SPTLC1

General Information

Gene Name       : SPTLC1
Gene ID             : ENSG00000090054.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SPTLC1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SPTLC1ENSG00000090054.1444.0738.2241.14ENCSR000AEF
HepG2SPTLC1ENSG00000090054.1443.6964.6254.16ENCSR985KAT
K562SPTLC1ENSG00000090054.1456.2967.9762.13ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SPTLC1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SPTLC1 RNA is bound by 18 proteins.  







eCLIP assay for SPTLC1 is not avaliable on ENCORE database.





18 proteins are bound to SPTLC1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr99484179294841834-3'-UTR,intron-Distal3.467583.12941K562UCHL5
chr99484163294841769-3'-UTR,intron-Distal,intron-Proximal3.388676.57673K562KHSRP
chr99479463894794735-3'-UTR,intron-Distal4.122348.48553HepG2LIN28B
chr99479475894794846-CDS,intron-Distal3.788094.68902HepG2PPIG
chr99483026294830320-CDS,intron-Distal3.418043.17744HepG2GRWD1
chr99487481594874860-CDS,intron-Distal,intron-Proximal3.304503.65452K562BUD13
chr99482155194821593-CDS,intron-Distal,intron-Proximal3.800104.54968K562PUM2
chr99480946894809549-CDS,intron-Distal3.831404.67599HepG2SND1
chr99483032094830382-CDS,intron-Distal,intron-Proximal4.630084.91614HepG2GRWD1
chr99484315094843183-CDS,intron-Distal,intron-Proximal3.236275.13799K562SND1
chr99483032194830375-CDS,intron-Distal3.804835.15500HepG2BCLAF1
chr99483031694830371-CDS,intron-Distal4.098035.08388K562UCHL5
chr99481224994812348-CDS,intron-Distal3.498597.20615HepG2BCLAF1
chr99480939494809466-CDS,intron-Distal,intron-Proximal3.653386.74060K562PRPF8
chr99481755994817695-CDS,intron-Distal,intron-Proximal3.388105.96041K562KHSRP
chr99481224894812318-CDS,intron-Distal4.1603711.23424HepG2SND1
chr99480940794809459-CDS,intron-Distal,intron-Proximal4.942344.86944K562AQR
chr99483032894830378-CDS,intron-Distal3.392076.97987K562ZNF622
chr99484229994842356-CDS,intron-Distal4.1162110.71118K562ZNF622
chr99482502494825088-intron-Distal4.272283.30696K562EXOSC5
chr99483252194832602-intron-Distal3.520053.32861HepG2U2AF2
chr99487748994877549-intron-Distal3.538674.28285K562AQR
chr99485107594851240-intron-Distal4.270024.78128HepG2SUGP2
chr99487755594877595-intron-Distal3.388893.04871K562AQR
chr99486298794863053-intron-Distal3.419643.90822HepG2HNRNPM
chr99483290394833019-intron-Distal3.333806.39842HepG2QKI
chr99480445194804597-intron-Distal3.435094.18806HepG2U2AF2
chr99479608594796153-intron-Distal4.773198.64310HepG2AQR
chr99485808694858161-intron-Distal4.306914.53347HepG2SUGP2
chr99481758494817687-intron-Distal,intron-Proximal4.305926.35873K562PRPF8
chr99481211394812180-intron-Distal,intron-Proximal4.245663.49003K562PRPF8
chr99479606194796133-intron-Distal5.6528218.05428K562SF3B4
chr99485347894853556-intron-Distal3.689603.06150K562KHSRP
chr99485713294857205-intron-Distal3.270024.08528HepG2SUGP2
chr99481757294817684-intron-Distal,intron-Proximal3.531115.34337K562AQR
chr99479604994796158-intron-Distal3.614997.12014K562AQR
chr99479698594797092-intron-Distal,intron-Proximal3.964544.49024K562AQR
chr99481216294812241-intron-Distal,intron-Proximal3.683426.32052K562AQR
chr99483858594838662-intron-Distal3.659234.38996HepG2HNRNPM
chr99482485494824915-intron-Distal4.007023.01456K562EXOSC5
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SPTLC1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SPTLC1 is not available on ENCORE database.

  • 74 RBPs can affect the levels of SPTLC1.  








