SPCS2

General Information

Gene Name       : SPCS2
Gene ID             : ENSG00000118363.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SPCS2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SPCS2ENSG00000118363.11138.79119.51129.15ENCSR000AEF
HepG2SPCS2ENSG00000118363.1194.73165.23129.98ENCSR985KAT
K562SPCS2ENSG00000118363.1191.11129.65110.38ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SPCS2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SPCS2 RNA is bound by 12 proteins.  







eCLIP assay for SPCS2 is not avaliable on ENCORE database.





12 proteins are bound to SPCS2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr117468861474688656+3'-UTR3.818213.21228K562TIA1
chr117468818974688267+3'-UTR4.1844525.61009K562FAM120A
chr117466031374660441+5'-UTR,CDS,intron-Proximal3.2710013.82842HepG2RPS3
chr117468053074680615+CDS,intron-Distal,intron-Proximal3.131916.00234K562KHSRP
chr117468071574680731+CDS,intron-Distal3.618476.64821HepG2SND1
chr117468790174687920+CDS,intron-Distal,intron-Proximal3.927735.51172HepG2SND1
chr117468073174680747+CDS,intron-Distal,intron-Proximal3.663036.92877HepG2SND1
chr117468070974680745+CDS,intron-Distal,intron-Proximal6.1082715.59328K562SND1
chr117468784174687930+CDS,intron-Distal,intron-Proximal5.820457.91936K562SF3B4
chr117468790074687937+CDS,intron-Distal,intron-Proximal4.9931312.45981K562SND1
chr117467618674676238+intron-Distal,intron-Proximal4.3817410.81737K562TIA1
chr117468461874684678+intron-Distal3.542923.39827HepG2MATR3
chr117466711274667227+intron-Distal4.290043.98115K562MATR3
chr117468460274684675+intron-Distal3.800426.43962K562MATR3
chr117468629274686390+intron-Distal3.501553.10639HepG2PTBP1
chr117468628274686352+intron-Distal3.616343.68462HepG2MATR3
chr117468492874684974+intron-Distal4.843325.43236K562PTBP1
chr117468199874682100+intron-Distal3.453945.35441K562HNRNPL
chr117468554374685614+intron-Distal3.298636.31916HepG2SUGP2
chr117468447974684574+intron-Distal3.217153.63194K562HNRNPL
chr117467616774676220+intron-Distal,intron-Proximal3.789903.65261HepG2TIA1
chr117466709174667138+intron-Distal3.685053.04224HepG2SUGP2
chr117468501674685113+intron-Distal4.9941915.10611K562PTBP1
chr117467617274676186+intron-Distal,intron-Proximal4.937407.61377K562TIA1
chr117468074474680802+intron-Distal,intron-Proximal4.784595.26064K562AQR
chr117467703074677113+intron-Distal,intron-Proximal3.374794.30679K562KHSRP
chr117468492374684974+intron-Distal4.764596.08961HepG2PTBP1
chr117468405774684119+intron-Distal4.023643.80299K562HNRNPL
chr117468269874682762+intron-Distal3.749903.19036K562HNRNPL
chr117466756074667632+intron-Distal3.122293.23296HepG2SUGP2
chr117468502874685110+intron-Distal4.005717.92999HepG2PTBP1
chr117466692774666989+intron-Distal4.603144.80665HepG2QKI
chr117468516374685206+intron-Distal3.137623.45178K562MATR3
chr117468480974684857+intron-Distal3.258803.59523HepG2SUGP2
chr117468619374686379+intron-Distal4.1532311.54864K562MATR3
chr117468446374684529+intron-Distal3.308123.80761K562PTBP1
chr117468470674684783+intron-Distal3.405854.36461K562MATR3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SPCS2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SPCS2 is not available on ENCORE database.

  • 107 RBPs can affect the levels of SPCS2.  








The Knockdown/knockout RNA-Seq assay for SPCS2 is not available on ENCORE database.





