COPS8

General Information

Gene Name       : COPS8
Gene ID             : ENSG00000198612.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: COPS8)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878COPS8ENSG00000198612.1052.6349.1650.89ENCSR000AEF
HepG2COPS8ENSG00000198612.1055.21101.7378.47ENCSR985KAT
K562COPS8ENSG00000198612.1025.5230.9628.24ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for COPS8 is not avaliable on ENCORE database.



Proteins bound to RNA
  • COPS8 RNA is bound by 11 proteins.  







eCLIP assay for COPS8 is not avaliable on ENCORE database.





11 proteins are bound to COPS8 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2238006955238007011+3'-UTR,intron-Distal3.125943.34065K562IGF2BP1
chr2238007173238007238+3'-UTR,intron-Distal5.5108613.70562K562LIN28B
chr2238007120238007207+3'-UTR,intron-Distal3.699265.15749K562YBX3
chr2238006960238007041+3'-UTR,intron-Distal3.160703.46578HepG2ZC3H11A
chr2238006830238006895+3'-UTR,intron-Distal4.123613.51789K562IGF2BP2
chr2237998500237998567+5'-UTR,CDS,intron-Proximal4.056564.31428K562YBX3
chr2237994659237994751+5'-UTR,CDS,intron-Proximal5.0302218.46362HepG2PRPF8
chr2237994555237994639+5'-UTR,CDS3.269173.39415HepG2DDX3X
chr2237994558237994658+5'-UTR,CDS4.8230916.02973K562DDX3X
chr2238001006238001095+intron-Distal3.732843.00914HepG2PTBP1
chr2237994808237994862+intron-Distal3.530594.79018HepG2EFTUD2
chr2237994756237994865+intron-Distal,intron-Proximal3.375664.76009HepG2PRPF4
chr2237997312237997392+intron-Proximal3.638553.24603K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for COPS8 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for COPS8 is not available on ENCORE database.

  • 89 RBPs can affect the levels of COPS8.  








The Knockdown/knockout RNA-Seq assay for COPS8 is not available on ENCORE database.