The Knockdown/knockout RNA-Seq assay for SPTLC1 is not available on ENCORE database.





74 RBPs can affect the gene expression of SPTLC1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SPTLC1ENSG00000090054.9653.756101212.50820-0.8912020.8548019.03610HepG2AKAP8L
SPTLC1ENSG00000090054.92011.727201486.160100.436705.475704.43830HepG2CALR
SPTLC1ENSG00000090054.91027.507301206.59170-0.231802.417001.78730HepG2CKAP4
SPTLC1ENSG00000090054.9357.265901144.05680-1.6791049.9427046.49030HepG2DDX1
SPTLC1ENSG00000090054.91262.08310970.657000.378703.358202.34620HepG2DDX24
SPTLC1ENSG00000090054.91086.291701772.14300-0.706107.965506.95410HepG2DDX3X
SPTLC1ENSG00000090054.9842.152301451.26730-0.7852010.584008.75830HepG2DDX5
SPTLC1ENSG00000090054.9881.123701111.91180-0.335604.347903.56390HepG2DNAJC2
SPTLC1ENSG00000090054.91108.098501463.43450-0.401302.958502.34500HepG2EIF2S1
SPTLC1ENSG00000090054.92142.147901853.813800.208502.367501.80350HepG2ETF1
SPTLC1ENSG00000090054.91174.522101513.67710-0.366002.396401.77460HepG2G3BP1
SPTLC1ENSG00000090054.9591.85100920.13190-0.636605.808604.50700HepG2GEMIN5
SPTLC1ENSG00000090054.91303.700601705.51730-0.387602.729002.09200HepG2GPKOW
SPTLC1ENSG00000090054.9552.702101426.14960-1.3676054.2080051.70420HepG2HNRNPL
SPTLC1ENSG00000090054.91062.730502209.60250-1.0560013.8925012.06750HepG2LARP4
SPTLC1ENSG00000090054.9647.357201680.06350-1.3759024.8889023.12350HepG2NCBP2
SPTLC1ENSG00000090054.9672.937201496.30290-1.1529018.3038016.49990HepG2PABPC4
SPTLC1ENSG00000090054.91245.691501437.78180-0.206901.979001.45200HepG2PCBP1
SPTLC1ENSG00000090054.9917.046801116.18010-0.283502.528001.82020HepG2PPIL4
SPTLC1ENSG00000090054.91669.458101216.630900.456407.535006.33580HepG2PRPF4
SPTLC1ENSG00000090054.9978.399901462.96650-0.5804010.519009.58540HepG2PTBP1
SPTLC1ENSG00000090054.91317.520001573.25290-0.255903.185302.55950HepG2PUM1
SPTLC1ENSG00000090054.91851.761701572.085000.236102.080301.49390HepG2PUM2
SPTLC1ENSG00000090054.9956.596001229.17880-0.361704.772004.00490HepG2PUS1
SPTLC1ENSG00000090054.91241.733201584.49320-0.351703.881903.15880HepG2QKI
SPTLC1ENSG00000090054.91785.407101549.453600.204401.867701.42040HepG2RBM22
SPTLC1ENSG00000090054.91174.300201628.16630-0.471407.662506.84270HepG2NELFE
SPTLC1ENSG00000090054.91249.224701516.37020-0.279603.181902.52700HepG2RECQL
SPTLC1ENSG00000090054.9531.265501009.23940-0.9258011.702009.83640HepG2SERBP1
SPTLC1ENSG00000090054.92180.605601610.984600.436704.340203.47400HepG2SF3B1
SPTLC1ENSG00000090054.9705.646701785.40050-1.339204.834502.84070HepG2SFPQ
SPTLC1ENSG00000090054.91019.466701792.51320-0.814206.620205.40330HepG2SNRNP70
SPTLC1ENSG00000090054.91243.794601750.06570-0.492709.804309.01850HepG2SRFBP1
SPTLC1ENSG00000090054.91351.166401589.85960-0.234702.640402.17520HepG2SRSF1
SPTLC1ENSG00000090054.91126.491901293.41650-0.199301.880901.41000HepG2SRSF9
SPTLC1ENSG00000090054.91198.398401519.49720-0.342504.613603.98500HepG2SSB
SPTLC1ENSG00000090054.91125.345601428.96650-0.344603.962703.31080HepG2TAF15
SPTLC1ENSG00000090054.91232.143701586.54920-0.364702.956102.20960HepG2TARDBP
SPTLC1ENSG00000090054.9844.439001215.99560-0.526106.521705.81420HepG2TIAL1
SPTLC1ENSG00000090054.9537.826501226.87410-1.1898036.4196034.66620HepG2TRIM56
SPTLC1ENSG00000090054.9956.491601408.29890-0.558105.531404.66050HepG2U2AF1
