AACS

General Information

Gene Name       : AACS
Gene ID             : ENSG00000081760.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: AACS)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878AACSENSG00000081760.166.2414.0210.13ENCSR000AEF
HepG2AACSENSG00000081760.1624.2617.5620.91ENCSR985KAT
K562AACSENSG00000081760.164.505.074.79ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for AACS is not avaliable on ENCORE database.



Proteins bound to RNA
  • AACS RNA is bound by 19 proteins.  







eCLIP assay for AACS is not avaliable on ENCORE database.





19 proteins are bound to AACS RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr12125575967125576122+3'-UTR,5'-UTR,CDS,intron-Proximal4.476298.40228HepG2PPIG
chr12125627002125627067+3'-UTR3.891493.45012HepG2UPF1
chr12125576041125576116+3'-UTR,CDS,intron-Proximal4.4090411.17766HepG2PRPF8
chr12125627233125627322+3'-UTR3.364093.37083K562UPF1
chr12125587224125587293+3'-UTR,CDS,intron-Proximal4.120223.20743HepG2PPIG
chr12125609237125609330+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.747893.91876HepG2U2AF2
chr12125627334125627403+3'-UTR3.286283.86052K562YBX3
chr12125618469125618555+3'-UTR,CDS,intron-Proximal4.254754.24670HepG2SF3B4
chr12125627192125627351+3'-UTR5.2261610.05440HepG2UPF1
chr12125570891125571003+3'-UTR,CDS,intron-Proximal5.067346.71715HepG2BCLAF1
chr12125587541125587622+3'-UTR,CDS,intron-Proximal4.316383.20743HepG2PPIG
chr12125605295125605346+5'-UTR,intron-Distal4.816467.52645K562TARDBP
chr12125605522125605625+5'-UTR,intron-Distal4.411836.48336HepG2XPO5
chr12125608778125608832+5'-UTR,intron-Distal5.7305316.66352HepG2DKC1
chr12125610517125610574+5'-UTR,intron-Distal3.794243.21162HepG2HNRNPC
chr12125591794125591859+5'-UTR,CDS,intron-Proximal3.712885.73990HepG2PRPF8
chr12125605440125605582+5'-UTR,intron-Distal5.6469014.12399K562TARDBP
chr12125605346125605440+5'-UTR,intron-Distal5.5960013.12320K562TARDBP
chr12125585754125585855+5'-UTR,intron-Distal4.8156517.41591HepG2QKI
chr12125613976125614048+CDS,intron-Distal,intron-Proximal5.080488.04585HepG2PRPF8
chr12125626607125626699+CDS,intron-Proximal3.331864.18806HepG2U2AF2
chr12125550157125550268+CDS,intron-Proximal3.248966.47139HepG2PPIG
chr12125621391125621455+CDS,intron-Distal,intron-Proximal3.471345.13777HepG2PRPF8
chr12125574796125574884+intron-Distal4.319053.56692HepG2AGGF1
chr12125582544125582657+intron-Distal3.504283.76275K562PTBP1
chr12125550471125550544+intron-Distal3.834643.40087HepG2RBFOX2
chr12125574478125574567+intron-Distal4.650115.04227HepG2HNRNPL
chr12125624438125624508+intron-Distal3.138503.10640HepG2SUGP2
chr12125601403125601554+intron-Distal6.1819215.19890HepG2PCBP2
chr12125580079125580171+intron-Distal4.000483.27829HepG2MATR3
chr12125574784125574836+intron-Distal4.7948012.33615K562AGGF1
chr12125574934125575029+intron-Distal6.2016616.62195K562AGGF1
chr12125574836125574924+intron-Distal5.2926017.30888K562AGGF1
chr12125582588125582637+intron-Distal4.186353.78533HepG2PTBP1
chr12125574814125574893+intron-Distal3.600963.51804HepG2HNRNPL
chr12125574492125574527+intron-Distal4.666879.99749K562AGGF1
chr12125575210125575298+intron-Distal5.759259.70777K562AGGF1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for AACS is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for AACS is not available on ENCORE database.

  • 80 RBPs can affect the levels of AACS.  








