DIS3

General Information

Gene Name       : DIS3
Gene ID             : ENSG00000083520.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: DIS3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DIS3ENSG00000083520.1443.0438.6540.84ENCSR000AEF
HepG2DIS3ENSG00000083520.1412.4722.3017.39ENCSR985KAT
K562DIS3ENSG00000083520.1426.8327.7527.29ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
DIS3K562CRISPRBGKcLV38-15,BGKcLV38-16BGKcLV38-1,BGKcLV38-2no clear band on the position,NotSatisfiedENCORE2
DIS3K562CRISPRBGKcLV46-21,BGKcLV46-22BGKcLV46-1,BGKcLV46-281.8,85.2ExperimentedENCORE2
DIS3K562CRISPRBGKcLV46-23,BGKcLV46-24BGKcLV46-1,BGKcLV46-288.4,86.4ExperimentedENCORE2
DIS3HepG2CRISPRBGHcLV39-23,BGHcLV39-24BGHcLV39-1,BGHcLV39-2no clear band on the position,NotSatisfiedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for DIS3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • DIS3 RNA is bound by 14 proteins.  







eCLIP assay for DIS3 is not avaliable on ENCORE database.





14 proteins are bound to DIS3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr137333370473333763-3'-UTR,intron-Distal,intron-Proximal3.794664.93097K562YBX3
chr137334293573342954-3'-UTR,CDS,intron-Distal4.220393.02457HepG2BCLAF1
chr137333312173333190-3'-UTR,intron-Distal,intron-Proximal,polyA_site3.418388.99831K562PUM2
chr137335245973352532-5'-UTR,CDS,intron-Distal,intron-Proximal3.930873.58455K562U2AF2
chr137335573073355751-5'-UTR,CDS,intron-Distal4.072515.05356HepG2PRPF8
chr137335584273355893-5'-UTR,CDS,intron-Distal3.4996311.08616K562YBX3
chr137335575973355874-5'-UTR,CDS,intron-Distal4.967716.76290HepG2GRWD1
chr137335589373355901-5'-UTR,CDS,intron-Distal5.2543110.97360K562YBX3
chr137335247873352562-5'-UTR,CDS,intron-Distal,intron-Proximal4.157909.06734HepG2U2AF2
chr137335593373356017-5'-UTR,CDS,intron-Distal,intron-Proximal4.741275.17013K562RBM15
chr137335569673355745-5'-UTR,CDS,intron-Distal4.603316.99120K562AQR
chr137335232273352422-5'-UTR,CDS,intron-Distal,intron-Proximal3.120825.10726K562UCHL5
chr137335155773351631-CDS,intron-Distal,intron-Proximal3.909628.04012K562ZNF622
chr137334809173348156-CDS,intron-Distal5.136096.71715HepG2BCLAF1
chr137335157773351632-CDS,intron-Distal,intron-Proximal3.503087.42278HepG2BCLAF1
chr137334934973349498-CDS,intron-Distal4.127859.93259HepG2BCLAF1
chr137335155773351632-CDS,intron-Distal,intron-Proximal3.943969.17402K562UCHL5
chr137335021473350231-CDS,intron-Distal,intron-Proximal4.261623.45943HepG2BCLAF1
chr137335016773350232-CDS,intron-Distal,intron-Proximal3.127683.26275K562BUD13
chr137335155773351577-CDS,intron-Distal,intron-Proximal3.026884.61799HepG2BCLAF1
chr137334523173345270-CDS,intron-Distal3.928103.01428K562UCHL5
chr137334808273348122-CDS,intron-Distal,intron-Proximal3.726574.76274K562UCHL5
chr137334808473348139-CDS,intron-Distal5.176485.34688K562DDX24
chr137334812273348198-CDS,intron-Distal,intron-Proximal5.476069.64872K562UCHL5
chr137334934773349416-CDS,intron-Distal,intron-Proximal3.769647.25346K562UCHL5
chr137334594973346011-CDS,intron-Distal,intron-Proximal5.250268.41647HepG2BCLAF1
chr137334782073347857-CDS,intron-Distal,intron-Proximal4.491344.34038HepG2BCLAF1
chr137335282273352972-intron-Distal4.9932913.54317K562KHSRP
chr137335282573352975-intron-Distal3.902565.30252HepG2KHSRP
chr137335569573355730-intron-Distal4.297846.23016HepG2PRPF8
chr137335558473355704-intron-Distal,intron-Proximal4.9326313.71476HepG2EFTUD2
chr137335266973352756-intron-Distal3.709318.36543HepG2U2AF2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for DIS3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for DIS3 is not available on ENCORE database.