SPTLC1ENSG00000090054.91273.710701547.33090-0.280703.466602.69900HepG2UPF1
SPTLC1ENSG00000090054.9642.61860902.31700-0.489702.197301.30840HepG2UPF2
SPTLC1ENSG00000090054.91721.374701493.887400.204401.891201.37600HepG2UTP3
SPTLC1ENSG00000090054.9758.277901032.56330-0.445402.507301.47050HepG2XPO5
SPTLC1ENSG00000090054.9844.885401356.88910-0.683505.180803.75640HepG2XRCC6
SPTLC1ENSG00000090054.9651.88980969.90400-0.573204.360103.45580HepG2XRN2
SPTLC1ENSG00000090054.9970.356801200.64530-0.307203.703102.94530HepG2ZC3H8
SPTLC1ENSG00000090054.91398.657201701.76800-0.283004.242503.60400HepG2ZNF622
SPTLC1ENSG00000090054.91999.761501595.770400.325504.570203.87270K562AGGF1
SPTLC1ENSG00000090054.92072.659601742.206800.250502.513901.64560K562ATP5C1
SPTLC1ENSG00000090054.9983.640301183.18220-0.266502.632501.69920K562BCLAF1
SPTLC1ENSG00000090054.91938.986902318.63140-0.258002.935301.79280K562CPEB4
SPTLC1ENSG00000090054.91321.687201772.66550-0.423504.858403.82370K562CPSF6
SPTLC1ENSG00000090054.9304.74440801.94400-1.3959010.016106.66900K562DDX1
SPTLC1ENSG00000090054.9910.480901124.44340-0.304502.288201.34390K562DDX3X
SPTLC1ENSG00000090054.92266.529301786.834600.343004.622503.44680K562DKC1
SPTLC1ENSG00000090054.91374.408201612.98110-0.230902.071601.43370K562EIF2S2
SPTLC1ENSG00000090054.91316.439401803.59780-0.454204.446903.36070K562FMR1
SPTLC1ENSG00000090054.91436.819201221.736500.233802.173501.62570K562FXR1
SPTLC1ENSG00000090054.9729.01090989.62930-0.440902.963101.48670K562GEMIN5
SPTLC1ENSG00000090054.91625.702602149.62110-0.403003.847102.96130K562GRSF1
SPTLC1ENSG00000090054.91914.866101456.029000.395103.177601.84570K562HNRNPK
SPTLC1ENSG00000090054.91032.928402168.21070-1.0698025.3133022.26970K562HNRNPL
SPTLC1ENSG00000090054.92131.931201762.198000.274702.236201.50440K562KIF1C
SPTLC1ENSG00000090054.91256.856801528.95120-0.282702.287501.45530K562MATR3
SPTLC1ENSG00000090054.91312.880201652.04000-0.331502.849501.95850K562METAP2
SPTLC1ENSG00000090054.91277.963701671.32370-0.387105.938304.78660K562MTPAP
SPTLC1ENSG00000090054.91791.181701383.699800.372302.092301.34770K562NAA15
SPTLC1ENSG00000090054.91458.634101856.98860-0.348306.629305.54210K562NSUN2
SPTLC1ENSG00000090054.91662.780802047.96530-0.300602.295201.54890K562PPIG
SPTLC1ENSG00000090054.91267.74300960.568200.400203.214502.40550K562PRPF8
SPTLC1ENSG00000090054.92033.962701646.789600.304502.121401.63340K562PUS1
SPTLC1ENSG00000090054.91883.134701604.493000.230902.067701.54150K562RBM15
SPTLC1ENSG00000090054.91433.537201832.37700-0.354104.502203.48280K562SF3A3
SPTLC1ENSG00000090054.91081.282401978.66040-0.871804.555802.71710K562SFPQ
SPTLC1ENSG00000090054.91678.006701207.418900.474706.175104.94110K562SYNCRIP
SPTLC1ENSG00000090054.91118.072501476.77480-0.401403.297202.52330K562TARDBP
SPTLC1ENSG00000090054.91142.454901424.48260-0.318302.768201.95050K562TIA1
SPTLC1ENSG00000090054.9764.602201276.72000-0.739703.959102.78410K562TRIM56
SPTLC1ENSG00000090054.91048.225601342.44550-0.356903.451402.55570K562U2AF2
SPTLC1ENSG00000090054.91714.348101969.00460-0.199802.046001.42210K562UPF1
SPTLC1ENSG00000090054.91405.473701684.81470-0.261502.110301.34710K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SPTLC1 is not available on ENCORE database.





