XRCC3

General Information

Gene Name       : XRCC3
Gene ID             : ENSG00000126215.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: XRCC3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878XRCC3ENSG00000126215.1334.8835.4135.14ENCSR000AEF
HepG2XRCC3ENSG00000126215.1318.0622.1420.10ENCSR985KAT
K562XRCC3ENSG00000126215.1332.1239.8635.99ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for XRCC3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • XRCC3 RNA is bound by 7 proteins.  







eCLIP assay for XRCC3 is not avaliable on ENCORE database.





7 proteins are bound to XRCC3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr14104177426104177493-3'-UTR,5'-UTR,intron-Distal5.002535.94584K562PABPC4
chr14104164243104164338-3'-UTR,intron-Distal5.8548313.64218K562UPF1
chr14104164742104164862-3'-UTR,intron-Distal5.5925618.31708HepG2XPO5
chr14104177377104177491-3'-UTR,5'-UTR,CDS,intron-Distal3.056734.14964K562UPF1
chr14104164421104164528-3'-UTR,intron-Distal5.6187911.61967K562UPF1
chr14104164528104164636-3'-UTR,intron-Distal5.510188.80636K562UPF1
chr14104179292104179351-5'-UTR,intron-Distal,intron-Proximal4.177373.75568K562SLTM
chr14104179294104179372-5'-UTR,intron-Distal,intron-Proximal4.099353.80512K562CSTF2T
chr14104180388104180519-5'-UTR,intron-Distal3.411904.13833K562FUS
chr14104180293104180388-intron-Distal3.897653.99124K562FUS
chr14104179351104179452-intron-Distal,intron-Proximal3.700303.04470K562FUS
chr14104179464104179592-intron-Distal4.067774.16295K562FUS
chr14104181587104181681-intron-Distal4.687575.54520K562GTF2F1
chr14104181559104181676-intron-Distal4.561125.56287HepG2GTF2F1
chr14104179740104179830-intron-Distal3.944693.41858K562FUS
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for XRCC3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for XRCC3 is not available on ENCORE database.

  • 88 RBPs can affect the levels of XRCC3.  








The Knockdown/knockout RNA-Seq assay for XRCC3 is not available on ENCORE database.





