ACTL6A

General Information

Gene Name       : ACTL6A
Gene ID             : ENSG00000136518.16
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: ACTL6A)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878ACTL6AENSG00000136518.1688.2074.0581.12ENCSR000AEF
HepG2ACTL6AENSG00000136518.1664.4885.3874.93ENCSR985KAT
K562ACTL6AENSG00000136518.16134.42119.78127.10ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for ACTL6A is not avaliable on ENCORE database.



Proteins bound to RNA
  • ACTL6A RNA is bound by 11 proteins.  







eCLIP assay for ACTL6A is not avaliable on ENCORE database.





11 proteins are bound to ACTL6A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr3179306069179306186+3'-UTR3.195673.37451K562APOBEC3C
chr3179294611179294700+3'-UTR,CDS,intron-Proximal3.559404.14618K562ZNF622
chr3179298445179298486+3'-UTR,CDS3.372623.07653K562ZNF622
chr3179294032179294095+3'-UTR,CDS4.7372713.66569K562LIN28B
chr3179287647179287687+3'-UTR,5'-UTR,CDS4.369843.49905HepG2PPIG
chr3179306042179306086+3'-UTR3.362876.79091K562PUM2
chr3179294605179294686+3'-UTR,CDS,intron-Proximal4.123514.60638K562GRWD1
chr3179306013179306100+3'-UTR3.323058.40205K562PABPC4
chr3179280748179280904+5'-UTR,CDS,intron-Distal,intron-Proximal3.5401917.87959K562DDX3X
chr3179298910179298960+CDS,intron-Proximal3.261543.77649K562EFTUD2
chr3179298960179299044+CDS,intron-Proximal4.062176.89981K562EFTUD2
chr3179292120179292189+CDS,intron-Proximal5.027319.56266K562AQR
chr3179303900179304107+intron-Distal3.178885.40698K562KHSRP
chr3179290990179291131+intron-Distal,intron-Proximal3.223154.76345K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for ACTL6A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for ACTL6A is not available on ENCORE database.

  • 99 RBPs can affect the levels of ACTL6A.  








The Knockdown/knockout RNA-Seq assay for ACTL6A is not available on ENCORE database.





