POLR1B

General Information

Gene Name       : POLR1B
Gene ID             : ENSG00000125630.15
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLR1B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLR1BENSG00000125630.1523.9022.8823.39ENCSR000AEF
HepG2POLR1BENSG00000125630.1533.0935.6834.39ENCSR985KAT
K562POLR1BENSG00000125630.1528.6327.0227.82ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLR1B is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLR1B RNA is bound by 11 proteins.  







eCLIP assay for POLR1B is not avaliable on ENCORE database.





11 proteins are bound to POLR1B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2113333122113333176+3'-UTR,CDS4.134623.46958K562YBX3
chr2113308441113308515+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.067343.68471HepG2BCLAF1
chr2113321984113322058+3'-UTR,CDS,intron-Proximal4.135434.15726HepG2G3BP1
chr2113309351113309431+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.430184.94406K562YBX3
chr2113305065113305147+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.081123.34184HepG2GRWD1
chr2113309518113309575+3'-UTR,5'-UTR,CDS,intron-Distal3.080343.85381HepG2BCLAF1
chr2113333398113333474+3'-UTR4.322814.12025K562YBX3
chr2113330190113330237+3'-UTR,CDS,intron-Proximal3.636093.68471HepG2BCLAF1
chr2113316970113317103+3'-UTR,CDS,intron-Distal3.111473.67092HepG2G3BP1
chr2113322069113322116+3'-UTR,CDS,intron-Distal,intron-Proximal3.603133.54718K562PRPF8
chr2113322016113322119+3'-UTR,CDS,intron-Distal,intron-Proximal6.9454922.91628HepG2PRPF8
chr2113330153113330235+3'-UTR,CDS,intron-Proximal4.031184.01763HepG2GRWD1
chr2113306862113306976+3'-UTR,5'-UTR,CDS,intron-Distal3.567347.01246HepG2BCLAF1
chr2113325632113325699+3'-UTR,CDS4.630113.89826HepG2BCLAF1
chr2113316991113317071+3'-UTR,CDS,intron-Distal3.038724.24993HepG2PPIG
chr2113304702113304749+5'-UTR,CDS,intron-Distal3.869373.67607K562YBX3
chr2113310375113310443+5'-UTR,CDS,intron-Distal,intron-Proximal3.477363.54718K562PRPF8
chr2113300203113300315+5'-UTR,CDS,intron-Proximal5.1283225.92827HepG2PRPF8
chr2113300031113300134+5'-UTR,CDS3.007465.93610HepG2NCBP2
chr2113310221113310261+5'-UTR,CDS,intron-Distal,intron-Proximal4.567343.89826HepG2BCLAF1
chr2113300142113300292+5'-UTR,CDS,intron-Proximal4.706137.46830HepG2SRSF1
chr2113300147113300276+5'-UTR,CDS,intron-Proximal3.297965.73981HepG2GRWD1
chr2113300214113300313+5'-UTR,CDS,intron-Proximal3.845328.25843K562PRPF8
chr2113304722113304782+5'-UTR,CDS,intron-Distal,intron-Proximal4.522745.34978HepG2PRPF8
chr2113304637113304702+5'-UTR,CDS,intron-Distal,intron-Proximal3.973916.00726K562YBX3
chr2113300044113300126+5'-UTR,CDS3.494907.64752HepG2SRSF1
chr2113303230113303296+intron-Distal3.924715.60471HepG2U2AF2
chr2113310393113310437+intron-Distal,intron-Proximal5.353348.03507K562AQR
chr2113300255113300323+intron-Proximal4.252675.92879HepG2RBM22
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLR1B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLR1B is not available on ENCORE database.

  • 99 RBPs can affect the levels of POLR1B.  








The Knockdown/knockout RNA-Seq assay for POLR1B is not available on ENCORE database.





