CEP290

General Information

Gene Name       : CEP290
Gene ID             : ENSG00000198707.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: CEP290)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CEP290ENSG00000198707.149.888.078.98ENCSR000AEF
HepG2CEP290ENSG00000198707.143.476.244.86ENCSR985KAT
K562CEP290ENSG00000198707.149.758.889.32ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CEP290 is not avaliable on ENCORE database.



Proteins bound to RNA
  • CEP290 RNA is bound by 8 proteins.  







eCLIP assay for CEP290 is not avaliable on ENCORE database.





8 proteins are bound to CEP290 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr128852976688529859-3'-UTR,intron-Distal3.733594.30679K562KHSRP
chr128852987588529928-3'-UTR,intron-Distal4.394034.10688K562KHSRP
chr128852998088530038-3'-UTR,intron-Distal3.477583.28806K562KHSRP
chr128852981388529854-3'-UTR,intron-Distal4.135343.47043HepG2KHSRP
chr128852960288529671-3'-UTR,intron-Distal3.365064.31768HepG2KHSRP
chr128850547188505505-3'-UTR,5'-UTR,CDS,intron-Distal4.602544.34038HepG2BCLAF1
chr128850550088505570-3'-UTR,5'-UTR,CDS,intron-Distal3.512843.61259K562ZNF622
chr128849707188497224-5'-UTR,intron-Distal3.362204.06432HepG2KHSRP
chr128851226988512334-5'-UTR,CDS,intron-Distal,intron-Proximal4.527135.10960K562ZNF622
chr128849732788497447-5'-UTR,intron-Distal3.501247.02852K562KHSRP
chr128850037088500463-5'-UTR,CDS,intron-Distal,intron-Proximal3.410663.13218K562PRPF8
chr128850047188500486-5'-UTR,CDS,intron-Distal3.920633.20027K562ZNF622
chr128852419188524239-CDS,intron-Distal,intron-Proximal4.930434.90235K562SF3B4
chr128847147388471503-CDS,intron-Distal,intron-Proximal4.741305.68196HepG2BCLAF1
chr128852356888523646-CDS,intron-Distal,intron-Proximal5.496787.95223HepG2BCLAF1
chr128848451688484587-CDS,intron-Distal5.4691410.12910HepG2BCLAF1
chr128852357588523644-CDS,intron-Distal,intron-Proximal3.271415.04943K562ZNF622
chr128852428388524380-CDS,intron-Distal,intron-Proximal4.170019.23765K562SF3B4
chr128849673688496765-CDS,intron-Distal4.385593.45943HepG2BCLAF1
chr128847110388471122-CDS,intron-Distal,intron-Proximal4.319363.71570HepG2BCLAF1
chr128852408588524172-CDS,intron-Distal,intron-Proximal4.6390710.47008HepG2BCLAF1
chr128849066688490694-CDS,intron-Distal3.310053.28366HepG2BCLAF1
chr128844305888443137-CDS,intron-Distal5.320527.73487HepG2BCLAF1
chr128847770288477732-CDS,intron-Distal,intron-Proximal4.594594.77252K562ZNF622
chr128848157088481613-CDS,intron-Distal3.205793.31745K562ZNF622
chr128847836288478392-CDS,intron-Distal,intron-Proximal4.527135.24929K562ZNF622
chr128848452788484576-CDS,intron-Distal3.660223.95301K562ZNF622
chr128852494688525005-CDS,intron-Distal,intron-Proximal4.651574.64001HepG2U2AF2
chr128852408188524180-CDS,intron-Distal,intron-Proximal4.304528.50824K562ZNF622
chr128853251088532537-intron-Distal5.119078.69493K562EXOSC5
chr128852443788524544-intron-Distal,intron-Proximal4.568534.54401K562KHSRP
chr128850010988500308-intron-Distal4.8771415.42369K562QKI
chr128850014788500236-intron-Distal4.525974.85866HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CEP290 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CEP290 is not available on ENCORE database.

  • 86 RBPs can affect the levels of CEP290.  








The Knockdown/knockout RNA-Seq assay for CEP290 is not available on ENCORE database.





