DBNL

General Information

Gene Name       : DBNL
Gene ID             : ENSG00000136279.20
Essential Gene : No

Functions

Localization

Domains (AlphaFold: DBNL)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DBNLENSG00000136279.2019.0753.1736.12ENCSR000AEF
HepG2DBNLENSG00000136279.2038.4613.8726.16ENCSR985KAT
K562DBNLENSG00000136279.2042.0535.0438.55ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq DBNL-BGKcLV28-K562ENCSR593NFADBNLK562ReleasedENCSR220DTX   CRISPRKD% = 57.4,57.6
knockdown followed by RNA-seq DBNL-BGHcLV29-HepG2ENCSR256UIADBNLHepG2ReleasedENCSR462MFN   CRISPRKD% = 64.8,64.0






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
DBNLENCAB188XWIA303-351A1BGKcLV28-59, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
DBNLK562CRISPRENCSR593NFAENCSR220DTXDBNL-BGKcLV28-59,DBNL-BGKcLV28-60NT-BGKcLV28-1,NT-BGKcLV28-257.4,57.6ReleasedENCODE4
DBNLHepG2CRISPRENCSR256UIAENCSR462MFNDBNL-BGHcLV29-59,DBNL-BGHcLV29-60NT-BGHcLV29-1,NT-BGHcLV29-264.8,64.0ReleasedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
DBNLProduct_ID: A303-351A
Lot_ID: 1
Source: Bethyl Labs
Target Name: DBNL-human		 DBNL-K562-CRISPR-A303-351A.png<br>Caption: Western blot following CRISPR against DBNL in K562 whole cell lysate using DBNL specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against DBNL. DBNL protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for DBNL is not avaliable on ENCORE database.



Proteins bound to RNA
  • DBNL RNA is bound by 20 proteins.  







eCLIP assay for DBNL is not avaliable on ENCORE database.





20 proteins are bound to DBNL RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr74409141944091478+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.288093.66193HepG2PPIG
chr74409914044099173+3'-UTR,CDS,intron-Proximal5.051127.65840HepG2PPIG
chr74409137844091435+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal5.856686.39134HepG2SF3A3
chr74409901244099049+3'-UTR,CDS,intron-Distal,intron-Proximal5.127125.56813HepG2PPIG
chr74410088944100982+3'-UTR3.339538.16191K562UPF1
chr74409921444099260+3'-UTR,CDS,intron-Proximal3.582254.77136HepG2PPIG
chr74410041944100473+3'-UTR,CDS4.267183.79199HepG2PPIG
chr74410060844100684+3'-UTR4.735265.14974HepG2UPF1
chr74410102444101095+3'-UTR4.360465.17229HepG2UPF1
chr74409740144097480+3'-UTR,CDS,intron-Proximal3.859803.12746HepG2GRWD1
chr74410222844102312+3'-UTR3.287965.11940HepG2NKRF
chr74409804744098074+3'-UTR,CDS4.652443.79199HepG2PPIG
chr74410069144100758+3'-UTR3.319423.56282HepG2AKAP1
chr74410087944100951+3'-UTR4.852495.94150HepG2UPF1
chr74409852744098584+3'-UTR,CDS,intron-Proximal3.898695.86107HepG2PPIG
chr74409246644092558+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.281183.72946HepG2PPIG
chr74409744144097475+3'-UTR,CDS,intron-Proximal3.484065.30777HepG2PPIG
chr74410076644100841+3'-UTR5.3987310.50616HepG2UPF1
chr74409782944097880+3'-UTR,CDS,intron-Proximal4.160688.40792HepG2PPIG
chr74410098244101144+3'-UTR3.463498.16191K562UPF1
chr74409635644096444+3'-UTR,CDS,intron-Distal4.071207.55042HepG2PPIG
chr74410088744100938+3'-UTR4.521624.92727HepG2AKAP1
chr74409803044098047+3'-UTR,CDS,intron-Proximal3.531783.32039HepG2PPIG
chr74409776444097877+3'-UTR,CDS4.652287.17283HepG2GRWD1
chr74410288444102963+3'-UTR3.224154.28038HepG2HNRNPC
chr74409772144097829+3'-UTR,CDS,intron-Proximal3.5878613.60410HepG2PPIG
chr74409743444097503+3'-UTR,CDS,intron-Proximal4.180265.64484HepG2PRPF8
chr74410223344102288+3'-UTR3.259806.10309HepG2XRN2
chr74408432244084411+5'-UTR,CDS3.314544.11395HepG2NCBP2
chr74408432544084420+5'-UTR,CDS,intron-Proximal3.972405.23852K562DDX3X
chr74408443444084541+CDS,intron-Distal,intron-Proximal4.052314.61905HepG2MATR3
chr74408446444084548+CDS,intron-Distal,intron-Proximal5.287886.68817HepG2EFTUD2
chr74409841644098489+CDS,intron-Proximal4.455945.59044HepG2SF3B4
chr74408670944086743+intron-Distal3.500484.36087HepG2MATR3
chr74409751944097561+intron-Distal,intron-Proximal5.539234.77100HepG2BUD13
chr74409240544092465+intron-Distal,intron-Proximal3.390043.81705HepG2SF3B4
chr74408590644085982+intron-Distal3.459258.33119HepG2MATR3
chr74408694244087008+intron-Distal5.2859810.82239HepG2SUGP2
chr74408546244085515+intron-Distal3.811125.06177HepG2SUGP2
chr74408799944088109+intron-Distal3.812626.49112K562PTBP1
chr74408671144086756+intron-Distal3.267045.35016HepG2SUGP2
chr74408662544086712+intron-Distal4.137624.18579K562MATR3
chr74408640944086516+intron-Distal4.808825.79972HepG2RBFOX2
chr74408718044087232+intron-Distal3.766675.54651HepG2SUGP2
chr74408654944086649+intron-Distal3.219103.00914HepG2PTBP1
chr74408521944085292+intron-Distal4.159233.62366HepG2HNRNPM
chr74408446544084545+intron-Distal,intron-Proximal4.7666712.65415HepG2SUGP2
chr74408799144088104+intron-Distal4.504255.01208K562MATR3
chr74408679444086846+intron-Distal3.390493.84798HepG2MATR3
chr74408800344088104+intron-Distal3.250445.12973HepG2MATR3
chr74408991244089999+intron-Distal,intron-Proximal4.7226812.29596HepG2EFTUD2
chr74408489544084947+intron-Distal3.408633.68481HepG2HNRNPM
chr74408464344084720+intron-Distal4.362445.19780K562NONO
chr74408593544085998+intron-Distal3.966607.03506HepG2SUGP2
chr74408540744085451+intron-Distal4.732316.36848HepG2SUGP2
chr74408651844086571+intron-Distal3.450316.79980HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for DBNL is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for DBNL is not available on ENCORE database.

