TSC1

General Information

Gene Name       : TSC1
Gene ID             : ENSG00000165699.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: TSC1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TSC1ENSG00000165699.1416.6314.4015.52ENCSR000AEF
HepG2TSC1ENSG00000165699.1416.6619.2417.95ENCSR985KAT
K562TSC1ENSG00000165699.1412.2413.0612.65ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TSC1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TSC1 RNA is bound by 27 proteins.  







eCLIP assay for TSC1 is not avaliable on ENCORE database.





27 proteins are bound to TSC1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr9135810373135810539-5'-UTR,intron-Distal,intron-Proximal4.8997310.03191K562SF3B4
chr9135804256135804318-5'-UTR,CDS,intron-Distal3.079725.24703K562BUD13
chr9135804263135804394-5'-UTR,intron-Distal,intron-Proximal3.8413613.83283K562SF3B4
chr9135810424135810483-5'-UTR,intron-Distal,intron-Proximal3.985235.24452HepG2PPIG
chr9135804259135804341-5'-UTR,intron-Distal,intron-Proximal4.100896.36347HepG2PPIG
chr9135802584135802635-CDS,intron-Distal,intron-Proximal3.570993.63043HepG2GRWD1
chr9135772028135772118-CDS,intron-Distal3.351313.54210HepG2EIF3H
chr9135786077135786133-CDS,intron-Distal,intron-Proximal4.311916.59856K562SF3B4
chr9135777026135777087-CDS,intron-Distal,intron-Proximal3.983074.04622HepG2GRWD1
chr9135787825135787900-CDS,intron-Distal,intron-Proximal3.713955.47851K562SF3B4
chr9135777018135777078-CDS,intron-Distal3.300624.26492HepG2BCLAF1
chr9135796745135796804-CDS,intron-Distal,intron-Proximal4.026978.12130HepG2PPIG
chr9135772580135772652-CDS,intron-Distal4.395027.97334HepG2BCLAF1
chr9135796748135796792-CDS,intron-Distal,intron-Proximal5.099417.05570HepG2BCLAF1
chr9135798851135798938-CDS,intron-Distal,intron-Proximal3.969438.08874K562SF3B4
chr9135781480135781554-CDS,intron-Distal,intron-Proximal3.107243.80468K562BUD13
chr9135798831135798900-CDS,intron-Distal,intron-Proximal4.170897.39410K562BUD13
chr9135797152135797207-CDS,intron-Distal,intron-Proximal3.150674.38107K562AQR
chr9135802591135802663-CDS,intron-Distal3.898817.86788K562YBX3
chr9135798733135798770-CDS,intron-Distal,intron-Proximal3.842627.28307HepG2BCLAF1
chr9135786835135786950-CDS,intron-Distal,intron-Proximal3.667506.42383HepG2GRWD1
chr9135798813135798903-CDS,intron-Distal,intron-Proximal3.300863.74832K562U2AF2
chr9135781075135781123-CDS,intron-Distal4.055643.73331K562RBM15
chr9135781389135781449-CDS,intron-Distal4.240403.81597K562RBM15
chr9135781263135781346-CDS,intron-Distal3.747315.71420K562RBM15
chr9135778120135778168-CDS,intron-Distal4.630114.70478HepG2BCLAF1
chr9135798824135798900-CDS,intron-Distal,intron-Proximal3.274138.01175HepG2U2AF2
chr9135781267135781344-CDS,intron-Distal3.698734.35442HepG2RBM15
