SF3A1

General Information

Gene Name       : SF3A1
Gene ID             : ENSG00000099995.18
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SF3A1)


Antibody Validation


Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SF3A1ENSG00000099995.1828.2253.6940.95ENCSR000AEF
HepG2SF3A1ENSG00000099995.1847.6725.4736.57ENCSR985KAT
K562SF3A1ENSG00000099995.1881.8177.7479.78ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
eCLIPeCLIP: 4117ENCSR317QOXSF3A1HepG2ReleasedENCAB549NKFENCSR618TKA  
knockdown followed by RNA-seq SF3A1-BGKcLV17-K562ENCSR547ICRSF3A1K562ReleasedENCSR516TLX   CRISPRKD% = 76.8,77.378703
knockdown followed by RNA-seq SF3A1-BGHcLV18-HepG2ENCSR556TJUSF3A1HepG2ReleasedENCSR670KAS   CRISPRKD% = 96.2,93.3






  eCLIP  
  RBP    Exp_UID    Cell_Line    ENCODE_ACCESSION    Control_ENCODE_ACCESSION    ENCODE_Antibody_ID    Antibody    Lot_num    Status    Project  
SF3A14117HepG2ENCSR317QOXENCSR618TKAENCAB549NKFA301-601A1ReleasedENCODE4


  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
SF3A1ENCAB549NKFA301-601A1Released, ENCODE4BGHcLV18-43, Released, ENCODE4BGKcLV17-45, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
SF3A1K562CRISPRENCSR547ICRENCSR516TLXSF3A1-BGKcLV17-45,SF3A1-BGKcLV17-46NT-BGKcLV17-1,NT-BGKcLV17-276.8,77.378703ReleasedENCODE4
SF3A1HepG2CRISPRENCSR556TJUENCSR670KASSF3A1-BGHcLV18-43,SF3A1-BGHcLV18-44NT-BGHcLV18-1,NT-BGHcLV18-296.2,93.3ReleasedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
SF3A1Product_ID: A301-601A
Lot_ID: 1
Source: Bethyl Labs
Target Name: SF3A1-human
SF3A1-HEPG2-CRISPR-A301-601A.png<br>Caption: Western blot following CRISPR against SF3A1 in HepG2 whole cell lysate using SF3A1 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SF3A1. SF3A1 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
Bethyl_A301-601A_1_SF3A1.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the SF3A1 specific antibody, A301-601A. Lane 1 is 2.5% of five million whole cell lysate input. Lanes 2 and 3 are 50% of IP enrichment from five million whole cell lysate using normal IgG antibody and the SF3A1-specific antibody, A301-601A. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
SF3A1-K562-CRISPR-A301-601A.png<br>Caption: Western blot following CRISPR against SF3A1 in K562 whole cell lysate using SF3A1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SF3A1. SF3A1 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for SF3A1 is not avaliable on ENCORE database.



Proteins bound to RNA

  • SF3A1 RNA is bound by 24 proteins.  







eCLIP assay for SF3A1 is not avaliable on ENCORE database.





