EARS2

General Information

Gene Name       : EARS2
Gene ID             : ENSG00000103356.15
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: EARS2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878EARS2ENSG00000103356.1526.0432.5829.31ENCSR000AEF
HepG2EARS2ENSG00000103356.1554.0656.4855.27ENCSR985KAT
K562EARS2ENSG00000103356.1533.6639.4336.55ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for EARS2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • EARS2 RNA is bound by 12 proteins.  







eCLIP assay for EARS2 is not avaliable on ENCORE database.





12 proteins are bound to EARS2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr162353488423535020-3'-UTR,intron-Distal3.657559.01626K562UPF1
chr162354658323546680-3'-UTR,CDS,intron-Distal,intron-Proximal3.9315310.86690HepG2PPIG
chr162353490923535032-3'-UTR,intron-Distal3.633607.81366HepG2UPF1
chr162356346523563557-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.3444610.14543HepG2PPIG
chr162353427623534342-3'-UTR,intron-Distal,intron-Proximal3.846533.17740K562CSTF2T
chr162355583223555851-3'-UTR,CDS,intron-Distal,intron-Proximal4.412703.49332HepG2PPIG
chr162353469023534786-3'-UTR,intron-Distal,intron-Proximal4.259973.45012HepG2UPF1
chr162354656923546699-3'-UTR,CDS,intron-Distal,intron-Proximal3.650778.93345HepG2BUD13
chr162353558123535740-3'-UTR,CDS,intron-Distal4.580345.41965HepG2G3BP1
chr162354405923544086-CDS,intron-Distal,intron-Proximal4.165303.45943HepG2BCLAF1
chr162354084623540899-CDS,intron-Distal3.849946.06308HepG2PPIG
chr162356852523568657-CDS,intron-Distal,intron-Proximal4.874855.35746HepG2DDX3X
chr162354117123541230-CDS,intron-Distal,intron-Proximal4.069037.05872HepG2PPIG
chr162354082123540846-CDS,intron-Distal,intron-Proximal3.676894.52024HepG2PPIG
chr162354084423540931-CDS,intron-Distal4.221035.13243HepG2GRWD1
chr162356858523568652-CDS,intron-Distal,intron-Proximal3.212444.07798HepG2SRSF1
chr162354394123544018-CDS,intron-Distal,intron-Proximal3.663693.41051HepG2SRSF1
chr162354620423546255-CDS,intron-Distal,intron-Proximal3.741266.81103HepG2PPIG
chr162354616523546229-CDS,intron-Distal,intron-Proximal6.027566.69228HepG2PRPF8
chr162353656123536602-CDS,intron-Distal,intron-Proximal4.043456.06308HepG2PPIG
chr162354405923544088-CDS,intron-Distal,intron-Proximal3.223454.09741HepG2PPIG
chr162354106823541171-CDS,intron-Distal3.658638.46997HepG2PPIG
chr162354621023546267-CDS,intron-Distal3.791043.31827HepG2GRWD1
chr162356847723568542-CDS,intron-Distal,intron-Proximal3.950554.75655HepG2PRPF8
chr162354372223543839-intron-Distal,intron-Proximal3.627465.30252HepG2KHSRP
chr162354192523542008-intron-Distal3.475504.35223HepG2ILF3
chr162354213323542200-intron-Distal3.860486.08354HepG2ILF3
chr162354370723543839-intron-Distal,intron-Proximal4.739365.91698K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for EARS2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for EARS2 is not available on ENCORE database.

  • 91 RBPs can affect the levels of EARS2.  








The Knockdown/knockout RNA-Seq assay for EARS2 is not available on ENCORE database.





