MKL1

General Information

Gene Name       : MKL1
Gene ID             :
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MKL1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MKL1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MKL1 RNA is bound by 14 proteins.  







eCLIP assay for MKL1 is not avaliable on ENCORE database.





14 proteins are bound to MKL1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr224080632440806408-3'-UTR,intron-Distal4.595145.24231K562UPF1
chr224080656140806639-3'-UTR,intron-Distal4.306393.45716HepG2AKAP1
chr224080646640806577-3'-UTR,intron-Distal5.383229.76086HepG2UPF1
chr224080635440806438-3'-UTR,intron-Distal4.191533.92497HepG2UPF1
chr224080669540806775-3'-UTR,intron-Distal3.680703.95400K562UPF1
chr224080647140806561-3'-UTR,intron-Distal4.989556.92572HepG2AKAP1
chr224085922840859284-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.857873.11168K562ZNF622
chr224094810440948179-5'-UTR,intron-Distal,intron-Proximal3.816384.68902HepG2PPIG
chr224103252141032677-5'-UTR,intron-Distal3.508556.97307HepG2NCBP2
chr224094817940948255-5'-UTR,intron-Distal3.324264.51003HepG2PPIG
chr224082564940825711-CDS,intron-Distal4.515934.67689HepG2PPIG
chr224082571140825773-CDS,intron-Distal,intron-Proximal3.354963.32039HepG2PPIG
chr224085562340855723-intron-Distal3.909933.08314K562TARDBP
chr224095852040958628-intron-Distal6.0077010.39091HepG2PCBP2
chr224095840040958461-intron-Distal4.987676.57498HepG2PCBP2
chr224102279141022942-intron-Distal3.854413.08314K562TARDBP
chr224094536440945443-intron-Distal4.657536.27552K562KHSRP
chr224094519440945350-intron-Distal4.812626.94732K562KHSRP
chr224095841240958527-intron-Distal3.127543.59765K562ILF3
chr224098185240981936-intron-Distal4.275063.89294K562KHSRP
chr224094657140946734-intron-Distal3.231484.13575K562KHSRP
chr224094785140947915-intron-Distal3.662935.86177HepG2U2AF2
chr224095863840958711-intron-Distal3.900993.57018HepG2HNRNPK
chr224094792840948095-intron-Distal,intron-Proximal4.516619.20471K562KHSRP
chr224101307941013175-intron-Distal6.4077021.22776HepG2PCBP2
chr224092808340928142-intron-Distal5.043226.44072HepG2HNRNPM
chr224087375040873853-intron-Distal5.429748.60492HepG2PCBP2
chr224085338440853431-intron-Distal4.713094.90095K562PTBP1
chr224096031340960415-intron-Distal4.573034.67693K562PTBP1
chr224101305041013177-intron-Distal3.268145.19856HepG2PTBP1
chr224096086340960918-intron-Distal3.132583.57996HepG2XPO5
chr224101306041013146-intron-Distal3.305623.59765K562ILF3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MKL1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MKL1 is not available on ENCORE database.

  • 95 RBPs can affect the levels of MKL1.  








The Knockdown/knockout RNA-Seq assay for MKL1 is not available on ENCORE database.





