RHEB

General Information

Gene Name       : RHEB
Gene ID             : ENSG00000106615.9
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: RHEB)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878RHEBENSG00000106615.935.3024.4129.85ENCSR000AEF
HepG2RHEBENSG00000106615.935.6680.2957.98ENCSR985KAT
K562RHEBENSG00000106615.9109.54127.26118.40ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for RHEB is not avaliable on ENCORE database.



Proteins bound to RNA
  • RHEB RNA is bound by 35 proteins.  







eCLIP assay for RHEB is not avaliable on ENCORE database.





35 proteins are bound to RHEB RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr7151164171151164195-3'-UTR,intron-Distal,intron-Proximal4.7610831.17033K562YBX3
chr7151163720151163787-3'-UTR,intron-Distal4.004293.59342K562CSTF2T
chr7151167703151167758-3'-UTR,CDS,intron-Distal,intron-Proximal3.547728.74065K562SF3B4
chr7151174485151174502-3'-UTR,CDS,intron-Distal,intron-Proximal3.481677.02805K562YBX3
chr7151164202151164207-3'-UTR,intron-Distal4.5298721.94344K562YBX3
chr7151168634151168675-3'-UTR,CDS,intron-Distal,intron-Proximal3.383834.91258K562YBX3
chr7151164140151164233-3'-UTR,CDS,intron-Distal,intron-Proximal7.0139733.62161K562LIN28B
chr7151163819151163885-3'-UTR,intron-Distal,intron-Proximal3.012479.49425K562PUM2
chr7151164195151164202-3'-UTR,intron-Distal4.7352725.79512K562YBX3
chr7151163823151163874-3'-UTR,intron-Distal,intron-Proximal4.780994.80693HepG2FUBP3
chr7151164140151164226-3'-UTR,CDS,intron-Distal,intron-Proximal5.028504.31023HepG2LIN28B
chr7151167701151167758-3'-UTR,CDS,intron-Distal,intron-Proximal3.462655.71515K562GPKOW
chr7151216181151216239-5'-UTR,intron-Distal3.3143910.94981K562CSTF2T
chr7151216203151216286-5'-UTR,intron-Distal,intron-Proximal4.225127.60652K562DDX51
chr7151216211151216302-5'-UTR,intron-Distal,intron-Proximal4.224713.57264HepG2GTF2F1
chr7151216198151216291-5'-UTR,intron-Distal,intron-Proximal3.251327.73824K562EWSR1
chr7151216128151216239-5'-UTR,intron-Distal3.5690111.28284K562DROSHA
chr7151216183151216319-5'-UTR,intron-Distal,intron-Proximal4.8278111.08640K562XRN2
chr7151216189151216341-5'-UTR,intron-Distal,intron-Proximal3.204078.22374K562FUS
chr7151216119151216161-5'-UTR,intron-Distal3.340936.60059K562NONO
chr7151216239151216300-5'-UTR,intron-Distal,intron-Proximal4.1441811.98060K562DROSHA
chr7151216173151216253-5'-UTR,intron-Distal3.492094.78882K562IGF2BP2
chr7151216235151216300-5'-UTR,intron-Distal,intron-Proximal3.717928.33211K562GTF2F1
chr7151216470151216599-5'-UTR,CDS,intron-Distal4.903867.91635K562FUS
chr7151216206151216322-5'-UTR,intron-Distal,intron-Proximal3.962687.94468HepG2PRPF4
chr7151216247151216290-5'-UTR,intron-Distal,intron-Proximal3.816489.06112K562NONO
chr7151216556151216609-5'-UTR,CDS,intron-Distal3.873733.30425K562LIN28B
chr7151216554151216621-5'-UTR,CDS,intron-Distal3.653698.50482K562DDX3X
chr7151216621151216705-5'-UTR,intron-Distal4.5776812.22508K562DDX3X