  • 81 RBPs can affect the levels of DIS3.  








The Knockdown/knockout RNA-Seq assay for DIS3 is not available on ENCORE database.





81 RBPs can affect the gene expression of DIS3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
DIS3ENSG00000083520.101200.40830959.730600.322703.924403.22400HepG2ACO1
DIS3ENSG00000083520.10465.04190928.21680-0.9971013.4179011.47110HepG2ADAR
DIS3ENSG00000083520.101760.583501231.382200.515704.034503.40930HepG2AKAP1
DIS3ENSG00000083520.10682.04110946.83080-0.473202.573401.67240HepG2BCCIP
DIS3ENSG00000083520.101122.015801462.45930-0.382303.233302.59270HepG2BOP1
DIS3ENSG00000083520.101254.41070959.493100.386605.756804.86020HepG2CKAP4
DIS3ENSG00000083520.101012.434301342.61960-0.407203.249802.51040HepG2CPSF6
DIS3ENSG00000083520.101052.279201310.43080-0.316504.329303.43560HepG2DAZAP1
DIS3ENSG00000083520.10699.61250953.21090-0.446204.663403.18070HepG2DDX1
DIS3ENSG00000083520.10489.145001179.61300-1.2700019.7958018.28500HepG2DDX3X
DIS3ENSG00000083520.10732.777301013.21310-0.467503.010302.36860HepG2DDX6
DIS3ENSG00000083520.10715.74990934.68520-0.385003.858503.03960HepG2DNAJC21
DIS3ENSG00000083520.10753.23300926.39540-0.298503.212302.51830HepG2DNAJC2
DIS3ENSG00000083520.10930.04420671.665700.469503.615002.58930HepG2EIF3D
DIS3ENSG00000083520.101067.826501521.97040-0.511304.201503.42390HepG2GPKOW
DIS3ENSG00000083520.10745.97770943.63940-0.339102.430501.82270HepG2HNRNPA1
DIS3ENSG00000083520.10750.165301049.61230-0.484604.306703.45560HepG2HNRNPC
DIS3ENSG00000083520.10957.425001323.18760-0.466806.429605.39910HepG2HNRNPF
DIS3ENSG00000083520.101266.222301020.074000.311802.112001.49640HepG2HNRNPK
DIS3ENSG00000083520.10675.776601193.73550-0.8209020.8665019.18380HepG2HNRNPL
DIS3ENSG00000083520.10965.538701452.44380-0.589105.911905.02760HepG2HNRNPLL
DIS3ENSG00000083520.10733.143101042.67380-0.508107.508806.54820HepG2HNRNPU
DIS3ENSG00000083520.10934.317501302.97660-0.479805.146204.18980HepG2IGF2BP1
DIS3ENSG00000083520.10797.577101065.05880-0.417206.482105.40750HepG2ILF2
DIS3ENSG00000083520.101316.533201840.54020-0.483403.402202.48130HepG2LARP4
DIS3ENSG00000083520.10560.381801118.30720-0.9968012.3583011.07070HepG2NCBP2
DIS3ENSG00000083520.10672.83340929.98380-0.467005.320004.32710HepG2PPIL4
DIS3ENSG00000083520.10954.971601240.37450-0.377203.364502.71620HepG2PUF60
DIS3ENSG00000083520.10624.49510977.54370-0.6465011.2880010.18780HepG2PUS1
DIS3ENSG00000083520.101330.80040928.716400.518902.475601.80760HepG2RAVER1
DIS3ENSG00000083520.101215.55190962.054900.337302.394301.76230HepG2RBM25
DIS3ENSG00000083520.101153.530001425.17970-0.305102.104901.49940HepG2RPLP0
DIS3ENSG00000083520.101069.35310710.568200.589605.040004.01260HepG2RRP9
DIS3ENSG00000083520.10755.34250928.55420-0.297902.958802.29790HepG2SAFB2
DIS3ENSG00000083520.101951.485701268.263700.621604.584103.70570HepG2SF3A3
DIS3ENSG00000083520.101275.039001019.047900.323203.446902.79610HepG2SF3B4
DIS3ENSG00000083520.102186.171201599.621000.450602.464301.72750HepG2SNRNP70
DIS3ENSG00000083520.102008.501901583.681300.342705.312804.68050HepG2SRFBP1
DIS3ENSG00000083520.101880.837001063.648400.8223022.8579021.78280HepG2SRSF1
DIS3ENSG00000083520.10970.651901299.93790-0.421405.364704.44850HepG2SRSF7
DIS3ENSG00000083520.101043.397301374.98980-0.398105.728505.04190HepG2SSB
DIS3ENSG00000083520.101045.617301415.66600-0.437103.857503.01700HepG2TARDBP
DIS3ENSG00000083520.10737.492601013.19760-0.458204.838104.21460HepG2TIAL1
DIS3ENSG00000083520.10471.631601022.20630-1.1160028.8063027.22690HepG2TRIM56