24 proteins are bound to SF3A1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr223073818830738330-3'-UTR,CDS,intron-Distal,intron-Proximal3.293127.36517K562DDX24
chr223073829130738338-3'-UTR,CDS,intron-Distal,intron-Proximal3.198849.89473K562UCHL5
chr223072983530730005-3'-UTR,intron-Distal4.3297618.09052K562FAM120A
chr223073477630734855-3'-UTR,CDS,intron-Distal,intron-Proximal4.3100514.67529K562IGF2BP2
chr223072980730729903-3'-UTR,intron-Distal5.403487.35154K562UPF1
chr223073488930734979-3'-UTR,CDS,intron-Distal,intron-Proximal3.430746.50797HepG2G3BP1
chr223073824630738340-3'-UTR,CDS,intron-Distal,intron-Proximal3.2188921.50090K562ZNF622
chr223072887330728913-3'-UTR,intron-Distal4.257173.87930K562UPF1
chr223073016230730195-3'-UTR,intron-Distal4.7557228.70287K562YBX3
chr223073826130738338-3'-UTR,CDS,intron-Distal,intron-Proximal3.496145.41876K562PUM1
chr223073485530734927-3'-UTR,CDS,intron-Distal,intron-Proximal4.139424.23668K562LIN28B
chr223073008230730164-3'-UTR,intron-Distal4.565777.83850HepG2SUB1
chr223073377630733859-3'-UTR,CDS,intron-Distal,intron-Proximal3.3418011.45503K562IGF2BP2
chr223073375630733800-3'-UTR,CDS,intron-Distal,intron-Proximal3.553443.55142K562METAP2
chr223073824430738340-3'-UTR,CDS,intron-Distal,intron-Proximal3.408067.51172HepG2PPIG
chr223073825930738337-3'-UTR,CDS,intron-Distal,intron-Proximal3.165305.07457HepG2BCLAF1
chr223073022030730366-3'-UTR,intron-Distal3.101866.74715K562IGF2BP1
chr223073491130735007-3'-UTR,CDS,intron-Distal,intron-Proximal3.4609712.26691K562ZNF622
chr223073048530730567-3'-UTR,intron-Distal4.7013614.18762K562PCBP1
chr223073880930738846-3'-UTR,CDS,intron-Distal3.945787.80648K562YBX3
chr223073884830738868-3'-UTR,CDS,intron-Distal5.4062911.31254K562YBX3
chr223073500730735024-3'-UTR,CDS,intron-Distal,intron-Proximal3.7559910.48558K562ZNF622
chr223073882430738885-3'-UTR,CDS,intron-Distal,intron-Proximal4.158314.75425K562EFTUD2
chr223073818830738342-3'-UTR,CDS,intron-Distal,intron-Proximal3.1463412.03943K562ZNF800
chr223073024430730316-3'-UTR,intron-Distal3.862976.31152K562IGF2BP2
chr223073019530730219-3'-UTR,intron-Distal4.1591210.81363K562YBX3
chr223073490230735026-3'-UTR,CDS,intron-Distal,intron-Proximal3.5651213.94298K562UCHL5
chr223073011030730162-3'-UTR,intron-Distal4.5428415.65055K562YBX3
chr223075273630752816-5'-UTR,CDS,intron-Distal3.575994.47117K562DDX3X
chr223075281430752868-5'-UTR,intron-Distal3.411929.30098K562YBX3
chr223075281430752892-5'-UTR,intron-Distal,intron-Proximal3.799506.81630K562FMR1
chr223075281630752898-5'-UTR,intron-Distal,intron-Proximal4.214254.84938K562DDX3X
chr223075273130752797-5'-UTR,CDS,intron-Distal3.469154.31813HepG2G3BP1
chr223074241630742496-CDS,intron-Distal,intron-Proximal3.249859.81338K562YBX3
chr223073310430733169-CDS,intron-Distal3.7478810.60713K562YBX3
chr223074240030742416-CDS,intron-Distal3.0331310.73248K562YBX3
chr223073512930735216-CDS,intron-Distal,intron-Proximal3.3940212.80038K562ZNF622
chr223073668730736725-CDS,intron-Distal3.697684.06757K562UCHL5
chr223073820030738291-CDS,intron-Distal,intron-Proximal3.9631621.96277K562UCHL5
chr223074894230748978-CDS,intron-Distal3.194265.54400K562YBX3
chr223073668730736776-CDS,intron-Distal,intron-Proximal3.528947.11962HepG2G3BP1
chr223073511830735198-CDS,intron-Distal,intron-Proximal3.606586.25351HepG2G3BP1