chr7151216136151216235-5'-UTR,intron-Distal3.992536.39945K562GTF2F1
chr7151216187151216247-5'-UTR,intron-Distal6.0120718.83140K562NONO
chr7151216239151216305-5'-UTR,intron-Distal,intron-Proximal4.1420715.84061K562CSTF2T
chr7151216097151216172-5'-UTR,intron-Distal4.252975.33676K562FUS
chr7151215279151215333-intron-Distal4.156573.40087HepG2RBFOX2
chr7151168434151168475-intron-Distal,intron-Proximal5.129363.78571K562GPKOW
chr7151208506151208624-intron-Distal3.370904.44332K562HNRNPA1
chr7151204473151204525-intron-Distal3.007896.93547K562HNRNPL
chr7151214416151214447-intron-Distal3.801963.03613K562HNRNPC
chr7151196438151196514-intron-Distal3.4608113.55454K562PTBP1
chr7151168534151168588-intron-Distal,intron-Proximal5.1803912.52998K562SF3B4
chr7151212566151212672-intron-Distal3.046363.36386HepG2SFPQ
chr7151216467151216523-intron-Distal3.700663.80752K562AKAP8L
chr7151206077151206138-intron-Distal3.131303.93901K562KHSRP
chr7151216404151216437-intron-Distal4.780856.64314K562CSTF2T
chr7151169005151169076-intron-Distal4.715656.75032K562TARDBP
chr7151172928151172975-intron-Distal3.547556.59733K562KHSRP
chr7151215357151215435-intron-Distal3.883068.84380K562TIA1
chr7151215175151215247-intron-Distal,intron-Proximal4.6639212.93967K562NONO
chr7151216345151216412-intron-Distal,intron-Proximal3.119143.67576K562IGF2BP2
chr7151212612151212669-intron-Distal4.110926.59396K562NONO
chr7151216044151216095-intron-Distal3.038175.73446K562NONO
chr7151189752151189853-intron-Distal4.766676.13169K562ILF3
chr7151205999151206074-intron-Distal3.871704.93345K562LSM11
chr7151174374151174405-intron-Distal,intron-Proximal3.123636.02419K562AQR
chr7151187903151187976-intron-Distal,intron-Proximal3.431034.70224K562KHSRP
chr7151216319151216399-intron-Distal,intron-Proximal5.035336.49727K562XRN2
chr7151174246151174331-intron-Distal,intron-Proximal3.084657.11119K562KHSRP
chr7151212194151212300-intron-Distal3.223157.25130K562KHSRP
chr7151216351151216419-intron-Distal,intron-Proximal3.078205.90777K562NONO
chr7151215641151215723-intron-Distal4.3623915.27355K562CSTF2T
chr7151172731151172806-intron-Distal4.1417317.96395K562KHSRP
chr7151167758151167785-intron-Distal,intron-Proximal5.069206.47067K562SF3B4
chr7151205282151205343-intron-Distal3.263804.76345K562KHSRP
chr7151174109151174137-intron-Distal3.805263.66668K562KHSRP
chr7151215654151215679-intron-Distal3.546414.25440K562TIA1
chr7151174337151174388-intron-Distal,intron-Proximal4.803743.61992K562RBM22
chr7151216348151216403-intron-Distal,intron-Proximal3.554225.11725K562DROSHA
chr7151212603151212675-intron-Distal3.287888.24998K562KHSRP
chr7151174331151174395-intron-Distal,intron-Proximal3.658059.62501K562KHSRP
chr7151196415151196514-intron-Distal3.822325.07626HepG2PTBP1
chr7151215648151215701-intron-Distal3.594543.04470K562FUS
chr7151216371151216438-intron-Distal3.525344.44955K562LSM11
chr7151196621151196733-intron-Distal3.180495.20317K562NONO
chr7151212099151212125-intron-Distal3.205035.02670K562TIA1