DIS3ENSG00000083520.101341.161801038.416000.369002.461901.86690HepG2U2AF1
DIS3ENSG00000083520.10926.271201124.75580-0.280102.885802.17470HepG2UPF1
DIS3ENSG00000083520.10568.61720848.76340-0.577902.802201.79030HepG2UPF2
DIS3ENSG00000083520.10926.363001085.90790-0.229302.003101.47610HepG2UTP3
DIS3ENSG00000083520.10553.36030912.28030-0.721306.183605.11450HepG2XRN2
DIS3ENSG00000083520.102457.850303077.61580-0.324402.839001.59560K562ABCF1
DIS3ENSG00000083520.102582.449202217.959700.219402.770302.20210K562AGGF1
DIS3ENSG00000083520.102948.541802307.899200.353303.608802.85900K562AKAP8L
DIS3ENSG00000083520.103028.196002421.563800.322404.479003.28810K562ATP5C1
DIS3ENSG00000083520.101287.821101607.31390-0.319703.633802.08330K562BCCIP
DIS3ENSG00000083520.101277.507901553.25660-0.282003.304902.25300K562BCLAF1
DIS3ENSG00000083520.102456.836802888.43180-0.233502.729601.63130K562CPEB4
DIS3ENSG00000083520.101656.412501987.86460-0.263202.241101.52860K562CPSF6
DIS3ENSG00000083520.101528.428101875.53640-0.295303.298101.97180K562DDX21
DIS3ENSG00000083520.101091.219801691.87320-0.632709.415707.38500K562DDX3X
DIS3ENSG00000083520.102954.644402483.392000.250603.126502.18780K562DKC1
DIS3ENSG00000083520.101467.778402050.15540-0.482108.324007.17700K562EIF2S2
DIS3ENSG00000083520.101388.113701767.62970-0.348702.998202.14620K562EIF4A3
DIS3ENSG00000083520.102769.636703546.81450-0.356805.556304.24670K562EIF4G2
DIS3ENSG00000083520.101788.199302212.24200-0.307002.514701.70680K562FIP1L1
DIS3ENSG00000083520.101370.463902022.58640-0.561506.493205.16230K562FMR1
DIS3ENSG00000083520.101331.041501714.31630-0.365102.708801.80390K562FTO
DIS3ENSG00000083520.101530.166201838.26730-0.264702.727902.12660K562FXR1
DIS3ENSG00000083520.103130.106801957.432200.677106.309105.14310K562G3BP2
DIS3ENSG00000083520.102038.741502731.99200-0.422305.168804.13170K562GRSF1
DIS3ENSG00000083520.101212.474801701.03330-0.488505.662304.83850K562HNRNPC
DIS3ENSG00000083520.101160.128001518.86760-0.388703.577502.26570K562HNRNPF
DIS3ENSG00000083520.102017.650202701.07740-0.420905.047203.57290K562HNRNPL
DIS3ENSG00000083520.101587.275502080.37440-0.390305.084103.85990K562HNRNPU
DIS3ENSG00000083520.102017.773302999.37160-0.571907.528206.23410K562HSPD1
DIS3ENSG00000083520.103143.320702449.217200.359902.483401.70660K562KIF1C
DIS3ENSG00000083520.101311.155201724.90070-0.395703.022801.49080K562LIN28B
DIS3ENSG00000083520.101816.619002326.36980-0.356807.972306.79780K562NSUN2
DIS3ENSG00000083520.101838.683502511.29010-0.449804.796403.67090K562PPIG
DIS3ENSG00000083520.101764.268401234.276800.515305.398704.34680K562PRPF8
DIS3ENSG00000083520.10904.112801525.11080-0.754307.534905.89870K562PSIP1
DIS3ENSG00000083520.101660.221602030.09020-0.290202.679702.02450K562PTBP1
DIS3ENSG00000083520.103246.293004033.02880-0.313104.667003.40940K562PUM2
DIS3ENSG00000083520.103236.616302230.081400.5373010.787609.64040K562RBM15
DIS3ENSG00000083520.101268.303501733.00640-0.450403.853802.64770K562RPS3
DIS3ENSG00000083520.101221.525301673.25930-0.454004.029402.72530K562SRSF4
DIS3ENSG00000083520.101438.693102014.23550-0.485504.921203.96310K562TARDBP
DIS3ENSG00000083520.101473.641701942.92860-0.398804.580603.48790K562TIA1
DIS3ENSG00000083520.101077.184701466.92710-0.445502.583301.68250K562TIAL1
DIS3ENSG00000083520.10853.511901558.18510-0.8684013.9605011.47000K562TRIM56
DIS3ENSG00000083520.101733.602702110.67350-0.283902.559901.71480K562WDR3
DIS3ENSG00000083520.101916.711102194.89970-0.195502.307501.52870K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for DIS3 is not available on ENCORE database.