86 RBPs can affect the gene expression of CEP290 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CEP290ENSG00000198707.10728.67730568.333700.358402.296301.31740HepG2AATF
CEP290ENSG00000198707.101228.78060721.791400.767507.254706.43810HepG2AKAP1
CEP290ENSG00000198707.10363.41160597.25340-0.716704.295303.32570HepG2ASCC1
CEP290ENSG00000198707.10630.49080908.69640-0.527304.336803.49250HepG2CPSF6
CEP290ENSG00000198707.10473.98190646.02060-0.446702.877701.75070HepG2CPSF7
CEP290ENSG00000198707.10807.96740581.938700.473302.615701.31490HepG2CSTF2T
CEP290ENSG00000198707.10305.10240691.48950-1.180407.887906.88280HepG2DDX3X
CEP290ENSG00000198707.10342.70310593.84390-0.793105.045004.23300HepG2DDX6
CEP290ENSG00000198707.10507.45620645.23390-0.346502.570801.91520HepG2DKC1
CEP290ENSG00000198707.101208.32020791.914700.609502.912402.12260HepG2FIP1L1
CEP290ENSG00000198707.10574.06810319.746200.844204.235503.27350HepG2FUBP3
CEP290ENSG00000198707.10620.679401030.10270-0.730906.841905.86270HepG2GPKOW
CEP290ENSG00000198707.10364.07480517.43290-0.507103.417702.70900HepG2HNRNPA1
CEP290ENSG00000198707.10340.13010575.54250-0.758806.683805.64550HepG2HNRNPC
CEP290ENSG00000198707.10543.81330736.16840-0.436902.691201.98330HepG2HNRNPF
CEP290ENSG00000198707.10570.07260752.39490-0.400304.546603.70010HepG2HNRNPL
CEP290ENSG00000198707.10610.90450983.04380-0.686304.098003.34770HepG2HNRNPLL
CEP290ENSG00000198707.10292.09640571.73780-0.9689014.7005013.39590HepG2HNRNPU
CEP290ENSG00000198707.10372.27260724.92640-0.9615011.9543010.55660HepG2IGF2BP1
CEP290ENSG00000198707.10445.07140781.79720-0.812809.752008.72690HepG2PUF60
CEP290ENSG00000198707.10463.64110686.92780-0.567107.124906.21390HepG2PUS1
CEP290ENSG00000198707.10839.70350624.743600.426503.897703.17310HepG2QKI
CEP290ENSG00000198707.101182.54840841.772300.490303.616703.04560HepG2RBM22
CEP290ENSG00000198707.10778.32010642.009000.277702.100601.61590HepG2NELFE
CEP290ENSG00000198707.10820.01420597.976900.455503.416402.74060HepG2RECQL
CEP290ENSG00000198707.10532.47490792.87380-0.574403.192402.46630HepG2RPLP0
CEP290ENSG00000198707.10430.40420592.15940-0.460301.915101.39530HepG2RPS19
CEP290ENSG00000198707.10451.72790723.22420-0.679004.798203.92110HepG2SRSF7
CEP290ENSG00000198707.101173.58340877.868800.418705.802004.96090HepG2SUCLG1
CEP290ENSG00000198707.10867.37690563.520100.622108.041507.16570HepG2TAF15
CEP290ENSG00000198707.10498.09480958.09840-0.9438012.4564011.08470HepG2TARDBP
CEP290ENSG00000198707.10728.86400517.751400.493304.609803.53750HepG2TIA1
CEP290ENSG00000198707.10436.21400555.57250-0.348902.238301.77910HepG2TIAL1
CEP290ENSG00000198707.10461.50040560.51490-0.280401.950201.46070HepG2TRIM56
CEP290ENSG00000198707.10595.58340763.75120-0.358802.578501.73720HepG2TUFM
CEP290ENSG00000198707.10562.59580780.33230-0.472005.557104.62060HepG2UPF1
CEP290ENSG00000198707.10493.48740753.38110-0.610408.012207.07800HepG2UTP3
CEP290ENSG00000198707.10649.25490539.682400.266601.989501.40600HepG2ZC3H8
CEP290ENSG00000198707.101042.21940858.217000.280103.107102.53770HepG2ZNF622
CEP290ENSG00000198707.101614.354101968.16930-0.285902.164901.30820K562AKAP8
CEP290ENSG00000198707.10945.547101854.43520-0.9718011.7131010.62820K562AQR
CEP290ENSG00000198707.10791.46520987.52440-0.319303.181402.15510K562BCLAF1
CEP290ENSG00000198707.10883.794701341.59150-0.602206.224204.90430K562BOP1
CEP290ENSG00000198707.101725.907402140.41590-0.310502.998001.76220K562CCDC124
CEP290ENSG00000198707.101224.838801755.49240-0.519302.853601.39380K562CKAP4
CEP290ENSG00000198707.101700.924202824.18120-0.731505.137203.63840K562CNOT7
CEP290ENSG00000198707.101604.431202160.61540-0.429403.174601.98340K562CPEB4
CEP290ENSG00000198707.10766.697201426.48280-0.8957011.9351010.29520K562CPSF6
CEP290ENSG00000198707.10551.95080749.18450-0.440804.046002.73630K562CSTF2
CEP290ENSG00000198707.10680.255901095.70990-0.687707.846806.00350K562DDX3X
CEP290ENSG00000198707.101886.616302235.30340-0.244702.888202.22260K562DDX47
