PCSK7

General Information

Gene Name       : PCSK7
Gene ID             : ENSG00000160613.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PCSK7)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PCSK7ENSG00000160613.1226.8641.6234.24ENCSR000AEF
HepG2PCSK7ENSG00000160613.1217.0611.0714.06ENCSR985KAT
K562PCSK7ENSG00000160613.1214.3914.8914.64ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PCSK7 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PCSK7 RNA is bound by 8 proteins.  







eCLIP assay for PCSK7 is not avaliable on ENCORE database.





8 proteins are bound to PCSK7 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr11117094531117094616-5'-UTR,intron-Distal3.742784.06757K562UCHL5
chr11117094875117094934-5'-UTR,CDS,intron-Distal,intron-Proximal3.196223.73413HepG2PPIG
chr11117095416117095478-CDS,intron-Distal,intron-Proximal3.939933.86355HepG2PPIG
chr11117089788117089883-CDS,intron-Distal,intron-Proximal3.135403.55138K562ZNF622
chr11117100315117100400-CDS,intron-Distal4.073673.20743HepG2PPIG
chr11117089827117089883-CDS,intron-Distal,intron-Proximal3.223453.32039HepG2PPIG
chr11117095432117095475-CDS,intron-Distal,intron-Proximal3.983403.43980K562ZNF622
chr11117090404117090473-CDS,intron-Distal4.499724.08604HepG2PPIG
chr11117089774117089826-CDS,intron-Distal,intron-Proximal3.849943.16051HepG2PPIG
chr11117098931117099077-CDS,intron-Distal,intron-Proximal3.107784.51003HepG2PPIG
chr11117096619117096726-CDS,intron-Distal,intron-Proximal3.962483.44423K562BUD13
chr11117085095117085147-intron-Distal4.685565.05386K562PTBP1
chr11117085450117085502-intron-Distal3.573033.97268K562PTBP1
chr11117100982117101052-intron-Distal,intron-Proximal4.747594.13847K562AQR
chr11117080635117080710-intron-Distal3.293133.60809HepG2HNRNPK
chr11117088838117088917-intron-Distal3.895093.85148K562GTF2F1
chr11117088859117088925-intron-Distal3.859703.01994HepG2GTF2F1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PCSK7 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PCSK7 is not available on ENCORE database.

  • 113 RBPs can affect the levels of PCSK7.  








The Knockdown/knockout RNA-Seq assay for PCSK7 is not available on ENCORE database.





