SNRPC

General Information

Gene Name       : SNRPC
Gene ID             : ENSG00000124562.9
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SNRPC)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SNRPCENSG00000124562.9162.77251.55207.16ENCSR000AEF
HepG2SNRPCENSG00000124562.9348.84282.92315.88ENCSR985KAT
K562SNRPCENSG00000124562.9654.18583.65618.91ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
eCLIPeCLIP: 4187ENCSR959OKBSNRPCHepG2ReleasedENCAB311PIHENCSR981NWK  
eCLIPeCLIP: 4164ENCSR714FKKSNRPCK562ReleasedENCAB311PIHENCSR356XVB  
knockdown followed by RNA-seq SNRPC-BGKcLV23-K562ENCSR840JRUSNRPCK562ReleasedENCSR877JEM   CRISPRKD% = 68.1,68.7613052
knockdown followed by RNA-seq SNRPC-BGHcLV22-HepG2ENCSR005RURSNRPCHepG2ReleasedENCSR704VPL   CRISPRKD% = 75.6,73.9






  eCLIP  
  RBP    Exp_UID    Cell_Line    ENCODE_ACCESSION    Control_ENCODE_ACCESSION    ENCODE_Antibody_ID    Antibody    Lot_num    Status    Project  
SNRPC4187HepG2ENCSR959OKBENCSR981NWKENCAB311PIHA303-947A1ReleasedENCODE4
SNRPC4164K562ENCSR714FKKENCSR356XVBENCAB311PIHA303-947A1ReleasedENCODE4


  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
SNRPCENCAB311PIHA303-947A1BGHcLV22-53, Released, ENCODE4BGKcLV23-61, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
SNRPCK562CRISPRBGKcLV21-45,BGKcLV21-46BGKcLV21-1,BGKcLV21-230.6,28.0NotSatisfiedENCODE4
SNRPCK562CRISPRENCSR840JRUENCSR877JEMSNRPC-BGKcLV23-61,SNRPC-BGKcLV23-62NT-BGKcLV23-1,NT-BGKcLV23-268.1,68.7613052ReleasedENCODE4
SNRPCHepG2CRISPRENCSR005RURENCSR704VPLSNRPC-BGHcLV22-53,SNRPC-BGHcLV22-54NT-BGHcLV22-1,NT-BGHcLV22-275.6,73.9ReleasedENCODE4
SNRPCHepG2CRISPRBGHcLV22-55,BGHcLV22-56BGHcLV22-1,BGHcLV22-267.4,76.5NotSatisfiedENCODE4
SNRPCRibo-STAMP-293TshRNABGRSLV03-47,BGRSLV03-48BGRSLV03-1,BGRSLV03-2NotSatisfiedENCORE2
SNRPCRibo-STAMP-293TshRNABGRSLV04-55,BGRSLV04-56BGRSLV04-1,BGRSLV04-2NotSatisfiedENCORE2
SNRPCRibo-STAMP-293TshRNABGRSLV09-43,BGRSLV09-44BGRSLV09-1,BGRSLV09-2NotSatisfiedENCORE2
SNRPCRibo-STAMP-293TshRNABGRSLV09-45,BGRSLV09-46BGRSLV09-1,BGRSLV09-2NotSatisfiedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
SNRPCProduct_ID: A303-947A
Lot_ID: 1
Source: Bethyl Labs
Target Name: SNRPC-human		 SNRPC-HEPG2-CRISPR-A303-947A.png<br>Caption: Western blot following CRISPR against SNRPC in HepG2 whole cell lysate using SNRPC specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SNRPC. SNRPC protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
 SNRPC-K562-CRISPR-A303-947A.png<br>Caption: Western blot following CRISPR against SNRPC in K562 whole cell lysate using SNRPC specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SNRPC. SNRPC protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for SNRPC is not avaliable on ENCORE database.



Proteins bound to RNA
  • SNRPC RNA is bound by 19 proteins.  







eCLIP assay for SNRPC is not avaliable on ENCORE database.