107 RBPs can affect the gene expression of SPCS2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SPCS2ENSG00000118363.71430.382601732.74510-0.276703.671302.98960HepG2ACO1
SPCS2ENSG00000118363.71799.854403098.19600-0.783509.312108.39930HepG2AKAP1
SPCS2ENSG00000118363.71415.621001740.83880-0.298303.694502.82090HepG2AKAP8L
SPCS2ENSG00000118363.71721.441002293.35090-0.413806.751405.75270HepG2AUH
SPCS2ENSG00000118363.71455.564901212.031300.264102.231801.53430HepG2CALR
SPCS2ENSG00000118363.7813.159901763.88970-1.117109.952608.12180HepG2CCAR1
SPCS2ENSG00000118363.71123.349801732.31180-0.6249016.4078015.07660HepG2CKAP4
SPCS2ENSG00000118363.71356.099501602.51490-0.240902.951302.09170HepG2DDX19B
SPCS2ENSG00000118363.71013.884501404.80680-0.470504.763003.89970HepG2DDX21
SPCS2ENSG00000118363.72070.161602967.83900-0.519705.174404.34230HepG2DDX3X
SPCS2ENSG00000118363.71059.837801566.57670-0.563804.695503.71560HepG2DDX55
SPCS2ENSG00000118363.71246.300602549.43120-1.0325015.2773013.98610HepG2DDX6
SPCS2ENSG00000118363.71364.680201657.75280-0.280703.240702.51750HepG2DKC1
SPCS2ENSG00000118363.7902.384001172.78500-0.378104.202403.35170HepG2DNAJC21
SPCS2ENSG00000118363.7835.450401162.42740-0.476508.135507.08940HepG2DNAJC2
SPCS2ENSG00000118363.71734.138402450.83400-0.499104.797404.02890HepG2EIF2S1
SPCS2ENSG00000118363.71061.142602637.06380-1.3133018.7680017.09050HepG2EIF4B
SPCS2ENSG00000118363.71804.190702264.78460-0.328003.092902.21690HepG2EIF4G1
SPCS2ENSG00000118363.72694.365602169.535400.312502.014601.31250HepG2EIF4G2
SPCS2ENSG00000118363.72140.901702632.95030-0.298504.158003.44700HepG2ETF1
SPCS2ENSG00000118363.71053.693201476.12490-0.486403.569502.70240HepG2FIP1L1
SPCS2ENSG00000118363.71786.272402732.71840-0.613407.166006.08790HepG2FXR1
SPCS2ENSG00000118363.71583.282202535.00000-0.679107.666506.58580HepG2G3BP1
SPCS2ENSG00000118363.72124.796902691.22360-0.340902.661401.78950HepG2G3BP2
SPCS2ENSG00000118363.7669.18200902.54340-0.431603.100202.14840HepG2GEMIN5
SPCS2ENSG00000118363.7809.429701184.02060-0.548705.850604.95780HepG2HNRNPA1
SPCS2ENSG00000118363.71217.613301488.53360-0.289803.029402.28110HepG2HNRNPF
SPCS2ENSG00000118363.71316.831202566.91020-0.9630018.0574016.42320HepG2HNRNPK
SPCS2ENSG00000118363.71562.790902091.26660-0.420309.210808.04940HepG2HNRNPL
SPCS2ENSG00000118363.71573.444801169.520900.427902.806901.56600HepG2HSPD1
SPCS2ENSG00000118363.71739.620702576.77320-0.566806.078105.11420HepG2IGF2BP2
SPCS2ENSG00000118363.71114.629501336.38150-0.261803.262902.47270HepG2ILF2
SPCS2ENSG00000118363.71374.336501583.91100-0.204802.319401.38450HepG2KIF1C
SPCS2ENSG00000118363.71881.316302733.67240-0.539105.457004.54490HepG2MAGOH
SPCS2ENSG00000118363.71815.405802748.97340-0.598605.916005.01950HepG2MATR3
SPCS2ENSG00000118363.7743.166801060.90220-0.513502.381401.40180HepG2METAP2
SPCS2ENSG00000118363.71458.742602813.72790-0.9478014.5268013.14930HepG2NCBP2
SPCS2ENSG00000118363.7699.653001438.55130-1.039907.828805.96490HepG2NONO
SPCS2ENSG00000118363.71447.562001052.881300.459202.096301.34000HepG2PABPC1
SPCS2ENSG00000118363.71799.371702505.81160-0.477804.339503.44830HepG2PABPC4
SPCS2ENSG00000118363.7998.833701294.99000-0.374604.703803.63370HepG2PARN
SPCS2ENSG00000118363.71598.279102358.44040-0.5613012.9737011.81270HepG2PCBP1
