FLCN

General Information

Gene Name       : FLCN
Gene ID             : ENSG00000154803.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: FLCN)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FLCNENSG00000154803.123.076.294.68ENCSR000AEF
HepG2FLCNENSG00000154803.1211.796.649.21ENCSR985KAT
K562FLCNENSG00000154803.1210.457.188.81ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for FLCN is not avaliable on ENCORE database.



Proteins bound to RNA
  • FLCN RNA is bound by 20 proteins.  







eCLIP assay for FLCN is not avaliable on ENCORE database.





20 proteins are bound to FLCN RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr171711571917115777-3'-UTR,intron-Distal3.848127.11398HepG2HNRNPC
chr171713145417131525-3'-UTR,5'-UTR,intron-Distal,intron-Proximal3.870983.05889HepG2SF3B4
chr171713143817131526-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal6.4613346.26462K562SF3B4
chr171711614217116199-3'-UTR,intron-Distal5.039627.21253K562UPF1
chr171713142717131544-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.839927.49832K562SMNDC1
chr171711577717115792-3'-UTR,intron-Distal3.310754.48901HepG2HNRNPC
chr171712450517124550-3'-UTR,intron-Distal3.502433.84001K562HNRNPM
chr171713140217131546-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.0802812.29520K562BUD13
chr171712461317124682-3'-UTR,intron-Distal3.050723.40058K562PRPF8
chr171711646117116504-3'-UTR,intron-Distal4.121373.31330K562UPF1
chr171711578317115794-3'-UTR,intron-Distal3.231564.14815K562HNRNPC
chr171711570617115792-3'-UTR,intron-Distal3.0507015.78252K562UPF1
chr171713605517136114-5'-UTR,intron-Distal,intron-Proximal3.954758.17589HepG2PRPF8
chr171713515217135223-5'-UTR,intron-Distal,intron-Proximal3.841509.18050K562BUD13
chr171714009917140237-5'-UTR,intron-Distal4.8083525.42691K562EFTUD2
chr171713514017135245-5'-UTR,intron-Distal,intron-Proximal4.1163814.76150K562AQR
chr171712722617127278-CDS,intron-Distal,intron-Proximal4.525913.96990K562BUD13
chr171712476517124835-CDS,intron-Distal,intron-Proximal3.945567.64728K562AQR
chr171712476017124865-CDS,intron-Distal,intron-Proximal3.7970015.44663HepG2PRPF8
chr171712742017127502-CDS,intron-Distal,intron-Proximal5.181839.77805HepG2SF3B4
chr171713112517131204-CDS,intron-Distal,intron-Proximal4.471798.79285K562AQR
chr171712958617129652-CDS,intron-Distal,intron-Proximal4.101919.18050K562BUD13
chr171712478317124846-CDS,intron-Distal,intron-Proximal4.366974.42734K562UCHL5
chr171711978817119866-3'-UTR,CDS,intron-Distal,intron-Proximal4.9507917.10376K562SF3B4
chr171712235017122441-CDS,intron-Distal,intron-Proximal4.359824.34038HepG2BCLAF1
chr171712743917127493-CDS,intron-Distal,intron-Proximal5.030657.50129HepG2SF3A3
chr171712483517124852-CDS,intron-Distal,intron-Proximal3.623634.41130K562AQR
chr171712247717122645-CDS,intron-Distal,intron-Proximal4.5781614.75387K562SF3B4
chr171712475017124816-CDS,intron-Distal,intron-Proximal4.969434.26208K562SF3B4
chr171712743117127505-CDS,intron-Distal,intron-Proximal6.041639.95947K562SF3B4
chr171711979717119879-3'-UTR,CDS,intron-Distal,intron-Proximal4.157713.98427HepG2SF3B4
chr171712716817127238-CDS,intron-Distal,intron-Proximal3.136867.13900K562AQR
chr171712944317129536-CDS,intron-Distal,intron-Proximal4.1002710.32997HepG2PRPF8
chr171712473617124868-CDS,intron-Distal,intron-Proximal3.5751914.90738K562BUD13