19 proteins are bound to SNRPC RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr63474147834741525+3'-UTR3.489619.93776K562PABPC4
chr63474137834741433+3'-UTR4.2470519.51754HepG2LARP4
chr63474138234741478+3'-UTR4.1601410.53006HepG2DDX55
chr63474137634741452+3'-UTR3.9349911.06619K562NOLC1
chr63474137634741473+3'-UTR5.5598738.23527HepG2SUB1
chr63474143334741478+3'-UTR4.6495716.20745HepG2LARP4
chr63474142734741478+3'-UTR3.6844939.18724K562PABPC4
chr63473032934730409+5'-UTR,CDS,intron-Proximal3.896879.31583K562SF3B4
chr63472532634725367+5'-UTR,CDS,intron-Proximal4.574994.97857HepG2AQR
chr63473037134730384+5'-UTR,CDS,intron-Proximal3.2000915.81839K562YBX3
chr63472531334725329+5'-UTR,CDS,intron-Proximal4.4372719.85118K562DDX3X
chr63473037134730402+5'-UTR,CDS,intron-Proximal3.0458421.16154K562DDX3X
chr63472528334725313+5'-UTR4.2268518.44818K562DDX3X
chr63472533434725386+5'-UTR,intron-Proximal5.5498528.30163K562AQR
chr63473037034730428+5'-UTR,CDS,intron-Proximal3.317168.80002K562GRWD1
chr63472534434725398+5'-UTR,intron-Proximal4.676917.44508K562PRPF8
chr63472537234725397+5'-UTR,intron-Proximal3.775874.97821K562BUD13
chr63472547934725503+5'-UTR,intron-Distal3.939613.64144K562EFTUD2
chr63472532834725334+5'-UTR,intron-Proximal5.6045918.59418K562AQR
chr63472532634725372+5'-UTR,CDS,intron-Proximal4.2010511.70689HepG2PRPF8
chr63473570234735746+CDS3.3076838.48385K562YBX3
chr63472569234725732+CDS,intron-Distal,intron-Proximal3.822739.05952HepG2SUB1
chr63473806534738115+CDS,intron-Proximal4.051528.12409K562PCBP1
chr63474120634741265+CDS,intron-Proximal3.010384.70628K562U2AF2
chr63472567434725754+CDS,intron-Distal,intron-Proximal3.573359.48572K562EFTUD2
chr63472569634725734+CDS,intron-Distal,intron-Proximal4.282513.95187HepG2AQR
chr63473806834738080+CDS4.151465.75263HepG2LARP4
chr63474122234741261+CDS,intron-Proximal4.260297.95716HepG2G3BP1
chr63473806634738115+CDS,intron-Proximal4.9519442.69964K562RPS3
chr63473575334735775+CDS,intron-Proximal4.1369116.61760K562RPS3
chr63473566534735708+CDS,intron-Proximal3.637036.62600K562U2AF2
chr63474120134741263+CDS,intron-Proximal3.9029417.88439HepG2U2AF2
chr63472564934725709+CDS,intron-Distal,intron-Proximal3.2642715.13178K562AQR
chr63472569734725732+CDS,intron-Distal,intron-Proximal3.214476.37916K562GRWD1
chr63473815234738172+CDS3.660454.86632HepG2G3BP1
chr63473572834735774+CDS3.127947.34484K562PCBP1
chr63472569034725732+CDS,intron-Distal,intron-Proximal3.6894129.31166K562DDX3X
chr63472568834725690+CDS,intron-Distal,intron-Proximal3.600888.23377K562DDX3X
chr63472566334725726+CDS,intron-Distal,intron-Proximal3.227577.34034HepG2U2AF2
chr63473806934738103+CDS3.202904.70577HepG2G3BP1
chr63474127134741326+CDS5.7991814.16859HepG2LARP4
chr63473574634735774+CDS3.2141223.40612K562YBX3
chr63474118734741245+CDS,intron-Proximal3.179576.52492K562SF3B4
chr63474127434741335+CDS4.2586229.66390K562RPS3
chr63474120434741264+CDS,intron-Proximal3.710186.41587HepG2U2AF1
chr63472569434725733+CDS,intron-Distal,intron-Proximal3.1912122.02137K562YBX3
chr63473806734738118+CDS,intron-Proximal3.878065.15615HepG2RPS3
chr63474019834740259+intron-Distal4.714376.34785K562KHSRP
chr63474025934740319+intron-Distal4.019728.20650K562KHSRP
chr63474072934740830+intron-Distal,intron-Proximal4.458554.79379K562KHSRP
chr63472580634725848+intron-Distal,intron-Proximal4.660705.33214K562PRPF8
chr63472579134725834+intron-Distal,intron-Proximal3.977584.10688K562KHSRP
chr63474096834741122+intron-Distal3.898149.20203K562KHSRP
chr63474062634740706+intron-Distal,intron-Proximal3.396563.93901K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SNRPC is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SNRPC is not available on ENCORE database.