99 RBPs can affect the gene expression of POLR1B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLR1BENSG00000125630.111862.007701326.014700.489703.744303.13880HepG2AKAP1
POLR1BENSG00000125630.111388.712401964.04260-0.500109.383808.24270HepG2AUH
POLR1BENSG00000125630.11689.86330956.93450-0.472102.533801.67230HepG2BCLAF1
POLR1BENSG00000125630.111127.40990884.176200.350502.580802.00010HepG2BOP1
POLR1BENSG00000125630.111204.629601004.129200.262502.932302.25220HepG2CKAP4
POLR1BENSG00000125630.11630.12570811.71530-0.365302.337301.69780HepG2CPSF6
POLR1BENSG00000125630.111191.13910928.855600.358704.974303.90110HepG2DDX19B
POLR1BENSG00000125630.11682.916001091.09380-0.676005.651404.79610HepG2DDX6
POLR1BENSG00000125630.11683.40280920.32730-0.429404.581203.69460HepG2DNAJC21
POLR1BENSG00000125630.11681.56410912.12290-0.420405.637604.75320HepG2DNAJC2
POLR1BENSG00000125630.11472.563101048.97780-1.1504016.0642014.71420HepG2EIF2S1
POLR1BENSG00000125630.111760.134601128.649000.641004.904104.00540HepG2EIF4B
POLR1BENSG00000125630.111923.914302254.94070-0.229002.304001.74660HepG2ETF1
POLR1BENSG00000125630.11494.88210929.14340-0.9088012.1332010.93500HepG2HNRNPA1
POLR1BENSG00000125630.11834.900401033.47450-0.307802.034801.43000HepG2HNRNPC
POLR1BENSG00000125630.11977.669901412.14900-0.530508.835407.64550HepG2HNRNPF
POLR1BENSG00000125630.111497.836101098.502400.447204.018803.19090HepG2HNRNPK
POLR1BENSG00000125630.111091.933301307.49110-0.259903.166502.44880HepG2HNRNPL
POLR1BENSG00000125630.11602.43290878.09340-0.543604.338303.56530HepG2HNRNPLL
POLR1BENSG00000125630.11837.553401026.64370-0.293703.014302.38360HepG2HNRNPU
POLR1BENSG00000125630.11963.532401390.56670-0.529306.758305.67160HepG2IGF2BP1
POLR1BENSG00000125630.11867.637401048.68700-0.273402.892502.14440HepG2ILF2
POLR1BENSG00000125630.112002.417201176.523100.767108.636907.57380HepG2MATR3
POLR1BENSG00000125630.11604.85430895.58060-0.566202.975001.96590HepG2MTPAP
POLR1BENSG00000125630.111647.407001204.252800.452003.549802.83640HepG2NCBP2
POLR1BENSG00000125630.111175.313901423.23870-0.276102.621401.87910HepG2NOL12
POLR1BENSG00000125630.11607.25160778.61080-0.358602.177901.51190HepG2NSUN2
POLR1BENSG00000125630.111375.138701075.008100.355104.497103.75530HepG2PCBP1
POLR1BENSG00000125630.11729.91900915.68870-0.327102.923102.16780HepG2PPIL4
POLR1BENSG00000125630.11986.008101358.57100-0.462404.872904.10890HepG2PUF60
POLR1BENSG00000125630.111833.723401442.142200.346505.943505.14150HepG2PUM1
POLR1BENSG00000125630.11756.606801022.95200-0.435105.882905.04510HepG2PUS1
POLR1BENSG00000125630.112598.101401884.722100.463008.360107.57300HepG2RBM22
POLR1BENSG00000125630.111519.172501165.596900.382102.833701.83060HepG2RBM27
POLR1BENSG00000125630.111171.756301521.18410-0.376503.337302.59780HepG2RPLP0
POLR1BENSG00000125630.11764.57410616.690600.310002.024401.49110HepG2RPS19
POLR1BENSG00000125630.111419.959301097.332300.371702.660301.60670HepG2RPS5
POLR1BENSG00000125630.111512.412601139.098900.408902.115401.52420HepG2SF3A3
POLR1BENSG00000125630.111761.369202128.74020-0.273303.610203.06120HepG2SRFBP1
POLR1BENSG00000125630.111717.660501188.713200.5309010.133609.35500HepG2SRSF1
POLR1BENSG00000125630.111556.274501341.341900.214301.907701.37480HepG2SRSF5
POLR1BENSG00000125630.11901.557801387.37900-0.6219011.9345010.66310HepG2SRSF7
POLR1BENSG00000125630.111248.55970967.083000.368504.883204.18840HepG2SRSF9
POLR1BENSG00000125630.111553.898701848.27820-0.250302.017101.56160HepG2SSB
POLR1BENSG00000125630.112095.838001525.517300.458109.512508.47700HepG2SUCLG1
POLR1BENSG00000125630.11551.58830709.62910-0.363502.187601.34660HepG2SUPT6H
POLR1BENSG00000125630.11534.956201077.80440-1.010608.209407.14490HepG2SUPV3L1
POLR1BENSG00000125630.111440.770701068.466500.431205.583004.83490HepG2TAF15
POLR1BENSG00000125630.111190.64260981.770100.278202.141601.40450HepG2TIA1
POLR1BENSG00000125630.11651.77470997.67280-0.614208.005507.23480HepG2TIAL1
POLR1BENSG00000125630.11734.365601006.48760-0.454806.092705.31350HepG2TRIM56
POLR1BENSG00000125630.11805.96810636.761800.339902.342901.64320HepG2UCHL5
POLR1BENSG00000125630.11816.443401010.20590-0.307203.228902.48600HepG2UPF1
POLR1BENSG00000125630.11625.53650987.20720-0.658303.748102.56580HepG2UPF2
POLR1BENSG00000125630.111776.68340975.315100.8651024.8528023.33080HepG2UTP3
POLR1BENSG00000125630.11778.493501060.97720-0.446602.029101.40000HepG2XRN2
POLR1BENSG00000125630.11850.407401111.03410-0.385705.541404.83630HepG2ZNF622
POLR1BENSG00000125630.111305.93980858.700300.604803.601402.23540K562AARS
