SMC5

General Information

Gene Name       : SMC5
Gene ID             : ENSG00000198887.8
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SMC5)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SMC5ENSG00000198887.834.0226.3630.19ENCSR000AEF
HepG2SMC5ENSG00000198887.88.4318.5613.49ENCSR985KAT
K562SMC5ENSG00000198887.815.0516.7615.91ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SMC5 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SMC5 RNA is bound by 21 proteins.  







eCLIP assay for SMC5 is not avaliable on ENCORE database.





21 proteins are bound to SMC5 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr97296965772969763+3'-UTR4.966228.06346K562KHSRP
chr97287394572874049+5'-UTR,CDS3.605654.27210HepG2NCBP2
chr97291496172915047+CDS,intron-Proximal3.026306.16987K562UCHL5
chr97289229772892389+CDS,intron-Proximal4.048637.06029HepG2GRWD1
chr97287922972879285+CDS4.068363.18234K562BUD13
chr97296290472962951+CDS4.605659.14010HepG2BCLAF1
chr97289222672892321+CDS4.9985911.80957HepG2BCLAF1
chr97287411272874178+CDS3.778327.10975K562UCHL5
chr97289577972895814+CDS3.492743.73423K562UCHL5
chr97289340572893444+CDS,intron-Proximal4.315864.01763HepG2GRWD1
chr97288283772882893+CDS,intron-Proximal3.460497.59700K562ZNF622
chr97288285172882888+CDS3.187845.63425HepG2BCLAF1
chr97288283872882896+CDS,intron-Proximal3.371066.27819HepG2PPIG
chr97293045172930489+CDS3.969145.79432HepG2BCLAF1
chr97289738372897499+CDS6.2934718.45048HepG2BCLAF1
chr97287930772879364+CDS,intron-Proximal3.436954.24993HepG2PPIG
chr97289222572892258+CDS,intron-Proximal3.398433.90826K562ZNF622
chr97289578272895815+CDS3.537596.06436HepG2BCLAF1
chr97290112872901179+CDS5.130116.58593HepG2BCLAF1
chr97291307772913135+CDS4.471028.41475HepG2BCLAF1
chr97289340672893429+CDS,intron-Proximal3.104923.59602K562UCHL5
chr97287922672879289+CDS4.327428.27215K562ZNF622
chr97287931472879359+CDS4.223047.16838HepG2BCLAF1
chr97287928972879362+CDS,intron-Proximal4.6838411.63999K562ZNF622
chr97292022172920274+CDS4.585158.41475HepG2BCLAF1
chr97291308572913138+CDS,intron-Proximal3.330496.32494K562UCHL5
chr97287929172879362+CDS,intron-Proximal4.644955.35719HepG2GRWD1
chr97289340572893468+CDS,intron-Proximal5.1390714.71257HepG2BCLAF1
chr97293374972933868+CDS4.894996.92104HepG2GRWD1
chr97288283872882892+CDS,intron-Proximal3.394994.24070HepG2GRWD1
chr97293372872933770+CDS3.471834.22563K562UCHL5
chr97289234472892388+CDS3.131646.29223K562UCHL5
chr97291504072915115+CDS4.4336313.19442HepG2BCLAF1
chr97287930472879363+CDS,intron-Proximal3.354324.86973K562UCHL5
chr97287414972874225+CDS,intron-Proximal4.280035.05356HepG2PRPF8
chr97293380772933854+CDS5.283828.41647HepG2BCLAF1
chr97291496972915075+CDS3.203675.74981HepG2GRWD1
chr97296145972961562+CDS,intron-Proximal3.4569210.73881K562AQR
chr97291291872913072+CDS3.200688.77286K562UCHL5
chr97287401872874105+CDS3.265117.58463K562ZNF622
chr97289230372892388+CDS4.6965310.62290K562ZNF622
chr97293372672933776+CDS3.097845.00751HepG2BCLAF1
chr97291294372913043+CDS3.662178.94096K562ZNF622