chr171712595117125984-CDS,intron-Distal,intron-Proximal3.692203.99381K562BUD13
chr171712945417129518-CDS,intron-Distal,intron-Proximal4.223463.85435K562PRPF8
chr171712476117124847-CDS,intron-Distal,intron-Proximal3.976937.78906K562GPKOW
chr171711966717119696-3'-UTR,CDS,intron-Distal,intron-Proximal5.728358.88118K562AQR
chr171712474117124801-CDS,intron-Distal,intron-Proximal3.788114.95247K562PRPF8
chr171711862617118681-3'-UTR,CDS,intron-Distal,intron-Proximal4.787936.27794HepG2SF3A3
chr171711857917118616-3'-UTR,CDS,intron-Distal3.238873.65452K562BUD13
chr171712473717124863-CDS,intron-Distal,intron-Proximal3.413037.31683HepG2BUD13
chr171712958717129655-CDS,intron-Distal,intron-Proximal3.951964.69223K562SF3B4
chr171712020217120296-intron-Distal,intron-Proximal3.2550910.05781K562AATF
chr171712015517120202-intron-Distal,intron-Proximal4.842566.02937K562AATF
chr171712015117120212-intron-Distal,intron-Proximal4.125508.40726K562SMNDC1
chr171712323817123306-intron-Distal4.013063.59941K562UCHL5
chr171712434317124387-intron-Distal,intron-Proximal4.116153.97018HepG2HNRNPM
chr171713569117135758-intron-Distal3.881903.34627K562HNRNPK
chr171712021817120274-intron-Distal,intron-Proximal5.4796521.58982HepG2DKC1
chr171712032617120334-intron-Distal,intron-Proximal6.5020516.52001K562ZRANB2
chr171713604117136056-intron-Distal,intron-Proximal6.0903112.64691K562AQR
chr171711963817119692-intron-Distal,intron-Proximal3.526554.54206HepG2PRPF8
chr171713504117135085-intron-Distal,intron-Proximal4.954493.65355K562EFTUD2
chr171711964917119667-intron-Distal,intron-Proximal5.875769.41643K562AQR
chr171713551917135536-intron-Distal3.127683.26275K562BUD13
chr171712027617120322-intron-Distal,intron-Proximal6.6420138.82635K562ZRANB2
chr171713605617136065-intron-Distal,intron-Proximal7.6833137.83487K562AQR
chr171713991317139985-intron-Distal3.531603.27704K562HNRNPM
chr171711864017118701-intron-Distal,intron-Proximal4.522646.53298K562SF3B4
chr171713993617139988-intron-Distal3.265933.42785HepG2HNRNPM
chr171713175717131819-intron-Distal3.266593.80983K562TIA1
chr171712328017123320-intron-Distal3.275873.75245K562BUD13
chr171713606517136101-intron-Distal,intron-Proximal6.7383037.50196K562AQR
chr171712398217124028-intron-Distal4.442673.79026K562HNRNPM
chr171713256917132621-intron-Distal4.411837.14115HepG2XPO5
chr171713602017136041-intron-Distal,intron-Proximal5.172066.75320K562AQR
chr171712936417129429-intron-Distal,intron-Proximal5.232096.15027K562EFTUD2
chr171712027417120288-intron-Distal,intron-Proximal5.4617016.45291HepG2DKC1
chr171714010117140183-intron-Distal3.385063.72952K562EXOSC5
chr171712028817120339-intron-Distal,intron-Proximal4.903828.17426HepG2DKC1
chr171714009817140180-intron-Distal4.404409.23607HepG2EFTUD2
chr171713237117132483-intron-Distal4.308483.82414HepG2HNRNPK
chr171712022117120262-intron-Distal,intron-Proximal5.071049.10971K562ZRANB2
chr171713226617132361-intron-Distal3.986636.20952K562HNRNPK
chr171714010017140214-intron-Distal3.234655.47590K562PRPF8
chr171713504117135081-intron-Distal,intron-Proximal4.549854.48002K562AQR
chr171713154617131609-intron-Distal,intron-Proximal3.796205.29272K562BUD13
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for FLCN is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for FLCN is not available on ENCORE database.