  • 111 RBPs can affect the levels of DBNL.  








The Knockdown/knockout RNA-Seq assay for DBNL is not available on ENCORE database.





111 RBPs can affect the gene expression of DBNL :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
DBNLENSG00000136279.14646.68760828.68160-0.357702.087901.40160HepG2ASCC1
DBNLENSG00000136279.14922.19940622.895200.566004.107803.03250HepG2BCLAF1
DBNLENSG00000136279.141440.22160689.794301.0620019.0295017.66750HepG2BOP1
DBNLENSG00000136279.14571.90340787.31610-0.461203.164202.33870HepG2CIRBP
DBNLENSG00000136279.14675.840601101.53630-0.7048015.0680013.77450HepG2CKAP4
DBNLENSG00000136279.14883.14170633.249800.479803.673102.89190HepG2CPSF6
DBNLENSG00000136279.141253.08090888.726400.495607.000106.06650HepG2CELF1
DBNLENSG00000136279.141135.05540955.380400.248502.960902.19780HepG2DAZAP1
DBNLENSG00000136279.14877.51840675.091000.378202.816802.13420HepG2DDX21
DBNLENSG00000136279.14592.39770959.35430-0.695506.429105.51610HepG2DDX3X
DBNLENSG00000136279.14901.72430686.606800.393102.949101.61210HepG2DDX47
DBNLENSG00000136279.141095.68040788.913600.473804.017602.80710HepG2DDX5
DBNLENSG00000136279.141062.25960824.285500.365802.088501.54510HepG2DDX6
DBNLENSG00000136279.14697.04650500.906100.476603.736302.60480HepG2DHX30
DBNLENSG00000136279.14730.63580519.339200.492405.099204.17020HepG2DNAJC21
DBNLENSG00000136279.14684.26350514.769800.410504.468703.67580HepG2DNAJC2
DBNLENSG00000136279.141553.28800792.226700.9712013.7842012.52890HepG2EIF2S1
DBNLENSG00000136279.141356.82020875.417000.632105.508104.60710HepG2EIF4A3
DBNLENSG00000136279.141817.375801432.727800.343004.596003.85690HepG2ETF1
DBNLENSG00000136279.14759.409001076.63730-0.503605.275404.12430HepG2EWSR1
DBNLENSG00000136279.14641.24350489.586200.389202.882501.68830HepG2FAM120A
DBNLENSG00000136279.141135.68870883.521100.362102.309101.67470HepG2FXR1
DBNLENSG00000136279.141462.19890819.457500.835309.831008.61560HepG2G3BP1
DBNLENSG00000136279.141140.23380870.139300.389902.707301.82720HepG2G3BP2
DBNLENSG00000136279.14968.06120717.786000.431402.721402.08520HepG2GPKOW
DBNLENSG00000136279.14767.52960524.314800.549702.640202.00650HepG2HNRNPA1
DBNLENSG00000136279.141078.07930583.208700.8863012.2060010.83980HepG2HNRNPC
DBNLENSG00000136279.141080.11830870.212100.311704.176303.36090HepG2HNRNPL
DBNLENSG00000136279.14992.11310685.001100.534304.384103.60690HepG2HNRNPLL
DBNLENSG00000136279.14834.36170579.352500.526106.909805.98970HepG2HNRNPU
DBNLENSG00000136279.141115.28750900.894200.307902.659901.94870HepG2IGF2BP1
DBNLENSG00000136279.141221.81370832.911600.552704.895304.02040HepG2IGF2BP2
DBNLENSG00000136279.14798.86510591.788500.432803.374402.57090HepG2ILF2
DBNLENSG00000136279.141521.33400946.297600.684905.905904.68150HepG2LARP4
DBNLENSG00000136279.141177.99140883.830700.414402.897402.22710HepG2MAGOH
DBNLENSG00000136279.141296.87430888.734800.545104.259203.49270HepG2MATR3
DBNLENSG00000136279.141213.73110947.365000.357402.101201.43520HepG2NOL12
DBNLENSG00000136279.14304.08530521.58450-0.778404.124203.02450HepG2PABPC1
DBNLENSG00000136279.141163.14910809.929900.522104.234303.35240HepG2PABPC4
DBNLENSG00000136279.14709.06060573.452900.306102.293801.51640HepG2PARN