chr7151216348151216430-intron-Distal,intron-Proximal3.266555.79046K562AATF
chr7151215399151215460-intron-Distal3.563639.04098K562NONO
chr7151215455151215539-intron-Distal3.087745.39247K562EWSR1
chr7151216347151216407-intron-Distal,intron-Proximal4.245025.47093K562DDX51
chr7151188100151188147-intron-Distal,intron-Proximal5.3566511.52732K562SF3B4
chr7151183969151184022-intron-Distal4.285553.72005K562MATR3
chr7151168807151168869-intron-Distal3.584133.92720K562TARDBP
chr7151209527151209620-intron-Distal3.117453.07368K562TARDBP
chr7151174950151175038-intron-Distal3.201423.51248K562PTBP1
chr7151187892151187984-intron-Distal,intron-Proximal4.288113.89565K562PRPF8
chr7151174027151174081-intron-Distal3.546946.80241K562KHSRP
chr7151216345151216404-intron-Distal,intron-Proximal3.284368.50497K562CSTF2T
chr7151167547151167629-intron-Distal,intron-Proximal3.311766.04213K562PRPF8
chr7151215341151215399-intron-Distal3.254907.75493K562NONO
chr7151168527151168583-intron-Distal,intron-Proximal6.2481910.90867K562EFTUD2
chr7151215648151215706-intron-Distal4.0794111.11767K562NONO
chr7151215288151215341-intron-Distal3.608527.59385K562NONO
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for RHEB is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for RHEB is not available on ENCORE database.

  • 83 RBPs can affect the levels of RHEB.  








The Knockdown/knockout RNA-Seq assay for RHEB is not available on ENCORE database.





83 RBPs can affect the gene expression of RHEB :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
RHEBENSG00000106615.5636.53180835.14360-0.391804.019903.10730HepG2AKAP8L
RHEBENSG00000106615.51143.541701690.49340-0.563904.234403.01500HepG2CCAR1
RHEBENSG00000106615.5704.65660831.05180-0.238002.007901.42910HepG2CKAP4
RHEBENSG00000106615.5621.37670883.23670-0.507302.511401.78490HepG2CNOT7
RHEBENSG00000106615.5539.50800673.76310-0.320601.942601.36160HepG2DDX21
RHEBENSG00000106615.5607.31580931.14880-0.616605.427304.17350HepG2EEF2
RHEBENSG00000106615.5605.804901079.42350-0.833309.378508.32540HepG2EIF2S1
RHEBENSG00000106615.5858.098501192.76030-0.475103.398102.69130HepG2EIF4A3
RHEBENSG00000106615.5825.828201161.56680-0.492202.889602.18750HepG2EIF4B
RHEBENSG00000106615.5952.323301203.83710-0.338102.155101.54080HepG2FXR1
RHEBENSG00000106615.5800.155901116.52930-0.480703.546802.79740HepG2G3BP1
RHEBENSG00000106615.5494.60950672.99700-0.444302.789901.88660HepG2GEMIN5
RHEBENSG00000106615.5835.251801070.92720-0.358602.100701.53830HepG2GPKOW
RHEBENSG00000106615.5679.32710868.20080-0.353902.358401.71290HepG2HNRNPC
RHEBENSG00000106615.5878.223001131.06840-0.365002.620601.93930HepG2HNRNPK
RHEBENSG00000106615.5880.074301154.38390-0.391405.976205.01790HepG2HNRNPL
RHEBENSG00000106615.5761.190201022.00310-0.425103.026702.37230HepG2HNRNPLL
RHEBENSG00000106615.5594.98980862.46180-0.535607.232606.28850HepG2HNRNPU
RHEBENSG00000106615.5864.989601069.73280-0.306502.446001.76350HepG2IGF2BP1