chr223074090930740989-CDS,intron-Distal,intron-Proximal4.272784.72880HepG2GRWD1
chr223073784430737875-CDS,intron-Distal,intron-Proximal3.287863.47314HepG2G3BP1
chr223073674930736802-CDS,intron-Distal,intron-Proximal5.1814610.25943K562LIN28B
chr223074100830741079-CDS,intron-Distal,intron-Proximal3.167266.03207K562FMR1
chr223073632730736367-CDS,intron-Distal4.211864.42709HepG2G3BP1
chr223074231930742505-CDS,intron-Distal,intron-Proximal3.016466.84360K562PUM1
chr223073769430737795-CDS,intron-Distal3.9615912.89449HepG2G3BP1
chr223073367530733693-CDS,intron-Distal,intron-Proximal4.980213.92758K562PCBP1
chr223074894330748991-CDS,intron-Distal3.735693.45590K562GRWD1
chr223073301830733057-CDS,intron-Distal4.674035.86954K562UCHL5
chr223073511830735129-CDS,intron-Distal,intron-Proximal4.374088.85033K562ZNF622
chr223073301630733123-CDS,intron-Distal3.325378.24916K562FAM120A
chr223073672530736795-CDS,intron-Distal,intron-Proximal3.131105.17653K562UCHL5
chr223074085730740925-CDS,intron-Distal,intron-Proximal3.780037.56654HepG2PRPF8
chr223073632930736357-CDS,intron-Distal3.617363.12941K562UCHL5
chr223073818830738231-CDS,intron-Distal,intron-Proximal3.427606.57537HepG2G3BP1
chr223073370230733776-CDS,intron-Distal,intron-Proximal3.6347911.55294K562IGF2BP2
chr223074092130740956-CDS,intron-Distal,intron-Proximal3.7516212.74366K562YBX3
chr223073768030737755-CDS,intron-Distal,intron-Proximal5.8099917.11009K562LIN28B
chr223073663630736692-CDS,intron-Distal,intron-Proximal5.778566.75320K562AQR
chr223073306230733114-CDS,intron-Distal4.758066.88889HepG2G3BP1
chr223073769230737792-CDS,intron-Distal3.1565013.31533K562UCHL5
chr223074230030742370-CDS,intron-Distal,intron-Proximal3.469154.31813HepG2G3BP1
chr223073511830735184-CDS,intron-Distal,intron-Proximal4.074975.35382K562ZNF800
chr223073621030736262-CDS,intron-Distal4.260963.35417K562METAP2
chr223073765430737684-CDS,intron-Distal,intron-Proximal3.082406.02419K562AQR
chr223073823130738286-CDS,intron-Distal,intron-Proximal4.153258.24268HepG2G3BP1
chr223073301430733062-CDS,intron-Distal,intron-Proximal4.353484.96722HepG2G3BP1
chr223073308730733171-CDS,intron-Distal,intron-Proximal4.7039412.33972K562PCBP1
chr223073311430733162-CDS,intron-Distal3.365923.77614HepG2G3BP1
chr223073510230735256-CDS,intron-Distal,intron-Proximal3.851554.57180HepG2AQR
chr223073361330733680-CDS,intron-Distal,intron-Proximal3.8594410.78170K562AQR
chr223073621930736271-CDS,intron-Distal4.113903.68241HepG2G3BP1
chr223074897830748995-CDS,intron-Distal4.192894.51688K562YBX3
chr223073850330738578-intron-Distal,intron-Proximal3.882233.58455K562U2AF2
chr223074225730742282-intron-Distal,intron-Proximal4.734824.86944K562AQR
chr223074091430740921-intron-Distal,intron-Proximal3.582404.98672K562AQR
chr223074089530740914-intron-Distal,intron-Proximal4.167365.63763K562AQR
chr223073851930738581-intron-Distal,intron-Proximal3.566615.76944HepG2U2AF2
chr223073763630737654-intron-Distal,intron-Proximal5.360597.81430K562AQR
chr223073614230736185-intron-Distal,intron-Proximal3.942344.89208K562AQR
chr223073814530738187-intron-Distal,intron-Proximal4.268384.49024K562AQR
chr223074087830740895-intron-Distal,intron-Proximal5.247596.44303K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SF3A1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SF3A1 is not available on ENCORE database.