88 RBPs can affect the gene expression of XRCC3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
XRCC3ENSG00000126215.9234.98760299.96720-0.352201.815401.30400HepG2ACO1
XRCC3ENSG00000126215.9187.85940301.35280-0.681804.971203.96990HepG2AKAP8L
XRCC3ENSG00000126215.929.50030128.85930-2.1270010.994109.50820HepG2ASCC1
XRCC3ENSG00000126215.9207.15400443.03150-1.096709.951808.78350HepG2AUH
XRCC3ENSG00000126215.9107.01380195.11190-0.866503.498002.49070HepG2BCLAF1
XRCC3ENSG00000126215.976.32900184.36100-1.272205.994605.15350HepG2BOP1
XRCC3ENSG00000126215.969.06190212.56430-1.6219012.0193010.59890HepG2CALR
XRCC3ENSG00000126215.9109.22190299.87340-1.4571017.3684016.01350HepG2CKAP4
XRCC3ENSG00000126215.9106.00680169.24350-0.674902.323801.68620HepG2CPSF6
XRCC3ENSG00000126215.9210.41930277.41360-0.398802.268501.50840HepG2DDX19B
XRCC3ENSG00000126215.985.42810163.39010-0.935504.253303.43030HepG2DDX21
XRCC3ENSG00000126215.977.13830159.94350-1.052005.080303.83440HepG2DDX24
XRCC3ENSG00000126215.971.06690149.17340-1.069704.420703.64380HepG2DDX3X
XRCC3ENSG00000126215.932.2941077.56520-1.264103.707202.21900HepG2DDX47
XRCC3ENSG00000126215.9125.46200220.85020-0.815803.212402.38810HepG2DDX55
XRCC3ENSG00000126215.982.96530192.19170-1.212004.148502.96470HepG2DDX59
XRCC3ENSG00000126215.963.62800128.19880-1.010603.412402.73450HepG2DDX6
XRCC3ENSG00000126215.9179.47080286.97990-0.677204.451203.62940HepG2DKC1
XRCC3ENSG00000126215.952.53750150.50370-1.518407.736505.92680HepG2AGO1
XRCC3ENSG00000126215.933.29730123.18530-1.887408.703707.68990HepG2EIF2S1
XRCC3ENSG00000126215.989.14800137.37720-0.623902.168701.35900HepG2EIF3D
XRCC3ENSG00000126215.9265.71100508.72000-0.937007.437406.53180HepG2ETF1
XRCC3ENSG00000126215.9193.49790303.46730-0.649202.616701.86680HepG2FIP1L1
XRCC3ENSG00000126215.995.03850154.50170-0.701002.573601.81400HepG2FUBP3
XRCC3ENSG00000126215.9299.78500137.407701.125406.677005.63100HepG2FXR1
XRCC3ENSG00000126215.9198.95940286.36550-0.525403.409102.33220HepG2HDGF
XRCC3ENSG00000126215.9124.74170228.70820-0.874605.179503.96840HepG2HNRNPA2B1
XRCC3ENSG00000126215.9213.00860298.70570-0.487802.881502.15140HepG2HNRNPF
XRCC3ENSG00000126215.982.94520183.06300-1.142105.265204.42660HepG2HNRNPLL
XRCC3ENSG00000126215.9200.86840294.13990-0.550303.039402.28340HepG2IGF2BP1
XRCC3ENSG00000126215.971.53130129.50770-0.856402.850802.16680HepG2IGF2BP2
XRCC3ENSG00000126215.9102.3891041.102301.316704.840803.20810HepG2KHDRBS1
XRCC3ENSG00000126215.9303.64770137.456101.143308.050006.94160HepG2MAGOH
XRCC3ENSG00000126215.9297.60640138.212201.106406.927305.96150HepG2MATR3
XRCC3ENSG00000126215.9112.83560206.23720-0.870104.706003.12520HepG2NAA15
XRCC3ENSG00000126215.9337.71190246.755000.452602.205801.52420HepG2NOL12
XRCC3ENSG00000126215.994.86680162.34020-0.775002.629201.89880HepG2NSUN2
XRCC3ENSG00000126215.955.88920167.83600-1.586404.592503.28030HepG2PCBP2
XRCC3ENSG00000126215.9126.16590228.46920-0.856705.675904.61000HepG2PRPF4
XRCC3ENSG00000126215.944.51430170.23930-1.9352010.109808.68620HepG2PRPF8
XRCC3ENSG00000126215.9318.25580250.062600.347802.051001.52520HepG2PUM1
XRCC3ENSG00000126215.9170.03260249.87460-0.555402.585901.93710HepG2PUM2
XRCC3ENSG00000126215.9121.81030175.17120-0.524101.943901.40560HepG2QKI
XRCC3ENSG00000126215.9165.74590299.36760-0.852906.340605.10920HepG2RBM15
XRCC3ENSG00000126215.9111.01870425.18320-1.9373018.7965017.69110HepG2RBM22
XRCC3ENSG00000126215.9101.91540158.97270-0.641402.436201.79980HepG2RBM25
XRCC3ENSG00000126215.9342.52660166.158701.043606.793305.23390HepG2RBM27
XRCC3ENSG00000126215.9253.68790179.993100.495002.163801.67350HepG2NELFE
XRCC3ENSG00000126215.9247.13620167.627100.560002.737902.12440HepG2RECQL
XRCC3ENSG00000126215.978.13360321.77840-2.0421023.0094021.43500HepG2RPLP0
XRCC3ENSG00000126215.978.10330159.17470-1.027202.718101.78210HepG2RPS10
XRCC3ENSG00000126215.937.64520168.38930-2.1613012.1643010.70390HepG2RRP9