RHEBENSG00000106615.5756.846201134.85430-0.584405.347304.43590HepG2IGF2BP2
RHEBENSG00000106615.5556.286801065.30710-0.937404.282103.06140HepG2IGF2BP3
RHEBENSG00000106615.5811.584901239.40800-0.610805.522104.64200HepG2NCBP2
RHEBENSG00000106615.5360.96770717.63520-0.991404.171002.81040HepG2NONO
RHEBENSG00000106615.5575.16510906.18140-0.655806.214305.12090HepG2NSUN2
RHEBENSG00000106615.5825.085301103.53550-0.419502.928602.18710HepG2PABPC4
RHEBENSG00000106615.5843.561201071.27340-0.344803.813603.12520HepG2PCBP1
RHEBENSG00000106615.5483.72260625.08680-0.369902.629601.43220HepG2PKM
RHEBENSG00000106615.5764.763501090.04760-0.511307.194906.39360HepG2PTBP1
RHEBENSG00000106615.5949.394401199.46650-0.337302.656602.07070HepG2PUF60
RHEBENSG00000106615.5590.41490846.69330-0.520107.102806.19310HepG2PUS1
RHEBENSG00000106615.5955.097001180.57650-0.305802.697602.08000HepG2QKI
RHEBENSG00000106615.51735.99050817.369101.086609.176907.94350HepG2RAVER1
RHEBENSG00000106615.5852.659701071.43850-0.329502.593401.93760HepG2RBM25
RHEBENSG00000106615.5948.159601213.12930-0.355504.041403.41000HepG2NELFE
RHEBENSG00000106615.5901.966701129.84530-0.325003.432002.75490HepG2RECQL
RHEBENSG00000106615.5881.281701170.24510-0.409103.390202.64480HepG2RPLP0
RHEBENSG00000106615.5451.17470735.51260-0.705107.549806.59490HepG2RPS19
RHEBENSG00000106615.5585.84770806.80180-0.461703.254002.38600HepG2RPS2
RHEBENSG00000106615.5637.71410886.35960-0.475002.697501.90800HepG2RPS3A
RHEBENSG00000106615.5522.79580738.16930-0.497703.644602.56010HepG2SERBP1
RHEBENSG00000106615.51297.565001011.596900.359102.767802.06110HepG2SF3B1
RHEBENSG00000106615.5970.617001134.90380-0.225601.902801.39700HepG2SF3B4
RHEBENSG00000106615.5983.271601150.01080-0.226002.336801.68330HepG2SLBP
RHEBENSG00000106615.51581.045601347.723200.230302.637402.14370HepG2SRFBP1
RHEBENSG00000106615.5998.730701346.85870-0.431407.078606.16390HepG2SUCLG1
RHEBENSG00000106615.5728.72860940.81430-0.368502.957801.98820HepG2SUPT6H
RHEBENSG00000106615.5280.56590777.99910-1.4714019.3684017.85880HepG2SUPV3L1
RHEBENSG00000106615.5775.92360996.06420-0.360302.467701.77740HepG2TARDBP
RHEBENSG00000106615.5330.40170838.09160-1.3429027.5778026.30130HepG2TIAL1
RHEBENSG00000106615.5719.73670845.53110-0.232401.860101.37980HepG2TRIM56
RHEBENSG00000106615.5867.498801049.20270-0.274402.732602.03660HepG2UPF1
RHEBENSG00000106615.5862.416101012.96160-0.232101.898301.38240HepG2UTP3
RHEBENSG00000106615.5584.99510765.85470-0.388602.190701.53930HepG2XRN2
RHEBENSG00000106615.51572.634801153.920000.446508.929308.09020HepG2ZNF622
RHEBENSG00000106615.57633.262103720.210801.0368063.0652060.43320K562AGGF1
RHEBENSG00000106615.55648.946204088.233500.466404.049102.81080K562AKAP8
RHEBENSG00000106615.55778.804003871.117900.577909.626408.31650K562AKAP8L
RHEBENSG00000106615.55337.457704564.542900.225601.806401.31210K562AQR
RHEBENSG00000106615.55409.462804061.866600.413207.071205.51850K562ATP5C1