chr97289222672892285+CDS3.992746.40330K562UCHL5
chr97287411772874171+CDS3.748656.44455K562ZNF622
chr97289235372892388+CDS4.7728111.47391HepG2BCLAF1
chr97291302272913138+CDS,intron-Proximal3.255033.46619K562GRWD1
chr97287922672879280+CDS4.095203.90287K562LIN28B
chr97287922572879294+CDS5.296995.73530K562DDX24
chr97287922372879291+CDS4.444765.13243HepG2GRWD1
chr97289744172897488+CDS3.559403.90826K562ZNF622
chr97289222372892305+CDS,intron-Proximal3.306573.34034HepG2HLTF
chr97289745072897480+CDS3.670814.40383K562UCHL5
chr97293053872930696+intron-Distal,intron-Proximal3.109103.73266K562KHSRP
chr97293714472937212+intron-Distal3.727584.78196HepG2PTBP1
chr97294547972945490+intron-Distal3.162733.85440HepG2HNRNPC
chr97289936272899455+intron-Distal4.231484.72162K562KHSRP
chr97291918072919281+intron-Distal4.475094.36866HepG2ILF3
chr97290099172901055+intron-Distal,intron-Proximal3.076953.55116K562KHSRP
chr97288836872888434+intron-Distal3.874363.45805K562KHSRP
chr97295155472951674+intron-Distal4.097743.42844K562KHSRP
chr97288845172888518+intron-Distal3.609103.02234K562KHSRP
chr97289015872890204+intron-Distal3.931733.24322HepG2MATR3
chr97291993372920045+intron-Distal4.053133.45805K562KHSRP
chr97289887172898958+intron-Distal3.148103.73266K562KHSRP
chr97293400772934093+intron-Distal4.413858.31636HepG2U2AF2
chr97291834272918524+intron-Distal3.290804.52210K562KHSRP
chr97293814972938219+intron-Distal3.902563.16986HepG2QKI
chr97289138672891490+intron-Distal3.868263.24603K562KHSRP
chr97295919572959252+intron-Proximal4.603314.65563K562AQR
chr97296143972961514+intron-Proximal3.113955.12902K562SF3B4
chr97296146072961515+intron-Proximal4.425213.93614HepG2AQR
chr97293908472939141+intron-Proximal5.211537.84090K562RBM22
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SMC5 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SMC5 is not available on ENCORE database.

  • 66 RBPs can affect the levels of SMC5.  








The Knockdown/knockout RNA-Seq assay for SMC5 is not available on ENCORE database.





66 RBPs can affect the gene expression of SMC5 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SMC5ENSG00000198887.71014.640001231.80850-0.279803.146002.50450HepG2ACO1
SMC5ENSG00000198887.71010.391901278.62160-0.339701.842401.39860HepG2AKAP1
SMC5ENSG00000198887.7962.132701237.66680-0.363304.401403.44910HepG2AKAP8L
SMC5ENSG00000198887.7721.479601057.98380-0.552304.584603.58590HepG2ASCC1
SMC5ENSG00000198887.7560.40340974.65940-0.798406.660705.17170HepG2BCCIP
SMC5ENSG00000198887.71174.127101841.19520-0.649108.629507.64230HepG2BOP1
SMC5ENSG00000198887.7959.355701231.62600-0.360405.076204.22580HepG2CKAP4
SMC5ENSG00000198887.71311.527101690.33200-0.366102.870302.17270HepG2CPSF6
SMC5ENSG00000198887.7970.641801139.28560-0.231102.345101.57240HepG2DDX19B
SMC5ENSG00000198887.7694.67480940.46130-0.437003.106902.39160HepG2DDX21
SMC5ENSG00000198887.7751.92100948.57680-0.335202.367201.46090HepG2DHX30
SMC5ENSG00000198887.7694.20700974.83700-0.489807.626706.61680HepG2DNAJC2