  • 78 RBPs can affect the levels of SF3A1.  








The Knockdown/knockout RNA-Seq assay for SF3A1 is not available on ENCORE database.





78 RBPs can affect the gene expression of SF3A1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SF3A1ENSG00000099995.142070.515401744.226600.247303.290802.63730HepG2ACO1
SF3A1ENSG00000099995.142919.460901858.337400.651606.592605.81110HepG2AKAP1
SF3A1ENSG00000099995.141061.211001409.66590-0.409602.645501.76470HepG2BCLAF1
SF3A1ENSG00000099995.142599.533103818.59240-0.554806.849305.95560HepG2BOP1
SF3A1ENSG00000099995.141632.689202039.73010-0.321103.104302.29090HepG2CALR
SF3A1ENSG00000099995.142021.588301460.799800.468604.281103.33320HepG2CIRBP
SF3A1ENSG00000099995.142587.029703505.74530-0.438403.987303.17550HepG2CPSF6
SF3A1ENSG00000099995.14986.808201403.79830-0.508507.360505.71870HepG2YBX3
SF3A1ENSG00000099995.142573.458002184.282500.236402.862902.21150HepG2CELF1
SF3A1ENSG00000099995.141889.466801613.107800.228002.900202.04800HepG2DDX19B
SF3A1ENSG00000099995.14886.433501208.37920-0.447003.074301.60150HepG2DDX28
SF3A1ENSG00000099995.142102.138501458.451400.527305.407204.15600HepG2EEF2
SF3A1ENSG00000099995.14908.602901338.26150-0.558604.153702.78220HepG2AGO1
SF3A1ENSG00000099995.142600.620102029.944400.357303.931702.54360HepG2EIF2S2
SF3A1ENSG00000099995.141458.299601991.49570-0.449603.731401.67850HepG2EIF3H
SF3A1ENSG00000099995.142377.362501624.252300.549504.882104.03670HepG2EIF4A3
SF3A1ENSG00000099995.141778.683802317.05680-0.381506.010504.86180HepG2EIF4G1
SF3A1ENSG00000099995.141381.118102219.56660-0.684409.354307.89280HepG2EIF4G2
SF3A1ENSG00000099995.141677.563801215.581000.464602.473001.72960HepG2FUBP3
SF3A1ENSG00000099995.142049.613801639.310200.322202.215101.59330HepG2FXR1
SF3A1ENSG00000099995.141338.956601054.100900.345002.449801.61110HepG2GEMIN5
SF3A1ENSG00000099995.142783.288303974.22550-0.513904.992604.14890HepG2GPKOW
SF3A1ENSG00000099995.141608.736902158.39520-0.424006.948605.58440HepG2HNRNPA2B1
SF3A1ENSG00000099995.142210.130001540.200200.520905.765604.78580HepG2HNRNPK
SF3A1ENSG00000099995.141811.472202139.23040-0.239903.352402.61670HepG2HNRNPL
SF3A1ENSG00000099995.143018.940303792.65940-0.329202.673002.05220HepG2HNRNPLL
SF3A1ENSG00000099995.141900.484101537.692400.305504.184303.45150HepG2HNRNPU
SF3A1ENSG00000099995.14811.816901302.57540-0.682104.969303.17720HepG2ILF3
SF3A1ENSG00000099995.142038.547201639.884800.313802.080101.50820HepG2MAGOH
SF3A1ENSG00000099995.142355.788603867.60410-0.715206.198704.71540HepG2MTPAP
SF3A1ENSG00000099995.141781.842102328.75140-0.386204.974103.95570HepG2NOL12
SF3A1ENSG00000099995.142607.863603362.77990-0.366802.982602.20620HepG2NSUN2
SF3A1ENSG00000099995.141852.650001573.643300.235401.974501.44800HepG2PCBP1
SF3A1ENSG00000099995.141868.275801601.340400.222302.114101.62370HepG2PTBP1
SF3A1ENSG00000099995.141272.139601734.07920-0.446905.683104.83460HepG2QKI
SF3A1ENSG00000099995.141697.584101152.028000.559207.316906.37400HepG2RPS19
SF3A1ENSG00000099995.142688.687003754.09330-0.481605.838204.84670HepG2SF3B1
SF3A1ENSG00000099995.141845.551201596.925500.208702.653902.02070HepG2SMN1
SF3A1ENSG00000099995.142720.546104177.04780-0.618604.512403.50410HepG2SNRNP70
SF3A1ENSG00000099995.143332.106402674.131100.317305.157004.53230HepG2SRFBP1
SF3A1ENSG00000099995.142395.454001740.084600.4610010.037409.26220HepG2SRSF1
SF3A1ENSG00000099995.141187.760301587.83550-0.418802.725202.05220HepG2SUPV3L1
SF3A1ENSG00000099995.141290.328101564.25790-0.277702.471301.93780HepG2TAF15
SF3A1ENSG00000099995.142682.886003696.16460-0.462202.146001.49560HepG2TARDBP