The Knockdown/knockout RNA-Seq assay for AACS is not available on ENCORE database.





80 RBPs can affect the gene expression of AACS :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
AACSENSG00000081760.12928.840401909.30910-1.0395014.0481012.94620HepG2AKAP1
AACSENSG00000081760.12339.76240478.13990-0.492903.054502.42890HepG2BOP1
AACSENSG00000081760.12690.474701064.53930-0.6246011.9281010.74370HepG2CKAP4
AACSENSG00000081760.12684.39900993.48430-0.537702.811602.04020HepG2CNOT7
AACSENSG00000081760.12671.68570438.954800.613603.390402.63760HepG2CPSF6
AACSENSG00000081760.12893.42010712.310900.326702.748701.73380HepG2YBX3
AACSENSG00000081760.121739.894801160.501400.584208.544907.53410HepG2CELF1
AACSENSG00000081760.121419.962201828.87680-0.365102.617602.00780HepG2DDX3X
AACSENSG00000081760.12620.286401018.66810-0.7157012.2465011.03500HepG2DKC1
AACSENSG00000081760.12487.97380663.95520-0.444302.867401.73990HepG2EFTUD2
AACSENSG00000081760.12988.692501510.27460-0.611206.013405.15710HepG2EIF2S1
AACSENSG00000081760.12747.641801668.92150-1.1585017.1656015.58030HepG2EIF4A3
AACSENSG00000081760.12980.657301231.03610-0.328103.230802.34070HepG2EIF4G1
AACSENSG00000081760.12794.879201040.46750-0.388403.372402.44990HepG2EWSR1
AACSENSG00000081760.12795.505501006.19190-0.339002.581001.82010HepG2FUBP3
AACSENSG00000081760.12882.979801684.20330-0.9316013.4873012.08150HepG2FXR1
AACSENSG00000081760.121044.135401562.17110-0.581205.337504.42690HepG2G3BP1
AACSENSG00000081760.12536.88570706.13910-0.395302.597401.96930HepG2HNRNPA1
AACSENSG00000081760.12392.89200785.44800-0.9994012.6978011.31020HepG2HNRNPC
AACSENSG00000081760.12897.71610724.069000.310002.589201.89460HepG2HNRNPF
AACSENSG00000081760.121299.449901136.489900.193202.080301.48470HepG2HNRNPL
AACSENSG00000081760.12459.75690622.93250-0.438202.434301.54050HepG2HNRNPM
AACSENSG00000081760.12627.84620780.25520-0.313502.721502.11970HepG2HNRNPU
AACSENSG00000081760.121140.901001597.22260-0.485403.208802.11810HepG2KHSRP
AACSENSG00000081760.12802.317201684.79270-1.0703016.6127015.07230HepG2MAGOH
AACSENSG00000081760.12964.953201694.16840-0.812009.189208.09370HepG2MATR3
AACSENSG00000081760.12999.223501734.03170-0.795309.610908.47020HepG2NCBP2
AACSENSG00000081760.121083.612501544.06700-0.510904.426803.52650HepG2PABPC4
AACSENSG00000081760.12951.811201540.54200-0.6947015.6993014.44500HepG2PCBP1
AACSENSG00000081760.12560.19550940.15450-0.747005.309603.90290HepG2PCBP2
AACSENSG00000081760.12447.19220588.77190-0.396802.387801.63530HepG2PRPF8
AACSENSG00000081760.12754.838101567.52810-1.0543031.4117029.96920HepG2PTBP1
AACSENSG00000081760.12823.442001181.05620-0.520305.231204.44440HepG2PUF60
AACSENSG00000081760.121042.901001253.79190-0.265702.971402.36200HepG2PUM1
AACSENSG00000081760.12566.248201084.50190-0.9375023.1302021.67020HepG2PUS1
AACSENSG00000081760.121044.510401697.73760-0.7008013.1511011.93500HepG2QKI
AACSENSG00000081760.12557.22410907.07080-0.703003.831103.00580HepG2RAVER1
AACSENSG00000081760.12948.906201540.78110-0.6993010.766609.49630HepG2RBM25
AACSENSG00000081760.121224.923101744.53400-0.510209.168208.28720HepG2NELFE
AACSENSG00000081760.121307.438501624.74970-0.313503.973603.25210HepG2RECQL
AACSENSG00000081760.12474.58610780.10110-0.717007.903606.84110HepG2RPLP0
AACSENSG00000081760.12441.96380629.11860-0.509404.005503.28000HepG2RPS19
AACSENSG00000081760.12655.19340924.45080-0.496704.360803.36630HepG2RPS2
AACSENSG00000081760.12711.42010997.77290-0.488002.881502.06500HepG2RPS3A
AACSENSG00000081760.12263.77520582.39580-1.1427011.7706010.32730HepG2RRP9
AACSENSG00000081760.12877.90090694.852400.337303.494502.78570HepG2SAFB2
