53BENSG00000189319.1310.074.627.35ENCSR985KAT
K562FAM53BENSG00000189319.135.413.364.38ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for FAM53B is not avaliable on ENCORE database.



Proteins bound to RNA
  • FAM53B RNA is bound by 16 proteins.  







eCLIP assay for FAM53B is not avaliable on ENCORE database.





16 proteins are bound to FAM53B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr10126309976126309987-3'-UTR,intron-Distal3.107405.74118K562YBX3
chr10126311430126311503-3'-UTR,intron-Distal3.975053.70195HepG2UPF1
chr10126308094126308154-3'-UTR,intron-Distal4.095146.36782K562UPF1
chr10126308087126308148-3'-UTR,intron-Distal5.470715.63073HepG2DDX55
chr10126309992126310033-3'-UTR,intron-Distal4.600465.25389K562UPF1
chr10126308499126308620-3'-UTR,intron-Distal3.136678.63173K562UPF1
chr10126432769126432836-5'-UTR,intron-Distal4.659535.35746HepG2DDX3X
chr10126431440126431515-5'-UTR,intron-Distal4.436785.40320K562NONO
chr10126370837126370934-3'-UTR,CDS,intron-Distal3.957764.04622HepG2GRWD1
chr10126370427126370536-3'-UTR,CDS,intron-Distal4.637784.28365K562NOLC1
chr10126370628126370795-3'-UTR,CDS,intron-Distal3.865894.71531K562NOLC1
chr10126370317126370382-3'-UTR,CDS,intron-Distal4.904835.85529K562RBM15
chr10126431933126432035-intron-Distal3.032483.71727HepG2NKRF
chr10126428230126428303-intron-Distal3.674388.17775HepG2RBFOX2
chr10126432345126432411-intron-Distal4.143684.03786HepG2NKRF
chr10126358940126359000-intron-Distal3.185063.23466HepG2CSTF2T
chr10126432207126432266-intron-Distal3.166083.72734HepG2CSTF2T
chr10126423330126423394-intron-Distal4.366754.90578HepG2HNRNPM
chr10126333958126334021-intron-Distal3.752163.06347K562NONO
chr10126359824126359956-intron-Distal3.888004.14602K562FUS
chr10126350929126351022-intron-Distal3.776944.64795K562EIF4G2
chr10126431911126431966-intron-Distal4.214713.76710K562NONO
chr10126416525126416578-intron-Distal3.485743.39857HepG2HNRNPM
chr10126348859126349061-intron-Distal4.239163.30664K562NONO
chr10126358404126358501-intron-Distal5.7666613.49443HepG2PCBP2
chr10126359052126359123-intron-Distal4.527893.13028HepG2FAM120A
chr10126358772126358889-intron-Distal4.122803.96304K562CSTF2T
chr10126339137126339311-intron-Distal3.927104.18190K562FUS
chr10126428238126428313-intron-Distal3.679973.06347K562NONO
chr10126364071126364188-intron-Distal4.044643.98553K562NONO
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for FAM53B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for FAM53B is not available on ENCORE database.

  • 86 RBPs can affect the levels of FAM53B.  








The Knockdown/knockout RNA-Seq assay for FAM53B is not available on ENCORE database.





