USP40

General Information

Gene Name       : USP40
Gene ID             : ENSG00000085982.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: USP40)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878USP40ENSG00000085982.139.159.479.31ENCSR000AEF
HepG2USP40ENSG00000085982.1324.2921.4522.87ENCSR985KAT
K562USP40ENSG00000085982.137.676.246.96ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for USP40 is not avaliable on ENCORE database.



Proteins bound to RNA
  • USP40 RNA is bound by 16 proteins.  







eCLIP assay for USP40 is not avaliable on ENCORE database.





16 proteins are bound to USP40 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2234384998234385079-3'-UTR,intron-Distal3.360403.07801K562UPF1
chr2234385568234385642-3'-UTR,intron-Distal4.560015.94150HepG2UPF1
chr2234394501234394622-3'-UTR,CDS,intron-Distal3.7029610.46300HepG2PPIG
chr2234384414234384489-3'-UTR,intron-Distal3.225444.05213HepG2LSM11
chr2234397971234398029-3'-UTR,CDS,intron-Distal,intron-Proximal4.780036.01989HepG2PRPF8
chr2234420354234420428-5'-UTR,CDS,intron-Distal,intron-Proximal4.6792911.38699HepG2PPIG
chr2234420409234420438-5'-UTR,CDS,intron-Distal,intron-Proximal4.319366.23296HepG2BCLAF1
chr2234399647234399743-CDS,intron-Distal,intron-Proximal4.2048910.13167HepG2U2AF2
chr2234399808234399906-CDS,intron-Distal,intron-Proximal3.490504.73488HepG2GRWD1
chr2234457864234457875-CDS,intron-Distal5.424597.95223HepG2BCLAF1
chr2234399651234399734-CDS,intron-Distal,intron-Proximal3.796673.01911HepG2U2AF1
chr2234436205234436225-CDS,intron-Distal,intron-Proximal4.950115.03746HepG2BCLAF1
chr2234405402234405430-CDS,intron-Distal,intron-Proximal3.846597.83567HepG2BCLAF1
chr2234421214234421268-CDS,intron-Distal,intron-Proximal3.974137.28307HepG2BCLAF1
chr2234460055234460100-CDS,intron-Distal3.617227.42278HepG2BCLAF1
chr2234465553234465633-CDS,intron-Distal3.318763.63043HepG2GRWD1
chr2234434136234434146-CDS,intron-Distal,intron-Proximal3.554104.09885HepG2BCLAF1
chr2234460020234460055-CDS,intron-Distal,intron-Proximal4.2878610.24470HepG2BCLAF1
chr2234457747234457762-CDS,intron-Distal4.124074.93978HepG2BCLAF1
chr2234463027234463095-CDS,intron-Distal4.2467613.37200HepG2BCLAF1
chr2234463024234463139-CDS,intron-Distal,intron-Proximal4.094593.43980K562ZNF622
chr2234402157234402198-CDS,intron-Distal,intron-Proximal4.512879.80976HepG2BCLAF1
chr2234418721234418767-CDS,intron-Distal3.097813.41665HepG2GRWD1
chr2234418768234418782-CDS,intron-Distal,intron-Proximal4.393964.08604HepG2PPIG
chr2234418711234418768-CDS,intron-Distal3.091933.22545HepG2PPIG
chr2234402066234402120-CDS,intron-Distal,intron-Proximal3.200546.00907HepG2PPIG
chr2234463025234463130-CDS,intron-Distal,intron-Proximal4.346709.37945HepG2GRWD1
chr2234436020234436087-CDS,intron-Distal,intron-Proximal5.5611531.55603HepG2PRPF8
chr2234465503234465569-CDS,intron-Distal3.399136.59678HepG2BCLAF1
chr2234429637234429697-CDS,intron-Distal5.3446416.89254HepG2BCLAF1
chr2234405403234405438-CDS,intron-Distal,intron-Proximal3.357613.40321HepG2GRWD1
chr2234402176234402198-CDS,intron-Distal,intron-Proximal3.357195.30777HepG2PPIG
