KRAS

General Information

Gene Name       : KRAS
Gene ID             : ENSG00000133703.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: KRAS)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878KRASENSG00000133703.117.926.367.14ENCSR000AEF
HepG2KRASENSG00000133703.114.9810.357.67ENCSR985KAT
K562KRASENSG00000133703.1112.7413.3113.03ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for KRAS is not avaliable on ENCORE database.



Proteins bound to RNA
  • KRAS RNA is bound by 9 proteins.  







eCLIP assay for KRAS is not avaliable on ENCORE database.





9 proteins are bound to KRAS RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr122536265725362717-3'-UTR,intron-Distal5.4700317.76940K562PUM2
chr122536208425362133-3'-UTR,intron-Distal,intron-Proximal4.808445.69206K562CPEB4
chr122535824625358291-3'-UTR,intron-Distal4.5143015.90101K562PABPC4
chr122538697925387060-3'-UTR,intron-Distal4.239364.10688K562KHSRP
chr122536009925360120-3'-UTR,intron-Distal3.514125.32768K562YBX3
chr122535823925358284-3'-UTR,intron-Distal4.674943.27332K562DDX6
chr122536258525362657-3'-UTR,intron-Distal3.361807.83509K562PUM2
chr122540368425403819-5'-UTR,intron-Distal,intron-Proximal3.928674.84938K562DDX3X
chr122536643525366558-intron-Distal6.1306611.26038K562QKI
chr122540335925403417-intron-Distal4.896474.14061K562DROSHA
chr122536701725367135-intron-Distal5.3195119.33988K562QKI
chr122538575625385852-intron-Distal4.114713.42844K562KHSRP
chr122536304025363148-intron-Distal4.207304.54401K562KHSRP
chr122536701225367123-intron-Distal4.6051011.12558HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for KRAS is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for KRAS is not available on ENCORE database.

  • 93 RBPs can affect the levels of KRAS.  








The Knockdown/knockout RNA-Seq assay for KRAS is not available on ENCORE database.





