APC

General Information

Gene Name       : APC
Gene ID             : ENSG00000134982.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: APC)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878APCENSG00000134982.169.358.508.93ENCSR000AEF
HepG2APCENSG00000134982.165.635.825.72ENCSR985KAT
K562APCENSG00000134982.1610.6610.3810.52ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for APC is not avaliable on ENCORE database.



Proteins bound to RNA
  • APC RNA is bound by 14 proteins.  







eCLIP assay for APC is not avaliable on ENCORE database.





14 proteins are bound to APC RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr5112179902112179981+3'-UTR,intron-Distal5.199086.34419K562PUM2
chr5112174977112175021+3'-UTR,CDS,intron-Distal3.857873.11168K562ZNF622
chr5112151241112151300+3'-UTR,CDS,intron-Proximal3.920633.20027K562ZNF622
chr5112175148112175212+3'-UTR,CDS,intron-Distal3.482364.06757K562UCHL5
chr5112177866112177981+3'-UTR,CDS,intron-Distal3.246323.55860K562SAFB2
chr5112175134112175179+3'-UTR,CDS,intron-Distal3.205793.31745K562ZNF622
chr5112175552112175594+3'-UTR,CDS,intron-Distal3.869373.67607K562YBX3
chr5112177929112178011+3'-UTR,CDS,intron-Distal3.936503.26547HepG2HLTF
chr5112176964112177037+3'-UTR,CDS,intron-Distal4.276855.43239K562YBX3
chr5112174941112175017+3'-UTR,CDS,intron-Distal4.372823.38968HepG2BCLAF1
chr5112090571112090717+3'-UTR,5'-UTR,CDS,intron-Distal3.498693.99381K562BUD13
chr5112180562112180630+3'-UTR,intron-Distal4.800105.82129K562PUM2
chr5112175789112175859+3'-UTR,CDS,intron-Distal4.151973.73331K562RBM15
chr5112177101112177147+3'-UTR,CDS,intron-Distal3.900533.32022K562UCHL5
chr5112174957112175004+3'-UTR,CDS,intron-Distal3.331783.73423K562UCHL5
chr5112102022112102062+CDS,intron-Proximal4.220583.59941K562UCHL5
chr5112111325112111404+CDS,intron-Proximal3.522403.95301K562ZNF622
chr5112102018112102102+CDS,intron-Proximal3.715074.46864HepG2BCLAF1
chr5112090617112090726+CDS,intron-Distal,intron-Proximal3.328987.28841K562ZNF622
chr5112136973112137037+CDS,intron-Proximal3.450113.68471HepG2BCLAF1
chr5112102024112102084+CDS4.483404.90367K562ZNF622
chr5112105686112105802+intron-Distal5.344757.54661K562QKI
chr5112160801112160848+intron-Distal3.873543.29248HepG2SUGP2
chr5112161070112161125+intron-Distal4.082983.63454HepG2SUGP2
chr5112161758112161806+intron-Distal3.767793.29248HepG2SUGP2
chr5112080891112081007+intron-Distal3.023243.70419K562KHDRBS1
chr5112054143112054220+intron-Distal3.977533.04224HepG2SUGP2
chr5112045652112045739+intron-Distal4.223354.03269HepG2PTBP1
chr5112112948112113053+intron-Distal3.858323.30829HepG2CSTF2
chr5112161202112161294+intron-Distal3.830835.54651HepG2SUGP2
chr5112091759112091871+intron-Distal3.524603.27944K562PTBP1
chr5112091917112091978+intron-Distal4.519574.30178K562PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for APC is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for APC is not available on ENCORE database.

  • 97 RBPs can affect the levels of APC.  








The Knockdown/knockout RNA-Seq assay for APC is not available on ENCORE database.