113 RBPs can affect the gene expression of PCSK7 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PCSK7ENSG00000160613.81000.41170616.774200.6977013.0468011.92980HepG2ACO1
PCSK7ENSG00000160613.8320.27330466.38930-0.542202.685101.70130HepG2ADAR
PCSK7ENSG00000160613.8925.24200403.349001.197709.845108.90870HepG2AKAP1
PCSK7ENSG00000160613.8744.94910501.209200.571604.054002.79880HepG2AKAP8
PCSK7ENSG00000160613.8897.70070619.657500.534707.133305.96650HepG2AKAP8L
PCSK7ENSG00000160613.8833.74500588.886000.501502.789201.84770HepG2BCCIP
PCSK7ENSG00000160613.8896.70860616.622700.540208.168707.14320HepG2CKAP4
PCSK7ENSG00000160613.8847.55770442.039400.939006.864505.65940HepG2CNOT7
PCSK7ENSG00000160613.8431.88360598.73660-0.471302.974102.26450HepG2CPSF6
PCSK7ENSG00000160613.8957.25520765.931900.321603.705202.86800HepG2DAZAP1
PCSK7ENSG00000160613.8796.68560430.895300.886608.684107.55230HepG2DDX21
PCSK7ENSG00000160613.8694.28690386.332200.845607.720906.72370HepG2DDX3X
PCSK7ENSG00000160613.81043.24250579.018300.849307.711906.49820HepG2DDX55
PCSK7ENSG00000160613.8623.75720331.974700.909807.688106.70560HepG2DDX6
PCSK7ENSG00000160613.8576.35290465.454500.308202.468401.84650HepG2DNAJC2
PCSK7ENSG00000160613.8531.57810384.518100.467102.734401.63220HepG2EFTUD2
PCSK7ENSG00000160613.8616.64950319.028800.950709.141308.10200HepG2EIF2S1
PCSK7ENSG00000160613.8685.76720499.612500.456803.380002.08200HepG2EIF2S2
PCSK7ENSG00000160613.8577.96520352.512800.713205.131504.26230HepG2EIF4A3
PCSK7ENSG00000160613.8613.77740343.319000.838105.630704.67260HepG2EIF4B
PCSK7ENSG00000160613.81045.10180665.187200.651704.865603.86890HepG2FIP1L1
PCSK7ENSG00000160613.8339.61860481.92070-0.504903.129301.78040HepG2FKBP4
PCSK7ENSG00000160613.8454.23760263.698700.784506.404505.23790HepG2FUBP3
PCSK7ENSG00000160613.8909.24150475.140700.936208.122106.31330HepG2FUS
PCSK7ENSG00000160613.8989.44310355.826601.4753024.2574022.43450HepG2FXR1
PCSK7ENSG00000160613.8686.38560329.999301.0565011.3249010.02330HepG2G3BP1
PCSK7ENSG00000160613.8797.14460477.247300.740006.533504.94850HepG2GNB2L1
PCSK7ENSG00000160613.8658.74110409.202800.686804.217702.84740HepG2GRSF1
PCSK7ENSG00000160613.8596.81600863.88020-0.533505.862804.86960HepG2HNRNPF
PCSK7ENSG00000160613.8507.54830334.345700.602104.029503.20010HepG2HNRNPK
PCSK7ENSG00000160613.8373.05260647.68990-0.795907.176306.21670HepG2HNRNPLL
PCSK7ENSG00000160613.8640.38610458.842200.480803.436202.38430HepG2HNRNPM
PCSK7ENSG00000160613.8684.59140523.905000.385803.499602.82570HepG2HNRNPU
PCSK7ENSG00000160613.8641.70530850.66570-0.406702.950902.20520HepG2IGF2BP1
PCSK7ENSG00000160613.8646.81780335.407900.947309.548008.37910HepG2IGF2BP2
PCSK7ENSG00000160613.8679.00740314.883401.108504.990703.68650HepG2IGF2BP3
PCSK7ENSG00000160613.8473.55900337.417600.488902.286801.38790HepG2KHSRP
PCSK7ENSG00000160613.8434.29770563.79810-0.376503.291402.18030HepG2KIF1C
PCSK7ENSG00000160613.81055.13170781.845600.432402.512401.72270HepG2LARP4
PCSK7ENSG00000160613.8729.06960355.951501.0343011.3103010.01670HepG2MAGOH
PCSK7ENSG00000160613.8996.60240357.918301.4773021.5785019.95110HepG2MATR3
PCSK7ENSG00000160613.8880.47260538.186800.710107.707806.42220HepG2MSI2
PCSK7ENSG00000160613.81024.21140366.328701.4832023.4965021.77430HepG2NCBP2
PCSK7ENSG00000160613.8288.49010574.31770-0.993309.880008.53150HepG2NSUN2
PCSK7ENSG00000160613.8774.56930326.144901.2478016.3697014.66870HepG2PABPC4
PCSK7ENSG00000160613.8645.62880449.760500.521402.683101.66070HepG2PCBP2
PCSK7ENSG00000160613.8343.92480580.61430-0.755504.068803.15000HepG2PRPF4
PCSK7ENSG00000160613.8631.64900446.553100.500202.896202.06980HepG2PRPF8
PCSK7ENSG00000160613.81047.14390348.301301.5880047.9282046.25510HepG2PTBP1
PCSK7ENSG00000160613.8886.15360725.028700.289401.958001.44450HepG2PUF60
PCSK7ENSG00000160613.81074.11610769.672600.480708.243707.33360HepG2PUM1
PCSK7ENSG00000160613.8944.34450628.221900.587909.361008.33960HepG2PUS1
PCSK7ENSG00000160613.8800.82580377.189701.0861018.1093016.70700HepG2QKI
PCSK7ENSG00000160613.8926.74560387.614601.2575028.0670026.71390HepG2NELFE
PCSK7ENSG00000160613.8560.21250361.030900.633806.535805.64630HepG2RECQL
PCSK7ENSG00000160613.8596.11920930.75530-0.642807.035706.02160HepG2RPLP0
PCSK7ENSG00000160613.8712.95490364.404000.9682012.4013011.21380HepG2RPS19
PCSK7ENSG00000160613.8784.74260520.039900.593504.613803.59590HepG2RPS2
PCSK7ENSG00000160613.8537.99010365.669000.556903.554402.48510HepG2SERBP1
PCSK7ENSG00000160613.81773.84780603.939801.5543019.7042017.85750HepG2SF3A3
PCSK7ENSG00000160613.8454.75540641.07180-0.495403.467302.68630HepG2SF3B1
PCSK7ENSG00000160613.8800.86200362.602101.1431022.2552020.84580HepG2SF3B4
PCSK7ENSG00000160613.8569.26620695.23590-0.288402.203601.56570HepG2SLBP