  • 93 RBPs can affect the levels of SNRPC.  








The Knockdown/knockout RNA-Seq assay for SNRPC is not available on ENCORE database.





93 RBPs can affect the gene expression of SNRPC :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SNRPCENSG00000124562.52307.921002842.70830-0.300704.455403.62060HepG2AUH
SNRPCENSG00000124562.51172.454801695.89690-0.532504.802403.64700HepG2BCLAF1
SNRPCENSG00000124562.51509.801202476.04160-0.713708.935807.90900HepG2EIF2S1
SNRPCENSG00000124562.51902.646302664.27920-0.485703.247802.50530HepG2EIF4B
SNRPCENSG00000124562.52239.668602981.07220-0.412507.961106.67980HepG2EIF4G1
SNRPCENSG00000124562.52271.826402855.67030-0.330002.147501.42370HepG2EIF4G2
SNRPCENSG00000124562.52520.393203263.84950-0.372907.257906.36160HepG2ETF1
SNRPCENSG00000124562.52115.655601679.853100.332703.202502.30570HepG2EWSR1
SNRPCENSG00000124562.51877.258003267.86680-0.799703.305402.19120HepG2FTO
SNRPCENSG00000124562.51706.261102033.55710-0.253202.052301.36690HepG2FUBP3
SNRPCENSG00000124562.51951.441302561.10090-0.392202.974802.28610HepG2G3BP1
SNRPCENSG00000124562.52377.149503698.87940-0.637902.402401.80190HepG2GPKOW
SNRPCENSG00000124562.52314.316102776.99730-0.262903.417102.39350HepG2HNRNPA2B1
SNRPCENSG00000124562.51447.354501875.39010-0.373803.406602.64410HepG2HNRNPC
SNRPCENSG00000124562.52634.346003012.49700-0.193501.972101.35970HepG2HNRNPF
SNRPCENSG00000124562.52163.313201862.991000.215502.488301.91260HepG2HNRNPU
SNRPCENSG00000124562.51857.403002603.24820-0.487004.621603.76910HepG2IGF2BP2
SNRPCENSG00000124562.51781.245302618.52550-0.555904.327703.04530HepG2KHSRP
SNRPCENSG00000124562.52170.051702761.98980-0.348002.620401.98190HepG2MAGOH
SNRPCENSG00000124562.52093.116302842.78520-0.441703.771603.03620HepG2NCBP2
SNRPCENSG00000124562.5917.615401762.37270-0.941606.851005.10890HepG2NONO
SNRPCENSG00000124562.51454.753103129.57650-1.105205.066204.06700HepG2NSUN2
SNRPCENSG00000124562.51263.365402531.50750-1.0027016.2437014.55290HepG2PABPC4
SNRPCENSG00000124562.51976.798802489.00750-0.332404.996404.21800HepG2PCBP1
SNRPCENSG00000124562.51645.830502532.78730-0.6219015.1652014.08320HepG2PTBP1
SNRPCENSG00000124562.52452.993103034.01800-0.306703.469802.72270HepG2PUM2
SNRPCENSG00000124562.51639.187102742.79610-0.7427017.0961015.73470HepG2QKI
SNRPCENSG00000124562.52098.088402727.96590-0.378805.749205.07080HepG2RBM22
SNRPCENSG00000124562.5903.081902489.36770-1.4629046.5826044.14550HepG2RBM25
SNRPCENSG00000124562.51968.562902818.64180-0.5179011.3700010.41580HepG2NELFE
SNRPCENSG00000124562.52057.492102625.37630-0.351605.665004.82200HepG2RECQL
SNRPCENSG00000124562.51106.674601464.22340-0.403902.814002.02170HepG2RRP9
SNRPCENSG00000124562.52075.368603494.13170-0.751603.100602.35500HepG2SF3B1
SNRPCENSG00000124562.51893.336102636.72710-0.477809.800908.78880HepG2SF3B4
SNRPCENSG00000124562.52180.509102742.51410-0.330806.570905.56320HepG2SLBP
SNRPCENSG00000124562.52654.514103081.12240-0.215003.051302.53340HepG2SRFBP1
SNRPCENSG00000124562.53098.466602752.266700.170802.104201.67580HepG2SRSF1
SNRPCENSG00000124562.52056.505002824.04830-0.457609.544508.47600HepG2SRSF5
SNRPCENSG00000124562.52531.312202959.60500-0.225502.650801.96940HepG2SRSF7
SNRPCENSG00000124562.51552.863802239.19690-0.5281012.1027011.09210HepG2SRSF9
SNRPCENSG00000124562.52295.096502675.11790-0.221002.883602.36290HepG2SSB
SNRPCENSG00000124562.51295.362501799.38420-0.474102.690301.50470HepG2SUB1
SNRPCENSG00000124562.51911.618702413.37190-0.336303.224902.21530HepG2SUPT6H
SNRPCENSG00000124562.51887.538802474.10670-0.390405.487904.74430HepG2TAF15
SNRPCENSG00000124562.52301.117503439.33570-0.579802.271901.60600HepG2TARDBP
SNRPCENSG00000124562.51804.952202273.08890-0.332703.444402.51530HepG2TIA1
SNRPCENSG00000124562.52420.913801810.240900.419303.446402.90100HepG2TIAL1
SNRPCENSG00000124562.51598.961601826.42640-0.191901.926501.43940HepG2TRIM56
SNRPCENSG00000124562.51629.132202957.75430-0.8604011.736409.97180HepG2UBE2L3
SNRPCENSG00000124562.53429.450802528.063800.4398010.223209.18770HepG2UTP3