SF3A1ENSG00000099995.14834.821701064.29290-0.350402.208501.30690HepG2TFIP11
SF3A1ENSG00000099995.141784.079701494.140900.255802.364001.89510HepG2TIAL1
SF3A1ENSG00000099995.142933.300602311.463800.343602.817802.18400HepG2U2AF1
SF3A1ENSG00000099995.14677.00200938.00850-0.470403.406702.56890HepG2UCHL5
SF3A1ENSG00000099995.141748.780902240.96470-0.357806.294305.31090HepG2UPF1
SF3A1ENSG00000099995.141059.352601454.06820-0.456902.438201.49990HepG2UPF2
SF3A1ENSG00000099995.142545.620502163.561400.234503.134702.50390HepG2UTP3
SF3A1ENSG00000099995.148165.731105104.096400.6778028.4173026.69400K562AGGF1
SF3A1ENSG00000099995.146744.131305608.660900.265902.441801.52820K562AKAP8
SF3A1ENSG00000099995.147046.791605311.051200.407902.835802.17430K562AKAP8L
SF3A1ENSG00000099995.144460.478205714.29910-0.357404.750803.72750K562CPSF6
SF3A1ENSG00000099995.147411.470606598.116000.167602.065201.48850K562DDX47
SF3A1ENSG00000099995.144215.616503177.637900.407704.032202.37650K562DHX30
SF3A1ENSG00000099995.147189.759705715.024400.331105.935204.58340K562DKC1
SF3A1ENSG00000099995.143957.325204524.46120-0.193202.230301.57390K562EIF2S2
SF3A1ENSG00000099995.143892.695802886.922700.431102.466101.52150K562EIF3A
SF3A1ENSG00000099995.142571.974202026.246600.344004.965703.91560K562EIF3G
SF3A1ENSG00000099995.141408.672302147.01810-0.608003.258302.48030K562G3BP2
SF3A1ENSG00000099995.144223.792206028.95810-0.513408.664007.30670K562GRSF1
SF3A1ENSG00000099995.143504.860302805.935800.320802.530401.35510K562HNRNPK
SF3A1ENSG00000099995.144703.167007076.24600-0.589404.595403.57560K562HSPD1
SF3A1ENSG00000099995.143639.175802810.775000.372502.632501.64050K562IGF2BP2
SF3A1ENSG00000099995.143474.611902858.494700.281502.418601.32550K562IGF2BP3
SF3A1ENSG00000099995.146910.783605636.326400.294003.378602.45660K562KIF1C
SF3A1ENSG00000099995.146739.804805395.372600.320902.313501.35960K562MAK16
SF3A1ENSG00000099995.148002.643406314.112900.341804.290903.11460K562MBNL1
SF3A1ENSG00000099995.146707.834204571.594800.553002.425401.51210K562PABPN1
SF3A1ENSG00000099995.143839.553602886.984600.411305.623803.62890K562PCBP1
SF3A1ENSG00000099995.145277.658106571.30660-0.316302.419801.64350K562PCBP3
SF3A1ENSG00000099995.143956.856905040.18770-0.349102.036601.34970K562POLR2G
SF3A1ENSG00000099995.148694.588905267.052200.723004.073703.43390K562PUS1
SF3A1ENSG00000099995.147568.924505131.993000.5605010.751609.60580K562RBM15
SF3A1ENSG00000099995.143570.164402932.592100.283702.959201.93260K562RCC2
SF3A1ENSG00000099995.142865.567505907.23600-1.0437047.5488044.82310K562SF3A3
SF3A1ENSG00000099995.148113.227804801.370100.756703.746702.23560K562SNRNP200
SF3A1ENSG00000099995.143385.584902779.988100.284202.453701.50160K562SRFBP1
SF3A1ENSG00000099995.143391.667002812.723600.269902.658901.96500K562SRSF1
SF3A1ENSG00000099995.143280.734902745.738300.256702.389001.63570K562TIA1
SF3A1ENSG00000099995.143399.644502695.015100.335003.105801.93740K562TRA2A
SF3A1ENSG00000099995.144395.992903284.360800.420505.178603.78330K562TRIM56
SF3A1ENSG00000099995.142681.241903368.91890-0.329402.754101.73800K562UCHL5
SF3A1ENSG00000099995.145457.397806348.03670-0.218102.967902.22260K562UPF1
SF3A1ENSG00000099995.144234.393606055.11650-0.516005.365503.69550K562UTP3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SF3A1 is not available on ENCORE database.





1 RBPs can affect the splicing of SF3A1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSSF3A1ENSG00000099995.14chr22-3073301430733227307330143073316930733678307338860.204000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SF3A1 is not avaliable on ENCORE database.