chr9135786848135786922-CDS,intron-Distal3.064426.38443HepG2BCLAF1
chr9135781476135781550-CDS,intron-Distal,intron-Proximal3.791628.36335HepG2U2AF2
chr9135798840135798924-CDS,intron-Distal,intron-Proximal3.800456.79537K562AQR
chr9135797320135797350-CDS,intron-Distal3.676663.87469HepG2BCLAF1
chr9135796746135796835-CDS,intron-Distal,intron-Proximal3.067924.35477K562UCHL5
chr9135776999135777082-CDS,intron-Distal3.267143.17151K562UCHL5
chr9135781141135781188-CDS,intron-Distal4.002193.73331K562RBM15
chr9135779698135779819-CDS,intron-Distal,intron-Proximal3.318744.07440K562PRPF8
chr9135798731135798765-CDS,intron-Distal,intron-Proximal3.238873.65452K562BUD13
chr9135798838135798907-CDS,intron-Distal,intron-Proximal3.026383.52329HepG2U2AF1
chr9135798853135798896-CDS,intron-Distal,intron-Proximal3.242274.73001HepG2SF3A3
chr9135798863135798941-CDS,intron-Distal,intron-Proximal5.6661413.25000HepG2SF3B4
chr9135781493135781588-CDS,intron-Distal,intron-Proximal4.896873.91589K562SF3B4
chr9135771758135771804-CDS,intron-Distal4.602563.33922HepG2EIF3H
chr9135779698135779849-CDS,intron-Distal,intron-Proximal4.049855.47926K562AQR
chr9135781267135781352-CDS,intron-Distal3.190924.14618K562ZNF622
chr9135780968135781035-CDS,intron-Distal3.300604.27261HepG2GRWD1
chr9135786848135786933-CDS,intron-Distal3.279216.21602K562ZNF622
chr9135786286135786359-intron-Distal,intron-Proximal3.731409.33622K562TIA1
chr9135819303135819364-intron-Distal3.077713.25653K562CSTF2T
chr9135819421135819492-intron-Distal4.348883.41592K562XRCC6
chr9135819428135819482-intron-Distal3.887514.85687K562DROSHA
chr9135819123135819180-intron-Distal4.082904.32964K562HNRNPM
chr9135798926135799080-intron-Distal,intron-Proximal4.004145.95946K562KHSRP
chr9135794803135794854-intron-Distal3.844943.95434K562HNRNPM
chr9135794813135794876-intron-Distal4.288134.64592HepG2HNRNPM
chr9135819413135819470-intron-Distal4.658355.54639K562CSTF2T
chr9135795544135795609-intron-Distal4.783296.41216K562EXOSC5
chr9135793997135794080-intron-Distal4.175837.32380K562HNRNPM
chr9135819853135819907-intron-Distal3.124023.01436K562CSTF2T
chr9135794796135794850-intron-Distal4.873096.73731K562EXOSC5
chr9135819431135819519-intron-Distal3.322633.51298K562AKAP8L
chr9135810246135810361-intron-Distal,intron-Proximal4.211774.75425K562EFTUD2
chr9135795042135795118-intron-Distal3.689235.22442K562MATR3
chr9135819819135819902-intron-Distal4.021583.88726HepG2TIAL1
chr9135819117135819185-intron-Distal4.237184.13641K562TARDBP
chr9135798896135798939-intron-Distal,intron-Proximal4.834497.17972HepG2SF3A3
chr9135793963135794112-intron-Distal6.1955017.32358K562EXOSC5
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TSC1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TSC1 is not available on ENCORE database.