RHEBENSG00000106615.54244.036505080.11630-0.259404.030003.26310K562DDX47
RHEBENSG00000106615.55698.707904165.161700.452204.010802.93070K562DKC1
RHEBENSG00000106615.52062.949202657.98380-0.365605.904604.10800K562EIF2S1
RHEBENSG00000106615.51195.060401678.31250-0.489902.421901.48630K562EIF3A
RHEBENSG00000106615.51659.764502190.70800-0.400405.546404.43410K562EIF3G
RHEBENSG00000106615.52017.067702528.09570-0.325802.906302.06580K562EIF4A3
RHEBENSG00000106615.51778.084002276.71090-0.356604.526902.98620K562EIF4B
RHEBENSG00000106615.55541.138104223.297800.391702.363101.57950K562FIP1L1
RHEBENSG00000106615.53870.556106788.35270-0.810504.846902.03380K562FXR2
RHEBENSG00000106615.55134.302204235.385600.277602.825702.06270K562GRSF1
RHEBENSG00000106615.52202.549803238.22790-0.556008.709807.70040K562HNRNPC
RHEBENSG00000106615.53483.005804591.02660-0.398505.033503.56270K562HNRNPL
RHEBENSG00000106615.55950.649003473.339300.776607.369705.73800K562HNRNPM
RHEBENSG00000106615.52303.076703078.10360-0.418503.147802.02890K562IGF2BP2
RHEBENSG00000106615.52017.238103131.32790-0.634407.714605.60080K562IGF2BP3
RHEBENSG00000106615.56333.473104107.978500.624505.431604.19240K562KIF1C
RHEBENSG00000106615.55416.823703932.545100.461902.989301.86180K562MAK16
RHEBENSG00000106615.56994.713304602.007800.603907.365305.74110K562MBNL1
RHEBENSG00000106615.52839.487303478.28670-0.292702.780901.90190K562METAP2
RHEBENSG00000106615.53103.501903486.92400-0.168102.037201.33800K562MTPAP
RHEBENSG00000106615.55391.826803225.695700.741106.453304.89290K562NAA15
RHEBENSG00000106615.53092.620203874.22650-0.325109.027007.78330K562NSUN2
RHEBENSG00000106615.52359.425101822.138900.372703.326302.50170K562PRPF8
RHEBENSG00000106615.52055.693402903.37430-0.498106.278604.83180K562PSIP1
RHEBENSG00000106615.56950.804805691.326100.288302.292601.55000K562PUF60
RHEBENSG00000106615.58386.053106054.574700.469905.164803.67370K562PUM1
RHEBENSG00000106615.58808.202203838.587101.1982033.9783032.04030K562PUS1
RHEBENSG00000106615.56919.675503740.538900.8874022.2707020.51770K562RBM15
RHEBENSG00000106615.52309.339202938.94670-0.347802.855301.45360K562RBM34
RHEBENSG00000106615.52061.695102648.77820-0.361504.068102.86390K562RCC2
RHEBENSG00000106615.51909.812702756.13470-0.529205.733204.22450K562RPS3
RHEBENSG00000106615.52597.871001863.125600.479503.421001.93250K562RRP9
RHEBENSG00000106615.51883.983602660.96770-0.498205.001403.51270K562SRSF4
RHEBENSG00000106615.5584.980201764.33000-1.5927032.9879029.65090K562SUPV3L1
RHEBENSG00000106615.52174.567403119.54320-0.520606.027204.95450K562TARDBP
RHEBENSG00000106615.52524.108603009.07630-0.253502.034501.33930K562TIA1
RHEBENSG00000106615.51853.951102792.58170-0.591006.724205.20970K562TIAL1
RHEBENSG00000106615.53194.304904107.92920-0.362907.596206.47920K562UPF1
RHEBENSG00000106615.56057.580503892.432700.638002.866401.54510K562UTP18
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for RHEB is not available on ENCORE database.





