HMGCL

General Information

Gene Name       : HMGCL
Gene ID             : ENSG00000117305.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: HMGCL)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878HMGCLENSG00000117305.1417.6823.2820.48ENCSR000AEF
HepG2HMGCLENSG00000117305.1412.3714.3413.36ENCSR985KAT
K562HMGCLENSG00000117305.1417.2915.2216.25ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for HMGCL is not avaliable on ENCORE database.



Proteins bound to RNA
  • HMGCL RNA is bound by 2 proteins.  







eCLIP assay for HMGCL is not avaliable on ENCORE database.





2 proteins are bound to HMGCL RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr12412874924128857-3'-UTR,intron-Distal4.730533.92497HepG2UPF1
chr12412854824128713-3'-UTR,intron-Distal4.650293.92497HepG2UPF1
chr12412863524128764-3'-UTR,intron-Distal3.913858.82905K562UPF1
chr12414700924147084-5'-UTR,CDS,intron-Distal,intron-Proximal3.852675.63105K562DDX3X
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for HMGCL is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for HMGCL is not available on ENCORE database.

  • 110 RBPs can affect the levels of HMGCL.  








The Knockdown/knockout RNA-Seq assay for HMGCL is not available on ENCORE database.





110 RBPs can affect the gene expression of HMGCL :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
HMGCLENSG00000117305.10218.00050555.11470-1.3485017.7448015.40850HepG2AATF
HMGCLENSG00000117305.101130.386901855.28870-0.714807.141806.33140HepG2AKAP1
HMGCLENSG00000117305.10501.97000323.353400.634404.730903.97430HepG2BOP1
HMGCLENSG00000117305.10651.29270495.986400.392902.797402.02180HepG2CALR
HMGCLENSG00000117305.101103.118201458.44050-0.402803.082202.26790HepG2CIRBP
HMGCLENSG00000117305.10502.57420674.30440-0.424104.463703.65790HepG2CKAP4
HMGCLENSG00000117305.10510.03020296.853600.780706.288805.28210HepG2CPSF6
HMGCLENSG00000117305.10980.54490782.680200.325102.983702.32010HepG2CELF1
HMGCLENSG00000117305.101177.02140841.611700.483808.179007.00780HepG2DAZAP1
HMGCLENSG00000117305.10505.27810623.81180-0.304002.554601.75080HepG2DDX19B
HMGCLENSG00000117305.10760.24100612.175300.312401.924001.34610HepG2DDX21
HMGCLENSG00000117305.10686.64690434.665800.659604.409402.83460HepG2DDX27
HMGCLENSG00000117305.10884.00220502.277000.815506.070104.62870HepG2DDX5
HMGCLENSG00000117305.10751.10120500.823900.584605.400604.06010HepG2DHX30
HMGCLENSG00000117305.10784.37740645.328700.281402.151401.54210HepG2DKC1
HMGCLENSG00000117305.10879.64970519.285700.7603011.8286010.45600HepG2DNAJC21
HMGCLENSG00000117305.10649.95790514.585900.336802.227701.63010HepG2DNAJC2
HMGCLENSG00000117305.101190.629501467.61020-0.301701.835501.33960HepG2EIF2S1
HMGCLENSG00000117305.10303.44310490.63860-0.693205.087003.88810HepG2EIF3D
HMGCLENSG00000117305.10500.756801579.15140-1.6570025.2452023.32760HepG2EIF4B
HMGCLENSG00000117305.10617.90930386.646400.676305.287303.57510HepG2FKBP4
HMGCLENSG00000117305.10566.40870297.367500.929503.825802.63000HepG2FTO
HMGCLENSG00000117305.10797.057901636.45790-1.0378016.0992014.57610HepG2FXR1