chr2234433137234433156-CDS,intron-Distal,intron-Proximal3.665306.67313HepG2BCLAF1
chr2234435989234436086-CDS,intron-Distal,intron-Proximal3.074845.19487K562PRPF8
chr2234442232234442286-CDS,intron-Distal4.593119.30195HepG2BCLAF1
chr2234438076234438115-CDS,intron-Distal,intron-Proximal5.7103811.85134HepG2BCLAF1
chr2234405403234405429-CDS,intron-Distal,intron-Proximal3.142425.97777HepG2PPIG
chr2234436134234436159-CDS,intron-Distal3.837625.06180HepG2BCLAF1
chr2234399893234399907-CDS,intron-Distal4.308413.79199HepG2PPIG
chr2234434140234434234-CDS,intron-Distal,intron-Proximal4.209315.67291HepG2U2AF2
chr2234428261234428279-CDS,intron-Distal4.916556.37937HepG2BCLAF1
chr2234420357234420402-CDS,intron-Distal4.264126.22576HepG2BCLAF1
chr2234450925234451001-CDS,intron-Distal3.223453.73413HepG2PPIG
chr2234442122234442159-CDS,intron-Distal,intron-Proximal3.305355.40132HepG2BCLAF1
chr2234418704234418762-CDS,intron-Distal3.622558.25092HepG2BCLAF1
chr2234407193234407232-CDS,intron-Distal,intron-Proximal4.076284.04622HepG2GRWD1
chr2234429697234429739-CDS,intron-Distal4.5299613.19442HepG2BCLAF1
chr2234429739234429760-CDS,intron-Distal3.4556610.08874HepG2BCLAF1
chr2234443895234443963-intron-Distal4.062503.54208HepG2SUGP2
chr2234422108234422180-intron-Distal3.676537.15670HepG2HNRNPL
chr2234461691234461777-intron-Distal5.160888.32953HepG2QKI
chr2234397513234397561-intron-Distal4.400265.65979HepG2PTBP1
chr2234438947234439056-intron-Distal3.044973.48890K562KHSRP
chr2234434847234434915-intron-Distal4.7993012.88973HepG2QKI
chr2234413862234414003-intron-Distal4.415523.27829HepG2MATR3
chr2234427900234427944-intron-Distal4.072473.48210HepG2HNRNPL
chr2234444139234444210-intron-Distal4.270024.36036HepG2SUGP2
chr2234395639234395759-intron-Distal3.211294.40773HepG2SUGP2
chr2234462766234462795-intron-Distal4.570615.03746HepG2BCLAF1
chr2234426437234426510-intron-Distal3.5947710.48875HepG2HNRNPL
chr2234462771234462862-intron-Distal3.145825.40232HepG2U2AF2
chr2234439076234439200-intron-Distal3.336385.36888K562KHSRP
chr2234435587234435645-intron-Distal3.379763.64762HepG2QKI
chr2234423075234423208-intron-Distal4.8504821.28489HepG2QKI
chr2234411431234411471-intron-Distal4.053543.04224HepG2SUGP2
chr2234456415234456524-intron-Distal3.165993.51804HepG2HNRNPL
chr2234422759234422815-intron-Distal4.690575.51162HepG2U2AF2
chr2234452652234452732-intron-Distal3.763675.37814HepG2HNRNPM
chr2234427814234427876-intron-Distal4.159424.45537HepG2HNRNPL
chr2234462958234463006-intron-Distal,intron-Proximal3.689976.46902HepG2U2AF2
chr2234422027234422108-intron-Distal4.0066311.50587HepG2HNRNPL
chr2234438284234438332-intron-Distal3.709314.36528HepG2U2AF2
chr2234460233234460360-intron-Distal,intron-Proximal3.193683.53952HepG2KHSRP
chr2234462337234462390-intron-Distal4.342755.04227HepG2HNRNPL
chr2234441593234441647-intron-Distal5.157888.48075HepG2PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for USP40 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for USP40 is not available on ENCORE database.

  • 98 RBPs can affect the levels of USP40.  








The Knockdown/knockout RNA-Seq assay for USP40 is not available on ENCORE database.