91 RBPs can affect the gene expression of EARS2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
EARS2ENSG00000103356.111653.453701310.064100.335702.185901.34420HepG2ABCF1
EARS2ENSG00000103356.11804.558001207.97310-0.5863010.983409.93960HepG2ACO1
EARS2ENSG00000103356.111180.73980917.935100.363102.729602.13500HepG2BOP1
EARS2ENSG00000103356.11741.13960981.40200-0.405103.543102.15820HepG2BUD13
EARS2ENSG00000103356.111659.714401207.665000.458609.174608.09960HepG2CKAP4
EARS2ENSG00000103356.111138.29130842.689500.433703.438202.67970HepG2CPSF6
EARS2ENSG00000103356.111096.195101460.37920-0.413805.199104.36830HepG2CELF1
EARS2ENSG00000103356.111062.050101455.27480-0.454403.498902.80550HepG2DDX3X
EARS2ENSG00000103356.11697.832601180.78010-0.758807.055905.88870HepG2DDX55
EARS2ENSG00000103356.11784.351701249.98800-0.672305.766804.90380HepG2DDX6
EARS2ENSG00000103356.11875.888201201.76600-0.456303.386602.73520HepG2EIF2S1
EARS2ENSG00000103356.11472.49670766.68890-0.698305.483804.24310HepG2EIF3D
EARS2ENSG00000103356.111232.499001549.14050-0.329903.848602.89020HepG2EIF4G1
EARS2ENSG00000103356.111489.133402124.08350-0.512407.484006.57600HepG2ETF1
EARS2ENSG00000103356.11764.133601005.30100-0.395702.771401.75330HepG2GNB2L1
EARS2ENSG00000103356.11946.603101153.24080-0.284902.972601.96430HepG2HDGF
EARS2ENSG00000103356.11836.548801070.31340-0.355502.573801.90280HepG2HNRNPC
EARS2ENSG00000103356.111011.940601430.16370-0.499109.292108.12470HepG2HNRNPL
EARS2ENSG00000103356.11919.932401086.05290-0.239502.194301.53310HepG2ILF2
EARS2ENSG00000103356.11586.53000831.62100-0.503702.704201.40420HepG2ILF3
EARS2ENSG00000103356.111649.835501340.337600.299601.891201.34370HepG2MAGOH
EARS2ENSG00000103356.11614.28930833.93320-0.441003.343401.58090HepG2MARK2
EARS2ENSG00000103356.111086.249601379.64190-0.344902.161901.59950HepG2NCBP2
EARS2ENSG00000103356.11651.12380890.65530-0.451903.859202.16590HepG2NIP7
EARS2ENSG00000103356.11622.80500808.31980-0.376102.463801.75740HepG2NSUN2
EARS2ENSG00000103356.11511.46620779.63300-0.608203.021202.09050HepG2PABPC1
EARS2ENSG00000103356.111577.656801238.089600.349604.590703.84240HepG2PCBP1
EARS2ENSG00000103356.11749.61780948.31420-0.339203.122302.34360HepG2PPIL4
EARS2ENSG00000103356.111537.006001064.853500.529409.523608.21350HepG2PRPF4
EARS2ENSG00000103356.11719.41510910.44950-0.339802.367101.61720HepG2PRPF8
EARS2ENSG00000103356.11643.249801259.77350-0.9697023.9353022.62640HepG2PTBP1
EARS2ENSG00000103356.111944.596801576.586200.302603.243502.51690HepG2PUM2
EARS2ENSG00000103356.11886.844901230.39230-0.472407.630806.69140HepG2PUS1
EARS2ENSG00000103356.11953.825701364.42750-0.516506.988806.06130HepG2QKI
EARS2ENSG00000103356.11660.548501034.18970-0.646803.389802.61150HepG2RAVER1
EARS2ENSG00000103356.11979.973401437.60380-0.552907.910806.56490HepG2RBM15
EARS2ENSG00000103356.112073.613501775.311100.224001.987901.52960HepG2RBM22
EARS2ENSG00000103356.11937.998901238.28230-0.400703.813803.03130HepG2RBM25
EARS2ENSG00000103356.11675.19020964.58900-0.514602.996101.89220HepG2RCC2
EARS2ENSG00000103356.111116.209401402.03100-0.328903.908203.28620HepG2NELFE