86 RBPs can affect the gene expression of FAM53B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FAM53BENSG00000189319.9454.85340553.08760-0.282101.961601.43290HepG2ACO1
FAM53BENSG00000189319.9644.12150823.26060-0.354002.095301.48250HepG2AUH
FAM53BENSG00000189319.9199.50440414.29640-1.0542010.229108.88650HepG2CALR
FAM53BENSG00000189319.9289.88140408.06820-0.493302.272201.64130HepG2CPSF6
FAM53BENSG00000189319.9786.82530492.627700.675405.549604.69140HepG2DDX3X
FAM53BENSG00000189319.9428.57570529.14940-0.304101.952201.36810HepG2DKC1
FAM53BENSG00000189319.9400.70620309.885400.370702.176301.58520HepG2DNAJC2
FAM53BENSG00000189319.9205.79060306.62330-0.575302.649101.56960HepG2AGO1
FAM53BENSG00000189319.9673.66820437.793200.621703.537202.76380HepG2EIF4B
FAM53BENSG00000189319.9324.37030523.39460-0.690307.025205.80300HepG2EIF4G1
FAM53BENSG00000189319.9216.46310408.81030-0.917302.854201.82310HepG2FTO
FAM53BENSG00000189319.9663.00690453.758600.547003.733102.93900HepG2FXR1
FAM53BENSG00000189319.9385.62330281.880400.452002.315201.50320HepG2GEMIN5
FAM53BENSG00000189319.9382.01100528.02740-0.467004.245203.05370HepG2HDGF
FAM53BENSG00000189319.9317.28410487.56620-0.619805.737504.47270HepG2HNRNPA2B1
FAM53BENSG00000189319.9607.53400426.398000.510703.298702.53780HepG2HNRNPK
FAM53BENSG00000189319.9183.27200441.39740-1.268108.404507.37180HepG2HNRNPLL
FAM53BENSG00000189319.9465.83970348.736700.417602.638002.04560HepG2HNRNPU
FAM53BENSG00000189319.9402.80640505.57820-0.327802.442001.48290HepG2KIF1C
FAM53BENSG00000189319.9662.61330453.918100.545603.704602.94570HepG2MAGOH
FAM53BENSG00000189319.9843.32930456.418800.885608.361207.31410HepG2MATR3
FAM53BENSG00000189319.9252.91440450.29060-0.832203.565902.45670HepG2MTPAP
FAM53BENSG00000189319.9234.58900403.72480-0.783206.115404.31960HepG2NAA15
FAM53BENSG00000189319.9757.69330467.137600.697705.699604.80580HepG2NCBP2
FAM53BENSG00000189319.9663.44230398.808800.734202.990601.84940HepG2NONO
FAM53BENSG00000189319.9210.91500391.42390-0.892102.226201.55260HepG2NSUN2
FAM53BENSG00000189319.9620.11280415.580100.577306.279005.42180HepG2PCBP1
FAM53BENSG00000189319.9302.46470500.33530-0.726107.935406.71170HepG2PRPF4
FAM53BENSG00000189319.9777.28300422.866700.8781014.6369013.57160HepG2PTBP1
FAM53BENSG00000189319.9746.94290533.082200.486506.151705.34050HepG2PUM1
FAM53BENSG00000189319.9325.10420457.97840-0.494403.392002.70950HepG2QKI
FAM53BENSG00000189319.9610.32040790.09400-0.372502.012601.55230HepG2RBM22
FAM53BENSG00000189319.9807.59170470.611300.7790011.2472010.29620HepG2NELFE
FAM53BENSG00000189319.9655.36440438.308100.580306.198105.32620HepG2RECQL
FAM53BENSG00000189319.9437.83050308.068500.507003.195902.54150HepG2RPS19
FAM53BENSG00000189319.9445.85220310.557100.521604.473303.68780HepG2SAFB2
FAM53BENSG00000189319.9622.70360440.261600.500104.574703.84250HepG2SF3B4
FAM53BENSG00000189319.9468.43430362.147900.371202.703002.06420HepG2SMN1
FAM53BENSG00000189319.9212.78130486.09920-1.191907.621006.31700HepG2SNRNP70
FAM53BENSG00000189319.9637.81320892.34060-0.484503.187402.66240HepG2SRFBP1
FAM53BENSG00000189319.9634.11760495.826000.354802.861702.22530HepG2SRSF5
FAM53BENSG00000189319.9442.69960570.49790-0.365902.768502.07270HepG2SRSF7
FAM53BENSG00000189319.9237.34150373.85660-0.655505.559704.82480HepG2SRSF9
FAM53BENSG00000189319.9590.74080774.69050-0.391101.901401.45560HepG2SSB
FAM53BENSG00000189319.9272.41470396.82100-0.542702.609401.40200HepG2STAU1
FAM53BENSG00000189319.9383.41230250.663300.613003.353402.12810HepG2STIP1
FAM53BENSG00000189319.9859.79720563.890100.608509.343908.31590HepG2SUCLG1
FAM53BENSG00000189319.9252.04890401.16070-0.670504.782303.56270HepG2SUPT6H
FAM53BENSG00000189319.9233.93680432.08210-0.885205.612104.70130HepG2SUPV3L1
FAM53BENSG00000189319.9644.98730490.605400.394602.699201.83730HepG2TUFM
FAM53BENSG00000189319.9647.32680445.757800.538105.703804.89480HepG2UTP3
FAM53BENSG00000189319.9257.61090493.76200-0.9386012.7310011.46140HepG2ZC3H8
FAM53BENSG00000189319.9346.64740507.78700-0.550805.702204.99060HepG2ZNF622
FAM53BENSG00000189319.9235.49680345.63840-0.553603.055701.80770K562AARS
FAM53BENSG00000189319.91195.32090703.656900.7644015.7404014.50130K562AGGF1
FAM53BENSG00000189319.9493.05180365.561000.431503.482801.76690K562AKAP1
FAM53BENSG00000189319.91109.31810773.254300.520605.498003.99920K562AKAP8