11 RBPs can affect the splicing of SPTLC1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESPTLC1ENSG00000090054.9chr9-9487720394877348948747369487484494877595948776640.136000.000000.00000includedK562AQR
SESPTLC1ENSG00000090054.9chr9-948422979484237094830247948303809487102194871116-0.075000.000440.00611excludedK562AQR
SESPTLC1ENSG00000090054.9chr9-948772039487734894874736948748449487759594877664-0.084000.000190.03759excludedK562DROSHA
SESPTLC1ENSG00000090054.9chr9-9484171594841848948302479483038094842297948423700.065000.000710.04391includedHepG2NCBP2
SESPTLC1ENSG00000090054.9chr9-9487720394877348948747369487484494877595948776640.077000.000010.02792includedK562DDX6
SESPTLC1ENSG00000090054.9chr9-9481257794812773948122419481234994817686948177760.181000.000000.00000includedHepG2HNRNPL
SESPTLC1ENSG00000090054.9chr9-9484171594841848948302479483038094842297948423700.079000.000770.05537includedHepG2HNRNPL
SESPTLC1ENSG00000090054.9chr9-9481257794812773948122419481234994817686948177760.529000.000000.00000includedK562HNRNPL
SESPTLC1ENSG00000090054.9chr9-9484171594841848948302479483038094842297948423700.075000.000020.00282includedK562HNRNPL
SESPTLC1ENSG00000090054.9chr9-948772039487734894874736948748449487759594877664-0.055000.001730.05122excludedK562UTP18
SESPTLC1ENSG00000090054.9chr9-948772039487734894874736948748449487759594877664-0.052000.003540.07047excludedK562RBM15
A3SSSPTLC1ENSG00000090054.9chr9-9480052994800766948005299480064794808280948083620.090000.000000.00000longerK562AQR
A3SSSPTLC1ENSG00000090054.9chr9-9480945394809633948094539480955094809894948100540.056000.000000.00003longerK562AQR
A3SSSPTLC1ENSG00000090054.9chr9-9479709194797303947970919479716594800529948007400.103000.000000.00000longerK562AQR
A3SSSPTLC1ENSG00000090054.9chr9-9479463594794870947946359479484094797091947971650.068000.000000.00000longerK562AQR
MXESPTLC1ENSG00000090054.9chr9-9481257794812773948166989481679894812241948123499481768694817776-0.334000.000610.053822includedK562HNRNPL
MXESPTLC1ENSG00000090054.9chr9-9483907994839317948417159484184894830247948303809484229794842370-0.229000.000460.032232includedK562UTP18
MXESPTLC1ENSG00000090054.9chr9-94839079948393179484171594841848948302479483038094842297948423700.302000.004200.090901includedK562EFTUD2
MXESPTLC1ENSG00000090054.9chr9-9483907994839317948417159484184894830247948303809484229794842370-0.163000.007800.083982includedHepG2HNRNPUL1
MXESPTLC1ENSG00000090054.9chr9-9483907994839317948417159484184894830247948303809484229794842370-0.299000.000000.000752includedK562SBDS
MXESPTLC1ENSG00000090054.9chr9-9483907994839317948417159484184894830247948303809484229794842370-0.213000.000080.005712includedK562PPIL4

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SPTLC1 is not avaliable on ENCORE database.