DBNLENSG00000136279.14527.06510682.86400-0.373603.396602.54830HepG2PRPF4
DBNLENSG00000136279.14416.08620543.65580-0.385802.057601.35690HepG2PRPF8
DBNLENSG00000136279.141133.07880898.600400.334403.223902.64250HepG2PTBP1
DBNLENSG00000136279.141225.41960960.135100.351904.074703.38480HepG2PUM1
DBNLENSG00000136279.141217.44300959.389700.343603.540802.78670HepG2PUM2
DBNLENSG00000136279.141156.75670973.189900.249201.885901.35510HepG2QKI
DBNLENSG00000136279.14394.07190623.99830-0.663103.137602.38960HepG2RAVER1
DBNLENSG00000136279.14804.521901197.49310-0.573808.033307.25810HepG2RBM22
DBNLENSG00000136279.141256.290701000.049500.329003.504602.91120HepG2NELFE
DBNLENSG00000136279.141201.34640985.478900.285702.090501.48720HepG2RPLP0
DBNLENSG00000136279.14967.83730613.168200.658404.185703.02930HepG2RPS10
DBNLENSG00000136279.14825.01660533.011100.630206.598305.69460HepG2RPS19
DBNLENSG00000136279.141079.43180737.993400.548504.531303.52110HepG2RPS2
DBNLENSG00000136279.14989.31200573.102000.787506.442105.22540HepG2RPS3A
DBNLENSG00000136279.14301.41950537.77770-0.835206.503405.35480HepG2RRP9
DBNLENSG00000136279.14604.166001100.03480-0.864507.824606.65010HepG2SF3A3
DBNLENSG00000136279.14435.51680677.98570-0.638505.411004.44850HepG2SF3B1
DBNLENSG00000136279.141182.05680867.327500.446607.736706.65260HepG2SLBP
DBNLENSG00000136279.14799.19510601.662900.409504.798103.98840HepG2SMN1
DBNLENSG00000136279.14979.78220636.864000.621404.359803.13980HepG2SMNDC1
DBNLENSG00000136279.141028.395201352.52040-0.395305.398604.76280HepG2SRFBP1
DBNLENSG00000136279.14688.43490976.51220-0.504306.424805.77720HepG2SRSF1
DBNLENSG00000136279.141198.18180893.051600.423901.958001.42000HepG2SRSF5
DBNLENSG00000136279.141064.32430898.818700.243702.256501.62140HepG2SRSF7
DBNLENSG00000136279.141064.04280794.449600.421405.183404.47010HepG2SRSF9
DBNLENSG00000136279.14990.54380719.095300.461902.690001.46850HepG2STAU1
DBNLENSG00000136279.141403.062001015.573000.466209.043408.02890HepG2SUCLG1
DBNLENSG00000136279.14968.70090726.972900.414003.660802.58960HepG2SUPT6H
DBNLENSG00000136279.14899.38670667.801800.429403.193202.41960HepG2TARDBP
DBNLENSG00000136279.14973.13960562.928600.7896012.0632011.14760HepG2TIAL1
DBNLENSG00000136279.14874.72720567.982900.622909.620208.66710HepG2TRIM56
DBNLENSG00000136279.141271.06610883.679700.524302.332201.53670HepG2TUFM
DBNLENSG00000136279.14419.84710920.98580-1.1333015.6708014.12550HepG2U2AF1
DBNLENSG00000136279.141654.43550935.437200.822508.812107.28670HepG2UBE2L3
DBNLENSG00000136279.141294.87880975.560700.408405.876504.92000HepG2UPF1
DBNLENSG00000136279.141197.352501002.754400.255802.287601.32140HepG2UTP18
DBNLENSG00000136279.14728.48560941.86850-0.370603.889003.19710HepG2UTP3
DBNLENSG00000136279.14755.51620513.335100.557503.305702.09860HepG2XPO5
DBNLENSG00000136279.14955.57110673.923600.503706.530005.56950HepG2ZC3H8
DBNLENSG00000136279.141307.455001072.932800.285103.674903.06900HepG2ZNF622
DBNLENSG00000136279.14472.06070720.71860-0.610507.433106.56790K562AGGF1
DBNLENSG00000136279.14395.34480749.92700-0.9236011.6889010.22120K562AKAP8L
DBNLENSG00000136279.14634.366201257.42310-0.9871014.4064013.21320K562AQR