  • 73 RBPs can affect the levels of TSC1.  








The Knockdown/knockout RNA-Seq assay for TSC1 is not available on ENCORE database.





73 RBPs can affect the gene expression of TSC1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TSC1ENSG00000165699.91902.398201477.021000.365006.133705.30050HepG2ACO1
TSC1ENSG00000165699.91303.230501644.50610-0.335601.930401.47700HepG2AKAP1
TSC1ENSG00000165699.92599.151001853.266100.4879010.430609.23920HepG2AUH
TSC1ENSG00000165699.91639.061401317.879100.314602.439501.87360HepG2BOP1
TSC1ENSG00000165699.92442.386001593.446200.616004.032203.10310HepG2CNOT7
TSC1ENSG00000165699.91345.471201595.20530-0.245602.176501.59580HepG2CELF1
TSC1ENSG00000165699.92061.819201715.014000.265604.342603.44780HepG2DAZAP1
TSC1ENSG00000165699.91057.285501575.33430-0.575305.367104.52250HepG2DDX3X
TSC1ENSG00000165699.91320.917101053.943100.325602.550701.60860HepG2DHX30
TSC1ENSG00000165699.9911.096201083.13220-0.249502.611401.97490HepG2DNAJC2
TSC1ENSG00000165699.9831.805901065.60040-0.357302.405601.37460HepG2EFTUD2
TSC1ENSG00000165699.92507.437501300.908600.9466014.8912013.58440HepG2EIF2S1
TSC1ENSG00000165699.92305.921301437.681700.681507.215506.18330HepG2EIF4A3
TSC1ENSG00000165699.92873.294702127.779600.433308.611907.65180HepG2ETF1
TSC1ENSG00000165699.91157.188001443.13870-0.318602.692601.86820HepG2EWSR1
TSC1ENSG00000165699.92255.540301819.803600.309601.987101.32830HepG2FIP1L1
TSC1ENSG00000165699.91505.525701000.441900.589507.549006.28950HepG2FUBP3
TSC1ENSG00000165699.92113.203201345.577600.651106.945405.91050HepG2G3BP1
TSC1ENSG00000165699.91773.134601428.451700.311702.133101.35680HepG2G3BP2
TSC1ENSG00000165699.91666.723701320.363200.336003.948903.10800HepG2HNRNPF
TSC1ENSG00000165699.9836.382001255.72110-0.586306.946305.54060HepG2HNRNPM
TSC1ENSG00000165699.9762.202001219.00110-0.6775013.5296012.26970HepG2HNRNPU
TSC1ENSG00000165699.91575.131301300.166900.276702.053901.42400HepG2IGF2BP1
TSC1ENSG00000165699.91440.387501245.165900.210002.456901.76200HepG2ILF2
TSC1ENSG00000165699.91137.599201519.21200-0.417302.624201.47210HepG2KHDRBS1
TSC1ENSG00000165699.9911.229601459.12500-0.679206.445305.51510HepG2MATR3
TSC1ENSG00000165699.91112.521301473.04410-0.405003.683302.75210HepG2MSI2
TSC1ENSG00000165699.91402.158001700.61630-0.278402.459301.74320HepG2NOL12
TSC1ENSG00000165699.91291.407801623.44900-0.330102.641402.05670HepG2PUF60
TSC1ENSG00000165699.91441.080201723.43520-0.258103.247502.61610HepG2PUM1
TSC1ENSG00000165699.92066.815001722.131300.263102.679202.01890HepG2PUM2
TSC1ENSG00000165699.92056.887901547.023300.410905.500704.66430HepG2QKI
TSC1ENSG00000165699.93223.850401778.433700.8581025.9421024.68080HepG2RBM22
TSC1ENSG00000165699.91091.356401384.61970-0.343402.433901.51010HepG2RBM27
TSC1ENSG00000165699.91960.467401422.562900.462604.428903.59490HepG2RPLP0
TSC1ENSG00000165699.91898.122201295.470900.551006.445505.40590HepG2SF3B1
TSC1ENSG00000165699.91084.249301265.92990-0.223502.382001.77910HepG2SMN1
TSC1ENSG00000165699.93859.817902008.682000.9422045.7775044.38610HepG2SRFBP1
TSC1ENSG00000165699.91812.880101262.916300.5214011.1718010.19350HepG2SRSF9