POLR1BENSG00000125630.11692.49520859.44200-0.311602.789102.21910K562AGGF1
POLR1BENSG00000125630.112945.230702260.938700.381402.810001.56260K562APOBEC3C
POLR1BENSG00000125630.111635.197502282.30430-0.481002.439801.88250K562AQR
POLR1BENSG00000125630.111138.889901413.80440-0.312003.874202.72470K562BCLAF1
POLR1BENSG00000125630.11623.19730829.65070-0.412802.775301.89980K562BOP1
POLR1BENSG00000125630.11410.77020583.44100-0.506302.427701.45360K562CCAR1
POLR1BENSG00000125630.11622.19980882.17750-0.503704.942103.90040K562CPSF6
POLR1BENSG00000125630.11804.696801072.58150-0.414604.028602.72340K562CSTF2
POLR1BENSG00000125630.11656.98740849.61290-0.370902.942701.86460K562DDX3X
POLR1BENSG00000125630.112694.105701805.317700.5775010.767809.57880K562DDX47
POLR1BENSG00000125630.111238.27200962.403900.363503.800002.75080K562DKC1
POLR1BENSG00000125630.111261.979302049.44730-0.6995016.0122014.49570K562EIF2S2
POLR1BENSG00000125630.111200.07140859.636500.481206.030504.86910K562EIF3G
POLR1BENSG00000125630.111065.673201617.48610-0.602007.306205.86650K562FIP1L1
POLR1BENSG00000125630.11629.53290897.55440-0.511704.303803.23720K562FMR1
POLR1BENSG00000125630.11524.09390760.74090-0.537604.097802.96740K562FTO
POLR1BENSG00000125630.111618.58200923.078300.8101018.5278017.07040K562FXR1
POLR1BENSG00000125630.111032.898101262.88360-0.290002.735001.60170K562GLRX3
POLR1BENSG00000125630.11535.32910842.27900-0.653906.724505.48940K562GPKOW
POLR1BENSG00000125630.111769.336802731.21060-0.6263010.110708.64270K562GRSF1
POLR1BENSG00000125630.11910.550701391.48700-0.611808.462806.67940K562HNRNPA1
POLR1BENSG00000125630.11712.90300939.57450-0.398303.181002.54640K562HNRNPC
POLR1BENSG00000125630.111305.528501540.98960-0.239202.114601.33560K562HNRNPU
POLR1BENSG00000125630.111763.345702192.92990-0.314502.500701.74080K562HSPD1
POLR1BENSG00000125630.11835.206001091.76230-0.386502.262401.36160K562IGF2BP2
POLR1BENSG00000125630.111597.109301146.896900.477605.100003.95220K562MAGOH
POLR1BENSG00000125630.111936.659702731.15660-0.495903.209601.98900K562MSI2
POLR1BENSG00000125630.11705.568001327.74210-0.9121023.3739021.36110K562MTPAP
POLR1BENSG00000125630.111106.867201475.32650-0.414607.214706.09140K562NSUN2
POLR1BENSG00000125630.11397.56330648.91160-0.706802.979501.94170K562PABPN1
POLR1BENSG00000125630.111435.501601020.362500.492404.736103.44780K562PCBP2
POLR1BENSG00000125630.11838.160601351.96100-0.689807.305305.95390K562PCBP3
POLR1BENSG00000125630.11786.776201037.01390-0.398403.623502.70060K562POLR2G
POLR1BENSG00000125630.111348.472901836.20570-0.445404.278403.22680K562PPIG
POLR1BENSG00000125630.11518.77910842.42900-0.699406.864405.32600K562PSIP1
POLR1BENSG00000125630.111399.355501114.319700.328502.953702.27000K562PTBP1
POLR1BENSG00000125630.11704.89600886.99020-0.331502.371601.86030K562PUS1
POLR1BENSG00000125630.111155.80550923.961400.322902.459701.44340K562SAFB
POLR1BENSG00000125630.11610.17350800.97670-0.392502.218701.35720K562SF3B1
POLR1BENSG00000125630.111164.47870914.022800.349302.476501.66960K562SF3B4
POLR1BENSG00000125630.11561.58440728.62710-0.375702.393701.45720K562SRFBP1
POLR1BENSG00000125630.11736.120101031.88690-0.487304.390803.01780K562SRSF5
POLR1BENSG00000125630.11983.229901234.84740-0.328703.250201.97400K562SRSF7
POLR1BENSG00000125630.11761.810301190.05800-0.643505.765504.26160K562SUPV3L1
POLR1BENSG00000125630.111627.963901040.133000.6462010.509008.90530K562SYNCRIP
POLR1BENSG00000125630.11751.554101105.52050-0.556805.324604.32550K562TARDBP
POLR1BENSG00000125630.11497.28480810.27460-0.704306.360404.88250K562TIAL1
POLR1BENSG00000125630.11805.760201046.77400-0.377502.620601.56140K562TRA2A
POLR1BENSG00000125630.11565.00360860.82250-0.607505.922204.42220K562TRIM56
POLR1BENSG00000125630.111263.981901856.77050-0.554809.264106.92130K562TROVE2
POLR1BENSG00000125630.111112.80420879.839400.338802.069001.37540K562U2AF2
POLR1BENSG00000125630.11643.761101259.42990-0.9682013.6509011.32410K562UCHL5
POLR1BENSG00000125630.111041.131201564.31320-0.5874012.0859010.71640K562UPF1
POLR1BENSG00000125630.11797.692801338.54450-0.7468011.669509.82280K562WDR3
POLR1BENSG00000125630.111641.518601391.854800.237902.576601.75740K562WDR43
POLR1BENSG00000125630.112012.693102703.33710-0.425602.790901.49420K562WRN
POLR1BENSG00000125630.111398.15800862.293000.697203.402801.60190K562XRCC6
POLR1BENSG00000125630.11982.629101282.29410-0.384002.704001.51500K562XRN2
POLR1BENSG00000125630.111424.583902571.47180-0.852106.526705.11170K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLR1B is not available on ENCORE database.