98 RBPs can affect the gene expression of USP40 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
USP40ENSG00000085982.91908.629801463.143200.383402.662801.73760HepG2ABCF1
USP40ENSG00000085982.9882.802201207.74400-0.452203.235602.11400HepG2AKAP8
USP40ENSG00000085982.91219.066401419.25300-0.219402.064501.38860HepG2AKAP8L
USP40ENSG00000085982.91682.315101137.926400.563905.527304.43660HepG2ASCC1
USP40ENSG00000085982.91613.688502105.68190-0.383906.148505.18920HepG2AUH
USP40ENSG00000085982.9833.581401109.97490-0.413103.355902.70370HepG2BOP1
USP40ENSG00000085982.91498.450701081.104600.470904.105303.17380HepG2CIRBP
USP40ENSG00000085982.91689.788701412.296300.258703.468302.73920HepG2CKAP4
USP40ENSG00000085982.91268.37350914.733800.471502.374401.66940HepG2CNOT7
USP40ENSG00000085982.91351.693701019.017700.407503.256602.51640HepG2CPSF6
USP40ENSG00000085982.91287.177301509.28400-0.229702.069901.49990HepG2CELF1
USP40ENSG00000085982.91398.755501622.85760-0.214402.455101.75120HepG2DAZAP1
USP40ENSG00000085982.91597.402201306.490200.289904.056003.06980HepG2DDX19B
USP40ENSG00000085982.91351.061601053.529700.358802.910902.21700HepG2DDX21
USP40ENSG00000085982.91577.706901057.143300.577604.764003.13600HepG2DDX27
USP40ENSG00000085982.9808.736001157.16940-0.516902.398501.48860HepG2DDX59
USP40ENSG00000085982.9823.779401131.63340-0.458102.981302.34220HepG2DDX6
USP40ENSG00000085982.91194.57410889.597900.425203.815502.67320HepG2DHX30
USP40ENSG00000085982.91238.49000922.341000.425105.294304.34860HepG2DNAJC21
USP40ENSG00000085982.91413.139801084.137000.382302.843901.91120HepG2EEF2
USP40ENSG00000085982.91407.206001087.926700.371202.574702.00280HepG2EIF2S1
USP40ENSG00000085982.91224.00130994.841300.299002.379601.37780HepG2EIF3G
USP40ENSG00000085982.92510.290901202.316001.0619016.0289014.50430HepG2EIF4A3
USP40ENSG00000085982.92010.983701170.567900.780607.099606.02620HepG2EIF4B
USP40ENSG00000085982.91933.130201601.042800.271803.372102.46420HepG2EIF4G1
USP40ENSG00000085982.91907.781901533.697600.314802.413601.65060HepG2EIF4G2
USP40ENSG00000085982.9943.038101380.37250-0.549706.742305.44300HepG2EWSR1
USP40ENSG00000085982.91260.786601003.939100.328602.600301.48670HepG2FASTKD2
USP40ENSG00000085982.9915.428201477.40640-0.690506.767805.61970HepG2FIP1L1
USP40ENSG00000085982.91178.43980785.108300.585806.629305.44260HepG2FUBP3
USP40ENSG00000085982.91588.426701212.998500.388902.903102.19340HepG2FXR1
USP40ENSG00000085982.91752.943901125.280200.639406.475905.48210HepG2G3BP1
USP40ENSG00000085982.91821.956901194.568800.608906.688305.29190HepG2G3BP2
USP40ENSG00000085982.91574.94320931.177300.7581011.3376010.16950HepG2HNRNPA1
USP40ENSG00000085982.9818.289801035.76350-0.340002.373701.72600HepG2HNRNPC
USP40ENSG00000085982.91528.084401300.141500.233002.121701.48720HepG2HNRNPF
USP40ENSG00000085982.91616.609501102.368300.552305.604704.74160HepG2HNRNPLL
USP40ENSG00000085982.91576.763601028.915600.6157013.2370011.98750HepG2HNRNPU
USP40ENSG00000085982.91572.636001280.260000.296602.579001.88040HepG2IGF2BP1
USP40ENSG00000085982.91780.419901143.839200.638207.000405.97460HepG2IGF2BP2
USP40ENSG00000085982.91235.883101051.003100.233702.735402.00630HepG2ILF2