SMC5ENSG00000198887.71417.399101088.306900.381101.996501.40590HepG2EIF4B
SMC5ENSG00000198887.7965.98250632.256100.611406.657505.46870HepG2FUBP3
SMC5ENSG00000198887.7807.350501046.23280-0.373902.263301.65800HepG2G3BP1
SMC5ENSG00000198887.7537.05470763.07570-0.506803.741202.68450HepG2GEMIN5
SMC5ENSG00000198887.71520.212301916.16300-0.333902.168301.59770HepG2GPKOW
SMC5ENSG00000198887.7940.833401176.07620-0.322003.581202.48060HepG2HDGF
SMC5ENSG00000198887.7453.154601104.43560-1.2852023.4780021.68340HepG2HNRNPC
SMC5ENSG00000198887.71094.335201278.65650-0.224602.032201.44300HepG2HNRNPL
SMC5ENSG00000198887.71267.557501828.62600-0.528705.280604.44110HepG2HNRNPLL
SMC5ENSG00000198887.7620.387201097.13280-0.8225017.5968016.17130HepG2HNRNPU
SMC5ENSG00000198887.7874.415401120.68260-0.358005.135104.16300HepG2ILF2
SMC5ENSG00000198887.7871.125101126.08040-0.370405.132503.75220HepG2KIF1C
SMC5ENSG00000198887.7766.68170978.55250-0.352003.384202.57620HepG2PPIL4
SMC5ENSG00000198887.7695.55320931.17010-0.420904.891703.89300HepG2PRPF4
SMC5ENSG00000198887.7897.457901328.50440-0.565907.058706.16330HepG2PUF60
SMC5ENSG00000198887.7941.037501254.68930-0.415006.155705.30210HepG2PUS1
SMC5ENSG00000198887.71463.276101847.14380-0.336103.326402.39500HepG2RBM15
SMC5ENSG00000198887.71174.206601373.73710-0.226401.928201.47500HepG2RBM22
SMC5ENSG00000198887.71501.620801030.202100.543506.843005.82320HepG2RBM25
SMC5ENSG00000198887.71381.297801086.444600.346303.032702.39110HepG2RECQL
SMC5ENSG00000198887.7965.021101296.01940-0.425502.891802.19530HepG2RPLP0
SMC5ENSG00000198887.7625.12170833.90170-0.415703.301802.63760HepG2RPS19
SMC5ENSG00000198887.7953.957901139.37780-0.256202.809602.16160HepG2SMN1
SMC5ENSG00000198887.71511.549202013.93590-0.414002.106801.42780HepG2SNRNP70
SMC5ENSG00000198887.72004.312801551.607600.369206.319305.64640HepG2SRFBP1
SMC5ENSG00000198887.72194.334101138.998000.9459032.7033031.47080HepG2SRSF1
SMC5ENSG00000198887.71125.172601311.59270-0.221202.298001.72070HepG2SRSF5
SMC5ENSG00000198887.7920.141101182.11110-0.361403.875203.07150HepG2SRSF7
SMC5ENSG00000198887.71130.24130926.655000.286403.077402.50120HepG2SRSF9
SMC5ENSG00000198887.71697.736801347.201200.333504.869504.22600HepG2SSB
SMC5ENSG00000198887.71233.360201782.23840-0.531105.750204.76060HepG2TARDBP
SMC5ENSG00000198887.7732.229201066.02030-0.541906.364305.66280HepG2TIAL1
SMC5ENSG00000198887.7575.153001075.60260-0.9031020.6768019.31620HepG2TRIM56
SMC5ENSG00000198887.71790.036701313.597600.446402.940502.29390HepG2U2AF1
SMC5ENSG00000198887.71147.941901709.36470-0.5744012.4639011.17790HepG2UPF1
SMC5ENSG00000198887.71387.147701757.00600-0.341002.800001.74770HepG2UTP18
SMC5ENSG00000198887.71529.490001101.703600.473202.767801.50140HepG2XRCC5
SMC5ENSG00000198887.7549.28280939.09370-0.773707.079405.93100HepG2XRN2
SMC5ENSG00000198887.71330.33020918.952700.533609.868208.73010HepG2ZC3H8
SMC5ENSG00000198887.71586.666001879.97740-0.244703.510702.91510HepG2ZNF622
SMC5ENSG00000198887.71400.808601750.17710-0.321202.623401.98640K562AKAP8L
SMC5ENSG00000198887.71625.881602010.08800-0.306002.964801.73660K562CCDC124