89 RBPs can affect the gene expression of COPS8 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
COPS8ENSG00000198612.61521.647801228.187200.309004.125903.41130HepG2ACO1
COPS8ENSG00000198612.6911.260401261.44030-0.469104.070802.88680HepG2ADAR
COPS8ENSG00000198612.63255.577402044.615400.671007.142906.33230HepG2AKAP1
COPS8ENSG00000198612.62253.860101857.902800.278602.924102.22150HepG2AUH
COPS8ENSG00000198612.61810.794801223.682700.565306.851605.95760HepG2BOP1
COPS8ENSG00000198612.61009.691001227.79290-0.282203.355902.63600HepG2CKAP4
COPS8ENSG00000198612.61614.841601147.330200.493002.639301.89280HepG2CNOT7
COPS8ENSG00000198612.6729.491701123.41860-0.622906.329405.32120HepG2CPSF6
COPS8ENSG00000198612.61035.796701293.57680-0.320603.207602.10960HepG2YBX3
COPS8ENSG00000198612.62104.301501726.189200.285703.309602.61940HepG2CELF1
COPS8ENSG00000198612.61596.724201856.25050-0.217303.021902.25240HepG2DAZAP1
COPS8ENSG00000198612.6971.918201135.83860-0.224902.222201.46880HepG2DDX19B
COPS8ENSG00000198612.61382.394101091.908400.340202.631701.36430HepG2DDX47
COPS8ENSG00000198612.61055.793501270.23310-0.266802.423401.75990HepG2DNAJC21
COPS8ENSG00000198612.61027.871801617.42550-0.654006.999806.08760HepG2EIF2S1
COPS8ENSG00000198612.61159.941201787.48250-0.623905.746004.82590HepG2EIF4A3
COPS8ENSG00000198612.61099.085301740.29420-0.663005.155604.23590HepG2EIF4B
COPS8ENSG00000198612.61479.499701200.045200.301902.051401.33390HepG2EWSR1
COPS8ENSG00000198612.6723.926001125.32090-0.636402.304201.38410HepG2FTO
COPS8ENSG00000198612.61379.381001775.98520-0.364602.729801.84580HepG2G3BP2
COPS8ENSG00000198612.6850.166801273.51310-0.583004.988404.14510HepG2GPKOW
COPS8ENSG00000198612.6678.432001282.40170-0.9186014.7749013.47550HepG2HNRNPA1
COPS8ENSG00000198612.6900.572401426.41670-0.663508.398307.24360HepG2HNRNPC
COPS8ENSG00000198612.61161.923401425.35680-0.294803.100002.34340HepG2HNRNPF
COPS8ENSG00000198612.61375.341601693.88650-0.300502.135601.51690HepG2HNRNPK
COPS8ENSG00000198612.61373.934801690.95470-0.299504.810203.93910HepG2HNRNPL
COPS8ENSG00000198612.6976.835201215.33430-0.315201.983501.44190HepG2HNRNPLL
COPS8ENSG00000198612.6884.066001416.98740-0.6806014.8352013.52400HepG2HNRNPU
COPS8ENSG00000198612.61034.390601403.57690-0.440304.828903.89780HepG2IGF2BP1
COPS8ENSG00000198612.6707.330501595.80730-1.173806.326004.86880HepG2IGF2BP3
COPS8ENSG00000198612.6963.578501447.40880-0.5870014.3156012.79460HepG2ILF2
COPS8ENSG00000198612.61451.072301856.87440-0.355802.421501.82650HepG2NCBP2
COPS8ENSG00000198612.61475.438501840.64490-0.319103.620902.74850HepG2NOL12
COPS8ENSG00000198612.6687.150801077.60400-0.649106.495605.37380HepG2NSUN2
COPS8ENSG00000198612.61250.725701653.73600-0.403002.991602.24230HepG2PABPC4
COPS8ENSG00000198612.61379.333601706.95300-0.307503.926603.23030HepG2PCBP1
COPS8ENSG00000198612.6735.741901263.84270-0.7805015.2077013.55570HepG2PPIL4
COPS8ENSG00000198612.6826.896901066.16160-0.366602.233901.50530HepG2PRPF8
COPS8ENSG00000198612.61434.404901757.00850-0.292702.516301.94430HepG2PUF60
COPS8ENSG00000198612.61516.216701863.75850-0.297703.057502.35170HepG2PUM2
COPS8ENSG00000198612.6587.175901197.58130-1.028307.670406.52980HepG2RAVER1
COPS8ENSG00000198612.62743.380901782.794700.6217014.1712013.18200HepG2RBM22
COPS8ENSG00000198612.61094.102101415.70120-0.371802.564701.61250HepG2RBM27
COPS8ENSG00000198612.61670.762201932.97010-0.210302.259601.76060HepG2NELFE
COPS8ENSG00000198612.61277.777401800.19140-0.494509.269208.24100HepG2RECQL
COPS8ENSG00000198612.61264.409001535.34840-0.280101.930701.34770HepG2RPLP0
COPS8ENSG00000198612.6883.415601151.63190-0.382502.011801.32990HepG2RPS3A