CEP290ENSG00000198707.10745.932101110.91140-0.574608.136005.61770K562DDX6
CEP290ENSG00000198707.10538.29900854.21070-0.666206.276704.85540K562EFTUD2
CEP290ENSG00000198707.10959.666301203.57060-0.326703.582502.18670K562EIF2S1
CEP290ENSG00000198707.10795.493301336.84310-0.748908.069506.93910K562EIF2S2
CEP290ENSG00000198707.10662.45760914.64540-0.465402.934301.86620K562EIF3D
CEP290ENSG00000198707.10817.078101144.75680-0.486504.701703.63280K562EIF4A3
CEP290ENSG00000198707.10769.830401030.92550-0.421304.518702.98060K562EIF4B
CEP290ENSG00000198707.10799.71370999.26260-0.321402.678001.41040K562EWSR1
CEP290ENSG00000198707.10857.756301391.19570-0.697705.097903.92340K562FIP1L1
CEP290ENSG00000198707.10777.417401451.43920-0.9007013.8674011.89230K562FMR1
CEP290ENSG00000198707.10879.503001230.23730-0.484203.929202.82400K562FTO
CEP290ENSG00000198707.10847.398501190.50070-0.490506.530505.65700K562FXR1
CEP290ENSG00000198707.102076.801601370.448100.599604.896403.89420K562G3BP2
CEP290ENSG00000198707.10747.440001361.92890-0.8656013.6312011.85360K562GPKOW
CEP290ENSG00000198707.10997.928001781.64870-0.836208.444507.10970K562GRSF1
CEP290ENSG00000198707.10461.89100978.07470-1.082407.102306.18870K562HNRNPC
CEP290ENSG00000198707.101245.92350906.576800.458604.893002.42600K562HNRNPH1
CEP290ENSG00000198707.101449.940802020.21600-0.478505.873204.27270K562HNRNPL
CEP290ENSG00000198707.101143.416901886.30490-0.722205.182604.10920K562HSPD1
CEP290ENSG00000198707.101471.341501893.30100-0.363803.389602.16310K562MAK16
CEP290ENSG00000198707.10832.172501329.39930-0.675809.179307.51350K562METAP2
CEP290ENSG00000198707.102261.983302836.79140-0.326702.886201.72800K562MSI2
CEP290ENSG00000198707.10860.381001143.09430-0.409904.002802.50580K562NCBP2
CEP290ENSG00000198707.10592.10050841.56700-0.507203.669202.13610K562NONO
CEP290ENSG00000198707.101235.893901618.68450-0.389307.533806.38690K562NSUN2
CEP290ENSG00000198707.101979.179702713.20490-0.455102.615101.42410K562PABPC1
CEP290ENSG00000198707.101330.515501987.54900-0.579002.160201.30700K562PABPN1
CEP290ENSG00000198707.101066.56470840.539000.343503.017902.18030K562POLR2G
CEP290ENSG00000198707.10858.825801579.13950-0.878706.788905.40400K562PPIG
CEP290ENSG00000198707.10515.32200831.24420-0.689806.379105.24160K562PRPF8
CEP290ENSG00000198707.101981.686102903.80120-0.551208.224906.81700K562PUF60
CEP290ENSG00000198707.102289.267203026.25390-0.402606.897105.36520K562PUM2
CEP290ENSG00000198707.10974.884601421.68140-0.544303.025802.14180K562RBM22
CEP290ENSG00000198707.10894.407901300.42760-0.540006.078304.02430K562RBM25
CEP290ENSG00000198707.10476.25710799.74120-0.747804.717003.41870K562RCC2
CEP290ENSG00000198707.10525.93150846.74810-0.687105.498504.34520K562RPS19
CEP290ENSG00000198707.10938.542501818.27140-0.954102.441501.34130K562SF1
CEP290ENSG00000198707.101197.618201597.18210-0.415405.635104.50160K562SF3A3
CEP290ENSG00000198707.10957.500901295.28310-0.435903.112102.07900K562SF3B1
CEP290ENSG00000198707.10920.411701425.54670-0.631209.687608.03990K562SF3B4
CEP290ENSG00000198707.101207.616502217.56140-0.876803.961002.28880K562SFPQ
CEP290ENSG00000198707.10507.32120758.16450-0.579603.613202.39490K562SRFBP1
CEP290ENSG00000198707.101982.876801636.343400.277002.914501.95750K562SRPK2
CEP290ENSG00000198707.10719.511401452.90150-1.013808.388207.16350K562SRSF1
CEP290ENSG00000198707.10856.541501080.46440-0.335103.620702.27080K562SRSF7
CEP290ENSG00000198707.10677.713501470.64270-1.117707.651606.40650K562TARDBP
CEP290ENSG00000198707.10961.483501418.54530-0.561103.902402.90790K562TIA1
CEP290ENSG00000198707.10516.32740843.45220-0.708004.227303.04940K562TIAL1
CEP290ENSG00000198707.101059.771901391.51380-0.392902.544801.50570K562TRA2A
CEP290ENSG00000198707.10608.39770895.72220-0.558002.527101.62950K562TRIM56
CEP290ENSG00000198707.101107.923101716.32300-0.6315014.6328013.13300K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CEP290 is not available on ENCORE database.