SMC5ENSG00000198887.71833.301402225.69130-0.279803.231302.02930K562CPEB4
SMC5ENSG00000198887.71271.540601731.92470-0.445805.258904.18570K562CPSF6
SMC5ENSG00000198887.7616.20960781.03230-0.342002.694201.65010K562CSTF2
SMC5ENSG00000198887.7741.18350979.76990-0.402602.431801.45770K562DDX3X
SMC5ENSG00000198887.71998.237702303.16710-0.204902.292301.69010K562DDX47
SMC5ENSG00000198887.71179.457701498.59170-0.345502.727102.01250K562EIF2S2
SMC5ENSG00000198887.71310.227101704.51780-0.379503.392002.44530K562FIP1L1
SMC5ENSG00000198887.71868.777201226.357800.607604.949303.93940K562G3BP2
SMC5ENSG00000198887.71320.465001653.48970-0.324502.745401.95370K562GPKOW
SMC5ENSG00000198887.71121.064401997.21810-0.833108.443707.10950K562GRSF1
SMC5ENSG00000198887.7523.567801037.99900-0.9874015.6544014.31870K562HNRNPC
SMC5ENSG00000198887.7982.113901401.95260-0.513504.236503.06860K562HNRNPM
SMC5ENSG00000198887.71543.561402311.01710-0.582307.400706.11570K562HSPD1
SMC5ENSG00000198887.71194.438301934.91060-0.695909.601907.81800K562PPIG
SMC5ENSG00000198887.7950.342101246.09190-0.390903.216301.38020K562RECQL
SMC5ENSG00000198887.7643.79480847.25450-0.396202.021901.32950K562RPS19
SMC5ENSG00000198887.71912.309901266.187700.594706.876605.76990K562SRSF1
SMC5ENSG00000198887.7791.770801112.52650-0.490702.504301.51020K562SRSF4
SMC5ENSG00000198887.71241.33910925.652200.423304.534103.47530K562SYNCRIP
SMC5ENSG00000198887.7668.93900950.82480-0.507304.406603.15090K562TRIM56
SMC5ENSG00000198887.71599.470401189.487600.427203.184602.00030K562U2AF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SMC5 is not available on ENCORE database.





19 RBPs can affect the splicing of SMC5 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESMC5ENSG00000198887.7chr9+729615207296156572959059729591857296198172962077-0.401000.000090.00291excludedK562SRSF1
SESMC5ENSG00000198887.7chr9+729590597295918572938936729390597296198172962077-0.344000.000310.00806excludedK562SF3B4
SESMC5ENSG00000198887.7chr9+729652917296538772965029729652097296710672967161-0.157000.002530.07393excludedK562PRPF8
SESMC5ENSG00000198887.7chr9+729652917296538772965029729652097296710672967161-0.195000.000010.00033excludedHepG2U2AF1
SESMC5ENSG00000198887.7chr9+729590597295918572938936729390597296198172962077-0.210000.001790.04916excludedK562AKAP8L
SESMC5ENSG00000198887.7chr9+7296152072961565729590597295918572961981729620770.346000.000010.00046includedHepG2HNRNPK
SESMC5ENSG00000198887.7chr9+7296152072961565729590597295918572961981729620770.220000.001020.01436includedHepG2U2AF2
SESMC5ENSG00000198887.7chr9+729011157290118772897281728974997291288172913137-0.089000.005820.05264excludedK562AQR
SESMC5ENSG00000198887.7chr9+729590597295918572938920729390597296198172962077-0.241000.000350.00497excludedK562AQR
SESMC5ENSG00000198887.7chr9+729652917296538772964990729652097296710672967161-0.069000.000760.00975excludedK562AQR
SESMC5ENSG00000198887.7chr9+7296152072961565729590597295918572961981729620770.294000.000040.00286includedK562FXR1
