KLC2

General Information

Gene Name       : KLC2
Gene ID             : ENSG00000174996.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: KLC2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878KLC2ENSG00000174996.112.037.014.52ENCSR000AEF
HepG2KLC2ENSG00000174996.1115.427.1611.29ENCSR985KAT
K562KLC2ENSG00000174996.1113.029.8511.43ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for KLC2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • KLC2 RNA is bound by 15 proteins.  







eCLIP assay for KLC2 is not avaliable on ENCORE database.





15 proteins are bound to KLC2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr116603477766034841+3'-UTR,CDS6.735289.84608K562PUM2
chr116603482166034916+3'-UTR,CDS4.099814.01795HepG2LARP4
chr116603455566034697+3'-UTR,CDS,intron-Distal,intron-Proximal3.320003.72310K562HNRNPK
chr116602597366026032+5'-UTR,intron-Proximal4.060868.27931K562AQR
chr116602524966025338+5'-UTR,intron-Distal,intron-Proximal3.687574.13833K562GTF2F1
chr116602539466025508+5'-UTR,intron-Distal,intron-Proximal4.156964.35952HepG2PRPF4
chr116602554666025665+5'-UTR,intron-Distal3.934196.00287K562GEMIN5
chr116602544466025520+5'-UTR,intron-Distal4.083673.09880K562DROSHA
chr116602567566025729+5'-UTR,intron-Distal3.059383.01436K562CSTF2T
chr116603046666030550+CDS,intron-Proximal3.591495.76569HepG2PRPF8
chr116603356366033629+CDS,intron-Distal,intron-Proximal4.370765.79396K562DDX24
chr116603109366031144+CDS,intron-Distal,intron-Proximal5.656425.75771HepG2SF3A3
chr116603027266030317+CDS,intron-Proximal3.158643.01994K562BUD13
chr116603330066033349+CDS,intron-Distal,intron-Proximal4.073673.79199HepG2PPIG
chr116602534466025385+intron-Distal,intron-Proximal3.860594.00320K562AQR
chr116602540266025479+intron-Distal,intron-Proximal3.480383.80752K562AKAP8L
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for KLC2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for KLC2 is not available on ENCORE database.

  • 97 RBPs can affect the levels of KLC2.  








The Knockdown/knockout RNA-Seq assay for KLC2 is not available on ENCORE database.