17 RBPs can affect the splicing of CEP290 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.581000.000000.00000excludedK562SRSF1
SECEP290ENSG00000198707.10chr12-8851279788512927885124198851252088513890885140530.196000.000130.00378includedK562SF3B4
SECEP290ENSG00000198707.10chr12-885108098851092288508874885089598851225988512347-0.373000.005290.07712excludedK562SF3B4
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.408000.000000.00000excludedK562AKAP8L
SECEP290ENSG00000198707.10chr12-885249418852499588524044885241978853041988530563-0.278000.000010.00098excludedK562AKAP8L
SECEP290ENSG00000198707.10chr12-885108098851092288508874885089598851225988512347-0.460000.000360.00595excludedHepG2U2AF2
SECEP290ENSG00000198707.10chr12-885243218852434288524044885241978853041988530563-0.392000.002990.03499excludedHepG2U2AF2
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.228000.000130.00210excludedK562AQR
SECEP290ENSG00000198707.10chr12-885124198851252088512259885123478851389088514053-0.168000.006240.05586excludedK562AQR
SECEP290ENSG00000198707.10chr12-8850925488509347885088748850895988510809885109220.293000.000330.06701includedK562HNRNPA1
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.477000.000000.00000excludedK562PUS1
SECEP290ENSG00000198707.10chr12-885347328853481088533271885333418853498288535111-0.186000.008540.09319excludedK562PUS1
SECEP290ENSG00000198707.10chr12-885249418852499588524044885241978853041988530563-0.303000.001760.02707excludedK562PUS1
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.446000.000030.00426excludedHepG2NCBP2
SECEP290ENSG00000198707.10chr12-885243218852434288524044885241978853041988530563-0.325000.003850.06672excludedK562U2AF1
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.589000.000000.00005excludedHepG2SRSF1
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.322000.000030.00234excludedK562UTP18
SECEP290ENSG00000198707.10chr12-8851279788512927885124198851252088513890885140530.174000.000100.00276includedK562U2AF2
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.202000.002990.04813excludedK562U2AF2
SECEP290ENSG00000198707.10chr12-885249418852499588524044885241978853041988530563-0.417000.000830.01709excludedK562U2AF2
SECEP290ENSG00000198707.10chr12-8851279788512927885124198851252088513890885140530.184000.000690.02830includedK562HNRNPU
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.404000.000000.00000excludedK562RBM15
SECEP290ENSG00000198707.10chr12-884481168844819088447428884475238844935288449494-0.431000.000000.00000excludedK562AGGF1
SECEP290ENSG00000198707.10chr12-885249418852499588524044885241978853041988530563-0.335000.000000.00009excludedK562AGGF1
SECEP290ENSG00000198707.10chr12-8844811688448190884474288844752388449352884494940.193000.000630.02792includedK562PTBP1
SECEP290ENSG00000198707.10chr12-884546068845477188453674884537978845646888456555-0.262000.000300.00694excludedK562HNRNPC
A3SSCEP290ENSG00000198707.10chr12-8846229888462479884622988846242288465070884652260.116000.000610.05372longerK562AKAP8L
A3SSCEP290ENSG00000198707.10chr12-8847762388477758884776238847773188478362884786290.053000.008800.04737longerK562AQR
A3SSCEP290ENSG00000198707.10chr12-8846229888462479884622988846242288465070884652260.165000.002430.01532longerK562AQR
A3SSCEP290ENSG00000198707.10chr12-8844296088443207884429608844319188444130884442510.060000.003270.01989longerK562AQR
MXECEP290ENSG00000198707.10chr12-8852432188524342885249418852499588524044885241978853041988530563-0.316000.004840.067462includedK562PUS1
MXECEP290ENSG00000198707.10chr12-88524321885243428852494188524977885240448852419788530419885305630.232000.003270.080921includedHepG2SF3A3
MXECEP290ENSG00000198707.10chr12-8852494188524995885304198853056388524321885243428853292188532968-0.222000.000010.001152includedK562SBDS

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CEP290 is not avaliable on ENCORE database.