SNRPCENSG00000124562.51969.251902258.01020-0.197402.447701.80980HepG2ZC3H8
SNRPCENSG00000124562.52438.572702879.85310-0.240004.186103.55140HepG2ZNF622
SNRPCENSG00000124562.57660.944205043.628000.6030021.7760020.29220K562AGGF1
SNRPCENSG00000124562.56837.302705248.051000.381503.493102.75520K562AKAP8L
SNRPCENSG00000124562.57474.476405511.243500.439504.079403.39420K562AQR
SNRPCENSG00000124562.52833.528203744.37410-0.402105.888204.47080K562BCLAF1
SNRPCENSG00000124562.55405.308907163.16040-0.406202.330301.53610K562BOP1
SNRPCENSG00000124562.56820.171708033.75190-0.236303.603902.33400K562CPEB4
SNRPCENSG00000124562.55113.211307616.45080-0.5749011.528809.91200K562CPSF6
SNRPCENSG00000124562.54210.720704884.62110-0.214202.723501.52300K562DDX21
SNRPCENSG00000124562.57337.879005647.733700.377607.070105.56180K562DKC1
SNRPCENSG00000124562.53981.204105022.87340-0.335305.639504.66700K562EIF2S2
SNRPCENSG00000124562.53087.534702503.750800.302303.579902.68140K562EIF3G
SNRPCENSG00000124562.52969.997902279.363000.381705.370203.45620K562EWSR1
SNRPCENSG00000124562.55818.748507749.64310-0.413404.831403.69870K562FMR1
SNRPCENSG00000124562.54300.823606568.55850-0.611008.030806.38460K562FTO
SNRPCENSG00000124562.54035.153202715.619600.5712014.2443012.97750K562FXR1
SNRPCENSG00000124562.54152.944706239.25610-0.587203.810401.30950K562FXR2
SNRPCENSG00000124562.52249.039602987.62360-0.409703.433401.82220K562GEMIN5
SNRPCENSG00000124562.55178.397607271.80100-0.489807.218605.93530K562GPKOW
SNRPCENSG00000124562.53549.108404464.09540-0.330903.839502.57720K562HNRNPA1
SNRPCENSG00000124562.52811.111804584.67000-0.7057014.5485013.26710K562HNRNPC
SNRPCENSG00000124562.54067.566102928.117400.474104.996603.28280K562HNRNPK
SNRPCENSG00000124562.52411.783203139.48690-0.380403.086301.50170K562ILF3
SNRPCENSG00000124562.56614.484805569.748000.247902.278501.53910K562KIF1C
SNRPCENSG00000124562.56434.960505331.413200.271302.264601.32350K562MAK16
SNRPCENSG00000124562.57706.893306239.489200.304602.609501.73030K562MBNL1
SNRPCENSG00000124562.54913.404707098.10400-0.530708.456506.86810K562METAP2
SNRPCENSG00000124562.54535.099605603.96450-0.305304.548403.53360K562MTPAP
SNRPCENSG00000124562.56045.559704373.407700.467003.519702.49800K562NAA15
SNRPCENSG00000124562.54261.087606226.87840-0.5473013.1727011.71310K562NSUN2
SNRPCENSG00000124562.56592.842304058.991800.699702.516001.58380K562PABPN1
SNRPCENSG00000124562.53468.186102741.523800.339103.326102.25360K562PCBP2
SNRPCENSG00000124562.54502.690905671.99940-0.333102.664301.85030K562PCBP3
SNRPCENSG00000124562.53285.804704350.67640-0.405005.788104.63370K562POLR2G
SNRPCENSG00000124562.54803.510902899.875200.7280012.2586010.67320K562PRPF8
SNRPCENSG00000124562.53723.447902993.784100.314603.459702.72780K562PTBP1
SNRPCENSG00000124562.58187.989105205.145800.6535010.898509.86900K562PUS1
SNRPCENSG00000124562.56345.846005071.200100.323403.806603.12720K562RBM15
SNRPCENSG00000124562.53919.996102954.017000.408103.514302.59040K562RPS19
SNRPCENSG00000124562.56224.114103710.961700.746002.913601.66650K562SF1
SNRPCENSG00000124562.54736.253406143.78870-0.375405.030203.95650K562SF3A3
SNRPCENSG00000124562.53273.138902566.269300.350904.450803.35590K562SF3B4
SNRPCENSG00000124562.57534.048904263.507600.821302.750401.52530K562SNRNP200
SNRPCENSG00000124562.54421.397503555.199800.314503.002001.92170K562SRFBP1
SNRPCENSG00000124562.54992.171706294.39440-0.334406.517805.15160K562SRPK2
SNRPCENSG00000124562.53885.356102934.982200.404605.320404.34550K562SRSF1
SNRPCENSG00000124562.52100.166202808.00580-0.419003.327802.20450K562SUPV3L1
SNRPCENSG00000124562.53071.061702392.419900.360202.672701.60140K562U2AF1
SNRPCENSG00000124562.52881.364902470.578700.221802.030901.34360K562U2AF2
SNRPCENSG00000124562.52209.522502971.77830-0.427603.963902.72210K562UCHL5
SNRPCENSG00000124562.54870.801506602.46180-0.438807.688406.56470K562UPF1
SNRPCENSG00000124562.53892.782905649.56590-0.537309.310007.66510K562WDR3
SNRPCENSG00000124562.54642.462706208.91020-0.419405.274804.01900K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SNRPC is not available on ENCORE database.