97 RBPs can affect the gene expression of KLC2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
KLC2ENSG00000174996.71029.26550483.868901.088808.541907.66300HepG2AKAP1
KLC2ENSG00000174996.7983.09220721.521100.446202.891301.83150HepG2AKAP8
KLC2ENSG00000174996.7278.79450400.32290-0.522002.203401.49790HepG2ASCC1
KLC2ENSG00000174996.71246.60720846.927400.557609.112407.98640HepG2AUH
KLC2ENSG00000174996.71418.66510827.432600.7777010.931309.84360HepG2BOP1
KLC2ENSG00000174996.7672.01190373.456600.847405.379104.31020HepG2CNOT7
KLC2ENSG00000174996.7779.33260504.476100.627405.257904.42420HepG2CELF1
KLC2ENSG00000174996.7531.29780289.711700.8748010.051508.07440HepG2DDX1
KLC2ENSG00000174996.71023.82370463.428301.1434015.2846013.93210HepG2DDX3X
KLC2ENSG00000174996.7768.28160398.286400.947704.256503.50300HepG2DDX6
KLC2ENSG00000174996.7352.59700622.87610-0.8209010.844809.68600HepG2DKC1
KLC2ENSG00000174996.7546.28700284.081700.9433012.5680011.15900HepG2DNAJC21
KLC2ENSG00000174996.7399.63350281.559300.505104.160003.39200HepG2DNAJC2
KLC2ENSG00000174996.7682.85140382.691900.835307.643206.69340HepG2EIF2S1
KLC2ENSG00000174996.7503.66340339.836900.567503.579302.55820HepG2EIF3D
KLC2ENSG00000174996.7711.10160411.857700.787805.250204.32330HepG2EIF4B
KLC2ENSG00000174996.71461.64680972.391000.5879010.438509.39160HepG2ETF1
KLC2ENSG00000174996.71176.39890892.126100.399002.601001.85260HepG2FIP1L1
KLC2ENSG00000174996.7692.35530426.893900.697505.470404.51950HepG2FXR1
KLC2ENSG00000174996.7734.59150395.860100.891908.678707.53600HepG2G3BP1
KLC2ENSG00000174996.7531.32500315.921900.749904.840302.97980HepG2HNRNPA0
KLC2ENSG00000174996.7553.69520319.010900.795407.023305.96020HepG2HNRNPC
KLC2ENSG00000174996.7609.00930401.186600.602103.271902.51400HepG2HNRNPK
KLC2ENSG00000174996.7636.74560821.71130-0.367902.278201.70130HepG2HNRNPLL
KLC2ENSG00000174996.7432.32570316.902100.448003.356202.69420HepG2HNRNPU
KLC2ENSG00000174996.7505.26390323.705800.642307.904006.73280HepG2ILF2
KLC2ENSG00000174996.7537.50720355.978700.594403.553602.17070HepG2KHDRBS1
KLC2ENSG00000174996.7486.41080316.552900.619604.250802.83840HepG2LARP7
KLC2ENSG00000174996.7746.33560429.389000.797406.624305.67990HepG2MATR3
KLC2ENSG00000174996.7611.78150355.679400.782304.167902.88900HepG2METAP2
KLC2ENSG00000174996.7561.64280838.12580-0.577502.960601.95450HepG2MTPAP
KLC2ENSG00000174996.71020.67540439.466601.215609.906108.75080HepG2NCBP2
KLC2ENSG00000174996.7704.04130347.771801.017403.961602.63540HepG2NONO
KLC2ENSG00000174996.7438.60310728.63310-0.732306.682105.54600HepG2NSUN2
KLC2ENSG00000174996.7554.05940391.204300.502003.006902.25600HepG2PABPC4
KLC2ENSG00000174996.7406.06650313.684600.372302.280001.50490HepG2PARN
KLC2ENSG00000174996.7545.88570418.561400.383102.923302.30240HepG2PCBP1
KLC2ENSG00000174996.7247.83260579.26130-1.2248021.2260019.43610HepG2PRPF4
KLC2ENSG00000174996.7714.06130425.900800.7454010.688109.74740HepG2PTBP1
KLC2ENSG00000174996.71034.01380544.982100.9239010.301709.30880HepG2PUM1
KLC2ENSG00000174996.7534.40230663.13300-0.311402.574101.97410HepG2PUS1
KLC2ENSG00000174996.7753.13540461.263400.707208.351607.35460HepG2QKI
KLC2ENSG00000174996.7573.58610418.625300.454303.182302.46400HepG2RBM25
KLC2ENSG00000174996.7575.96280381.719600.593403.822202.64270HepG2RBM27
KLC2ENSG00000174996.7768.63090473.987600.697309.041308.16510HepG2NELFE
KLC2ENSG00000174996.7661.31280330.664500.9999012.9468011.73840HepG2RPS19
KLC2ENSG00000174996.7588.95970352.032400.742405.866704.72630HepG2RPS2
KLC2ENSG00000174996.7519.60210359.364000.531903.142201.99250HepG2RPS5
KLC2ENSG00000174996.7472.71310282.218100.744108.389507.35780HepG2SAFB2
KLC2ENSG00000174996.7596.31880813.30890-0.447703.284702.52170HepG2SF3B1
KLC2ENSG00000174996.7588.23280443.419600.407603.165002.53750HepG2SF3B4
KLC2ENSG00000174996.7931.06980463.581301.006002.837201.36550HepG2SFPQ
KLC2ENSG00000174996.7673.96860329.118501.0340019.7791018.30050HepG2SMN1
KLC2ENSG00000174996.7623.13350312.829000.994103.295702.24060HepG2SMNDC1
KLC2ENSG00000174996.71354.60530917.955700.5613010.033409.24040HepG2SRFBP1
KLC2ENSG00000174996.7682.79940506.912300.429603.214102.54750HepG2SRSF5