SESMC5ENSG00000198887.7chr9+7296644072966632729652917296538772967106729671610.059000.000940.01609includedK562PUS1
SESMC5ENSG00000198887.7chr9+729590597295918572938936729390597296198172962077-0.242000.000050.00130excludedK562PUS1
SESMC5ENSG00000198887.7chr9+728915847289164772882838728828917289222572892388-0.113000.001380.02218excludedK562PUS1
SESMC5ENSG00000198887.7chr9+729652917296538772965029729652097296710672967161-0.071000.000480.00916excludedK562PUS1
SESMC5ENSG00000198887.7chr9+729590597295918572938936729390597296152072961565-0.197000.003460.06130excludedK562U2AF1
SESMC5ENSG00000198887.7chr9+729652917296538772965029729652097296710672967161-0.220000.000130.00417excludedK562U2AF1
SESMC5ENSG00000198887.7chr9+7296152072961565729590597295918572961981729620770.263000.000090.01012includedHepG2HNRNPL
SESMC5ENSG00000198887.7chr9+7296152072961565729590597295918572961981729620770.181000.000150.01515includedK562HNRNPL
SESMC5ENSG00000198887.7chr9+729615207296156572959059729591857296198172962077-0.475000.000000.00005excludedHepG2SRSF1
SESMC5ENSG00000198887.7chr9+729652917296538772965029729652097296710672967161-0.107000.000020.00125excludedHepG2SF3A3
SESMC5ENSG00000198887.7chr9+729615207296156572959059729591857296198172962077-0.346000.001240.05673excludedHepG2PCBP1
SESMC5ENSG00000198887.7chr9+7296152072961565729590597295918572961981729620770.186000.000220.04011includedK562SRSF7
SESMC5ENSG00000198887.7chr9+729590597295918572938936729390597296198172962077-0.282000.000010.00073excludedK562UTP18
SESMC5ENSG00000198887.7chr9+7289153472891647728828387288289172892225728923880.199000.003450.05402includedK562U2AF2
SESMC5ENSG00000198887.7chr9+7296644072966632729652917296538772967106729698040.158000.000000.00014includedK562U2AF2
SESMC5ENSG00000198887.7chr9+729590597295918572938936729390597296198172962077-0.252000.000070.00348excludedK562RBM15
SESMC5ENSG00000198887.7chr9+729652917296538772965029729652097296710672967161-0.070000.000750.02189excludedK562RBM15
SESMC5ENSG00000198887.7chr9+729615207296156572959059729591857296198172962077-0.183000.003370.06946excludedK562AGGF1
SESMC5ENSG00000198887.7chr9+7296152072961565729590597295918572961981729620770.193000.000800.03750includedK562HNRNPK
SESMC5ENSG00000198887.7chr9+7296152072961565729590597295918572961981729620770.193000.002600.08222includedK562PTBP1
SESMC5ENSG00000198887.7chr9+729615207296156572959059729591857296198172962077-0.335000.000170.00425excludedK562HNRNPC
A3SSSMC5ENSG00000198887.7chr9+7291492772915116729149617291511672912881729131370.092000.000010.00007longerK562AQR
MXESMC5ENSG00000198887.7chr9+7295905972959185729615207296156572938936729390597296198172962077-0.249000.000700.014982includedK562U2AF1
MXESMC5ENSG00000198887.7chr9+72959059729591857296152072961565729389367293905972961981729620770.231000.000460.011191includedK562PUS1
MXESMC5ENSG00000198887.7chr9+7295905972959185729615207296156572938936729390597296198172962077-0.230000.008860.085332includedK562U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SMC5 is not avaliable on ENCORE database.