DBNLENSG00000136279.14578.49810443.887700.382002.360901.63040K562CPSF6
DBNLENSG00000136279.14598.22550807.05890-0.432004.453003.30390K562DKC1
DBNLENSG00000136279.14347.19040590.89640-0.767207.292205.74530K562EFTUD2
DBNLENSG00000136279.141238.98130962.670600.363904.101403.25140K562EIF2S2
DBNLENSG00000136279.14393.50350632.56370-0.684805.098903.64130K562EIF3D
DBNLENSG00000136279.14491.03660296.782500.726307.021605.76530K562EIF3G
DBNLENSG00000136279.141082.794501349.38070-0.317503.529802.47010K562EIF4G2
DBNLENSG00000136279.14855.68640627.819500.446603.579002.60470K562FIP1L1
DBNLENSG00000136279.14293.59030542.14350-0.884907.799705.75940K562FKBP4
DBNLENSG00000136279.14726.13580426.882900.7663010.242409.16340K562FXR1
DBNLENSG00000136279.1455.80240188.27190-1.7544010.999109.40090K562G3BP2
DBNLENSG00000136279.14630.80800423.828100.573602.275201.55470K562GPKOW
DBNLENSG00000136279.14911.00520624.271800.545205.324504.52220K562HNRNPC
DBNLENSG00000136279.141118.11450907.676000.300702.241401.30110K562HNRNPL
DBNLENSG00000136279.14765.01190516.434600.566804.186403.02550K562HNRNPM
DBNLENSG00000136279.14497.90930795.90680-0.676707.018805.55900K562KIF1C
DBNLENSG00000136279.14374.07580624.95000-0.740404.983203.68530K562NAA15
DBNLENSG00000136279.14220.32450351.97060-0.675804.243103.02620K562PCBP2
DBNLENSG00000136279.141206.86290925.634900.382602.600801.79680K562PCBP3
DBNLENSG00000136279.14968.32810710.013800.447504.364703.35560K562POLR2G
DBNLENSG00000136279.141030.35550712.762900.531504.918503.77550K562PPIG
DBNLENSG00000136279.14365.55140575.01290-0.653505.008704.00290K562PRPF8
DBNLENSG00000136279.14653.88070384.414100.766306.331305.36110K562PTBP1
DBNLENSG00000136279.141187.956701472.24820-0.309502.065201.36020K562PUF60
DBNLENSG00000136279.14578.43890743.81740-0.362801.997801.52180K562PUS1
DBNLENSG00000136279.14446.37440724.65880-0.699008.457507.44580K562RBM15
DBNLENSG00000136279.14593.67920368.446300.688106.355605.01210K562RBM22
DBNLENSG00000136279.14561.89390359.288000.645105.036902.98380K562RBM34
DBNLENSG00000136279.14655.96050387.768400.758303.838502.52590K562NELFE
DBNLENSG00000136279.14388.61450218.726900.829103.147602.07040K562RPS3
DBNLENSG00000136279.14877.33290632.575900.471804.134602.80170K562SAFB
DBNLENSG00000136279.14273.37070402.98590-0.559902.886801.89140K562SF3B1
DBNLENSG00000136279.14122.30470195.76980-0.678703.332102.39290K562SF3B4
DBNLENSG00000136279.14692.90770996.87640-0.524806.049204.72860K562SRPK2
DBNLENSG00000136279.14377.35710556.59760-0.560703.632002.45200K562SUPV3L1
DBNLENSG00000136279.14879.41770712.134400.304302.228601.49050K562SYNCRIP
DBNLENSG00000136279.14101.65880184.81110-0.862303.031301.47470K562TAF15
DBNLENSG00000136279.1479.39720182.49680-1.200706.310904.51620K562U2AF1
DBNLENSG00000136279.1464.31050188.47940-1.5513011.424309.78140K562U2AF2
DBNLENSG00000136279.141285.252901045.420700.297903.413802.62090K562UPF1
DBNLENSG00000136279.14425.29160754.05660-0.826204.338102.58460K562UTP18
DBNLENSG00000136279.14762.24250930.27850-0.287402.722001.88190K562WDR43
DBNLENSG00000136279.141140.308701416.65930-0.313102.262901.49490K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for DBNL is not available on ENCORE database.