99 RBPs can affect the gene expression of ACTL6A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
ACTL6AENSG00000136518.12903.494001061.49730-0.232502.129601.58160HepG2ACO1
ACTL6AENSG00000136518.121985.545501209.932300.714507.254306.43810HepG2AKAP1
ACTL6AENSG00000136518.12611.430601001.12180-0.711406.951405.73190HepG2ASCC1
ACTL6AENSG00000136518.121364.589201656.51450-0.279703.290502.55250HepG2AUH
ACTL6AENSG00000136518.12634.56270979.05210-0.625605.549604.32090HepG2BCLAF1
ACTL6AENSG00000136518.12742.140901179.90530-0.668907.801006.85900HepG2BOP1
ACTL6AENSG00000136518.12643.94290837.99030-0.380002.523101.34770HepG2BUD13
ACTL6AENSG00000136518.12773.076001030.24120-0.414303.989703.08700HepG2CALR
ACTL6AENSG00000136518.12874.621301061.26960-0.279103.026002.33750HepG2CKAP4
ACTL6AENSG00000136518.12895.51060616.352600.538902.747801.98570HepG2CNOT7
ACTL6AENSG00000136518.12558.528601083.22120-0.9556012.9209011.55450HepG2CPSF6
ACTL6AENSG00000136518.12721.19910921.12530-0.353002.323201.31230HepG2CPSF7
ACTL6AENSG00000136518.121267.336401520.77570-0.263002.495901.87940HepG2CELF1
ACTL6AENSG00000136518.121370.821901635.12010-0.254403.275902.48040HepG2DAZAP1
ACTL6AENSG00000136518.12586.41120941.96450-0.683807.805906.72470HepG2DDX21
ACTL6AENSG00000136518.12858.006901230.07600-0.519702.432801.51590HepG2DDX59
ACTL6AENSG00000136518.12610.76880919.96420-0.591005.569704.18520HepG2DDX5
ACTL6AENSG00000136518.12568.46650995.61120-0.808507.501406.52960HepG2DDX6
ACTL6AENSG00000136518.12638.32250862.95590-0.435003.510402.41220HepG2DHX30
ACTL6AENSG00000136518.12657.001701015.56600-0.628309.847408.72920HepG2DKC1
ACTL6AENSG00000136518.12603.57320894.71840-0.567907.242906.14850HepG2DNAJC21
ACTL6AENSG00000136518.12622.47760886.82060-0.510607.545506.54030HepG2DNAJC2
ACTL6AENSG00000136518.12723.09210957.12720-0.404502.585002.01170HepG2EIF2S1
ACTL6AENSG00000136518.121216.931601613.22140-0.406705.735304.60490HepG2EIF4G1
ACTL6AENSG00000136518.12964.807301545.34940-0.679608.436607.04570HepG2EIF4G2
ACTL6AENSG00000136518.121648.730001901.90130-0.206101.895001.37750HepG2ETF1
ACTL6AENSG00000136518.121332.675401067.191900.320402.014101.42050HepG2FXR1
ACTL6AENSG00000136518.12778.49060989.99390-0.346701.978201.41180HepG2G3BP1
ACTL6AENSG00000136518.12489.124001227.92630-1.3280020.5061018.93570HepG2GPKOW
ACTL6AENSG00000136518.12755.564201013.42790-0.423605.285903.98130HepG2HDGF
ACTL6AENSG00000136518.12692.39230903.29010-0.383602.811502.15970HepG2HNRNPA1
ACTL6AENSG00000136518.121244.165201502.76420-0.272402.741501.81000HepG2HNRNPA2B1
ACTL6AENSG00000136518.12747.636401232.27490-0.720905.227904.28080HepG2HNRNPF
ACTL6AENSG00000136518.121071.613201489.44290-0.475008.974307.82670HepG2HNRNPL
ACTL6AENSG00000136518.12649.066301171.83170-0.8523010.440509.31190HepG2HNRNPLL
ACTL6AENSG00000136518.12728.00540998.10130-0.455206.007405.14310HepG2HNRNPU
ACTL6AENSG00000136518.12683.402901213.45820-0.828308.442807.24210HepG2IGF2BP1
ACTL6AENSG00000136518.12771.698201006.31320-0.383002.473901.83160HepG2IGF2BP2
ACTL6AENSG00000136518.12743.703601019.52730-0.455107.213306.08980HepG2ILF2
ACTL6AENSG00000136518.12713.61960970.34350-0.443306.312904.80360HepG2KIF1C
ACTL6AENSG00000136518.12740.412701195.09270-0.690704.663803.38540HepG2MTPAP
ACTL6AENSG00000136518.12581.96500767.52810-0.399302.667401.47390HepG2NAA15