PCSK7ENSG00000160613.8846.61820544.117900.6377010.550809.42610HepG2SMN1
PCSK7ENSG00000160613.8840.385501097.06260-0.384504.827304.21810HepG2SRFBP1
PCSK7ENSG00000160613.8564.19850378.488100.575903.823103.28990HepG2SRSF1
PCSK7ENSG00000160613.8866.31180715.887300.275102.400501.81280HepG2SRSF5
PCSK7ENSG00000160613.8501.76330848.76710-0.7584013.1303011.80930HepG2SRSF7
PCSK7ENSG00000160613.8425.34490307.928900.465902.927102.36290HepG2SRSF9
PCSK7ENSG00000160613.8610.12450952.45300-0.642509.350708.51600HepG2SSB
PCSK7ENSG00000160613.8580.65930386.140600.588503.636902.35830HepG2STIP1
PCSK7ENSG00000160613.81138.70480814.137900.483903.403502.72750HepG2SUCLG1
PCSK7ENSG00000160613.8351.45960449.01850-0.353402.224801.37790HepG2SUPT6H
PCSK7ENSG00000160613.8341.60530576.37110-0.754705.858304.93110HepG2SUPV3L1
PCSK7ENSG00000160613.8512.89910312.593400.714306.912005.59730HepG2TIA1
PCSK7ENSG00000160613.8661.05630513.618000.364003.112702.52260HepG2TRIM56
PCSK7ENSG00000160613.8992.13540400.756301.307704.708503.39710HepG2U2AF2
PCSK7ENSG00000160613.81242.20290749.811300.728203.876102.87860HepG2UBE2L3
PCSK7ENSG00000160613.8501.23290340.457800.557903.470002.62430HepG2UCHL5
PCSK7ENSG00000160613.8807.50230535.602000.592208.431407.32190HepG2UPF1
PCSK7ENSG00000160613.8716.75060550.525700.380602.772001.72370HepG2UTP18
PCSK7ENSG00000160613.8860.20820517.103100.7341011.4226010.33810HepG2UTP3
PCSK7ENSG00000160613.8827.80580477.306300.794306.016804.49260HepG2XRCC6
PCSK7ENSG00000160613.8434.63380567.37520-0.384502.161801.51450HepG2XRN2
PCSK7ENSG00000160613.81218.85730589.060001.0489033.0869031.73470HepG2ZNF622
PCSK7ENSG00000160613.8532.48870905.02970-0.7652011.2394010.18990K562AGGF1
PCSK7ENSG00000160613.8804.66810994.38720-0.305402.237701.36490K562AKAP8
PCSK7ENSG00000160613.82519.057601381.837700.8662014.6491013.44790K562AQR
PCSK7ENSG00000160613.8741.74350988.02070-0.413604.292403.12740K562ATP5C1
PCSK7ENSG00000160613.81779.386301081.476700.718304.721903.28640K562CNOT7
PCSK7ENSG00000160613.82808.537802098.396100.420406.252004.79640K562CELF1
PCSK7ENSG00000160613.8648.511601013.49540-0.644108.021006.39650K562DKC1
PCSK7ENSG00000160613.81106.98040780.704400.503703.172901.79550K562EEF2
PCSK7ENSG00000160613.81167.90750754.268300.630706.338104.90980K562EFTUD2
PCSK7ENSG00000160613.8780.99400526.283200.569402.834001.81670K562EIF3A
PCSK7ENSG00000160613.8648.08740518.528600.321702.368801.62960K562EIF3G
PCSK7ENSG00000160613.8866.53570564.974200.617006.341805.10900K562EIF4A3
PCSK7ENSG00000160613.81020.37330587.548400.7962013.8653012.61560K562FXR1
PCSK7ENSG00000160613.8273.54390431.11260-0.656303.691002.84830K562G3BP2
PCSK7ENSG00000160613.81491.37770940.349400.6653011.980809.78960K562GLRX3
PCSK7ENSG00000160613.81008.95970634.936600.668107.921806.95950K562HNRNPC
PCSK7ENSG00000160613.81048.261701584.86840-0.596404.866603.81900K562HSPD1
PCSK7ENSG00000160613.8665.72660999.46730-0.586203.817102.82600K562KIF1C
PCSK7ENSG00000160613.8667.99520956.66370-0.518204.706103.19270K562MAK16
PCSK7ENSG00000160613.8758.63140588.878300.365302.726101.81130K562MATR3
PCSK7ENSG00000160613.8777.243501119.64340-0.526603.733202.65000K562MBNL1
PCSK7ENSG00000160613.81238.85060988.653800.325402.708101.90760K562MTPAP
PCSK7ENSG00000160613.8537.93680743.38730-0.466703.131501.73010K562NONO
PCSK7ENSG00000160613.81339.861901098.488400.286503.736002.88410K562NSUN2
PCSK7ENSG00000160613.81763.706301038.985100.763305.527303.76970K562PABPC1
PCSK7ENSG00000160613.8375.29950576.91020-0.620305.832203.79740K562PCBP1
PCSK7ENSG00000160613.81192.10610525.012401.1830022.4454019.62280K562PCBP2
PCSK7ENSG00000160613.81789.972001233.023700.537604.986903.87160K562PCBP3
PCSK7ENSG00000160613.81435.21150945.802300.601608.445407.07380K562POLR2G
PCSK7ENSG00000160613.81063.507501326.81770-0.319101.995401.30240K562PPIG
PCSK7ENSG00000160613.8616.57150934.08940-0.599304.533703.86200K562PUS1
PCSK7ENSG00000160613.8610.91580909.97820-0.574906.568205.68030K562RBM15
PCSK7ENSG00000160613.8862.20110549.661000.649406.827405.43820K562RBM22
PCSK7ENSG00000160613.8289.53530408.91460-0.498103.134101.71350K562RBM25
PCSK7ENSG00000160613.8519.25770750.41580-0.531203.084001.67730K562RRP9
PCSK7ENSG00000160613.81081.64210842.635100.360102.860601.75980K562SAFB
PCSK7ENSG00000160613.81737.883801083.919900.6810010.499608.98440K562SF3A3
PCSK7ENSG00000160613.8730.03770448.283400.703508.624107.07010K562SF3B4
PCSK7ENSG00000160613.81754.424701110.498600.6597016.8983014.86590K562SRPK2
PCSK7ENSG00000160613.8385.18850534.88020-0.473703.513902.04030K562SSB
PCSK7ENSG00000160613.8774.58620568.818200.445403.229302.46530K562TARDBP
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PCSK7 is not available on ENCORE database.