97 RBPs can affect the gene expression of APC :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
APCENSG00000134982.121133.25700737.071400.620504.908304.22700HepG2AKAP1
APCENSG00000134982.12835.36640993.37730-0.249902.092701.48020HepG2AUH
APCENSG00000134982.12444.58710632.43410-0.508402.516901.62600HepG2BCCIP
APCENSG00000134982.12977.692601193.53090-0.287801.927301.42040HepG2BOP1
APCENSG00000134982.12802.70090579.428900.470103.311402.47010HepG2CIRBP
APCENSG00000134982.12434.93810577.75690-0.409703.172802.08170HepG2YBX3
APCENSG00000134982.12748.92250544.307100.460302.267601.44990HepG2DDX24
APCENSG00000134982.121021.26420706.111500.532304.207903.44970HepG2DDX3X
APCENSG00000134982.12452.64390562.29970-0.313002.497501.87220HepG2DNAJC2
APCENSG00000134982.12601.74080467.086000.365402.119101.31930HepG2EIF3D
APCENSG00000134982.121204.77670644.463700.9025010.210909.00120HepG2EIF4A3
APCENSG00000134982.12845.47650627.361800.430402.147401.53890HepG2EIF4B
APCENSG00000134982.121378.792401140.543300.273602.858902.24950HepG2ETF1
APCENSG00000134982.121422.83030955.515700.574305.070804.05840HepG2FIP1L1
APCENSG00000134982.12515.82320366.491700.493003.218702.37530HepG2FUBP3
APCENSG00000134982.12788.64760603.117400.386802.265501.66000HepG2G3BP1
APCENSG00000134982.12945.41540640.162100.562404.760903.57770HepG2G3BP2
APCENSG00000134982.12561.27980415.885500.432402.806601.90160HepG2GEMIN5
APCENSG00000134982.12857.29940637.083800.428203.162002.42710HepG2HNRNPC
APCENSG00000134982.12495.31260666.84590-0.429004.687703.82720HepG2HNRNPL
APCENSG00000134982.12835.51430613.089500.446503.033902.33210HepG2IGF2BP2
APCENSG00000134982.121396.14790650.282101.1022016.5183014.98420HepG2MAGOH
APCENSG00000134982.121120.72350653.951100.777103.993703.24840HepG2MATR3
APCENSG00000134982.121176.88450669.379200.814008.867407.76920HepG2NCBP2
APCENSG00000134982.12793.75940449.113300.821504.990003.76920HepG2PABPC1
APCENSG00000134982.12911.05170596.235700.611605.217004.23710HepG2PABPC4
APCENSG00000134982.12800.44610600.390200.414804.026903.32240HepG2PCBP1
APCENSG00000134982.12643.34220479.786800.423102.689001.89180HepG2PRPF8
APCENSG00000134982.12970.12750610.889100.667208.033207.20000HepG2PTBP1
APCENSG00000134982.121056.16640735.458900.522008.443207.52500HepG2PUM1
APCENSG00000134982.12949.12570661.672700.520405.522504.68500HepG2QKI
APCENSG00000134982.121387.665101090.041300.348203.212902.29590HepG2RBM15
APCENSG00000134982.12998.02800600.486000.732809.332308.15020HepG2RBM25
APCENSG00000134982.12993.68020679.886100.547405.013304.32100HepG2NELFE
APCENSG00000134982.12866.73520633.175700.452904.799904.01760HepG2RECQL
APCENSG00000134982.121078.36500637.344800.758605.447304.14600HepG2RPS10
APCENSG00000134982.12613.65040454.478200.433103.095702.45030HepG2RPS19
APCENSG00000134982.12705.42540541.006400.382702.317301.58160HepG2RPS2
APCENSG00000134982.12635.49560474.620700.421002.450701.70630HepG2RRP9
APCENSG00000134982.12465.18750563.60350-0.276901.896601.34690HepG2SAFB2
APCENSG00000134982.122091.538201122.905000.897202.279701.66680HepG2SF3A3
APCENSG00000134982.121448.651201173.226900.304102.118801.49550HepG2SF3B1