HMGCLENSG00000117305.101063.611401518.01750-0.513204.266903.44940HepG2G3BP1
HMGCLENSG00000117305.101181.911001611.61870-0.447403.768602.71950HepG2G3BP2
HMGCLENSG00000117305.10291.05900436.84150-0.585803.926502.84500HepG2GEMIN5
HMGCLENSG00000117305.10835.56890336.500001.3121017.2710015.80980HepG2GPKOW
HMGCLENSG00000117305.10832.03420583.103600.512804.171303.33330HepG2HNRNPC
HMGCLENSG00000117305.10752.88920499.166300.592807.827906.70100HepG2HNRNPF
HMGCLENSG00000117305.10542.594601537.21700-1.5024033.3405031.20160HepG2HNRNPK
HMGCLENSG00000117305.10528.81830321.128800.719505.466104.61200HepG2HNRNPLL
HMGCLENSG00000117305.10401.46710579.25130-0.528902.862602.24670HepG2HNRNPU
HMGCLENSG00000117305.10705.863801016.72220-0.526503.477502.09560HepG2HSPD1
HMGCLENSG00000117305.10758.89070491.538400.626507.064705.95500HepG2IGF2BP1
HMGCLENSG00000117305.10904.392701543.01840-0.770709.257208.10360HepG2IGF2BP2
HMGCLENSG00000117305.10727.702401448.10940-0.992804.068602.87850HepG2IGF2BP3
HMGCLENSG00000117305.10778.07950616.558700.335603.421002.28630HepG2KIF1C
HMGCLENSG00000117305.10960.970401637.02950-0.768509.080207.90500HepG2MAGOH
HMGCLENSG00000117305.101058.880501646.18030-0.636605.918205.02090HepG2MATR3
HMGCLENSG00000117305.10536.68230327.524200.712403.702502.57170HepG2MTPAP
HMGCLENSG00000117305.10627.62780440.111600.511902.996501.73330HepG2NAA15
HMGCLENSG00000117305.10951.075001684.94770-0.8251010.228009.05310HepG2NCBP2
HMGCLENSG00000117305.10273.27310426.41270-0.641902.291201.30700HepG2NONO
HMGCLENSG00000117305.10511.09300284.746900.843807.181406.01240HepG2NSUN2
HMGCLENSG00000117305.10767.731701608.09800-1.0667033.4879031.77700HepG2PCBP1
HMGCLENSG00000117305.10829.92140573.465300.533203.519201.63070HepG2PHF6
HMGCLENSG00000117305.10696.67650556.061200.325102.665301.90460HepG2PRPF4
HMGCLENSG00000117305.10512.561601636.34740-1.6747071.3804069.49020HepG2PTBP1
HMGCLENSG00000117305.10544.76360796.62930-0.548305.096604.31760HepG2PUF60
HMGCLENSG00000117305.10472.40700845.64460-0.8400017.1747015.95770HepG2PUM1
HMGCLENSG00000117305.10305.92600587.30810-0.940905.481604.50940HepG2RAVER1
HMGCLENSG00000117305.10809.46070990.70340-0.291502.309601.82470HepG2RBM22
HMGCLENSG00000117305.10778.516001608.33590-1.0468021.9749020.18590HepG2RBM25
HMGCLENSG00000117305.10526.10030720.68270-0.454003.052302.00950HepG2RBM27
HMGCLENSG00000117305.10378.89250585.22610-0.627204.043102.75740HepG2RCC2
HMGCLENSG00000117305.10913.932101821.05800-0.9946029.7413028.36400HepG2NELFE
HMGCLENSG00000117305.10871.424001696.13970-0.9608027.8164026.22330HepG2RECQL
HMGCLENSG00000117305.101000.29260537.693100.8955012.2727011.01550HepG2RPLP0
HMGCLENSG00000117305.10369.91180576.90080-0.641103.512402.44890HepG2RPS10
HMGCLENSG00000117305.10228.81990354.58020-0.631902.887402.08650HepG2RRP9
HMGCLENSG00000117305.10899.16600515.871200.8015012.0809010.88250HepG2SAFB2
HMGCLENSG00000117305.10291.81930609.57410-1.062706.832305.74000HepG2SF3A3
HMGCLENSG00000117305.10546.45370317.850200.781706.893705.82140HepG2SF3B1
HMGCLENSG00000117305.10627.443501703.56360-1.4410055.1577053.19260HepG2SF3B4