95 RBPs can affect the gene expression of MKL1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MKL1ENSG00000196588.10935.21050471.969900.9865022.5217021.16390HepG2ACO1
MKL1ENSG00000196588.10705.13860520.784100.437102.492501.50240HepG2AKAP8
MKL1ENSG00000196588.10683.12190474.177400.526605.790404.71750HepG2AKAP8L
MKL1ENSG00000196588.10485.86210322.770900.589902.509801.75820HepG2ASCC1
MKL1ENSG00000196588.10755.19160615.256000.295602.368701.72450HepG2AUH
MKL1ENSG00000196588.10338.73580445.94380-0.396702.220501.52530HepG2CALR
MKL1ENSG00000196588.10592.01430471.855300.327202.656102.00090HepG2CKAP4
MKL1ENSG00000196588.10773.05190596.626400.373602.443501.40840HepG2CPSF7
MKL1ENSG00000196588.10712.67260389.582700.8712013.9361012.70890HepG2CELF1
MKL1ENSG00000196588.10401.60030288.338400.477903.060901.84870HepG2DDX1
MKL1ENSG00000196588.10386.08270286.898300.428302.306901.67960HepG2DDX21
MKL1ENSG00000196588.10689.87790373.642100.884605.983205.09660HepG2DDX3X
MKL1ENSG00000196588.10407.54490546.33640-0.422802.475601.51550HepG2DDX5
MKL1ENSG00000196588.10831.67380321.168001.3726017.5973016.21940HepG2DDX6
MKL1ENSG00000196588.10186.90110272.69480-0.545002.713501.73770HepG2DHX30
MKL1ENSG00000196588.10365.22320280.230600.382102.511201.88430HepG2DNAJC2
MKL1ENSG00000196588.10480.77040308.546400.639802.576302.00400HepG2EIF2S1
MKL1ENSG00000196588.10792.00290549.599700.527004.267802.82500HepG2EIF2S2
MKL1ENSG00000196588.10491.34280340.883200.527402.078901.52220HepG2EIF4A3
MKL1ENSG00000196588.10708.48500332.082501.093106.161505.16460HepG2EIF4B
MKL1ENSG00000196588.10944.05660706.411200.418304.407603.68000HepG2ETF1
MKL1ENSG00000196588.10675.80780461.188300.551204.927903.81620HepG2EWSR1
MKL1ENSG00000196588.101398.71880731.663200.9348010.842309.46100HepG2FIP1L1
MKL1ENSG00000196588.10653.67170344.229900.925108.192707.04880HepG2FXR1
MKL1ENSG00000196588.10491.63630319.169500.623203.162402.45290HepG2G3BP1
MKL1ENSG00000196588.10487.27780265.605300.875406.336004.76910HepG2GNB2L1
MKL1ENSG00000196588.10616.08880450.588900.451204.414503.20030HepG2HDGF
MKL1ENSG00000196588.10390.07240285.442200.450402.439801.83060HepG2HNRNPA1
MKL1ENSG00000196588.10466.89520323.547900.529002.150001.52890HepG2HNRNPK
MKL1ENSG00000196588.10729.93040504.753000.532104.580103.38880HepG2HNRNPM
MKL1ENSG00000196588.10692.96580324.374001.0950012.3966011.08310HepG2IGF2BP2
MKL1ENSG00000196588.10424.99510322.171600.399503.163902.38500HepG2ILF2
MKL1ENSG00000196588.101211.57990690.831700.810407.576506.18810HepG2LARP4
MKL1ENSG00000196588.10485.88000344.351300.496602.036801.47010HepG2MAGOH
MKL1ENSG00000196588.10714.52810346.231001.045208.275307.23400HepG2MATR3
MKL1ENSG00000196588.10809.73770592.060000.451603.567002.65040HepG2MSI2
MKL1ENSG00000196588.10728.49240354.347901.039608.337007.26670HepG2NCBP2
MKL1ENSG00000196588.10672.21100415.310200.694608.519007.20640HepG2NOL12
MKL1ENSG00000196588.10558.25880296.539400.912602.433701.41470HepG2NONO
MKL1ENSG00000196588.10496.14460687.65780-0.470902.689101.95120HepG2NSUN2
MKL1ENSG00000196588.10488.90530315.603700.631302.257201.46960HepG2PABPC1
MKL1ENSG00000196588.10552.06700315.391900.807605.751704.72390HepG2PABPC4
MKL1ENSG00000196588.10606.97130336.884400.8493011.8333010.71880HepG2PCBP1
MKL1ENSG00000196588.10403.65690499.06970-0.306102.020001.35160HepG2PRPF4
MKL1ENSG00000196588.10626.52460342.784700.8700011.8808010.90430HepG2PTBP1
MKL1ENSG00000196588.10521.32850420.893500.308602.520001.94870HepG2PUM1
MKL1ENSG00000196588.10829.14280420.571600.979205.942704.97340HepG2PUM2
MKL1ENSG00000196588.10483.99380371.260800.382502.260701.68590HepG2QKI
MKL1ENSG00000196588.10688.66090295.333001.221408.665007.46180HepG2RAVER1
MKL1ENSG00000196588.10920.29340692.678100.409803.627102.65980HepG2RBM15
MKL1ENSG00000196588.101260.61550590.426001.0942026.1611024.89360HepG2RBM22
MKL1ENSG00000196588.10530.67280336.936800.655205.325304.41910HepG2RBM25
MKL1ENSG00000196588.10404.48790254.886100.666103.227502.08130HepG2RCC2
MKL1ENSG00000196588.10723.97100381.492900.9242013.6986012.66490HepG2NELFE