17 RBPs can affect the splicing of DBNL :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEDBNLENSG00000136279.14chr7+4409757144097591440973804409745844097727440978790.078000.003890.03785includedK562AQR
RIDBNLENSG00000136279.14chr7+4409738044097879440973804409745844097727440978790.092000.001950.02316includedHepG2SF3A3
RIDBNLENSG00000136279.14chr7+4409738044097879440973804409745844097727440978790.168000.005750.09612includedHepG2UCHL5
RIDBNLENSG00000136279.14chr7+4409738044097879440973804409745844097727440978790.272000.000160.01525includedHepG2SUPV3L1
RIDBNLENSG00000136279.14chr7+4409803044098582440980304409807944098500440985820.174000.002910.02776includedK562AKAP8L
RIDBNLENSG00000136279.14chr7+4409738044097879440973804409745844097727440978790.132000.003060.03031includedHepG2U2AF1
RIDBNLENSG00000136279.14chr7+440973804409787944097380440974584409772744097879-0.203000.000080.00997excludedK562SBDS
RIDBNLENSG00000136279.14chr7+4409738044097879440973804409745844097727440978790.112000.001350.01597includedHepG2RBM22
MXEDBNLENSG00000136279.14chr7+44089823440898794409635544096502440843004408441944097380440974580.179000.003470.082821includedK562PTBP1
MXEDBNLENSG00000136279.14chr7+44092465440925404409635544096502440914284409154144097380440974580.204000.000480.018391includedK562UCHL5
MXEDBNLENSG00000136279.14chr7+4409142844091541440924654409254044089823440898794409635544096502-0.154000.003080.039622includedK562DROSHA
MXEDBNLENSG00000136279.14chr7+44092465440925404409635544096502440914284409154144097380440974580.199000.000300.013891includedK562XRN2
MXEDBNLENSG00000136279.14chr7+44092465440925404409635544096502440914284409154144097380440974580.196000.000340.032461includedK562NONO
MXEDBNLENSG00000136279.14chr7+44089823440898794409635544096502440843004408441944097380440974580.297000.000550.021121includedK562EFTUD2
MXEDBNLENSG00000136279.14chr7+44092465440925404409635544096502440914284409154144097380440974580.212000.000240.034531includedHepG2HLTF
MXEDBNLENSG00000136279.14chr7+4409142844091541440924654409254044089823440898794409635544096502-0.242000.000460.076422includedHepG2DKC1
MXEDBNLENSG00000136279.14chr7+44092465440925404409635544096502440914284409154144097380440974580.233000.000900.022441includedK562SUPV3L1
MXEDBNLENSG00000136279.14chr7+4409246544092540440963554409650244091428440915414409738044097458-0.093000.007620.080972includedK562HNRNPUL1
MXEDBNLENSG00000136279.14chr7+44092465440925404409635544096502440914284409154144097380440974580.225000.001480.076171includedK562SERBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for DBNL is not avaliable on ENCORE database.