  • 93 RBPs can affect the levels of FLCN.  








The Knockdown/knockout RNA-Seq assay for FLCN is not available on ENCORE database.





93 RBPs can affect the gene expression of FLCN :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FLCNENSG00000154803.8596.23520427.109700.481202.857301.90070HepG2ABCF1
FLCNENSG00000154803.8411.72210710.72560-0.787606.167405.40910HepG2AKAP1
FLCNENSG00000154803.8783.21980528.871300.566407.199706.02810HepG2AKAP8L
FLCNENSG00000154803.8940.78660784.315700.262302.030401.42470HepG2AUH
FLCNENSG00000154803.8261.86770356.00850-0.443102.353701.52690HepG2BCLAF1
FLCNENSG00000154803.8392.34530269.261700.543003.184702.54800HepG2BOP1
FLCNENSG00000154803.8696.59140453.476100.619203.909802.73720HepG2CCAR1
FLCNENSG00000154803.8830.51910558.689400.571904.596003.61270HepG2CIRBP
FLCNENSG00000154803.8729.69170526.275400.471405.602904.71630HepG2CKAP4
FLCNENSG00000154803.8345.74630247.195600.484002.303801.66830HepG2CPSF6
FLCNENSG00000154803.8622.81980344.377500.854709.190308.02960HepG2DDX21
FLCNENSG00000154803.8911.13280621.221300.552503.856803.10630HepG2EIF4A3
FLCNENSG00000154803.8954.79160604.946200.658304.397203.54090HepG2EIF4B
FLCNENSG00000154803.81300.57560900.521300.530208.337607.39100HepG2ETF1
FLCNENSG00000154803.8615.41150431.298800.512803.199002.37730HepG2FIP1L1
FLCNENSG00000154803.8534.92130364.887800.551803.260202.15040HepG2GNB2L1
FLCNENSG00000154803.8390.24970280.212100.477802.217801.64140HepG2GPKOW
FLCNENSG00000154803.8415.33830285.491400.540702.376601.77440HepG2HNRNPA1
FLCNENSG00000154803.8369.87760267.411900.467902.243001.67040HepG2HNRNPLL
FLCNENSG00000154803.81027.25590591.052200.797308.663807.54040HepG2IGF2BP2
FLCNENSG00000154803.8874.38260478.896100.868507.607206.21490HepG2LARP4
FLCNENSG00000154803.8869.29800627.164500.470903.187802.48410HepG2MAGOH
FLCNENSG00000154803.81030.99560630.648800.709006.183205.26930HepG2MATR3
FLCNENSG00000154803.8462.64510349.155400.405902.395401.63920HepG2MSI2
FLCNENSG00000154803.8843.21720645.483200.385402.208801.64080HepG2NCBP2
FLCNENSG00000154803.8611.93890370.178000.725102.905901.78320HepG2NONO
FLCNENSG00000154803.81096.05660551.293500.991304.048102.96100HepG2PABPC1
FLCNENSG00000154803.8673.48440561.263300.262901.915901.44480HepG2PTBP1
FLCNENSG00000154803.81065.08610568.282000.9062014.0012012.80050HepG2PUF60
FLCNENSG00000154803.8926.45740602.821400.619903.612802.85130HepG2PUM2
FLCNENSG00000154803.8649.16170367.739700.819804.494103.60710HepG2RAVER1
FLCNENSG00000154803.81071.69040752.664600.509704.666304.03870HepG2RBM22
FLCNENSG00000154803.8678.46370471.696500.524304.068503.26570HepG2RPLP0
FLCNENSG00000154803.8540.44860397.635300.442602.259101.53100HepG2RPS2
FLCNENSG00000154803.8561.77280405.926000.468702.464401.45140HepG2RPS5
FLCNENSG00000154803.8574.03470307.281900.901505.816604.71940HepG2RRP9
FLCNENSG00000154803.81015.59890465.135601.1265012.0357010.57070HepG2SF3A3
FLCNENSG00000154803.8373.41030264.682900.496402.616201.92970HepG2SF3B1