ACTL6AENSG00000136518.12681.84330907.18280-0.412003.105801.60740HepG2NIP7
ACTL6AENSG00000136518.121274.330701621.38640-0.347503.689202.80680HepG2NOL12
ACTL6AENSG00000136518.12773.849601039.04520-0.425103.327302.50640HepG2NSUN2
ACTL6AENSG00000136518.12545.92760978.60540-0.842009.138407.84370HepG2PABPC4
ACTL6AENSG00000136518.12613.64860986.21340-0.684504.660003.34030HepG2PCBP2
ACTL6AENSG00000136518.12619.56800890.22650-0.522906.293305.21470HepG2PPIL4
ACTL6AENSG00000136518.12596.34790775.36590-0.378703.579902.71010HepG2PRPF4
ACTL6AENSG00000136518.121128.625301547.77930-0.455604.738403.98400HepG2PUF60
ACTL6AENSG00000136518.121432.886401643.06430-0.197502.210901.66830HepG2PUM1
ACTL6AENSG00000136518.121239.367101641.84660-0.405704.539803.69120HepG2PUM2
ACTL6AENSG00000136518.12912.489401081.20430-0.244802.358001.77810HepG2PUS1
ACTL6AENSG00000136518.12878.607701209.80870-0.461503.759002.59230HepG2RBM27
ACTL6AENSG00000136518.12755.820901327.17430-0.812208.878707.76190HepG2RPLP0
ACTL6AENSG00000136518.12621.05990934.85010-0.590003.484402.42420HepG2RPS10
ACTL6AENSG00000136518.12876.979501115.76750-0.347402.352301.61020HepG2RPS2
ACTL6AENSG00000136518.12638.62430888.85280-0.477006.304005.39140HepG2SAFB2
ACTL6AENSG00000136518.12528.03500682.11710-0.369402.222001.37620HepG2SERBP1
ACTL6AENSG00000136518.12846.403201043.09010-0.301402.750402.16020HepG2SF3B4
ACTL6AENSG00000136518.121022.390501484.13700-0.5377010.830909.59290HepG2SLBP
ACTL6AENSG00000136518.12775.072401290.57670-0.735605.274704.18610HepG2SNRNP70
ACTL6AENSG00000136518.121466.935501795.43650-0.291503.853703.29180HepG2SRFBP1
ACTL6AENSG00000136518.121719.726601088.776100.6594014.7960013.88800HepG2SRSF1
ACTL6AENSG00000136518.121209.246001528.24040-0.337804.255403.50810HepG2SRSF5
ACTL6AENSG00000136518.12680.664501210.60290-0.830708.698707.58230HepG2SRSF7
ACTL6AENSG00000136518.12533.78870885.79100-0.7307012.6824011.65310HepG2SRSF9
ACTL6AENSG00000136518.121133.302201558.86340-0.460007.820707.04430HepG2SSB
ACTL6AENSG00000136518.12481.11620754.42420-0.649004.806703.22000HepG2STAU1
ACTL6AENSG00000136518.121470.429001738.00140-0.241202.873402.24240HepG2SUCLG1
ACTL6AENSG00000136518.12574.60580762.67040-0.408502.732301.79620HepG2SUPT6H
ACTL6AENSG00000136518.12562.424801102.86370-0.9715011.6239010.39770HepG2SUPV3L1
ACTL6AENSG00000136518.12510.088201142.14480-1.1629019.3905017.79450HepG2TARDBP
ACTL6AENSG00000136518.12516.56910969.83830-0.9088015.4826014.47120HepG2TIAL1
ACTL6AENSG00000136518.12622.38070978.51180-0.6528011.0638010.04860HepG2TRIM56
ACTL6AENSG00000136518.121210.466701512.16090-0.321002.687701.82800HepG2TUFM
ACTL6AENSG00000136518.121107.296401600.62880-0.531604.303303.24680HepG2UBE2L3
ACTL6AENSG00000136518.12658.51400882.49190-0.422405.048204.14840HepG2UPF1
ACTL6AENSG00000136518.12699.000701009.77760-0.530703.227002.14060HepG2UPF2
ACTL6AENSG00000136518.121044.04890852.014200.293102.655002.06840HepG2UTP3
ACTL6AENSG00000136518.12794.652201085.64960-0.450203.484102.67610HepG2XRN2
ACTL6AENSG00000136518.123251.619502406.641100.434009.432708.46410K562AGGF1
ACTL6AENSG00000136518.122993.740202504.215700.257502.115301.54080K562AKAP8L
ACTL6AENSG00000136518.121442.875401838.75590-0.349802.183501.41490K562BOP1
ACTL6AENSG00000136518.121394.383501955.19850-0.487704.045903.09740K562CPSF6