KLC2ENSG00000174996.7322.95000796.99970-1.3033030.2761028.99330HepG2SSB
KLC2ENSG00000174996.7530.02490326.363000.699504.702503.22900HepG2STIP1
KLC2ENSG00000174996.7935.69050576.429200.698807.073506.15920HepG2SUCLG1
KLC2ENSG00000174996.7752.03670602.521900.319702.215201.37080HepG2SUPT6H
KLC2ENSG00000174996.7275.37610416.01040-0.595203.996403.34160HepG2TAF15
KLC2ENSG00000174996.7389.72050307.946900.339701.734901.31920HepG2TIAL1
KLC2ENSG00000174996.7606.43170310.681200.9648015.3444014.16550HepG2TRIM56
KLC2ENSG00000174996.7916.09760531.014100.786705.467104.26700HepG2UBE2L3
KLC2ENSG00000174996.7373.30480222.479700.746604.146703.21670HepG2UCHL5
KLC2ENSG00000174996.7916.12840697.289900.393704.414503.68660HepG2UTP3
KLC2ENSG00000174996.7459.73340571.66380-0.314402.401201.76960HepG2ZC3H8
KLC2ENSG00000174996.71276.89710794.320700.6847016.4345015.38020HepG2ZNF622
KLC2ENSG00000174996.71225.05970738.145500.730808.489407.55220K562AQR
KLC2ENSG00000174996.7490.53680376.095500.383202.651201.71370K562BCLAF1
KLC2ENSG00000174996.7563.26170411.305800.453502.606501.59190K562CCAR1
KLC2ENSG00000174996.7479.92130329.795700.541104.008802.38740K562DDX27
KLC2ENSG00000174996.7677.00460360.265900.9100011.802109.47640K562DDX3X
KLC2ENSG00000174996.71592.64320860.043900.8888023.4604021.74680K562DDX47
KLC2ENSG00000174996.7681.04950328.020801.0539011.955109.91130K562EFTUD2
KLC2ENSG00000174996.7832.70830418.349000.993007.548705.84530K562EIF3A
KLC2ENSG00000174996.7657.63920351.071100.905407.617805.76130K562EIF3D
KLC2ENSG00000174996.7310.43560162.223300.936207.775806.44430K562EIF3G
KLC2ENSG00000174996.7624.01150376.387100.729306.432205.18870K562EIF4A3
KLC2ENSG00000174996.7481.63940338.955300.506804.193002.72270K562EIF4B
KLC2ENSG00000174996.7678.25070475.246700.513003.637702.65310K562FMR1
KLC2ENSG00000174996.7707.23660391.426400.8534012.3243011.14100K562FXR1
KLC2ENSG00000174996.737.67550138.61610-1.879409.750708.26400K562G3BP2
KLC2ENSG00000174996.7472.62810328.877200.523102.735901.32920K562GEMIN5
KLC2ENSG00000174996.71262.48930872.895600.532304.505303.54490K562GRSF1
KLC2ENSG00000174996.7596.95900454.934900.391902.480201.91120K562HNRNPC
KLC2ENSG00000174996.7620.21810442.358100.487502.944301.98150K562HNRNPM
KLC2ENSG00000174996.7911.49490729.171100.321902.022401.33730K562HSPD1
KLC2ENSG00000174996.7409.93540240.636700.768403.151802.03180K562IGF2BP2
KLC2ENSG00000174996.7544.18900252.596301.1072013.2371011.27860K562MAGOH
KLC2ENSG00000174996.7383.50960252.037700.605502.588201.69820K562MATR3
KLC2ENSG00000174996.7610.47140435.269100.487902.515401.68420K562METAP2
KLC2ENSG00000174996.7990.19230779.568600.344903.599802.68580K562MTPAP
KLC2ENSG00000174996.7393.86820247.055300.672803.157501.71620K562PCBP1
KLC2ENSG00000174996.7585.31690319.205500.874607.572306.32860K562PRPF8
KLC2ENSG00000174996.7607.73210407.900400.575104.893003.64550K562PSIP1
KLC2ENSG00000174996.7550.29170245.435801.164806.031605.08330K562PTBP1
KLC2ENSG00000174996.7427.54430235.177900.862204.755603.61950K562RBM22
KLC2ENSG00000174996.7350.26540229.380400.610602.863101.45810K562RBM34
KLC2ENSG00000174996.7513.90540372.173800.465403.146402.08250K562RCC2
KLC2ENSG00000174996.7765.65230325.045401.2359013.9537012.09220K562RPS19
KLC2ENSG00000174996.7473.40010307.588500.622003.709102.52880K562RPS3
KLC2ENSG00000174996.7215.31770144.133500.579002.876802.00340K562SF3B4
KLC2ENSG00000174996.71134.00280654.962200.791803.646802.06380K562SFPQ
KLC2ENSG00000174996.7497.16350352.809000.494703.136102.02780K562SRFBP1
KLC2ENSG00000174996.7536.26510240.643001.1560014.6875013.05410K562SRSF1
KLC2ENSG00000174996.7410.13070296.882500.466102.483101.49330K562SRSF4
KLC2ENSG00000174996.7491.60000308.878700.670304.182302.91110K562SUPV3L1
KLC2ENSG00000174996.7628.91290243.473001.369007.952506.67510K562TARDBP
KLC2ENSG00000174996.7422.70900234.876500.847702.763701.94660K562TIA1
KLC2ENSG00000174996.7380.45910230.657400.721902.360301.36830K562TRA2A
KLC2ENSG00000174996.7614.29570416.819300.559404.324003.08030K562TRIM56
KLC2ENSG00000174996.7463.40690327.000700.502902.471701.51540K562UCHL5
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for KLC2 is not available on ENCORE database.