10 RBPs can affect the splicing of RHEB :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SERHEBENSG00000106615.5chr7-1511818221511818901511686341511686911512165451512169370.728000.002210.02389includedK562AQR
SERHEBENSG00000106615.5chr7-151174418151174501151168634151168691151181822151181890-0.052000.000000.00000excludedK562AQR
SERHEBENSG00000106615.5chr7-1511951741511952661511880281511881001512165451512169370.084000.000000.00000includedHepG2SFPQ
A3SSRHEBENSG00000106615.5chr7-1511744181511746621511744181511745011511818221511820520.056000.000000.00000longerK562AQR
MXERHEBENSG00000106615.5chr7-1511744181511745011511818221511818901511686341511686911511880281511881000.074000.003580.090551includedK562LIN28B
MXERHEBENSG00000106615.5chr7-1511686341511688391511744181511745211511684851511685271511818221511818900.086000.000000.000001includedK562AQR
MXERHEBENSG00000106615.5chr7-1511744181511745211511818221511819441511686341511686911511880281511881000.070000.000000.000001includedK562AQR
MXERHEBENSG00000106615.5chr7-1511818221511818901511880281511881001511744181511745011512165451512170100.065000.010570.066231includedK562AQR
MXERHEBENSG00000106615.5chr7-1511744181511746621511818221511819441511686341511686911511880281511881000.071000.000000.000001includedK562AQR
MXERHEBENSG00000106615.5chr7-1511686341511686911511744181511745211511684791511685271511818221511818900.067000.000000.000001includedK562AQR
MXERHEBENSG00000106615.5chr7-1511744181511745011511818221511819441511686341511686911511880281511881000.064000.000000.000001includedK562AQR
MXERHEBENSG00000106615.5chr7-151181822151181890151188028151188100151168634151168691151216545151217010-0.124000.000000.000002includedK562AQR
MXERHEBENSG00000106615.5chr7-151168634151168691151174418151174501151167656151167738151181822151181890-0.083000.000000.000002includedK562AQR
MXERHEBENSG00000106615.5chr7-151168634151168691151174418151174501151168485151168527151181822151181890-0.093000.000890.068712includedK562PUM1
MXERHEBENSG00000106615.5chr7-151168634151168691151188028151188100151168479151168527151216545151217010-0.145000.000000.000262includedK562PUM1
MXERHEBENSG00000106615.5chr7-151174418151174501151181826151181890151168634151168691151188028151188100-0.088000.001430.094162includedK562PUM1
MXERHEBENSG00000106615.5chr7-151174418151174501151181822151181890151168634151168691151188028151188100-0.138000.000000.001062includedK562ZNF800
MXERHEBENSG00000106615.5chr7-1511818221511818901511880281511881001511744181511745011512165451512170100.169000.000000.000011includedK562DDX55
MXERHEBENSG00000106615.5chr7-1511744181511745011511818221511818901511686341511686911511880281511881000.116000.000000.000081includedK562DDX55
MXERHEBENSG00000106615.5chr7-1511744181511745011511818221511818901511686341511686911511880281511881000.115000.000150.029341includedK562EWSR1
MXERHEBENSG00000106615.5chr7-1511818221511818901511880281511881001511744181511745011512165451512170100.084000.006120.075841includedK562SF3B4
MXERHEBENSG00000106615.5chr7-1511686341511686911511744181511745011511684851511685271511818221511818900.123000.000390.014051includedK562FXR2
MXERHEBENSG00000106615.5chr7-151174418151174501151181822151181890151168634151168691151188028151188100-0.096000.000000.000002includedK562FXR2
MXERHEBENSG00000106615.5chr7-1511818221511818901511880281511881001511744181511745011512165451512170100.134000.001280.073021includedK562SERBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for RHEB is not avaliable on ENCORE database.