FLCNENSG00000154803.8449.28130327.609900.455503.621302.90150HepG2SMN1
FLCNENSG00000154803.81175.38750850.098900.467306.596005.91360HepG2SRFBP1
FLCNENSG00000154803.8817.49140561.113500.542807.012906.08040HepG2SRSF5
FLCNENSG00000154803.8600.38090496.205300.274802.038301.55020HepG2SRSF9
FLCNENSG00000154803.81179.31020738.073000.6760013.0952012.14300HepG2SSB
FLCNENSG00000154803.8382.70780291.311100.393602.138301.30580HepG2SUPT6H
FLCNENSG00000154803.8653.74480401.068900.704804.167603.36250HepG2SUPV3L1
FLCNENSG00000154803.8374.34060260.652900.522102.824302.09340HepG2TARDBP
FLCNENSG00000154803.8502.97220306.525300.714406.684905.96880HepG2TIAL1
FLCNENSG00000154803.8398.04250309.265500.364002.291801.76880HepG2TRIM56
FLCNENSG00000154803.8541.32370368.999600.552803.823603.08970HepG2U2AF1
FLCNENSG00000154803.8460.87470232.357600.987902.697401.72220HepG2U2AF2
FLCNENSG00000154803.8837.08660587.698800.510203.441402.50650HepG2UBE2L3
FLCNENSG00000154803.8440.04560236.887200.893406.854105.64580HepG2UCHL5
FLCNENSG00000154803.8528.59920412.505300.357702.743802.04680HepG2UPF1
FLCNENSG00000154803.8613.35220398.255900.622907.186306.29710HepG2UTP3
FLCNENSG00000154803.8778.56070453.675300.7790014.2589013.25810HepG2ZNF622
FLCNENSG00000154803.81495.88480754.339200.9876028.0989026.38650K562AGGF1
FLCNENSG00000154803.81249.30420828.984500.591607.295005.50590K562AKAP8
FLCNENSG00000154803.81757.32230784.943701.1626018.4227016.44290K562AKAP8L
FLCNENSG00000154803.82295.16340985.339901.2198028.2861026.61260K562AQR
FLCNENSG00000154803.8781.33750462.638700.756004.381803.00030K562CNOT7
FLCNENSG00000154803.8420.57480300.812700.483401.992301.31820K562CPSF6
FLCNENSG00000154803.81710.691401220.959900.486505.491004.11270K562CELF1
FLCNENSG00000154803.8921.10980644.376600.515406.168004.32280K562DDX21
FLCNENSG00000154803.8924.60640577.742400.678304.856003.11770K562EEF2
FLCNENSG00000154803.8770.25680558.132800.464603.062102.10010K562EFTUD2
FLCNENSG00000154803.8551.96610688.82740-0.319602.338001.66800K562EIF2S2
FLCNENSG00000154803.8882.81510597.456500.563203.766002.54210K562EIF3D
FLCNENSG00000154803.8509.51230372.011000.453702.893402.02540K562FIP1L1
FLCNENSG00000154803.8233.58420454.11020-0.959104.039703.14560K562G3BP2
FLCNENSG00000154803.8924.57570721.514800.357702.890101.79320K562HNRNPA1
FLCNENSG00000154803.8956.91900436.293601.133006.838704.62700K562HNRNPA2B1
FLCNENSG00000154803.81384.92850832.952700.7334011.499709.46010K562KIF1C
FLCNENSG00000154803.81121.95630797.396500.492504.978503.39840K562MAK16
FLCNENSG00000154803.81410.011601058.106400.414103.044501.85820K562MSI2
FLCNENSG00000154803.8676.73520539.330900.327302.570101.78920K562MTPAP
FLCNENSG00000154803.81091.15270654.060500.738306.316104.77890K562NAA15
FLCNENSG00000154803.8851.73510599.271200.507107.107205.99170K562NSUN2
FLCNENSG00000154803.8874.63310381.594901.196507.385905.50930K562PABPN1
FLCNENSG00000154803.8568.15430422.346200.427802.752501.93420K562PPIG