14 RBPs can affect the splicing of KLC2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEKLC2ENSG00000174996.7chr11+6603096666031039660303886603050766031130660312180.102000.000110.00545includedK562AKAP8L
SEKLC2ENSG00000174996.7chr11+6603096666031039660302846603050766031130660312180.060000.007910.06744includedK562AQR
SEKLC2ENSG00000174996.7chr11+6603096666031039660303886603050766031130660312180.119000.000030.00086includedK562PUS1
SEKLC2ENSG00000174996.7chr11+6603096666031039660303886603050766031130660312180.084000.000580.07531includedK562LARP4
SEKLC2ENSG00000174996.7chr11+6603096666031039660303886603050766031130660312180.143000.000000.00012includedK562RBM15
SEKLC2ENSG00000174996.7chr11+6603096666031039660303886603050766031130660312180.203000.000000.00001includedK562AGGF1
A3SSKLC2ENSG00000174996.7chr11+6602601766026293660260546602629366025173660253420.284000.000190.02318longerK562AGGF1
A3SSKLC2ENSG00000174996.7chr11+6603247566032543660324936603254366031815660319150.077000.000060.00053longerK562AQR
A5SSKLC2ENSG00000174996.7chr11+6603038866030631660303886603050766031130660312180.104000.000000.00039longerK562PUS1
A5SSKLC2ENSG00000174996.7chr11+6603038866030631660303886603050766031130660312180.108000.000000.00090longerK562AGGF1
A5SSKLC2ENSG00000174996.7chr11+6603038866030631660303886603050766031130660312180.093000.000030.00471longerK562RBM15
A5SSKLC2ENSG00000174996.7chr11+6603038866030631660303886603050766031130660312180.073000.000210.02411longerK562AKAP8L
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.185000.000480.03005includedHepG2BCCIP
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.250000.000010.00008includedK562PUS1
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.122000.000040.00094includedHepG2SF3A3
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.168000.004290.04848includedHepG2PRPF8
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.235000.000000.00003includedK562AGGF1
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.290000.000000.00000includedK562AKAP8L
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.202000.000000.00000includedHepG2U2AF1
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.178000.000180.00294includedK562RBM15
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.139000.003910.02881includedHepG2SF3B4
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.256000.000060.00142includedK562UTP18
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.222000.007470.06413includedK562EFTUD2
RIKLC2ENSG00000174996.7chr11+6603390366035330660339036603396166034343660353300.251000.000040.00038includedK562AQR
RIKLC2ENSG00000174996.7chr11+660339036603533066033903660339616603434366035330-0.209000.000000.00015excludedK562FXR1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for KLC2 is not avaliable on ENCORE database.