AACSENSG00000081760.12461.55260631.40570-0.452102.891301.92970HepG2SERBP1
AACSENSG00000081760.12644.919401055.97230-0.711405.336604.38250HepG2SF3A3
AACSENSG00000081760.12926.453001632.05460-0.8169020.7262019.35570HepG2SF3B4
AACSENSG00000081760.121479.562301132.548600.385506.659205.64590HepG2SLBP
AACSENSG00000081760.121296.986101732.73390-0.417907.484606.77090HepG2SRFBP1
AACSENSG00000081760.12810.059301703.48900-1.0724035.2765034.00970HepG2SRSF1
AACSENSG00000081760.12764.409601504.37140-0.9767029.2194027.95230HepG2SSB
AACSENSG00000081760.12959.319301531.09950-0.6745012.4111011.35270HepG2TAF15
AACSENSG00000081760.12353.21520462.85820-0.390001.957701.33450HepG2TARDBP
AACSENSG00000081760.12583.346101023.57980-0.811204.019602.74950HepG2TBRG4
AACSENSG00000081760.12397.81540758.16800-0.9304013.9319012.95870HepG2TIAL1
AACSENSG00000081760.12917.94480764.940900.263002.329301.80300HepG2TRIM56
AACSENSG00000081760.12604.82250772.41120-0.352901.831301.30950HepG2U2AF1
AACSENSG00000081760.12375.54480695.76440-0.889607.037905.39520HepG2UPF2
AACSENSG00000081760.12691.17130904.13830-0.387503.937803.24180HepG2UTP3
AACSENSG00000081760.12577.97710892.31710-0.626503.602002.13910HepG2XRCC5
AACSENSG00000081760.12710.33950997.73280-0.490102.773401.71740HepG2XRCC6
AACSENSG00000081760.12980.06080748.143200.389502.054101.42170HepG2XRN2
AACSENSG00000081760.12490.70490732.43990-0.577905.109404.24470HepG2ZC3H8
AACSENSG00000081760.12813.074501029.95410-0.341102.823602.27270HepG2ZNF622
AACSENSG00000081760.12345.84240571.32630-0.724205.514904.73570K562AQR
AACSENSG00000081760.12300.56480432.06700-0.523604.126803.35220K562DDX47
AACSENSG00000081760.12203.32970315.60660-0.634303.777302.69780K562EFTUD2
AACSENSG00000081760.12402.08760313.864800.357301.979201.35290K562EIF2S2
AACSENSG00000081760.12209.39480337.85280-0.690203.881002.63140K562EIF3D
AACSENSG00000081760.12146.49850224.06870-0.613102.588601.50450K562FKBP4
AACSENSG00000081760.12218.51380420.48410-0.944308.908507.89560K562FXR1
AACSENSG00000081760.12149.82340238.94500-0.673402.906902.17930K562G3BP2
AACSENSG00000081760.12330.91380434.96430-0.394402.333001.35280K562HNRNPA1
AACSENSG00000081760.12161.42130258.01100-0.676603.465202.80740K562HNRNPC
AACSENSG00000081760.12214.57490373.84340-0.801005.429003.64310K562HNRNPK
AACSENSG00000081760.12252.02920390.49720-0.631704.480003.09760K562HNRNPL
AACSENSG00000081760.12101.90640172.80540-0.761902.838201.89430K562HNRNPM
AACSENSG00000081760.12283.40150393.37690-0.473103.061202.17600K562MAGOH
AACSENSG00000081760.12220.90480350.01200-0.664004.241103.02480K562PCBP2
AACSENSG00000081760.12242.79900379.86390-0.645702.323401.56130K562PCBP3
AACSENSG00000081760.12505.19990670.82880-0.409103.230401.68380K562PNPT1
AACSENSG00000081760.12180.29050291.39640-0.692702.496401.73790K562POLR2G
AACSENSG00000081760.12138.69950307.12320-1.146908.461307.14420K562PRPF8
AACSENSG00000081760.12245.65330382.18860-0.637704.851103.99490K562PTBP1
AACSENSG00000081760.12397.56190712.29160-0.841308.633607.18140K562PUF60
AACSENSG00000081760.12493.26890757.74420-0.619307.131005.35790K562PUM1
AACSENSG00000081760.12598.84580742.32670-0.309902.424201.52350K562PUM2
AACSENSG00000081760.12298.22450483.76240-0.697905.052104.34670K562PUS1
AACSENSG00000081760.12146.22880259.55390-0.827803.022901.89210K562SAFB
AACSENSG00000081760.12245.24330391.95950-0.676502.591501.80140K562SF3A3
AACSENSG00000081760.12261.02970374.66970-0.521403.145102.39520K562SRSF1
AACSENSG00000081760.12203.15240297.27570-0.549202.560001.58630K562SUPV3L1
AACSENSG00000081760.12137.43500292.23970-1.088403.888002.91370K562SYNCRIP
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for AACS is not available on ENCORE database.