SPCS2ENSG00000118363.7591.17650838.27620-0.503805.100603.44910HepG2PKM
SPCS2ENSG00000118363.7985.780301166.89590-0.243302.016701.37850HepG2PPIL4
SPCS2ENSG00000118363.71246.195802399.83810-0.9454030.7099029.28070HepG2PTBP1
SPCS2ENSG00000118363.71790.948102306.72780-0.365108.075107.17240HepG2PUM1
SPCS2ENSG00000118363.71390.407101764.90490-0.344105.303604.50100HepG2PUS1
SPCS2ENSG00000118363.71541.928602599.00560-0.7532017.5211016.14270HepG2QKI
SPCS2ENSG00000118363.71107.445601647.01180-0.572602.991002.26010HepG2RAVER1
SPCS2ENSG00000118363.71050.131201429.49080-0.444905.624504.45510HepG2RBM15
SPCS2ENSG00000118363.71443.114902200.68500-0.6088011.7616010.84720HepG2RBM22
SPCS2ENSG00000118363.71803.810302358.79420-0.387004.302703.47690HepG2RBM25
SPCS2ENSG00000118363.71201.680201664.96210-0.470404.303203.04900HepG2RBM27
SPCS2ENSG00000118363.71342.763502670.75890-0.9920036.4377034.95330HepG2NELFE
SPCS2ENSG00000118363.71580.506402487.50430-0.6543017.3543016.02740HepG2RECQL
SPCS2ENSG00000118363.71231.428701603.37430-0.380803.263402.53110HepG2RPLP0
SPCS2ENSG00000118363.7620.57010986.33730-0.668508.012107.02900HepG2RPS19
SPCS2ENSG00000118363.7923.659601535.53370-0.733309.382107.98240HepG2RPS2
SPCS2ENSG00000118363.71888.060401165.096000.6964019.7398018.23970HepG2SAFB2
SPCS2ENSG00000118363.7728.26430989.95290-0.442903.251602.22870HepG2SERBP1
SPCS2ENSG00000118363.71342.843302498.47530-0.8958030.2670028.67900HepG2SF3B4
SPCS2ENSG00000118363.71759.316402083.52070-0.244003.526802.75010HepG2SLBP
SPCS2ENSG00000118363.7747.654501358.69940-0.8618025.7080024.07240HepG2SMN1
SPCS2ENSG00000118363.71261.811301678.70330-0.411902.410801.52100HepG2SMNDC1
SPCS2ENSG00000118363.7583.82880848.06800-0.538602.720701.94570HepG2SNRNP70
SPCS2ENSG00000118363.72038.258302485.63820-0.286304.216303.63630HepG2SRFBP1
SPCS2ENSG00000118363.72135.583802607.89420-0.288304.480703.91480HepG2SRSF1
SPCS2ENSG00000118363.71697.461602145.50430-0.337905.246004.42640HepG2SRSF5
SPCS2ENSG00000118363.71290.506802121.68400-0.7173020.8038019.54770HepG2SRSF9
SPCS2ENSG00000118363.72492.435902158.201900.207602.638602.13360HepG2SSB
SPCS2ENSG00000118363.72002.762202440.06580-0.284904.912504.12480HepG2SUCLG1
SPCS2ENSG00000118363.71098.726501559.49550-0.505203.942203.15710HepG2SUPV3L1
SPCS2ENSG00000118363.7929.342502344.15170-1.3348050.9358048.92490HepG2TAF15
SPCS2ENSG00000118363.71261.616402153.87680-0.7717015.0977013.18180HepG2TIA1
SPCS2ENSG00000118363.7772.820501271.25620-0.7180011.9379011.02720HepG2TIAL1
SPCS2ENSG00000118363.71085.550201282.61830-0.240702.372101.84160HepG2TRIM56
SPCS2ENSG00000118363.71579.259002247.01480-0.508804.500003.41490HepG2UBE2L3
SPCS2ENSG00000118363.7692.51760921.23700-0.411702.817802.05070HepG2UCHL5
SPCS2ENSG00000118363.71099.204201497.33390-0.445907.205506.31470HepG2UTP3
SPCS2ENSG00000118363.71366.183901811.16430-0.406802.276201.31840HepG2XRCC6
SPCS2ENSG00000118363.71092.56620899.893400.279802.517601.87150HepG2ZC3H8
SPCS2ENSG00000118363.72791.969902482.226200.169501.837301.35560K562AGGF1
SPCS2ENSG00000118363.71402.249201870.60230-0.415807.025105.46850K562BCLAF1
SPCS2ENSG00000118363.7299.14760655.77290-1.132305.751904.09000K562CCAR1
SPCS2ENSG00000118363.7789.735301151.86370-0.544506.202605.02980K562CPSF6
SPCS2ENSG00000118363.71076.533401419.13060-0.398604.639803.21800K562CSTF2