18 RBPs can affect the splicing of DIS3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEDIS3ENSG00000083520.10chr13-7335498373355141733523247335251873355426733554940.315000.000020.00069includedK562SRSF1
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335542673355494-0.273000.000000.00000excludedK562AKAP8L
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335542673355494-0.247000.000000.00017excludedHepG2DDX59
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335542673355494-0.216000.000110.00222excludedHepG2U2AF2
SEDIS3ENSG00000083520.10chr13-7335542673355494733549837335514173355742733562340.164000.005040.04686includedK562AQR
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335574273356071-0.077000.003270.03287excludedK562AQR
SEDIS3ENSG00000083520.10chr13-7335498373355141733523247335251873355426733554940.354000.000000.00006includedK562FXR1
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335542673355494-0.232000.000280.03269excludedHepG2SRSF7
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335574273355992-0.181000.000350.00712excludedK562PUS1
SEDIS3ENSG00000083520.10chr13-7335542673355494733549837335514173355742733562320.154000.000330.02710includedHepG2FTO
SEDIS3ENSG00000083520.10chr13-7335542673355494733549837335514173355742733562320.287000.001100.02441includedK562U2AF1
SEDIS3ENSG00000083520.10chr13-7335498373355141733523247335251873355426733554940.342000.000090.00355includedHepG2SRSF1
SEDIS3ENSG00000083520.10chr13-733554267335549473354983733551417335574273356232-0.222000.004190.07731excludedHepG2SRSF1
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335542673355494-0.188000.000000.00041excludedK562HNRNPUL1
SEDIS3ENSG00000083520.10chr13-7335498373355141733523247335251873355426733554940.440000.000050.02992includedHepG2GRSF1
SEDIS3ENSG00000083520.10chr13-7335542673355494733549837335514173355742733562320.269000.000410.01742includedK562UTP18
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335542673355494-0.206000.000020.00188excludedK562UTP18
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335574273355992-0.093000.003170.06496excludedK562RBM15
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335542673355494-0.211000.000020.00133excludedK562AGGF1
SEDIS3ENSG00000083520.10chr13-7335498373355141733523247335251873355426733554940.229000.000070.05424includedK562AARS
SEDIS3ENSG00000083520.10chr13-733549837335514173352324733525187335542673355494-0.220000.000040.01035excludedK562ZC3H8
SEDIS3ENSG00000083520.10chr13-7335498373355141733523247335251873355426733554940.251000.002920.09951includedK562HNRNPK
A3SSDIS3ENSG00000083520.10chr13-7334629673346460733462967334641373346830733470060.051000.000000.00000longerK562AQR
A3SSDIS3ENSG00000083520.10chr13-7333550073335691733355007333565973335783733359520.077000.000010.00015longerK562AQR
A3SSDIS3ENSG00000083520.10chr13-7333758873337822733375887333774573340109733401960.065000.000280.00219longerK562AQR
A3SSDIS3ENSG00000083520.10chr13-7334782173347999733478217334795973348083733482340.141000.000000.00000longerK562AQR
A3SSDIS3ENSG00000083520.10chr13-7334521873345314733452187334528373345932733460680.073000.000000.00000longerK562AQR
A3SSDIS3ENSG00000083520.10chr13-7333466673334864733346667333478973335500733356770.169000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for DIS3 is not avaliable on ENCORE database.