ACTL6AENSG00000136518.123335.331702694.737000.307604.328003.19950K562DKC1
ACTL6AENSG00000136518.122551.791602921.55720-0.195201.966801.34190K562EIF2S2
ACTL6AENSG00000136518.121567.931701989.22590-0.343302.800701.94200K562FMR1
ACTL6AENSG00000136518.121337.111201685.98670-0.334502.377701.53490K562FTO
ACTL6AENSG00000136518.121493.274501849.30640-0.308503.394501.89110K562FUS
ACTL6AENSG00000136518.122295.471302013.999800.188601.853701.33840K562FXR1
ACTL6AENSG00000136518.122912.504302136.374100.447003.079202.32640K562G3BP2
ACTL6AENSG00000136518.121279.059901866.79210-0.545505.233804.14850K562GPKOW
ACTL6AENSG00000136518.123291.042903893.36890-0.242502.192401.51500K562GRSF1
ACTL6AENSG00000136518.121370.463501868.19140-0.447005.070804.28470K562HNRNPC
ACTL6AENSG00000136518.123397.787302583.622200.395103.493002.08800K562HNRNPK
ACTL6AENSG00000136518.123410.342502718.453800.327003.372202.43820K562MAGOH
ACTL6AENSG00000136518.121880.662802401.33330-0.352606.155004.98950K562MTPAP
ACTL6AENSG00000136518.122761.218902086.796100.403902.653201.79230K562NAA15
ACTL6AENSG00000136518.122054.002202668.04650-0.377309.608008.32840K562NSUN2
ACTL6AENSG00000136518.122486.541301833.828600.439204.640203.67000K562PRPF8
ACTL6AENSG00000136518.121324.077001675.01580-0.339202.797901.88810K562PSIP1
ACTL6AENSG00000136518.123989.832702483.519600.6838010.301809.29970K562PUS1
ACTL6AENSG00000136518.122992.532902419.795200.306403.883503.19750K562RBM15
ACTL6AENSG00000136518.121119.551601448.67110-0.371803.008301.92680K562SRFBP1
ACTL6AENSG00000136518.123235.108302589.072800.321303.472302.68600K562SRSF1
ACTL6AENSG00000136518.122167.980502620.48390-0.273501.965301.36180K562TARDBP
ACTL6AENSG00000136518.121187.401301611.09300-0.440203.546702.48320K562TIAL1
ACTL6AENSG00000136518.122817.944902139.314400.397405.334004.22340K562U2AF2
ACTL6AENSG00000136518.122042.266902828.99030-0.4701010.765509.46470K562UPF1
ACTL6AENSG00000136518.121951.471002420.67110-0.310803.047302.13040K562WDR3
ACTL6AENSG00000136518.123549.861104948.16640-0.479107.037704.98370K562WRN
ACTL6AENSG00000136518.123326.826004704.99640-0.500006.915105.45190K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for ACTL6A is not available on ENCORE database.





6 RBPs can affect the splicing of ACTL6A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEACTL6AENSG00000136518.12chr3+1792931901792932921792921571792922551792940041792940990.150000.000000.00000includedHepG2SF3B4
A5SSACTL6AENSG00000136518.12chr3+1792807171792808561792807171792807611792876111792876710.137000.000520.06437longerK562SUPV3L1
A5SSACTL6AENSG00000136518.12chr3+1792807101792809051792807101792807611792876111792876880.178000.000200.01052longerHepG2U2AF2
A5SSACTL6AENSG00000136518.12chr3+1792807101792808561792807101792807611792876111792876710.136000.000810.07559longerK562EFTUD2
A5SSACTL6AENSG00000136518.12chr3+1792807101792808561792807101792807611792876111792876880.057000.000510.04530longerK562SF3B4
A5SSACTL6AENSG00000136518.12chr3+179280710179280905179280710179280761179287611179287671-0.152000.000000.00266shorterK562TAF15
A5SSACTL6AENSG00000136518.12chr3+1792807101792809051792807101792807611792876111792876880.215000.000000.00010longerHepG2FTO

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for ACTL6A is not avaliable on ENCORE database.