HMGCLENSG00000117305.10989.74590763.817600.373704.021103.19910HepG2SLBP
HMGCLENSG00000117305.10683.99490353.665500.951506.707005.48370HepG2SNRNP70
HMGCLENSG00000117305.101345.098901118.963800.265402.999102.48400HepG2SRFBP1
HMGCLENSG00000117305.10773.843301778.18630-1.2003043.0155041.64050HepG2SRSF1
HMGCLENSG00000117305.10581.41210786.54040-0.436003.525102.83410HepG2SRSF5
HMGCLENSG00000117305.10675.646201012.98610-0.584304.708403.08360HepG2SSRP1
HMGCLENSG00000117305.101393.984601025.573600.442702.689601.38480HepG2SUGP2
HMGCLENSG00000117305.10789.38670437.202800.8523010.296108.59120HepG2SUPT6H
HMGCLENSG00000117305.10747.94000462.428500.693605.696604.77960HepG2SUPV3L1
HMGCLENSG00000117305.101241.838701598.39980-0.364204.293603.61870HepG2TAF15
HMGCLENSG00000117305.10872.91680567.873100.620205.048304.33210HepG2TRIM56
HMGCLENSG00000117305.10540.18980778.25260-0.526804.814203.62970HepG2TUFM
HMGCLENSG00000117305.10365.76980554.04610-0.599102.532401.92920HepG2U2AF1
HMGCLENSG00000117305.101164.09350823.754700.498803.531502.58100HepG2UBE2L3
HMGCLENSG00000117305.10617.83590423.534400.544603.085402.02560HepG2UPF2
HMGCLENSG00000117305.10269.28630521.92930-0.954707.284906.38920HepG2UTP3
HMGCLENSG00000117305.10412.83940645.87580-0.645703.944302.67990HepG2XRCC6
HMGCLENSG00000117305.10747.78060455.209100.716006.533905.43580HepG2XRN2
HMGCLENSG00000117305.10957.89160594.556700.6879010.660809.76140HepG2ZNF622
HMGCLENSG00000117305.10379.42130586.75640-0.629003.870402.31250HepG2ZRANB2
HMGCLENSG00000117305.10317.88340456.90410-0.523403.267601.97020K562AARS
HMGCLENSG00000117305.10657.06610909.43170-0.468905.553904.79340K562AGGF1
HMGCLENSG00000117305.10772.30190946.29100-0.293101.943301.39290K562AKAP8L
HMGCLENSG00000117305.10695.74470892.72580-0.359702.581701.38550K562APOBEC3C
HMGCLENSG00000117305.10721.84360914.50380-0.341301.994301.48100K562AQR
HMGCLENSG00000117305.10467.49420314.193000.573203.550302.56240K562BOP1
HMGCLENSG00000117305.10785.346201018.36400-0.374904.058002.97010K562DKC1
HMGCLENSG00000117305.10612.57800425.503100.525602.950001.62520K562EEF2
HMGCLENSG00000117305.10271.43380411.08940-0.598903.884202.78910K562EFTUD2
HMGCLENSG00000117305.10679.44360548.813300.307902.420701.30240K562EIF2S1
HMGCLENSG00000117305.10558.80840435.160100.360702.566601.86910K562EIF2S2
HMGCLENSG00000117305.10312.93340440.10140-0.492002.652701.64040K562EIF3D
HMGCLENSG00000117305.10585.47200358.196800.708703.723302.72890K562FIP1L1
HMGCLENSG00000117305.10409.73920288.077900.508102.823801.89970K562FTO
HMGCLENSG00000117305.10290.69940542.85100-0.9010011.1980010.06690K562FXR1
HMGCLENSG00000117305.10320.88320456.32600-0.508002.532101.86070K562G3BP2
HMGCLENSG00000117305.10438.38010318.995600.458502.597101.82600K562GPKOW
HMGCLENSG00000117305.10778.31730579.876500.424503.002102.21610K562GRSF1
HMGCLENSG00000117305.10443.94110677.14710-0.609104.675203.03100K562HNRNPK
HMGCLENSG00000117305.10436.12240706.76800-0.696507.643706.16590K562HNRNPU
HMGCLENSG00000117305.10792.20870485.602000.706006.960205.70840K562HSPD1
HMGCLENSG00000117305.10431.22010712.55290-0.724608.348106.85260K562MAGOH