7 RBPs can affect the splicing of SNRPC :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESNRPCENSG00000124562.5chr6+347256253472573134725182347253283473037134730480-0.097000.000000.00000excludedK562SF3B4
SESNRPCENSG00000124562.5chr6+347256253472573134725182347253283473037134730480-0.057000.000000.00000excludedHepG2U2AF2
SESNRPCENSG00000124562.5chr6+347256253472573134725182347253283473037134730619-0.143000.000000.00000excludedK562AQR
SESNRPCENSG00000124562.5chr6+347256253472573134725182347253283473037134730480-0.051000.000000.00001excludedHepG2CDC40
SESNRPCENSG00000124562.5chr6+347256253472573134725182347253283473037134730480-0.135000.000000.00000excludedHepG2SF3A3
SESNRPCENSG00000124562.5chr6+347256883472573134725182347253283473037134730480-0.069000.000000.00000excludedK562SF3B1
MXESNRPCENSG00000124562.5chr6+3472568834725731347303243473048034725182347253283473568434735774-0.098000.000460.004652includedK562AQR
MXESNRPCENSG00000124562.5chr6+3472568834725731347303013473048034725182347253283473568434735774-0.098000.000480.004762includedK562AQR
MXESNRPCENSG00000124562.5chr6+3473037134730480347356843473577434725688347257313473806734738172-0.077000.000060.002652includedK562PRPF8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SNRPC is not avaliable on ENCORE database.