AKR1B1

General Information

Gene Name       : AKR1B1
Gene ID             : ENSG00000085662.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: AKR1B1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878AKR1B1ENSG00000085662.1369.1299.9984.56ENCSR000AEF
HepG2AKR1B1ENSG00000085662.13134.01111.19122.60ENCSR985KAT
K562AKR1B1ENSG00000085662.134.024.784.40ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for AKR1B1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • AKR1B1 RNA is bound by 9 proteins.  







eCLIP assay for AKR1B1 is not avaliable on ENCORE database.





9 proteins are bound to AKR1B1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr7134127342134127433-3'-UTR,intron-Distal3.434329.94546HepG2LARP4
chr7134135586134135654-3'-UTR,CDS,intron-Distal4.229594.50960HepG2GRWD1
chr7134127233134127298-3'-UTR,intron-Distal3.839705.14024HepG2LARP4
chr7134135490134135563-3'-UTR,CDS,intron-Distal,intron-Proximal4.427654.75655HepG2PRPF8
chr7134134469134134540-3'-UTR,CDS,intron-Distal,intron-Proximal4.337877.73437HepG2RPS3
chr7134127298134127342-3'-UTR,intron-Distal4.329534.91517HepG2LARP4
chr7134127340134127425-3'-UTR,intron-Distal3.344646.20983HepG2DDX55
chr7134143748134143858-5'-UTR,CDS,intron-Distal,intron-Proximal4.231765.22400HepG2DDX3X
chr7134133138134133191-CDS,intron-Distal,intron-Proximal3.882005.24452HepG2PPIG
chr7134132740134132809-CDS,intron-Distal,intron-Proximal3.303564.25541HepG2GRWD1
chr7134132735134132804-CDS,intron-Distal,intron-Proximal3.236253.50786HepG2G3BP1
chr7134133845134133872-CDS,intron-Distal,intron-Proximal5.206354.90304HepG2RPS3
chr7134133747134133793-CDS,intron-Distal,intron-Proximal4.130113.02457HepG2BCLAF1
chr7134132744134132812-CDS,intron-Distal,intron-Proximal3.223456.00907HepG2PPIG
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for AKR1B1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for AKR1B1 is not available on ENCORE database.

  • 98 RBPs can affect the levels of AKR1B1.  








The Knockdown/knockout RNA-Seq assay for AKR1B1 is not available on ENCORE database.