7 RBPs can affect the splicing of PCSK7 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPCSK7ENSG00000160613.8chr11-1170783691170784511170777821170778761170786851170787800.774000.000390.01229includedHepG2HNRNPK
SEPCSK7ENSG00000160613.8chr11-1170960711170961781170954151170954711170966461170967370.121000.007970.06781includedK562AQR
SEPCSK7ENSG00000160613.8chr11-117096646117096737117095416117095471117097872117098038-0.145000.012330.09582excludedK562AQR
A3SSPCSK7ENSG00000160613.8chr11-1170978721170980931170978721170980381170989311170990660.060000.012180.06254longerK562AQR
A3SSPCSK7ENSG00000160613.8chr11-1170954161170955421170954161170954711170966461170967370.222000.002750.01709longerK562AQR
RIPCSK7ENSG00000160613.8chr11-1170939231170949321170939231170940241170947931170949320.207000.001010.05195includedHepG2BCCIP
RIPCSK7ENSG00000160613.8chr11-117093923117094932117093923117094024117094793117094932-0.477000.000250.00941excludedK562HNRNPC
RIPCSK7ENSG00000160613.8chr11-1170939231170949321170939231170940241170947931170949320.476000.003640.07191includedHepG2UCHL5
RIPCSK7ENSG00000160613.8chr11-1170939231170949321170939231170940241170947931170949320.366000.009010.08310includedK562AGGF1
RIPCSK7ENSG00000160613.8chr11-117093923117094932117093923117094024117094793117094932-0.265000.001300.05616excludedHepG2HNRNPC
RIPCSK7ENSG00000160613.8chr11-1170939231170949321170939231170940241170947931170949320.445000.003270.03525includedHepG2HNRNPK
RIPCSK7ENSG00000160613.8chr11-1170939231170949321170939231170940241170947931170949320.422000.004590.04852includedK562UTP18
RIPCSK7ENSG00000160613.8chr11-1170939231170949321170939231170940241170947931170949320.164000.012680.06631includedK562AQR
MXEPCSK7ENSG00000160613.8chr11-1170954161170954711170978721170980381170947931170949321170989311170990660.151000.015760.091121includedK562AQR
MXEPCSK7ENSG00000160613.8chr11-1170954161170954711170978721170980931170947931170949321170989311170990660.071000.003870.029011includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PCSK7 is not avaliable on ENCORE database.