EARS2ENSG00000103356.11691.41410900.58100-0.381302.576501.81540HepG2RRP9
EARS2ENSG00000103356.111395.688101054.764400.404002.257001.40130HepG2SMNDC1
EARS2ENSG00000103356.111416.036202005.09620-0.5018010.017909.22530HepG2SRFBP1
EARS2ENSG00000103356.111790.938001369.045700.387405.832005.20880HepG2SRSF1
EARS2ENSG00000103356.11721.03400970.90670-0.429302.294901.39310HepG2SRSF3
EARS2ENSG00000103356.11891.669601113.77330-0.320903.338602.74410HepG2SRSF9
EARS2ENSG00000103356.111414.152701740.80670-0.299804.157803.55640HepG2SSB
EARS2ENSG00000103356.11516.78460744.81130-0.527303.264502.06240HepG2STIP1
EARS2ENSG00000103356.112120.456401668.916900.345406.530005.64540HepG2SUCLG1
EARS2ENSG00000103356.11655.593401175.32450-0.842208.291807.22230HepG2SUPV3L1
EARS2ENSG00000103356.111003.211901230.49290-0.294602.841002.27320HepG2TAF15
EARS2ENSG00000103356.11542.40150694.21580-0.356002.349301.64850HepG2UCHL5
EARS2ENSG00000103356.111062.784601308.29420-0.299803.506802.73520HepG2UPF1
EARS2ENSG00000103356.11895.357601050.83100-0.231002.072001.47830HepG2ZC3H8
EARS2ENSG00000103356.11945.179201534.99850-0.699608.779007.82950K562AQR
EARS2ENSG00000103356.11987.40590801.963100.300002.575001.69610K562ATP5C1
EARS2ENSG00000103356.11413.65100542.82780-0.392102.320301.37170K562CCAR1
EARS2ENSG00000103356.11801.936601130.75290-0.495702.240501.30410K562CNOT7
EARS2ENSG00000103356.111804.496202338.38100-0.373904.490303.23800K562CELF1
EARS2ENSG00000103356.11935.420001274.40670-0.446106.091605.17750K562DDX47
EARS2ENSG00000103356.11445.92620607.65940-0.446502.895701.53310K562DHX30
EARS2ENSG00000103356.11398.51760583.73790-0.550704.168702.49260K562DNAJC21
EARS2ENSG00000103356.11919.539301364.79280-0.569709.449908.24050K562EIF2S2
EARS2ENSG00000103356.11297.62740552.16410-0.891605.166803.75150K562EIF3A
EARS2ENSG00000103356.11583.76740782.51880-0.422702.631601.53710K562FKBP4
EARS2ENSG00000103356.11280.97340543.11570-0.950806.437705.11270K562FMR1
EARS2ENSG00000103356.11314.45700460.31040-0.549702.678301.77840K562FTO
EARS2ENSG00000103356.11374.73460520.47180-0.474003.292801.81760K562FUS
EARS2ENSG00000103356.111015.00680784.613800.371303.656302.97540K562FXR1
EARS2ENSG00000103356.11471.17080780.26460-0.727703.052701.75420K562HNRNPA2B1
EARS2ENSG00000103356.11511.21080901.94020-0.819108.499707.50450K562HNRNPC
EARS2ENSG00000103356.111110.877101386.12120-0.319403.179402.22450K562HNRNPU
EARS2ENSG00000103356.11342.25850567.09800-0.728506.159303.94780K562ILF3
EARS2ENSG00000103356.11596.35300872.96410-0.549805.102303.12460K562LARP7
EARS2ENSG00000103356.111106.50540821.877700.428904.071603.04640K562MAGOH
EARS2ENSG00000103356.111532.974402027.13440-0.403103.617202.32620K562MSI2
EARS2ENSG00000103356.11972.506401207.71160-0.312504.157403.26270K562NSUN2
EARS2ENSG00000103356.11761.642901086.32060-0.512302.610501.42240K562PABPC1
EARS2ENSG00000103356.11404.81740682.83510-0.754303.145502.07000K562PABPN1
EARS2ENSG00000103356.11608.069701063.34160-0.806308.722807.24850K562PCBP3
EARS2ENSG00000103356.11609.75000880.45780-0.530004.213002.39540K562PHF6