COPS8ENSG00000198612.6565.874001332.78450-1.2359021.4537018.61320HepG2RPS5
COPS8ENSG00000198612.6735.793801054.65850-0.519403.630002.74610HepG2RRP9
COPS8ENSG00000198612.61098.961601261.90060-0.199501.867701.32120HepG2SAFB2
COPS8ENSG00000198612.61740.473801196.893000.540104.097203.26890HepG2SF3A3
COPS8ENSG00000198612.61492.905101808.37880-0.276603.456002.80440HepG2SF3B4
COPS8ENSG00000198612.61414.715401684.58150-0.251903.444202.67610HepG2SLBP
COPS8ENSG00000198612.61247.462801471.60740-0.238402.847802.19630HepG2SMN1
COPS8ENSG00000198612.61432.278202013.65960-0.491505.042504.42330HepG2SRFBP1
COPS8ENSG00000198612.62983.253401887.503800.6603019.6375018.62010HepG2SRSF1
COPS8ENSG00000198612.61194.120301400.34050-0.229802.104501.48790HepG2SRSF7
COPS8ENSG00000198612.6939.814001535.53990-0.7083017.4874016.31800HepG2SRSF9
COPS8ENSG00000198612.6772.32560989.79690-0.357902.583401.67430HepG2SUPT6H
COPS8ENSG00000198612.61291.666801696.41710-0.393305.288404.55470HepG2TAF15
COPS8ENSG00000198612.6863.448901184.49340-0.456103.866803.02540HepG2TARDBP
COPS8ENSG00000198612.6858.097701376.93600-0.6822010.8936010.01460HepG2TIAL1
COPS8ENSG00000198612.6821.633301389.17180-0.7577017.7316016.46550HepG2TRIM56
COPS8ENSG00000198612.61393.387501716.43080-0.300802.749701.87970HepG2TUFM
COPS8ENSG00000198612.61566.652501024.799100.6122012.8733011.72190HepG2UTP3
COPS8ENSG00000198612.61056.684401354.32050-0.358002.327001.65750HepG2XRN2
COPS8ENSG00000198612.61381.540901128.262500.292103.667002.91150HepG2ZC3H8
COPS8ENSG00000198612.61527.207001167.404100.387506.831206.07170HepG2ZNF622
COPS8ENSG00000198612.61179.56410845.910100.479606.442705.62900K562AGGF1
COPS8ENSG00000198612.61172.23150880.191200.413302.902402.23320K562AKAP8L
COPS8ENSG00000198612.61531.621101239.851600.304802.003301.48860K562AQR
COPS8ENSG00000198612.6780.72990989.20990-0.341503.012901.85600K562CPEB4
COPS8ENSG00000198612.6530.72070743.93070-0.487204.155603.19110K562CPSF6
COPS8ENSG00000198612.6869.782501023.80440-0.235201.898601.34010K562DDX47
COPS8ENSG00000198612.61229.08960947.252900.375704.007202.92750K562DKC1
COPS8ENSG00000198612.6630.46320826.51650-0.390603.082102.32990K562EIF2S2
COPS8ENSG00000198612.6733.91550589.043800.317102.364401.79680K562FXR1
COPS8ENSG00000198612.6894.28410667.548500.421802.290401.65520K562G3BP2
COPS8ENSG00000198612.6722.09310925.18210-0.357602.766201.71170K562HNRNPL
COPS8ENSG00000198612.6964.73450727.537100.407002.571401.67780K562HNRNPM
COPS8ENSG00000198612.61568.957401199.241500.387603.203702.35150K562HSPD1
COPS8ENSG00000198612.6497.42170761.47900-0.614306.145304.26260K562IGF2BP3
COPS8ENSG00000198612.6394.95180606.54760-0.618902.157801.34500K562KRR1
COPS8ENSG00000198612.61033.43090733.507300.494502.299401.51260K562NAA15
COPS8ENSG00000198612.6919.65760536.200300.778203.394802.26460K562PABPN1
COPS8ENSG00000198612.61165.94890848.140100.459003.425102.49900K562PCBP3
COPS8ENSG00000198612.6944.26950650.559400.537405.904104.73760K562POLR2G
COPS8ENSG00000198612.61513.05700873.027000.7933010.835909.80900K562PUS1
COPS8ENSG00000198612.61152.13680850.534800.437804.697803.94540K562RBM15
COPS8ENSG00000198612.6810.61670490.235700.725402.466101.35840K562SF1
COPS8ENSG00000198612.6966.56610749.472400.366902.989902.25810K562SRSF1
COPS8ENSG00000198612.6829.07500652.518300.345402.220901.48410K562SYNCRIP
COPS8ENSG00000198612.6603.15770758.56640-0.330701.960301.35810K562TARDBP
COPS8ENSG00000198612.6571.70990731.70940-0.356002.494201.72290K562TIA1
COPS8ENSG00000198612.6852.95370668.330400.351802.852002.03610K562U2AF2
COPS8ENSG00000198612.6459.36120677.37580-0.560305.138103.92700K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for COPS8 is not available on ENCORE database.