FLCNENSG00000154803.8936.86350453.636201.046205.529003.23650K562PPP1R8
FLCNENSG00000154803.81993.053801083.108500.879702.853402.02510K562PUF60
FLCNENSG00000154803.81856.19940778.308401.253809.702508.73400K562PUS1
FLCNENSG00000154803.81267.82620758.460600.741105.751504.92290K562RBM15
FLCNENSG00000154803.8788.08970620.858900.344002.283001.52440K562RBM22
FLCNENSG00000154803.8890.10720469.460300.922904.193102.19220K562RBM39
FLCNENSG00000154803.8469.01470672.08840-0.519003.285602.18530K562RPS3
FLCNENSG00000154803.8760.14270348.956101.123104.153402.59780K562SF1
FLCNENSG00000154803.8847.97420591.288900.520105.831004.68070K562SF3A3
FLCNENSG00000154803.8789.36920425.384100.891803.977602.29870K562SFPQ
FLCNENSG00000154803.81008.13180400.789301.330708.278505.72590K562SNRNP200
FLCNENSG00000154803.8761.56350605.784700.330102.942301.98200K562SRPK2
FLCNENSG00000154803.8800.00010599.495800.416203.024501.91710K562SRSF5
FLCNENSG00000154803.8743.85930574.998600.371403.385802.08350K562SRSF7
FLCNENSG00000154803.8618.94390446.368600.471503.036601.71690K562STAU1
FLCNENSG00000154803.81185.69430479.382901.306405.551503.32250K562SUPT6H
FLCNENSG00000154803.8967.00190642.418700.589905.605804.57900K562TARDBP
FLCNENSG00000154803.8777.54730619.687000.327302.266701.53300K562TIA1
FLCNENSG00000154803.8521.15800329.530200.661204.626603.39160K562TIAL1
FLCNENSG00000154803.8824.18500608.111600.438503.289102.08040K562TRA2A
FLCNENSG00000154803.8634.73340435.024300.545003.976302.23380K562TRIP6
FLCNENSG00000154803.8801.08490635.417900.334102.994202.24640K562UPF1
FLCNENSG00000154803.81433.23680789.265600.860602.974001.61720K562UTP18
FLCNENSG00000154803.8822.25990543.710400.596706.249804.90440K562WDR3
FLCNENSG00000154803.8718.14270565.372600.345002.201801.44020K562WDR43
FLCNENSG00000154803.81512.569601167.795500.373103.620602.13230K562WRN
FLCNENSG00000154803.8907.84030471.640700.944704.550802.28060K562YTHDC2
FLCNENSG00000154803.81637.379401109.846300.560906.994805.51950K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for FLCN is not available on ENCORE database.





5 RBPs can affect the splicing of FLCN :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEFLCNENSG00000154803.8chr17-171272351712745717122332171225231712948917129636-0.280000.008690.07261excludedK562AQR
SEFLCNENSG00000154803.8chr17-171272351712745717125814171259751712948917129636-0.324000.000000.00002excludedK562PUS1
SEFLCNENSG00000154803.8chr17-171272351712745717125814171259751712948917129636-0.247000.000410.01730excludedK562UTP18
SEFLCNENSG00000154803.8chr17-171272351712745717125814171259751712948917129636-0.168000.005070.09404excludedK562AGGF1
A3SSFLCNENSG00000154803.8chr17-1712581417126034171258141712597517127235171274570.131000.000020.00021longerK562AQR
MXEFLCNENSG00000154803.8chr17-17127235171274571712948917129636171258141712597517131202171314750.230000.002600.064711includedK562EFTUD2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for FLCN is not avaliable on ENCORE database.