9 RBPs can affect the splicing of POLR1B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLR1BENSG00000125630.11chr2+1133034071133034991132997651133002481133045881133047560.104000.000080.03044includedK562PUM1
SEPOLR1BENSG00000125630.11chr2+1133034071133034991132997651133002481133045881133047560.097000.012900.09930includedK562AQR
SEPOLR1BENSG00000125630.11chr2+113316869113317151113310221113310393113321942113322076-0.097000.009900.08060excludedK562AQR
SEPOLR1BENSG00000125630.11chr2+113303407113303499113299765113300248113304588113304756-0.207000.000120.02743excludedHepG2TIA1
SEPOLR1BENSG00000125630.11chr2+113315486113315658113310221113310393113316869113317151-0.142000.004290.05537excludedK562PUS1
SEPOLR1BENSG00000125630.11chr2+113303407113303499113299765113300248113304588113304756-0.189000.000220.01561excludedHepG2PTBP1
SEPOLR1BENSG00000125630.11chr2+113303407113303499113299765113300248113304588113304756-0.192000.000000.00019excludedHepG2SRSF1
SEPOLR1BENSG00000125630.11chr2+1133034071133034991132997651133002481133045881133047560.110000.000060.04074includedK562PUM2
SEPOLR1BENSG00000125630.11chr2+1133034071133034991132997651133002481133045881133047560.124000.000420.06224includedK562ZC3H8
SEPOLR1BENSG00000125630.11chr2+1133034071133034991132997651133002481133045881133047560.259000.002750.08363includedHepG2HNRNPC
SEPOLR1BENSG00000125630.11chr2+1133034071133034991132997651133002481133045881133047560.342000.000000.00001includedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLR1B is not avaliable on ENCORE database.