TSC1ENSG00000165699.92115.099401744.023100.278203.876803.29250HepG2SSB
TSC1ENSG00000165699.92079.731601395.349800.5757010.847209.85290HepG2TAF15
TSC1ENSG00000165699.92004.969201556.845600.364903.217702.54390HepG2U2AF1
TSC1ENSG00000165699.91245.519401756.78360-0.496208.980308.00170HepG2UTP3
TSC1ENSG00000165699.91721.634701368.427200.331205.213104.33970HepG2ZC3H8
TSC1ENSG00000165699.94585.617101033.270002.1498091.1566088.26520K562AQR
TSC1ENSG00000165699.91073.84160734.599000.547704.844803.67760K562BOP1
TSC1ENSG00000165699.91747.471701053.849500.729504.690603.26240K562CNOT7
TSC1ENSG00000165699.9989.04660781.026900.340602.637101.87010K562CPSF6
TSC1ENSG00000165699.9890.09240638.517100.479103.196602.07910K562EIF3D
TSC1ENSG00000165699.91263.84540628.891501.0068017.5767015.35940K562EIF4A3
TSC1ENSG00000165699.91769.643101332.362500.409406.109004.72690K562EIF4G2
TSC1ENSG00000165699.9738.58890527.829600.484603.273902.02760K562FKBP4
TSC1ENSG00000165699.91075.25890794.797400.435903.412302.45940K562FMR1
TSC1ENSG00000165699.9929.26390673.715100.463803.313202.30590K562FTO
TSC1ENSG00000165699.9830.50220654.025700.344502.532901.94820K562FXR1
TSC1ENSG00000165699.9926.95590745.638500.313902.046701.36020K562GPKOW
TSC1ENSG00000165699.9791.36950607.774300.380702.732502.13910K562HNRNPC
TSC1ENSG00000165699.9531.27890739.33800-0.476803.017302.03920K562HNRNPM
TSC1ENSG00000165699.9983.596701218.62770-0.309102.130101.42870K562HSPD1
TSC1ENSG00000165699.91443.93420962.261300.585403.027901.53400K562ILF2
TSC1ENSG00000165699.9907.53870636.813400.511003.103402.10770K562KRR1
TSC1ENSG00000165699.9946.79040789.645900.261702.214901.48780K562MTPAP
TSC1ENSG00000165699.91087.68170877.409700.309803.083602.29980K562NSUN2
TSC1ENSG00000165699.91399.22750995.493400.491004.005503.00410K562PCBP3
TSC1ENSG00000165699.91094.49560763.592500.519305.913104.74590K562POLR2G
TSC1ENSG00000165699.9896.73890580.328200.627705.683404.60810K562PRPF8
TSC1ENSG00000165699.9520.49470762.81380-0.551405.598604.68300K562PTBP1
TSC1ENSG00000165699.92329.908201453.721900.6804010.583708.97480K562PUF60
TSC1ENSG00000165699.91401.23990999.763500.486904.536803.86470K562PUS1
TSC1ENSG00000165699.9746.63310504.932400.564202.753501.34500K562RAVER1
TSC1ENSG00000165699.91464.32760810.167500.853803.778401.91520K562RBM39
TSC1ENSG00000165699.9995.66600602.168800.725402.566201.42480K562SF1
TSC1ENSG00000165699.91092.84990865.716700.336003.241002.36180K562SF3A3
TSC1ENSG00000165699.9965.65600709.310900.445002.910901.91150K562SF3B1
TSC1ENSG00000165699.91313.07900886.939800.5659010.717809.01780K562SRPK2
TSC1ENSG00000165699.9765.48090561.876500.446002.802901.78020K562SUPV3L1
TSC1ENSG00000165699.9666.82600529.639000.332202.287001.55800K562U2AF2
TSC1ENSG00000165699.91151.11640930.332800.307103.185102.41710K562UPF1
TSC1ENSG00000165699.91078.31590796.061900.437704.163503.08300K562WDR3
TSC1ENSG00000165699.91108.43440827.774500.421105.858604.67650K562WDR43
TSC1ENSG00000165699.91465.723301163.882800.332602.778901.91420K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TSC1 is not available on ENCORE database.