MKL1ENSG00000196588.10680.40990268.473901.3415018.3262016.94770HepG2RPS19
MKL1ENSG00000196588.10450.85380289.458100.639203.738902.81320HepG2RPS2
MKL1ENSG00000196588.10504.82760295.498600.772505.512303.98040HepG2RPS5
MKL1ENSG00000196588.10392.25820246.085200.672503.093502.26870HepG2RRP9
MKL1ENSG00000196588.101395.25910551.840201.3381017.5489015.77660HepG2SF3A3
MKL1ENSG00000196588.10626.57790356.897000.8119010.234509.20430HepG2SF3B4
MKL1ENSG00000196588.10684.47090337.193201.021302.809001.34840HepG2SFPQ
MKL1ENSG00000196588.10550.74920327.555000.749609.861508.76590HepG2SMN1
MKL1ENSG00000196588.10481.12180301.928900.672103.870702.72080HepG2SMNDC1
MKL1ENSG00000196588.101501.06220666.858901.1704038.6456037.33860HepG2SRFBP1
MKL1ENSG00000196588.10564.39170372.517500.599305.070704.48060HepG2SRSF1
MKL1ENSG00000196588.10511.30840391.484100.385103.077502.42180HepG2SRSF5
MKL1ENSG00000196588.10426.95680303.058000.494402.933202.36830HepG2SRSF9
MKL1ENSG00000196588.10439.62000578.98170-0.397303.363102.80990HepG2SSB
MKL1ENSG00000196588.10704.10310445.201400.661209.693508.65000HepG2SUCLG1
MKL1ENSG00000196588.10185.80110334.81760-0.849607.080006.25460HepG2TAF15
MKL1ENSG00000196588.10355.91290215.280800.725203.589202.47220HepG2TFIP11
MKL1ENSG00000196588.10475.22240306.478600.632705.380304.72950HepG2TIAL1
MKL1ENSG00000196588.10470.81990309.209700.606505.971505.19880HepG2TRIM56
MKL1ENSG00000196588.10571.13000387.372200.560002.250801.46870HepG2TUFM
MKL1ENSG00000196588.101225.02900625.833200.9689013.4681012.04660HepG2U2AF1
MKL1ENSG00000196588.101241.37420361.089501.781408.230406.44340HepG2U2AF2
MKL1ENSG00000196588.10550.96160410.052300.426002.050401.33580HepG2UBE2L3
MKL1ENSG00000196588.10330.44290189.727600.800404.709503.71440HepG2UCHL5
MKL1ENSG00000196588.10970.95900472.493401.0390013.3671012.19700HepG2UTP3
MKL1ENSG00000196588.10469.57380324.933500.531102.480301.47910HepG2XRCC6
MKL1ENSG00000196588.10597.25270492.528400.278001.958101.37800HepG2ZC3H8
MKL1ENSG00000196588.10892.08540538.243400.7288014.1343013.13870HepG2ZNF622
MKL1ENSG00000196588.10480.80060320.425200.585404.149802.80280K562CCAR1
MKL1ENSG00000196588.10584.35370756.97430-0.373402.873001.88150K562CELF1
MKL1ENSG00000196588.10374.20840227.311300.719104.439503.26570K562EFTUD2
MKL1ENSG00000196588.10573.39720342.967300.741408.429207.27630K562EIF2S2
MKL1ENSG00000196588.10384.81670243.306700.661303.560602.37180K562EIF3D
MKL1ENSG00000196588.1041.00860103.76840-1.339404.859103.86100K562G3BP2
MKL1ENSG00000196588.10402.76820300.159700.424102.256001.70930K562HNRNPC
MKL1ENSG00000196588.10347.24530204.148500.766203.527302.31460K562IGF2BP2
MKL1ENSG00000196588.10859.19960677.660000.342302.775801.86480K562MBNL1
MKL1ENSG00000196588.10275.92850190.703600.532902.561301.62100K562PCBP2
MKL1ENSG00000196588.10373.57900208.288000.842707.534406.47640K562PTBP1
MKL1ENSG00000196588.10292.96490199.624100.553303.000902.12240K562RBM22
MKL1ENSG00000196588.10340.76620245.533800.472802.530701.58540K562RCC2
MKL1ENSG00000196588.10323.31760225.264800.521202.073201.37050K562RPS19
MKL1ENSG00000196588.10326.72670216.337800.594702.680201.69350K562RPS3
MKL1ENSG00000196588.10174.53750107.824000.694803.225802.30150K562SF3B4
MKL1ENSG00000196588.10377.98410232.760100.699404.693603.25620K562SRFBP1
MKL1ENSG00000196588.10319.08380204.212000.643803.960803.12080K562SRSF1
MKL1ENSG00000196588.10370.57510208.777700.827705.810604.18030K562SRSF4
MKL1ENSG00000196588.10299.23450206.632000.534102.716402.01490K562TARDBP
MKL1ENSG00000196588.10363.67180199.331400.867407.190305.77070K562TIA1
MKL1ENSG00000196588.10302.61770195.707400.628703.491102.23480K562TRA2A
MKL1ENSG00000196588.10340.59000230.838900.561002.831101.60670K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MKL1 is not available on ENCORE database.





1 RBPs can affect the splicing of MKL1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSMKL1ENSG00000196588.10chr22-4081334440813497408133444081345240814377408153880.066000.002970.06318longerHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MKL1 is not avaliable on ENCORE database.