USP40ENSG00000085982.91638.347601150.476000.509903.564702.40760HepG2KHSRP
USP40ENSG00000085982.91641.371301186.853900.467704.818103.20410HepG2LIN28B
USP40ENSG00000085982.92129.728401213.421600.8115010.791209.51960HepG2MAGOH
USP40ENSG00000085982.91551.488801124.270600.464602.436701.53200HepG2MTPAP
USP40ENSG00000085982.91299.953401021.980300.347002.745401.33490HepG2NIP7
USP40ENSG00000085982.91261.11060977.459700.367502.749202.00340HepG2NSUN2
USP40ENSG00000085982.9482.59990835.95380-0.792604.788703.59700HepG2PABPC1
USP40ENSG00000085982.91477.447601112.353400.409403.039602.28530HepG2PABPC4
USP40ENSG00000085982.91537.408701185.665600.374705.265404.47090HepG2PCBP1
USP40ENSG00000085982.91217.73540917.710300.408004.844103.89700HepG2PPIL4
USP40ENSG00000085982.9959.531301536.14120-0.678909.646308.62560HepG2PUF60
USP40ENSG00000085982.91669.504301306.613500.353503.889103.16540HepG2QKI
USP40ENSG00000085982.9698.403201117.88810-0.678603.746002.93070HepG2RAVER1
USP40ENSG00000085982.9795.192301185.84450-0.576506.818305.80030HepG2RBM25
USP40ENSG00000085982.92010.383701342.676200.5823012.0348011.05730HepG2NELFE
USP40ENSG00000085982.91678.273601250.536800.424303.306502.64090HepG2RECQL
USP40ENSG00000085982.91437.03070918.184900.646104.974903.90190HepG2RPS3A
USP40ENSG00000085982.91237.45930916.294300.433406.653105.71830HepG2SAFB2
USP40ENSG00000085982.9909.245501640.55970-0.851408.642707.39640HepG2SF3A3
USP40ENSG00000085982.91742.641801472.915300.242503.117902.37990HepG2SLBP
USP40ENSG00000085982.91414.967302282.29430-0.6897020.0121018.98720HepG2SRFBP1
USP40ENSG00000085982.91818.327201516.713000.261603.104102.44630HepG2SRSF5
USP40ENSG00000085982.91496.685701277.374600.228502.096001.48050HepG2SRSF7
USP40ENSG00000085982.91390.269601066.635900.382205.595104.85810HepG2SRSF9
USP40ENSG00000085982.92874.430401981.530600.5366013.7766012.80710HepG2SSB
USP40ENSG00000085982.9501.86690798.60130-0.670204.967103.44790HepG2STIP1
USP40ENSG00000085982.92108.837001724.922800.289804.506903.74840HepG2SUCLG1
USP40ENSG00000085982.91797.432201124.690400.676307.197006.18810HepG2SUPV3L1
USP40ENSG00000085982.9759.245401074.46560-0.501004.402203.51550HepG2TARDBP
USP40ENSG00000085982.91572.51760999.780100.6533010.738009.86380HepG2TIAL1
USP40ENSG00000085982.9856.484401008.72130-0.236002.139701.63150HepG2TRIM56
USP40ENSG00000085982.9642.248501263.78230-0.9765013.7854012.34650HepG2U2AF1
USP40ENSG00000085982.9534.519501517.24260-1.505106.301804.73950HepG2U2AF2
USP40ENSG00000085982.91188.439701495.45300-0.331503.977602.74450HepG2UTP18
USP40ENSG00000085982.9775.053901404.67290-0.8579021.4266019.99250HepG2UTP3
USP40ENSG00000085982.91342.834801170.878900.197601.943001.36520HepG2ZC3H8
USP40ENSG00000085982.91175.068101600.13940-0.445508.965608.12560HepG2ZNF622
USP40ENSG00000085982.9322.98780663.34500-1.0383016.8038015.52930K562AGGF1
USP40ENSG00000085982.9559.99280728.84540-0.380202.764001.78270K562AKAP8
USP40ENSG00000085982.9344.57380690.22320-1.0022012.9361011.37310K562AKAP8L
USP40ENSG00000085982.9396.88310669.84180-0.755106.736105.88560K562AQR
USP40ENSG00000085982.9437.52880724.17750-0.727009.745807.90120K562ATP5C1