APCENSG00000134982.12837.82130636.068900.397403.712103.04160HepG2SF3B4
APCENSG00000134982.121581.400501076.690300.5545011.4315010.60130HepG2SRFBP1
APCENSG00000134982.121274.12610663.895900.9404022.3019021.23560HepG2SRSF1
APCENSG00000134982.12687.80940540.095600.348702.968002.40040HepG2SRSF9
APCENSG00000134982.121349.03260934.813500.529109.227708.39760HepG2SSB
APCENSG00000134982.122199.12250817.551001.4274034.4615032.18230HepG2U2AF1
APCENSG00000134982.121699.34940917.943300.888402.625301.66480HepG2U2AF2
APCENSG00000134982.12241.28160365.69880-0.599901.988901.34570HepG2UCHL5
APCENSG00000134982.121208.72330961.449400.330103.752803.07200HepG2UTP3
APCENSG00000134982.12982.90330713.651500.461702.483001.48120HepG2XRCC6
APCENSG00000134982.12447.93640609.35590-0.444002.178001.52850HepG2XRN2
APCENSG00000134982.121064.04190849.145600.325403.786903.02220HepG2ZC3H8
APCENSG00000134982.121439.778901095.239000.394506.799406.04120HepG2ZNF622
APCENSG00000134982.121250.00400784.530800.671908.558506.47120K562AARS
APCENSG00000134982.12535.81240963.53820-0.846603.712403.07270K562AGGF1
APCENSG00000134982.12434.89060578.81080-0.412403.002701.42860K562AKAP1
APCENSG00000134982.12681.558201058.58030-0.635202.450801.53490K562AKAP8
APCENSG00000134982.12625.945001002.55540-0.679602.930902.25800K562AKAP8L
APCENSG00000134982.122489.097701805.709600.463004.578203.85790K562AQR
APCENSG00000134982.121350.479301624.80950-0.266802.227501.51680K562CPSF6
APCENSG00000134982.12522.69650774.61720-0.567505.398903.84560K562CSTF2
APCENSG00000134982.12393.13500586.41290-0.576905.122303.64620K562DDX3X
APCENSG00000134982.123174.203302384.169300.412804.520903.71490K562DDX47
APCENSG00000134982.12688.130001079.13390-0.649102.446101.62980K562DKC1
APCENSG00000134982.121522.641601024.011100.572204.516302.84780K562EEF2
APCENSG00000134982.121408.73280989.465200.509605.069403.81530K562EFTUD2
APCENSG00000134982.121131.00600616.840000.874506.286704.72400K562EIF3A
APCENSG00000134982.121747.727101059.534500.721903.924902.66660K562EIF3D
APCENSG00000134982.121330.761901050.316000.341303.588802.68960K562EIF3G
APCENSG00000134982.121455.04130612.619201.2479026.2188023.37160K562EIF4A3
APCENSG00000134982.121427.700102308.73420-0.6934010.452308.68520K562FIP1L1
APCENSG00000134982.121722.46010637.091801.4348018.1532016.71310K562FXR1
APCENSG00000134982.12524.02830914.24310-0.8029010.665107.85610K562G3BP1
APCENSG00000134982.12948.77160592.639600.678805.227304.18520K562G3BP2
APCENSG00000134982.121510.12490858.775800.8142013.7111012.46760K562HNRNPC
APCENSG00000134982.121541.351403130.25490-1.0221021.7852019.73560K562HSPD1
APCENSG00000134982.12572.26720956.16830-0.740606.470404.62040K562IGF2BP2
APCENSG00000134982.12712.69380972.59450-0.448603.939002.46270K562IGF2BP3
APCENSG00000134982.12681.518201064.13650-0.642902.553701.76590K562KIF1C
APCENSG00000134982.121592.732501004.998800.664203.995002.97910K562MAGOH
APCENSG00000134982.12637.568301018.49880-0.675802.635001.59420K562MAK16
APCENSG00000134982.121625.564201002.975700.6966011.027009.07510K562MATR3
APCENSG00000134982.12779.291301192.07730-0.613202.230101.42780K562MBNL1