14 RBPs can affect the splicing of TSC1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETSC1ENSG00000165699.9chr9-1358188541358190931358104191358104821358199291358200200.304000.003490.05715includedHepG2U2AF1
SETSC1ENSG00000165699.9chr9-135796749135796823135787668135787844135797205135797360-0.162000.001890.05124excludedK562AKAP8L
SETSC1ENSG00000165699.9chr9-135772570135772732135766736135772141135772809135772997-0.175000.000000.00000excludedHepG2U2AF2
SETSC1ENSG00000165699.9chr9-135796749135796823135787652135787844135797205135797360-0.212000.000030.00064excludedK562AQR
SETSC1ENSG00000165699.9chr9-135796749135796823135787668135787844135797205135797360-0.206000.000070.00173excludedK562PUS1
SETSC1ENSG00000165699.9chr9-1358065951358068141358041531358043391358104191358104820.060000.000180.01631includedHepG2NCBP2
SETSC1ENSG00000165699.9chr9-1358065951358068141358041531358043391358104191358104820.104000.001810.04089includedHepG2SRSF1
SETSC1ENSG00000165699.9chr9-135810419135810482135804153135804339135819958135819982-0.129000.001070.02875excludedK562RBM15
A3SSTSC1ENSG00000165699.9chr9-135786388135786602135786388135786500135786839135786955-0.314000.000000.00484shorterK562FXR2
A3SSTSC1ENSG00000165699.9chr9-1357863881357866021357863881357865001357868391357869550.156000.000100.01398longerK562AKAP8L
A3SSTSC1ENSG00000165699.9chr9-135786388135786602135786388135786500135786839135786955-0.154000.000010.01369shorterK562PPIL4
A3SSTSC1ENSG00000165699.9chr9-1357863881357866021357863881357865001357868391357869550.308000.001100.05610longerK562SF3B4
A3SSTSC1ENSG00000165699.9chr9-135785957135786079135785957135786076135786839135786955-0.091000.000180.05441shorterK562HNRNPUL1
A3SSTSC1ENSG00000165699.9chr9-1357972051357973891357972051357973601357987341357988790.101000.000010.00009longerK562AQR
A3SSTSC1ENSG00000165699.9chr9-1357790371357792391357790371357792041357797971357798410.288000.000010.00013longerK562AQR
A3SSTSC1ENSG00000165699.9chr9-1357779911357782361357779911357781741357790371357791890.177000.001080.00746longerK562AQR
A3SSTSC1ENSG00000165699.9chr9-1357821171357822421357821171357822221357826871357827570.260000.002620.01635longerK562AQR
A3SSTSC1ENSG00000165699.9chr9-1357863881357866021357863881357865001357868391357869550.124000.004330.02547longerK562AQR
A3SSTSC1ENSG00000165699.9chr9-135787652135787877135787652135787844135797205135797387-0.760000.009480.05054shorterK562AQR
A3SSTSC1ENSG00000165699.9chr9-135798697135798919135798697135798879135804153135804342-0.457000.018970.09114shorterK562AQR
A3SSTSC1ENSG00000165699.9chr9-1357863881357866021357863881357865001357868391357869550.307000.000000.00000longerK562PUS1
A3SSTSC1ENSG00000165699.9chr9-1357863881357866021357863881357865001357868391357869550.202000.000000.00092longerK562RBM15
A3SSTSC1ENSG00000165699.9chr9-135786388135786602135786388135786500135786839135786955-0.155000.000460.05617shorterK562HNRNPC
MXETSC1ENSG00000165699.9chr9-135802587135802691135804153135804339135798734135798879135810419135810482-0.112000.013880.082342includedK562AQR
MXETSC1ENSG00000165699.9chr9-1358009731358011261358025871358026911357987341357988791358041531358043420.470000.000020.026441includedK562RPS3

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TSC1 is not avaliable on ENCORE database.