SPCS2ENSG00000118363.7400.26000734.06240-0.875004.390702.65250K562DHX30
SPCS2ENSG00000118363.73224.375402779.364200.214202.313101.52170K562DKC1
SPCS2ENSG00000118363.71056.416301281.89040-0.279102.465601.39650K562EIF4B
SPCS2ENSG00000118363.7896.202301326.91700-0.566206.081904.16110K562EXOSC5
SPCS2ENSG00000118363.7761.70720993.39620-0.383102.469201.60670K562FTO
SPCS2ENSG00000118363.72016.637001480.332300.445907.199106.28590K562FXR1
SPCS2ENSG00000118363.71459.626001747.66930-0.259802.549801.45730K562GLRX3
SPCS2ENSG00000118363.7858.725901099.73810-0.356902.689201.90550K562GPKOW
SPCS2ENSG00000118363.72849.146603578.02980-0.328603.438102.59710K562GRSF1
SPCS2ENSG00000118363.7967.360901226.35070-0.342202.726102.13340K562HNRNPC
SPCS2ENSG00000118363.72002.706801475.531500.440603.532902.46780K562HNRNPM
SPCS2ENSG00000118363.73381.312602432.103500.475305.416204.31980K562HSPD1
SPCS2ENSG00000118363.7864.052401073.47060-0.313102.424401.60780K562METAP2
SPCS2ENSG00000118363.71433.354001837.43530-0.358305.578304.45460K562MTPAP
SPCS2ENSG00000118363.71559.793502041.61800-0.388408.589407.37810K562NSUN2
SPCS2ENSG00000118363.71271.354501687.83830-0.408802.415601.63930K562PCBP3
SPCS2ENSG00000118363.71876.620502445.81530-0.382203.033201.39730K562PKM
SPCS2ENSG00000118363.73306.000803980.46830-0.267902.736201.30590K562PNPT1
SPCS2ENSG00000118363.72024.168101489.595100.442304.341403.40270K562PRPF8
SPCS2ENSG00000118363.7793.274801099.51390-0.471004.100702.96930K562PSIP1
SPCS2ENSG00000118363.71794.711602150.32920-0.260802.276301.66640K562PTBP1
SPCS2ENSG00000118363.73525.985904405.01420-0.321104.483403.25460K562PUM2
SPCS2ENSG00000118363.73260.275802561.512000.347903.003002.44140K562PUS1
SPCS2ENSG00000118363.71557.745502062.09790-0.404703.939402.92190K562RBM22
SPCS2ENSG00000118363.7691.726501002.98060-0.536005.565804.15350K562RCC2
SPCS2ENSG00000118363.71671.483202169.98400-0.376603.180001.99920K562NELFE
SPCS2ENSG00000118363.72213.978301517.472400.544905.162804.04460K562RPS19
SPCS2ENSG00000118363.71716.087002014.46310-0.231302.464201.69160K562SF3A3
SPCS2ENSG00000118363.7715.41560950.81780-0.410403.101902.00130K562SRFBP1
SPCS2ENSG00000118363.71592.508001298.527300.294302.717001.90620K562SYNCRIP
SPCS2ENSG00000118363.71731.143902057.99690-0.249502.092501.38790K562TIA1
SPCS2ENSG00000118363.7770.824801057.57070-0.456303.336302.30310K562TIAL1
SPCS2ENSG00000118363.7827.991801123.32750-0.440103.776502.63900K562TRIM56
SPCS2ENSG00000118363.72115.083601654.288800.354402.426501.41340K562U2AF1
SPCS2ENSG00000118363.72034.231001708.440100.251702.265601.53970K562U2AF2
SPCS2ENSG00000118363.7621.927802164.76590-1.79940101.3786098.27190K562UPF1
SPCS2ENSG00000118363.71516.178001852.32990-0.288902.586301.73830K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SPCS2 is not available on ENCORE database.





2 RBPs can affect the splicing of SPCS2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSSPCS2ENSG00000118363.7chr11+7467674474676970746768987467697074676042746761620.607000.016620.08159longerK562AQR
MXESPCS2ENSG00000118363.7chr11+74676078746761627468068474680744746603087466044474687901746883930.111000.000480.037431includedK562TRA2A

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SPCS2 is not avaliable on ENCORE database.