15 RBPs can affect the splicing of AACS :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEAACSENSG00000081760.12chr12+1255626411255629161255610361255611571255708751255709890.079000.001390.01605includedK562AQR
SEAACSENSG00000081760.12chr12+1255626411255629161255610361255611571255708751255709890.059000.000600.07656includedK562LARP4
SEAACSENSG00000081760.12chr12+125621207125621410125619339125619398125626637125627862-0.510000.001580.07155excludedK562EFTUD2
RIAACSENSG00000081760.12chr12+125609250125609570125609250125609315125609447125609570-0.097000.001850.07058excludedHepG2SFPQ
RIAACSENSG00000081760.12chr12+1256092501256095701256092501256093151256094471256095700.138000.002330.02694includedHepG2SF3A3
RIAACSENSG00000081760.12chr12+1256092501256095701256092501256093151256094471256095700.078000.000680.01766includedHepG2IGF2BP3
RIAACSENSG00000081760.12chr12+1256092501256095701256092501256093151256094471256095700.068000.000050.00325includedHepG2MATR3
RIAACSENSG00000081760.12chr12+1256092501256095701256092501256093151256094471256095700.338000.002100.07503includedHepG2HNRNPC
RIAACSENSG00000081760.12chr12+1256092501256095701256092501256093151256094471256095700.172000.007650.09638includedHepG2TIAL1
RIAACSENSG00000081760.12chr12+1256092501256095701256092501256093151256094471256095700.100000.000000.00006includedHepG2NCBP2
RIAACSENSG00000081760.12chr12+1256092501256095701256092501256093151256094471256095700.085000.003610.05070includedHepG2SRSF9
RIAACSENSG00000081760.12chr12+1256092501256095701256092501256093151256094471256095700.063000.000100.00204includedHepG2HNRNPK
MXEAACSENSG00000081760.12chr12+125609447125609570125612766125612820125609250125609315125613880125614006-0.226000.000140.020442includedHepG2KHSRP
MXEAACSENSG00000081760.12chr12+1256031861256033111256138801256140061255990221255991031256185481256186180.329000.002030.046381includedK562TARDBP
MXEAACSENSG00000081760.12chr12+1256094471256095701256127061256128201256092501256093151256138801256140060.163000.002580.030181includedHepG2SFPQ
MXEAACSENSG00000081760.12chr12+1256031861256033111256092501256095701255990221255991031256127061256128200.175000.001200.044411includedHepG2HNRNPL

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for AACS is not avaliable on ENCORE database.