FAM53BENSG00000189319.91542.90260705.919201.1280020.6808019.25090K562AQR
FAM53BENSG00000189319.9541.97490419.996400.367702.488501.58110K562BCLAF1
FAM53BENSG00000189319.9372.03750274.645300.437802.471801.72750K562CPSF6
FAM53BENSG00000189319.9466.58530318.630100.550203.974802.67670K562CSTF2
FAM53BENSG00000189319.91327.81730997.203400.413004.003702.82090K562CELF1
FAM53BENSG00000189319.9970.51350691.894700.488105.668503.89480K562DDX21
FAM53BENSG00000189319.9897.08610654.287900.455205.373904.50930K562DDX47
FAM53BENSG00000189319.9491.19090375.602400.387002.814001.49470K562DDX6
FAM53BENSG00000189319.9477.68080333.226600.519403.261701.80620K562DHX30
FAM53BENSG00000189319.9475.30840596.43600-0.327502.355901.68350K562EIF2S2
FAM53BENSG00000189319.9492.25170302.749400.701203.375702.25600K562EIF3A
FAM53BENSG00000189319.9575.81770393.857300.547802.960201.88660K562EIF3D
FAM53BENSG00000189319.9331.77050200.033200.729805.912204.76210K562EIF3G
FAM53BENSG00000189319.9609.17820387.052700.654204.726603.65400K562EIF4A3
FAM53BENSG00000189319.9445.76860348.584100.354702.397201.34430K562EIF4B
FAM53BENSG00000189319.91309.69450810.944200.6915011.613209.75400K562EIF4G2
FAM53BENSG00000189319.9478.01970337.872200.500503.206701.79640K562EWSR1
FAM53BENSG00000189319.9616.52830402.522500.615003.681702.99900K562FXR1
FAM53BENSG00000189319.984.32250158.65940-0.911903.631602.79600K562G3BP2
FAM53BENSG00000189319.9535.46330368.961200.537202.911601.44810K562GEMIN5
FAM53BENSG00000189319.9676.80880535.332800.338202.519101.43470K562GLRX3
FAM53BENSG00000189319.9369.24760262.220000.493702.705101.91930K562GPKOW
FAM53BENSG00000189319.91042.83080642.015200.699707.844106.11930K562HNRNPA1
FAM53BENSG00000189319.9387.38950271.294600.513803.271501.94640K562IGF2BP3
FAM53BENSG00000189319.91066.88160777.008200.457304.560603.45900K562KIF1C
FAM53BENSG00000189319.9468.12020280.240100.740106.628805.30010K562MAGOH
FAM53BENSG00000189319.9462.84340279.651600.726806.635305.12140K562MATR3
FAM53BENSG00000189319.9751.61840562.829000.417203.559502.64900K562MTPAP
FAM53BENSG00000189319.9522.09490362.989800.524302.718601.44230K562NONO
FAM53BENSG00000189319.91003.53210625.374000.6822013.4259011.95540K562NSUN2
FAM53BENSG00000189319.9454.89080272.280700.740306.897905.88470K562PTBP1
FAM53BENSG00000189319.9960.12930707.502000.440404.767304.00950K562RBM15
FAM53BENSG00000189319.9424.94570261.012900.703105.312304.10400K562RBM22
FAM53BENSG00000189319.9318.53860164.880500.949904.879703.72910K562SF3B4
FAM53BENSG00000189319.9535.74720384.165100.479703.095501.96710K562SRSF4
FAM53BENSG00000189319.9394.23990252.141800.644704.445303.06260K562SRSF5
FAM53BENSG00000189319.9480.70890346.521800.472102.289601.37020K562SUPV3L1
FAM53BENSG00000189319.9381.90990270.129500.499502.793502.08330K562TARDBP
FAM53BENSG00000189319.9406.77390260.578800.642403.170702.28650K562TIA1
FAM53BENSG00000189319.9383.41470255.780500.583903.517802.25740K562TRA2A
FAM53BENSG00000189319.9526.11630346.445800.602704.150902.94390K562TRIM56
FAM53BENSG00000189319.9783.54100567.392700.465604.067202.99990K562WDR3
FAM53BENSG00000189319.9851.59590590.004400.529307.397206.07600K562WDR43
FAM53BENSG00000189319.9519.62950373.723100.475402.614801.45010K562XRN2
FAM53BENSG00000189319.91038.83010795.213600.385403.108802.18850K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for FAM53B is not available on ENCORE database.





6 RBPs can affect the splicing of FAM53B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEFAM53BENSG00000189319.9chr10-126384726126384781126370175126370948126395204126395456-0.329000.000000.00001excludedK562AKAP8L
SEFAM53BENSG00000189319.9chr10-126370175126370948126310239126312173126384726126384781-0.127000.001920.02904excludedK562PUS1
SEFAM53BENSG00000189319.9chr10-1263847261263847811263701751263709481263952041263954560.235000.000400.07183includedK562APOBEC3C
SEFAM53BENSG00000189319.9chr10-126384726126384781126370175126370948126395204126395456-0.313000.000000.00003excludedK562RBM15
SEFAM53BENSG00000189319.9chr10-126384726126384781126370175126370948126395204126395456-0.325000.000000.00000excludedK562AGGF1
MXEFAM53BENSG00000189319.9chr10-126370175126370948126384726126384781126310239126312173126395204126395456-0.301000.000040.014962includedK562HNRNPA1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for FAM53B is not avaliable on ENCORE database.