98 RBPs can affect the gene expression of AKR1B1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
AKR1B1ENSG00000085662.92052.739201652.033700.313204.882204.11760HepG2ACO1
AKR1B1ENSG00000085662.91205.560401502.26900-0.317401.745901.31280HepG2AKAP1
AKR1B1ENSG00000085662.91077.57590753.933500.515203.623302.43890HepG2AKAP8
AKR1B1ENSG00000085662.91297.839201659.88490-0.355004.947703.94890HepG2AKAP8L
AKR1B1ENSG00000085662.92485.368802857.88730-0.201502.328901.69010HepG2AUH
AKR1B1ENSG00000085662.9844.742301461.99300-0.791409.397807.87130HepG2BCLAF1
AKR1B1ENSG00000085662.9552.33910839.45480-0.603906.580505.45750HepG2CALR
AKR1B1ENSG00000085662.91901.990001382.500500.460103.061802.03270HepG2CCAR1
AKR1B1ENSG00000085662.9627.836401180.92750-0.9115011.7495010.26690HepG2CIRBP
AKR1B1ENSG00000085662.9479.63740702.08980-0.549704.173503.34540HepG2CPSF6
AKR1B1ENSG00000085662.91057.953701265.82260-0.258802.295201.36940HepG2YBX3
AKR1B1ENSG00000085662.91972.252702387.90220-0.275904.420603.51800HepG2DAZAP1
AKR1B1ENSG00000085662.9853.798601287.93280-0.593106.876005.85510HepG2DDX21
AKR1B1ENSG00000085662.9898.524901260.47810-0.488305.441004.15390HepG2DDX24
AKR1B1ENSG00000085662.91014.805401547.88140-0.609104.876903.22960HepG2DDX27
AKR1B1ENSG00000085662.9784.693601053.64190-0.425203.308302.21080HepG2DDX5
AKR1B1ENSG00000085662.93116.133201236.230501.3337024.6821023.10630HepG2DDX6
AKR1B1ENSG00000085662.9694.314601198.87050-0.7880011.104209.30850HepG2DHX30
AKR1B1ENSG00000085662.9866.430101580.57640-0.8673022.4756020.99500HepG2DKC1
AKR1B1ENSG00000085662.9796.899001243.02780-0.6414010.695309.38750HepG2DNAJC21
AKR1B1ENSG00000085662.9867.319401186.11280-0.451602.803901.69120HepG2AGO1
AKR1B1ENSG00000085662.91476.157501188.343100.312802.000701.48680HepG2EIF2S1
AKR1B1ENSG00000085662.9799.720201216.33580-0.605007.886806.23920HepG2EIF3G
AKR1B1ENSG00000085662.91130.080602355.94100-1.0599039.0701036.71910HepG2EIF4G1
AKR1B1ENSG00000085662.91450.668702256.81750-0.637608.305906.92980HepG2EIF4G2
AKR1B1ENSG00000085662.9882.610801178.68360-0.417302.807001.70470HepG2ESF1
AKR1B1ENSG00000085662.92077.065403281.27120-0.6597019.7379018.37810HepG2ETF1
AKR1B1ENSG00000085662.91068.472001614.42760-0.595508.150406.73170HepG2EWSR1
AKR1B1ENSG00000085662.9829.471501227.42600-0.565406.446204.82950HepG2FASTKD2
AKR1B1ENSG00000085662.9915.053201377.02100-0.589605.717103.95700HepG2FKBP4
AKR1B1ENSG00000085662.9293.83600703.29810-1.259106.573105.01450HepG2FTO
AKR1B1ENSG00000085662.9492.22990737.38180-0.583105.437904.34730HepG2FUBP3
AKR1B1ENSG00000085662.92009.398001325.096600.600606.412805.38300HepG2FXR1
AKR1B1ENSG00000085662.91008.860701304.99030-0.371302.633901.76620HepG2G3BP2
AKR1B1ENSG00000085662.9437.42060795.86710-0.863508.243207.18060HepG2GPKOW
AKR1B1ENSG00000085662.9812.507901264.27690-0.637903.508801.92510HepG2HLTF
AKR1B1ENSG00000085662.9708.756301254.93490-0.824308.621307.57480HepG2HNRNPA1
AKR1B1ENSG00000085662.91698.378202194.62270-0.369805.551104.30700HepG2HNRNPA2B1
AKR1B1ENSG00000085662.91321.21970917.731000.525603.396501.84110HepG2HNRNPAB
AKR1B1ENSG00000085662.91067.981501395.84220-0.386203.304602.55250HepG2HNRNPC
AKR1B1ENSG00000085662.91129.957801545.60320-0.451907.740206.62020HepG2HNRNPF
AKR1B1ENSG00000085662.92342.521301244.774700.9121015.9878014.45100HepG2HNRNPK
AKR1B1ENSG00000085662.9245.75010759.51120-1.6279025.6496024.04990HepG2HNRNPLL
AKR1B1ENSG00000085662.91103.711501386.61670-0.329202.510701.93290HepG2HNRNPU
AKR1B1ENSG00000085662.91147.26530820.886100.482803.041501.74500HepG2HSPD1
AKR1B1ENSG00000085662.91183.593001521.96310-0.362804.048003.18600HepG2IGF2BP1
AKR1B1ENSG00000085662.9930.991501249.39710-0.424403.039502.33690HepG2IGF2BP2
AKR1B1ENSG00000085662.9959.055901416.39010-0.5625012.7900011.34110HepG2ILF2
AKR1B1ENSG00000085662.91061.877801325.55970-0.320001.977201.41840HepG2MAGOH
AKR1B1ENSG00000085662.9873.692301111.72850-0.347602.496201.72610HepG2MSI2
AKR1B1ENSG00000085662.9462.79940774.61680-0.743104.309403.08680HepG2MTPAP
AKR1B1ENSG00000085662.9895.815601200.87480-0.422803.664602.02640HepG2NIP7
AKR1B1ENSG00000085662.9338.83830673.45660-0.9910010.374309.00140HepG2NSUN2
AKR1B1ENSG00000085662.9499.682601214.97110-1.2818020.5274018.61020HepG2PABPC4
AKR1B1ENSG00000085662.91065.499501372.56440-0.365303.415802.48390HepG2PARN
AKR1B1ENSG00000085662.9779.693701247.04450-0.677504.734503.40340HepG2PCBP2
AKR1B1ENSG00000085662.9847.738901236.75850-0.544908.036006.82960HepG2PPIL4
AKR1B1ENSG00000085662.9728.291901123.36570-0.6252010.649709.27490HepG2PRPF4
AKR1B1ENSG00000085662.9924.970301275.98970-0.464103.885902.94840HepG2PRPF8
AKR1B1ENSG00000085662.91021.166201323.65050-0.374304.857504.17610HepG2PTBP1
AKR1B1ENSG00000085662.91858.389402399.51880-0.368707.568006.68760HepG2PUM1
AKR1B1ENSG00000085662.91679.211402397.73600-0.513907.862106.75750HepG2PUM2
AKR1B1ENSG00000085662.9628.013001682.71920-1.4219062.7974060.67540HepG2PUS1
AKR1B1ENSG00000085662.91182.978601433.64540-0.277302.570801.96460HepG2QKI
AKR1B1ENSG00000085662.93153.017201203.054501.3899015.4161013.88520HepG2RAVER1
AKR1B1ENSG00000085662.93418.799102742.528400.317904.702404.07280HepG2RBM22
AKR1B1ENSG00000085662.9890.337701301.08780-0.547306.030605.06990HepG2RBM25
AKR1B1ENSG00000085662.91830.889101473.134600.313603.787003.17300HepG2NELFE
AKR1B1ENSG00000085662.91070.242001665.21460-0.637804.957804.07820HepG2RPLP0
AKR1B1ENSG00000085662.9718.585601182.44610-0.718505.040203.78780HepG2RPS10
AKR1B1ENSG00000085662.9497.82000816.77800-0.714308.478107.47180HepG2RPS19
AKR1B1ENSG00000085662.91017.240301477.03050-0.538004.268903.28200HepG2RPS2
AKR1B1ENSG00000085662.9625.338901115.94740-0.835605.827704.66910HepG2RPS3A
AKR1B1ENSG00000085662.9352.62830751.76230-1.0921014.0970012.63380HepG2SF3B1
AKR1B1ENSG00000085662.91048.637601378.17450-0.394205.401004.62200HepG2SF3B4
AKR1B1ENSG00000085662.91505.343702167.43090-0.5259013.0328011.70450HepG2SLBP
AKR1B1ENSG00000085662.91264.543201440.10500-0.187601.944001.38950HepG2SMN1
AKR1B1ENSG00000085662.92481.664101228.658101.0141011.821509.76560HepG2SMNDC1
AKR1B1ENSG00000085662.9504.72850836.46870-0.728804.575403.56160HepG2SNRNP70
AKR1B1ENSG00000085662.91856.021101438.481700.367605.433704.82700HepG2SRSF1
AKR1B1ENSG00000085662.9961.890301518.55520-0.6588014.7253013.34210HepG2SRSF7
AKR1B1ENSG00000085662.93597.426301170.252201.6200065.5396063.59640HepG2SRSF9
AKR1B1ENSG00000085662.91231.843302689.40410-1.1265050.9761049.45010HepG2SSB
AKR1B1ENSG00000085662.9663.58250917.45140-0.467402.987401.70780HepG2STAU1
AKR1B1ENSG00000085662.9792.374101124.38470-0.504902.589001.42900HepG2SUB1
AKR1B1ENSG00000085662.9444.926401646.90060-1.8881043.0132040.98070HepG2SUPV3L1
AKR1B1ENSG00000085662.9391.12870740.30540-0.9205010.559909.27720HepG2TARDBP
AKR1B1ENSG00000085662.9965.754201188.07070-0.298902.493001.69650HepG2TIA1
AKR1B1ENSG00000085662.9620.437401347.51070-1.1189014.1149013.13830HepG2TIAL1
AKR1B1ENSG00000085662.9782.033201175.29160-0.587704.373103.59180HepG2U2AF1
AKR1B1ENSG00000085662.91708.924602337.55960-0.451903.466802.52720HepG2UBE2L3
AKR1B1ENSG00000085662.91203.32250831.069800.533908.332307.38330HepG2UTP3
AKR1B1ENSG00000085662.9799.535901108.62380-0.471507.291306.28660HepG2ZC3H8
AKR1B1ENSG00000085662.91553.33260946.717300.7143020.2353019.09220HepG2ZNF622
AKR1B1ENSG00000085662.9876.320301202.61740-0.456602.687101.41310HepG2ZRANB2
AKR1B1ENSG00000085662.9129.2216086.797600.574001.822901.34300K562AGGF1
AKR1B1ENSG00000085662.969.88900119.84150-0.778002.381901.83100K562AQR
AKR1B1ENSG00000085662.936.1255068.08080-0.914202.246701.50490K562EIF4A3
AKR1B1ENSG00000085662.9108.9829042.628501.354104.844003.85380K562PRPF8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for AKR1B1 is not available on ENCORE database.