93 RBPs can affect the gene expression of KRAS :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
KRASENSG00000133703.7847.85270679.258200.319803.133102.49240HepG2ACO1
KRASENSG00000133703.7987.53500740.245500.415702.409001.90910HepG2AKAP1
KRASENSG00000133703.7960.809201153.57100-0.263802.380701.73540HepG2AUH
KRASENSG00000133703.7438.20650756.03020-0.786805.970104.56740HepG2BCCIP
KRASENSG00000133703.7388.65010656.97370-0.757405.794504.54560HepG2BCLAF1
KRASENSG00000133703.7485.85160712.01160-0.551404.419703.68410HepG2BOP1
KRASENSG00000133703.7435.18660581.91310-0.419202.336901.62070HepG2CIRBP
KRASENSG00000133703.7498.61800698.19890-0.485704.716603.39090HepG2YBX3
KRASENSG00000133703.7721.30770968.52350-0.425202.591201.86910HepG2DAZAP1
KRASENSG00000133703.7851.33450476.109300.838308.237007.13210HepG2DDX21
KRASENSG00000133703.7983.05460709.114600.471203.348702.66900HepG2DDX3X
KRASENSG00000133703.7529.96310743.31250-0.488102.572101.82240HepG2DDX55
KRASENSG00000133703.7457.47670661.28080-0.531604.355203.13490HepG2DHX30
KRASENSG00000133703.7528.92020685.64370-0.374403.118502.37640HepG2DNAJC21
KRASENSG00000133703.7321.08110679.49520-1.0815020.3446018.72940HepG2DNAJC2
KRASENSG00000133703.7639.42820438.120300.545403.155401.96500HepG2AGO1
KRASENSG00000133703.7541.94580915.10580-0.755805.335804.22570HepG2EIF4G2
KRASENSG00000133703.71110.68550834.563400.412302.674501.91680HepG2FIP1L1
KRASENSG00000133703.7409.19830654.76610-0.678202.367101.43430HepG2FTO
KRASENSG00000133703.7877.71320652.903500.426802.823102.12350HepG2FXR1
KRASENSG00000133703.7512.28020692.21130-0.434302.241401.65540HepG2HNRNPA1
KRASENSG00000133703.7564.96950885.33650-0.648106.651005.60380HepG2HNRNPF
KRASENSG00000133703.7675.71130882.34550-0.384902.150601.54620HepG2HNRNPL
KRASENSG00000133703.7490.14660764.83790-0.641906.941806.01850HepG2HNRNPU
KRASENSG00000133703.7549.30330871.81660-0.666405.838104.82630HepG2IGF2BP1
KRASENSG00000133703.7598.94720781.26190-0.383404.126603.24880HepG2ILF2
KRASENSG00000133703.7884.051901191.91620-0.431102.609401.80430HepG2LARP4
KRASENSG00000133703.7442.45590682.44240-0.625202.527301.48670HepG2NONO
KRASENSG00000133703.7473.71000627.02690-0.404502.270801.59120HepG2NSUN2
KRASENSG00000133703.7460.10350682.17970-0.568205.545004.53300HepG2PPIL4
KRASENSG00000133703.7330.29770691.88530-1.0668017.7399016.42280HepG2PUS1
KRASENSG00000133703.7855.30680593.682900.526602.330901.68000HepG2RAVER1
KRASENSG00000133703.71534.668001106.959300.471206.769606.04410HepG2RBM22
KRASENSG00000133703.7765.39050539.052500.505704.214303.39720HepG2RBM25
KRASENSG00000133703.71085.68980610.320400.830906.405905.64020HepG2NELFE
KRASENSG00000133703.7643.12300953.53110-0.568204.192303.37870HepG2RPLP0
KRASENSG00000133703.7518.59770729.60690-0.492502.710601.91960HepG2RPS3A
KRASENSG00000133703.7400.59540681.14040-0.765809.421608.34420HepG2SAFB2
KRASENSG00000133703.7332.21210447.96820-0.431302.203501.36080HepG2SERBP1
KRASENSG00000133703.71445.05020737.824700.969709.728008.40230HepG2SF3A3
KRASENSG00000133703.7789.81830571.006900.467904.632703.89740HepG2SF3B4
KRASENSG00000133703.7689.27520878.73490-0.350302.038001.41830HepG2SLBP
KRASENSG00000133703.71992.456801250.292700.6722018.2246017.23860HepG2SRFBP1
KRASENSG00000133703.71726.00620595.972901.5340062.0792060.50280HepG2SRSF1
KRASENSG00000133703.7515.20270904.95610-0.812706.475605.57310HepG2SRSF5
KRASENSG00000133703.7565.58750869.76920-0.620906.252905.27390HepG2SRSF7
KRASENSG00000133703.7621.61130484.825900.358401.858101.38960HepG2SRSF9
KRASENSG00000133703.7425.24560563.75510-0.406802.443201.55530HepG2SUPT6H
KRASENSG00000133703.7473.79480743.30000-0.649707.445406.69750HepG2TIAL1
KRASENSG00000133703.7367.85670749.81890-1.0274014.9209013.75950HepG2TRIM56
KRASENSG00000133703.7934.72460714.059500.388402.802902.17060HepG2U2AF1
KRASENSG00000133703.7248.54210437.15960-0.814706.135404.99480HepG2UCHL5
KRASENSG00000133703.7375.88660677.69790-0.850305.315403.90020HepG2UPF2
KRASENSG00000133703.7838.27730583.740000.522002.765301.49960HepG2XRCC5
KRASENSG00000133703.71063.58430652.861300.704005.149503.72940HepG2XRCC6
KRASENSG00000133703.7339.17780728.43910-1.1028012.0381010.54820HepG2XRN2
KRASENSG00000133703.72321.919201714.041300.437808.133707.23090K562AGGF1
KRASENSG00000133703.72547.543402012.472200.340002.727502.14290K562AQR