13 RBPs can affect the splicing of COPS8 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECOPS8ENSG00000198612.6chr2+237995769237995840237994585237994685237997247237997296-0.187000.000000.00020excludedK562SF3B4
SECOPS8ENSG00000198612.6chr2+2379953742379954392379945242379946852379957692379958400.087000.000270.02972includedK562XRCC6
SECOPS8ENSG00000198612.6chr2+2379961062379962062379957692379958402379972472379972960.082000.000270.02945includedK562XRCC6
SECOPS8ENSG00000198612.6chr2+237995769237995840237994585237994685237997247237997296-0.158000.000000.00005excludedHepG2U2AF2
SECOPS8ENSG00000198612.6chr2+237995769237995840237994585237994685237997247237997296-0.201000.000000.00000excludedK562AQR
SECOPS8ENSG00000198612.6chr2+2379953742379954392379945242379946852379957692379958400.097000.000130.00777includedK562FXR1
SECOPS8ENSG00000198612.6chr2+2379953742379954392379945242379946852379957692379958400.058000.000280.04692includedHepG2HNRNPA1
SECOPS8ENSG00000198612.6chr2+2379961062379962062379957692379958402379972472379972960.056000.000420.07654includedK562SBDS
SECOPS8ENSG00000198612.6chr2+2379953742379954392379945242379946852379957692379958400.057000.000010.00116includedHepG2PCBP1
SECOPS8ENSG00000198612.6chr2+237995769237995840237994585237994685237997247237997296-0.203000.000000.00010excludedK562U2AF2
SECOPS8ENSG00000198612.6chr2+2379953742379954392379945242379946852379957692379958400.093000.000510.02229includedK562TARDBP
SECOPS8ENSG00000198612.6chr2+237995769237995840237994585237994685237997247237997296-0.304000.000000.00000excludedK562TARDBP
SECOPS8ENSG00000198612.6chr2+237995769237995840237994585237994685237997247237997296-0.112000.002710.09462excludedK562HNRNPK
MXECOPS8ENSG00000198612.6chr2+2379985042379986372380027322380028402379972472379972962380044642380045270.175000.000310.046301includedHepG2FUS
MXECOPS8ENSG00000198612.6chr2+2379972472379972962379985042379986372379957692379958402380027322380028400.155000.000300.046301includedHepG2FUS
MXECOPS8ENSG00000198612.6chr2+237995769237995840237996160237996206237994526237994685237997247237997296-0.063000.007370.082592includedK562U2AF1
MXECOPS8ENSG00000198612.6chr2+237995769237995840237996106237996206237994551237994685237997247237997296-0.053000.006890.079222includedK562U2AF1
MXECOPS8ENSG00000198612.6chr2+2379972472379972962380027322380028402379945242379946852380044642380045270.145000.000000.000001includedK562AQR
MXECOPS8ENSG00000198612.6chr2+2379972472379972962379985042379986372379945242379946852380027322380028400.355000.000000.000001includedK562AQR
MXECOPS8ENSG00000198612.6chr2+2380027322380028402380054392380055122379945242379946852380063052380073180.061000.001030.009351includedK562AQR
MXECOPS8ENSG00000198612.6chr2+237998504237998637238002732238002840237997247237997296238004464238004527-0.148000.000010.000192includedK562AQR
MXECOPS8ENSG00000198612.6chr2+237998504237998637238002602238002840237997146237997296238004464238004527-0.134000.000140.001652includedK562AQR
MXECOPS8ENSG00000198612.6chr2+237995769237995840237996160237996206237994526237994685237997247237997296-0.085000.001170.017942includedK562U2AF2
MXECOPS8ENSG00000198612.6chr2+237995769237995840237996106237996206237994551237994685237997247237997296-0.076000.000400.007552includedK562U2AF2
MXECOPS8ENSG00000198612.6chr2+237998504237998637238002732238002840237997247237997296238004464238004527-0.097000.004880.092782includedHepG2XRN2
MXECOPS8ENSG00000198612.6chr2+2379972472379972962379985042379986372379945242379946852380027322380028400.206000.000780.006601includedHepG2U2AF2
MXECOPS8ENSG00000198612.6chr2+237998504237998637238002732238002840237997247237997296238004464238004527-0.233000.000000.000002includedHepG2U2AF2
MXECOPS8ENSG00000198612.6chr2+237998504237998637238002732238002840237997247237997296238004464238004527-0.170000.002590.057962includedK562SBDS
MXECOPS8ENSG00000198612.6chr2+237995769237995840237996106237996206237994551237994685237997247237997296-0.057000.000190.010812includedK562SBDS
MXECOPS8ENSG00000198612.6chr2+2379972472379972962379985042379986372379945242379946852380027322380028400.348000.000000.000071includedK562SF3B4

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for COPS8 is not avaliable on ENCORE database.