USP40ENSG00000085982.9693.71630902.73340-0.380003.144702.10690K562CELF1
USP40ENSG00000085982.9502.46360742.83830-0.564006.730105.26810K562DKC1
USP40ENSG00000085982.9624.04810468.472200.413602.525801.83260K562EIF2S2
USP40ENSG00000085982.9449.81400283.439900.666205.142104.02110K562EIF4A3
USP40ENSG00000085982.9274.43890392.30020-0.515503.004502.11810K562FIP1L1
USP40ENSG00000085982.9232.10980554.70770-1.256903.700202.21950K562HNRNPA2B1
USP40ENSG00000085982.9544.70150434.546300.325902.098801.32260K562HNRNPU
USP40ENSG00000085982.9479.40500732.56010-0.611705.742904.45440K562KIF1C
USP40ENSG00000085982.9455.24100701.19100-0.623202.333801.37430K562MAK16
USP40ENSG00000085982.9520.67620820.64380-0.656407.293905.68140K562MBNL1
USP40ENSG00000085982.9487.69010386.423700.335702.314101.57220K562MTPAP
USP40ENSG00000085982.9284.21680575.20660-1.017108.181506.35230K562NAA15
USP40ENSG00000085982.9305.72280445.34080-0.542703.549302.60100K562PPIG
USP40ENSG00000085982.9290.31140684.63600-1.2377016.0582014.79190K562PUS1
USP40ENSG00000085982.9301.19180666.97190-1.1469018.3046016.74730K562RBM15
USP40ENSG00000085982.9260.18890358.38900-0.462002.550101.74700K562RBM22
USP40ENSG00000085982.9117.13860218.74480-0.901005.123003.22920K562RBM25
USP40ENSG00000085982.9324.80880194.128600.742503.897502.68430K562RPS3
USP40ENSG00000085982.9123.00970444.24390-1.852605.235603.41350K562SF1
USP40ENSG00000085982.9319.66590423.68950-0.406402.282001.53600K562SF3A3
USP40ENSG00000085982.9151.88350239.80820-0.658903.843802.83030K562SF3B4
USP40ENSG00000085982.9249.25260509.88350-1.032602.747201.52290K562SNRNP200
USP40ENSG00000085982.9271.27910366.56640-0.434302.318001.66380K562SRSF1
USP40ENSG00000085982.9102.83590223.54550-1.120206.557204.72220K562U2AF1
USP40ENSG00000085982.9142.62770230.88130-0.694903.864902.91520K562U2AF2
USP40ENSG00000085982.9692.29800455.193200.604807.630406.51090K562UPF1
USP40ENSG00000085982.9420.52310694.02420-0.722803.178301.75960K562UTP18
USP40ENSG00000085982.9589.21250754.61560-0.357002.447401.64400K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for USP40 is not available on ENCORE database.





5 RBPs can affect the splicing of USP40 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEUSP40ENSG00000085982.9chr2-234420354234420443234418694234418781234428259234428317-0.103000.000000.00008excludedHepG2U2AF2
SEUSP40ENSG00000085982.9chr2-234434123234434208234433137234433208234436052234436224-0.201000.004400.04182excludedK562AQR
SEUSP40ENSG00000085982.9chr2-2344015162344017092343997812343999072344020702344021230.060000.000370.03059includedHepG2HNRNPL
SEUSP40ENSG00000085982.9chr2-2343996032343997172343980102343981292343998122343999070.237000.001380.04347includedK562UTP18
A3SSUSP40ENSG00000085982.9chr2-2344212142344213252344212142344212682344282592344283170.265000.000780.02167longerHepG2U2AF2
A3SSUSP40ENSG00000085982.9chr2-2344380762344383162344380762344381582344421242344424250.273000.015510.07691longerK562AQR
A3SSUSP40ENSG00000085982.9chr2-2344380762344383162344380762344381582344421242344424250.401000.000030.04323longerK562IGF2BP2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for USP40 is not avaliable on ENCORE database.