EARS2ENSG00000103356.11543.79620815.60610-0.584806.194205.00040K562POLR2G
EARS2ENSG00000103356.11625.88760800.63280-0.355202.021601.37570K562PRPF8
EARS2ENSG00000103356.11586.19410808.64200-0.464103.381202.36660K562PSIP1
EARS2ENSG00000103356.11594.63330798.51090-0.425303.702302.94550K562PTBP1
EARS2ENSG00000103356.111789.192602207.07710-0.302803.036501.91570K562PUM1
EARS2ENSG00000103356.111795.505802162.52210-0.268302.847001.87310K562PUM2
EARS2ENSG00000103356.11555.37450758.03780-0.448802.869002.31830K562PUS1
EARS2ENSG00000103356.11564.23650765.63850-0.440403.365402.43370K562RBM22
EARS2ENSG00000103356.11473.03640840.11440-0.828602.887001.31310K562RBM39
EARS2ENSG00000103356.11417.47600737.57900-0.821108.551206.80640K562RCC2
EARS2ENSG00000103356.11605.87960805.72090-0.411202.862901.74930K562NELFE
EARS2ENSG00000103356.11548.58270815.58920-0.572103.989503.00580K562RPS19
EARS2ENSG00000103356.11328.01000484.66650-0.563302.840901.85440K562SF3B1
EARS2ENSG00000103356.11368.46850717.08970-0.960604.485002.80490K562SNRNP200
EARS2ENSG00000103356.111414.220601220.956700.211902.158601.32300K562SRPK2
EARS2ENSG00000103356.11461.78570607.26970-0.395103.016001.67080K562SSB
EARS2ENSG00000103356.11540.07450775.28320-0.521603.482102.32820K562SUPV3L1
EARS2ENSG00000103356.111030.79170818.092400.333302.762801.94380K562SYNCRIP
EARS2ENSG00000103356.11454.35750619.37050-0.447002.997301.34070K562TBRG4
EARS2ENSG00000103356.11472.25460777.80280-0.719805.413604.06230K562TIAL1
EARS2ENSG00000103356.11576.82420749.95920-0.378702.554501.51210K562TRA2A
EARS2ENSG00000103356.111157.248801508.10330-0.382005.422203.63370K562TROVE2
EARS2ENSG00000103356.11762.56380594.840800.358302.817502.00650K562U2AF2
EARS2ENSG00000103356.111842.149502339.50900-0.344803.309301.75910K562UBE2L3
EARS2ENSG00000103356.11516.67950820.49300-0.667205.998304.43060K562UCHL5
EARS2ENSG00000103356.111050.812701280.56370-0.285303.052302.29880K562UPF1
EARS2ENSG00000103356.11837.417401095.73550-0.387903.449502.47510K562WDR3
EARS2ENSG00000103356.111218.369001729.39710-0.505304.934703.72850K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for EARS2 is not available on ENCORE database.





4 RBPs can affect the splicing of EARS2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEEARS2ENSG00000103356.11chr16-235577022355775523555861235560242356346923563625-0.229000.009050.08431excludedHepG2U2AF2
SEEARS2ENSG00000103356.11chr16-2356436423564444235635122356362523568525235686850.181000.000010.00540includedK562DROSHA
A3SSEARS2ENSG00000103356.11chr16-235410642354123823541064235412182354397723544086-0.399000.000330.01067shorterHepG2U2AF2
A3SSEARS2ENSG00000103356.11chr16-2354082223540981235408222354095323541064235412180.067000.006980.03870longerK562AQR
A3SSEARS2ENSG00000103356.11chr16-2355583423556048235558342355602423563469235636250.128000.000060.00058longerK562AQR
A3SSEARS2ENSG00000103356.11chr16-235410642354123823541064235412182354397723544086-0.399000.000570.08306shorterHepG2SFPQ

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for EARS2 is not avaliable on ENCORE database.