APCENSG00000134982.121222.561201514.21520-0.308702.561001.72280K562METAP2
APCENSG00000134982.121270.689601812.50730-0.512409.339208.07730K562NSUN2
APCENSG00000134982.122634.009101886.620300.481402.575801.39720K562PABPC1
APCENSG00000134982.12475.45140880.47760-0.889004.708203.32220K562PABPN1
APCENSG00000134982.12750.72190982.33460-0.387903.457301.94010K562PCBP1
APCENSG00000134982.121877.82140894.218901.0703022.4683019.63350K562PCBP2
APCENSG00000134982.123114.006101583.796700.9753016.0969014.14390K562PCBP3
APCENSG00000134982.122565.358201214.817401.0783024.1882022.01200K562POLR2G
APCENSG00000134982.121243.281402620.76570-1.0758022.6064019.26070K562PPIG
APCENSG00000134982.12566.508001046.66880-0.885604.484002.46270K562PPP1R8
APCENSG00000134982.121863.65780962.860500.9526015.8532014.03490K562PRPF8
APCENSG00000134982.12490.86040769.94060-0.649405.681704.31170K562PSIP1
APCENSG00000134982.121676.95420976.411500.7802013.9781012.54590K562PTBP1
APCENSG00000134982.124964.302502703.799200.8765014.8208012.91180K562PUF60
APCENSG00000134982.12571.92050994.61630-0.798302.897602.34430K562PUS1
APCENSG00000134982.12600.41920968.80830-0.690202.921402.31450K562RBM15
APCENSG00000134982.121395.75120985.312300.502304.692203.22400K562NELFE
APCENSG00000134982.12948.98270618.348300.617903.963302.73670K562RPS3
APCENSG00000134982.121552.116401082.458900.519806.098304.48580K562SAFB
APCENSG00000134982.121763.239901119.124800.655808.472406.05600K562SDAD1
APCENSG00000134982.12431.85560805.14820-0.898703.860502.36940K562SF1
APCENSG00000134982.121891.837901475.432600.358602.376801.48020K562SF3B1
APCENSG00000134982.12899.25530616.980100.543403.855802.84160K562SF3B4
APCENSG00000134982.121512.49450957.197200.659909.875508.55390K562SRSF1
APCENSG00000134982.12671.04920903.97190-0.429903.344202.17130K562SRSF5
APCENSG00000134982.121993.709501382.745600.527807.077404.65540K562SRSF9
APCENSG00000134982.12790.534501083.42510-0.454705.199203.35380K562SSB
APCENSG00000134982.121980.315501218.505500.7005012.9403011.16940K562SYNCRIP
APCENSG00000134982.121246.67220968.771000.363802.720202.01800K562TARDBP
APCENSG00000134982.12659.51340916.94600-0.475403.826902.50900K562TRA2A
APCENSG00000134982.121891.068502701.14610-0.514405.845803.70060K562TRIP6
APCENSG00000134982.121059.42000593.879100.8349010.638209.05930K562U2AF2
APCENSG00000134982.121587.145101921.83000-0.276002.143001.50470K562UPF1
APCENSG00000134982.122222.747901709.942900.378307.029305.73870K562WDR43
APCENSG00000134982.121593.174702034.40330-0.352703.019602.11280K562ZC3H8
APCENSG00000134982.121708.634601295.604500.399104.204201.98000K562ZNF800
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for APC is not available on ENCORE database.





1 RBPs can affect the splicing of APC :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEAPCENSG00000134982.12chr5+1120740491120741571120735911120736221120905691120907220.106000.006530.05791includedK562AQR
A3SSAPCENSG00000134982.12chr5+1121627681121629441121628041121629441121575921121576880.132000.019640.09389longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for APC is not avaliable on ENCORE database.