15 RBPs can affect the splicing of AKR1B1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEAKR1B1ENSG00000085662.9chr7-134133748134133871134133138134133245134134471134134549-0.070000.000100.00285excludedHepG2U2AF1
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.087000.000110.02339includedHepG2DDX59
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.310000.000000.00000includedHepG2DDX6
RIAKR1B1ENSG00000085662.9chr7-134132049134132813134132049134132133134132731134132813-0.185000.000000.00000excludedHepG2TBRG4
RIAKR1B1ENSG00000085662.9chr7-134132049134132813134132049134132133134132731134132813-0.186000.001390.07174excludedK562EIF4G2
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.076000.001170.03072includedHepG2UCHL5
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.092000.000350.01254includedHepG2FTO
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.116000.000000.00004includedHepG2PCBP1
RIAKR1B1ENSG00000085662.9chr7-134132049134132813134132049134132133134132731134132813-0.052000.000010.00051excludedHepG2SRSF1
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.100000.000030.00072includedHepG2QKI
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.065000.002630.02634includedHepG2TAF15
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.078000.000270.00743includedHepG2G3BP1
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.074000.001290.01148includedHepG2SF3B4
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.088000.000000.00008includedHepG2RBM22
RIAKR1B1ENSG00000085662.9chr7-1341320491341328131341320491341321331341327311341328130.157000.000000.00000includedHepG2HNRNPK

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for AKR1B1 is not avaliable on ENCORE database.