KRASENSG00000133703.7983.881701181.85780-0.264502.476301.57130K562BCLAF1
KRASENSG00000133703.71300.452401649.21550-0.342802.807901.51730K562CIRBP
KRASENSG00000133703.71798.315802191.42780-0.285202.862301.73360K562CPEB4
KRASENSG00000133703.71064.873801399.72880-0.394503.843202.91950K562CPSF6
KRASENSG00000133703.7727.56680896.61500-0.301402.322401.37070K562CSTF2
KRASENSG00000133703.7924.233901186.21840-0.360002.567601.56450K562DDX3X
KRASENSG00000133703.71951.110802267.17080-0.216602.169001.58030K562DDX47
KRASENSG00000133703.7745.574401068.13100-0.518704.499503.31910K562EFTUD2
KRASENSG00000133703.71121.060301390.92270-0.311203.265402.49460K562EIF2S2
KRASENSG00000133703.7815.297101143.63750-0.488203.429402.26700K562EIF3D
KRASENSG00000133703.7907.700601182.10430-0.381104.145803.18060K562EIF3G
KRASENSG00000133703.7801.444201239.36570-0.628904.496203.44960K562EIF4A3
KRASENSG00000133703.7854.391101116.17370-0.385602.411401.35460K562EIF4B
KRASENSG00000133703.71233.981501597.50820-0.372503.227902.30910K562FIP1L1
KRASENSG00000133703.72013.643401347.808700.579103.277802.49620K562G3BP2
KRASENSG00000133703.71194.234101853.60540-0.634209.187207.78900K562GRSF1
KRASENSG00000133703.71049.751901343.66800-0.356103.012802.39350K562HNRNPC
KRASENSG00000133703.7937.068401199.77600-0.356502.886501.72100K562HNRNPF
KRASENSG00000133703.71359.793302049.01980-0.591505.834504.24150K562HNRNPL
KRASENSG00000133703.7898.706801313.89090-0.547904.681303.44040K562HNRNPM
KRASENSG00000133703.71516.275402165.99740-0.514504.224203.24760K562HSPD1
KRASENSG00000133703.72434.285401892.809900.362902.199601.47420K562KIF1C
KRASENSG00000133703.7939.887101197.84920-0.349902.895701.32990K562LSM11
KRASENSG00000133703.71298.493101617.19760-0.316702.723101.89090K562MAGOH
KRASENSG00000133703.71218.654001613.95360-0.405304.303603.13150K562MATR3
KRASENSG00000133703.71021.545201304.48670-0.352702.971302.06170K562METAP2
KRASENSG00000133703.71162.153001521.37820-0.388605.668104.53700K562MTPAP
KRASENSG00000133703.7988.685801311.74390-0.407903.292301.71620K562PHF6
KRASENSG00000133703.71101.784401813.36900-0.718808.667507.01840K562PPIG
KRASENSG00000133703.7780.021701204.70540-0.627107.020405.46400K562PSIP1
KRASENSG00000133703.71023.677501571.19070-0.618109.205108.04070K562PTBP1
KRASENSG00000133703.72494.797202885.65620-0.210002.193801.33720K562PUM2
KRASENSG00000133703.72237.831001768.857600.339202.570002.04230K562PUS1
KRASENSG00000133703.72380.979001723.410500.466207.361206.42600K562RBM15
KRASENSG00000133703.71167.161701506.71650-0.368403.126402.22770K562RBM22
KRASENSG00000133703.7744.283201098.97510-0.562206.476604.95910K562RCC2
KRASENSG00000133703.71262.208801585.54720-0.329002.420101.40930K562NELFE
KRASENSG00000133703.7943.468701368.17510-0.536206.005603.39920K562RECQL
KRASENSG00000133703.7891.884801312.39700-0.557305.045703.63560K562RPS3
KRASENSG00000133703.7739.200501041.81580-0.495104.517703.11750K562SRFBP1
KRASENSG00000133703.7939.246901267.10430-0.432004.128202.80750K562SRSF4
KRASENSG00000133703.7757.710701006.36860-0.409402.606401.62200K562SUPV3L1
KRASENSG00000133703.7927.188401558.90580-0.749609.916708.44740K562TARDBP
KRASENSG00000133703.71118.246401503.72530-0.427304.727503.61350K562TIA1
KRASENSG00000133703.7933.443701230.83520-0.399003.407902.33780K562TRIM56
KRASENSG00000133703.71262.010301792.29860-0.506109.938908.68470K562UPF1
KRASENSG00000133703.7756.640601084.59930-0.519504.454002.78340K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for KRAS is not available on ENCORE database.





4 RBPs can affect the splicing of KRAS :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEKRASENSG00000133703.7chr12-253801672538034625378547253787072539820725398329-0.065000.002930.03441excludedHepG2U2AF2
SEKRASENSG00000133703.7chr12-253801672538034625378547253787072539820725398329-0.099000.000160.00968excludedK562SF3B1
SEKRASENSG00000133703.7chr12-2536837025368494253623642536284525378547253787070.209000.000540.09666includedK562SAFB
MXEKRASENSG00000133703.7chr12-25380167253803462539820725398329253785472537870725403684254037370.193000.001030.008321includedHepG2U2AF2
MXEKRASENSG00000133703.7chr12-2538016725380346253982072539832925378547253787072540368425403737-0.089000.001160.082622includedK562PUM1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for KRAS is not avaliable on ENCORE database.