XRCC3ENSG00000126215.997.64930181.18040-0.891703.918803.09120HepG2SF3B1
XRCC3ENSG00000126215.952.20330201.60060-1.949309.563608.12040HepG2SNRNP70
XRCC3ENSG00000126215.975.32260480.20640-2.6725028.2439027.08040HepG2SRFBP1
XRCC3ENSG00000126215.9152.90710293.46830-0.940507.926106.84880HepG2SRSF7
XRCC3ENSG00000126215.960.20410142.98500-1.247904.507803.83540HepG2SRSF9
XRCC3ENSG00000126215.9256.82840416.89380-0.698904.909204.26340HepG2SSB
XRCC3ENSG00000126215.964.62150151.30190-1.227303.361602.02880HepG2SUB1
XRCC3ENSG00000126215.9357.39350264.508200.434102.839102.21100HepG2SUCLG1
XRCC3ENSG00000126215.950.3569097.46850-0.952702.680601.37760HepG2SUGP2
XRCC3ENSG00000126215.938.20650219.81570-2.5244012.5550011.28870HepG2SUPV3L1
XRCC3ENSG00000126215.988.09650178.50220-1.018804.240103.36700HepG2TARDBP
XRCC3ENSG00000126215.9176.2541094.567400.898102.547201.51980HepG2TBRG4
XRCC3ENSG00000126215.973.85810147.31200-0.996003.401102.30580HepG2TFIP11
XRCC3ENSG00000126215.963.36250145.74190-1.201706.176905.48300HepG2TIAL1
XRCC3ENSG00000126215.9329.99490230.143300.519802.191801.42020HepG2TUFM
XRCC3ENSG00000126215.9148.82680259.59700-0.802603.748103.01970HepG2U2AF1
XRCC3ENSG00000126215.9134.46150242.53010-0.851005.894104.93640HepG2UPF1
XRCC3ENSG00000126215.9161.72360249.28370-0.624303.501602.33890HepG2UTP18
XRCC3ENSG00000126215.959.17180266.73600-2.1724028.0998026.82100HepG2ZNF622
XRCC3ENSG00000126215.9704.91140938.86310-0.413502.643802.06680K562AQR
XRCC3ENSG00000126215.9448.22390317.281700.498402.367501.40140K562CSTF2
XRCC3ENSG00000126215.91221.446501475.09760-0.272202.522301.59170K562CELF1
XRCC3ENSG00000126215.9370.35490215.862400.778706.376905.18520K562EIF3G
XRCC3ENSG00000126215.9342.02580470.14380-0.459002.508601.44230K562FKBP4
XRCC3ENSG00000126215.996.73640191.21900-0.983104.575103.61480K562G3BP2
XRCC3ENSG00000126215.9577.65680420.021400.459602.586701.68960K562HNRNPM
XRCC3ENSG00000126215.9483.90460294.885500.714502.666201.66430K562IGF2BP2
XRCC3ENSG00000126215.9147.29230275.19460-0.901803.975102.84020K562KRR1
XRCC3ENSG00000126215.9372.45510524.29120-0.493303.452201.86110K562LARP7
XRCC3ENSG00000126215.9472.93850309.823900.610104.825003.70630K562MAGOH
XRCC3ENSG00000126215.9452.69740309.181800.550004.127702.98380K562MATR3
XRCC3ENSG00000126215.9456.10550651.41890-0.514202.743501.86520K562NAA15
XRCC3ENSG00000126215.9345.63100461.97770-0.418602.535001.36240K562NCBP2
XRCC3ENSG00000126215.9744.78770579.694600.361402.253201.51420K562PPIG
XRCC3ENSG00000126215.9456.65320301.020000.601104.899304.03960K562PTBP1
XRCC3ENSG00000126215.91114.355501392.23380-0.321203.043901.92150K562PUM1
XRCC3ENSG00000126215.9505.01680775.27580-0.618404.820204.12870K562PUS1
XRCC3ENSG00000126215.9501.27750295.109900.764307.019505.90110K562SRSF1
XRCC3ENSG00000126215.9548.36820298.648900.876608.576507.24270K562TARDBP
XRCC3ENSG00000126215.9437.20730288.086300.601704.477403.39890K562TIA1
XRCC3ENSG00000126215.9415.02850282.749400.553603.416802.17630K562TRA2A
XRCC3ENSG00000126215.9522.50750375.755200.475602.619601.45330K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for XRCC3 is not available on ENCORE database.





2 RBPs can affect the splicing of XRCC3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEXRCC3ENSG00000126215.9chr14-104179211104179268104177802104177904104181760104181820-0.228000.009300.07666excludedK562AQR
SEXRCC3ENSG00000126215.9chr14-1041792111041793051041778021041779041041817601041817800.463000.000030.02151includedHepG2BCCIP
A3SSXRCC3ENSG00000126215.9chr14-1041657001041659251041657001041659131041695091041697100.111000.020160.09600longerK562AQR
A3SSXRCC3ENSG00000126215.9chr14-1041773691041776031041773691041775821041778021041779980.115000.000000.00000longerK562AQR
A3SSXRCC3ENSG00000126215.9chr14-1041654691041655491041654691041655161041657001041659130.058000.005880.03333longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for XRCC3 is not avaliable on ENCORE database.