HMGCLENSG00000117305.10913.024701125.06280-0.301302.509801.65110K562MBNL1
HMGCLENSG00000117305.10296.08360633.98760-1.0984013.7784011.47870K562PCBP2
HMGCLENSG00000117305.101064.12730609.250200.804508.589607.12650K562PCBP3
HMGCLENSG00000117305.10818.79970467.325000.8090011.093009.54190K562POLR2G
HMGCLENSG00000117305.10691.98410406.662200.766807.781006.25010K562PPIG
HMGCLENSG00000117305.10198.34000400.03860-1.012208.199106.90540K562PRPF8
HMGCLENSG00000117305.10255.98990692.29300-1.4353027.0275025.04780K562PTBP1
HMGCLENSG00000117305.10743.353401103.88270-0.570506.004604.80630K562PUF60
HMGCLENSG00000117305.10588.54190914.40330-0.635708.256707.26100K562RBM15
HMGCLENSG00000117305.10424.15440663.80230-0.646206.035404.73270K562RBM22
HMGCLENSG00000117305.10615.47870408.982800.589603.312601.85640K562RRP9
HMGCLENSG00000117305.10281.99040416.36870-0.562203.650102.39940K562SAFB
HMGCLENSG00000117305.10293.43270474.21090-0.692506.640205.27980K562SF3B4
HMGCLENSG00000117305.10400.76000734.19830-0.873403.954302.39150K562SNRNP200
HMGCLENSG00000117305.10656.09660469.938200.481303.338201.82600K562SSRP1
HMGCLENSG00000117305.10577.53710429.794500.426202.532301.33830K562STAU1
HMGCLENSG00000117305.10228.08370468.72630-1.0392011.8867010.18580K562SYNCRIP
HMGCLENSG00000117305.10511.33460686.86070-0.425802.872402.15270K562TARDBP
HMGCLENSG00000117305.10618.09900418.873000.561204.259202.42810K562TRIP6
HMGCLENSG00000117305.10361.26490456.60030-0.337902.006801.32310K562U2AF2
HMGCLENSG00000117305.10600.67670409.897800.551203.753902.55140K562UCHL5
HMGCLENSG00000117305.10713.24820552.413900.368602.721901.85210K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for HMGCL is not available on ENCORE database.





11 RBPs can affect the splicing of HMGCL :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.324000.000150.00686excludedK562AKAP8L
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.311000.000010.00053excludedHepG2HNRNPK
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.224000.005670.06841excludedK562PUS1
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.161000.000480.04316excludedHepG2DDX6
SEHMGCLENSG00000117305.10chr1-2414909224149255241469992414708324151845241519060.078000.000300.07327includedK562PPIL4
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.397000.000060.00281excludedK562RBM15
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.335000.000190.00732excludedK562AGGF1
SEHMGCLENSG00000117305.10chr1-2414909224149255241469992414708324151845241519060.220000.001340.05109includedK562SF3B1
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.339000.000010.00131excludedK562HNRNPK
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.347000.000860.03824excludedHepG2HNRNPU
SEHMGCLENSG00000117305.10chr1-241406792414082824134624241348132414316424143260-0.363000.000010.00066excludedK562PTBP1
SEHMGCLENSG00000117305.10chr1-2414909224149255241469992414708324151845241519060.211000.000000.00003includedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for HMGCL is not avaliable on ENCORE database.