ISCU

General Information

Gene Name       : ISCU
Gene ID             : ENSG00000136003.15
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: ISCU)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878ISCUENSG00000136003.1580.4883.3381.91ENCSR000AEF
HepG2ISCUENSG00000136003.1571.5393.6082.56ENCSR985KAT
K562ISCUENSG00000136003.1550.1652.2951.22ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for ISCU is not avaliable on ENCORE database.



Proteins bound to RNA
  • ISCU RNA is bound by 20 proteins.  







eCLIP assay for ISCU is not avaliable on ENCORE database.





20 proteins are bound to ISCU RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr12108962682108962745+3'-UTR,CDS3.843789.88356K562YBX3
chr12108962868108962987+3'-UTR3.559484.18336HepG2DDX55
chr12108961755108961879+3'-UTR,intron-Distal,intron-Proximal3.048883.51437HepG2QKI
chr12108963007108963061+3'-UTR5.799626.76667HepG2DDX6
chr12108962942108963045+3'-UTR3.811103.44763HepG2LSM11
chr12108962745108962789+3'-UTR3.279937.76316K562YBX3
chr12108962901108962998+3'-UTR3.670134.43569HepG2ZC3H11A
chr12108962728108962830+3'-UTR3.205529.60326HepG2BCLAF1
chr12108963004108963065+3'-UTR5.631678.79083HepG2DDX55
chr12108962883108962996+3'-UTR5.3012546.23735K562PUM2
chr12108961027108961109+3'-UTR,CDS,intron-Proximal3.736504.93376K562PRPF8
chr12108962903108962970+3'-UTR3.575675.73852HepG2FUBP3
chr12108963067108963091+3'-UTR4.253557.04643K562PUM2
chr12108961013108961045+3'-UTR,CDS,intron-Proximal3.533783.57857HepG2BCLAF1
chr12108961040108961087+3'-UTR,CDS,intron-Proximal4.842334.48002K562AQR
chr12108962587108962652+3'-UTR,CDS,intron-Proximal3.309433.91614K562BUD13
chr12108958161108958212+5'-UTR,CDS,intron-Proximal4.530823.89565K562PRPF8
chr12108958045108958113+5'-UTR,CDS,intron-Proximal4.950114.34038HepG2BCLAF1
chr12108958113108958169+5'-UTR,CDS,intron-Proximal3.261624.61799HepG2BCLAF1
chr12108959096108959144+5'-UTR,CDS,intron-Proximal4.127123.79199HepG2PPIG
chr12108956378108956505+5'-UTR,CDS5.6964612.43092HepG2DDX3X
chr12108957789108957856+5'-UTR,CDS,intron-Distal,intron-Proximal4.930434.90235K562SF3B4
chr12108959144108959212+5'-UTR,CDS,intron-Proximal3.138483.73413HepG2PPIG
chr12108956380108956510+5'-UTR,CDS5.7470920.77932K562DDX3X
chr12108958059108958169+5'-UTR,CDS,intron-Proximal3.915017.03378HepG2GRWD1
chr12108957824108957884+5'-UTR,CDS,intron-Distal,intron-Proximal3.277345.40232HepG2U2AF2
chr12108958156108958204+5'-UTR,CDS,intron-Proximal4.589836.81564HepG2PRPF8
chr12108956525108956675+intron-Distal,intron-Proximal5.6964127.98801HepG2EFTUD2
chr12108957944108958012+intron-Distal,intron-Proximal3.171633.94979HepG2BCLAF1
chr12108957976108958052+intron-Proximal4.7821313.35160HepG2RBM5
chr12108960889108960961+intron-Proximal4.993204.69961K562SF3B4
chr12108956534108956610+intron-Proximal3.252674.80699HepG2RBM22
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for ISCU is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for ISCU is not available on ENCORE database.

  • 74 RBPs can affect the levels of ISCU.  








The Knockdown/knockout RNA-Seq assay for ISCU is not available on ENCORE database.





74 RBPs can affect the gene expression of ISCU :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
ISCUENSG00000136003.112029.641301119.123400.8588011.568709.86140HepG2ABCF1
ISCUENSG00000136003.111461.514101000.731400.546304.174503.53950HepG2AKAP1
ISCUENSG00000136003.111172.18590880.535200.412605.363304.32970HepG2AKAP8L
ISCUENSG00000136003.111307.86530827.981600.659406.674005.48020HepG2ASCC1
ISCUENSG00000136003.111062.40930766.014200.471802.664501.74680HepG2BCCIP
ISCUENSG00000136003.111304.07610786.652300.729108.250306.97240HepG2CIRBP
ISCUENSG00000136003.111276.09680876.228100.5423010.463509.33980HepG2CKAP4
ISCUENSG00000136003.11542.46970770.30050-0.505905.264603.86230HepG2YBX3
ISCUENSG00000136003.11996.61970473.073001.0749015.5480013.36240HepG2CSTF2
ISCUENSG00000136003.11973.470101206.16810-0.309203.190902.51050HepG2CELF1
ISCUENSG00000136003.111051.22140810.558900.375005.008103.93070HepG2DDX19B
ISCUENSG00000136003.111326.08270711.140200.8989014.0742012.68590HepG2DDX21
ISCUENSG00000136003.11875.14480695.653800.331102.343701.50990HepG2DDX24
ISCUENSG00000136003.111879.47250958.540000.9713014.1716012.86560HepG2DDX3X
ISCUENSG00000136003.111121.47300838.491000.419405.185204.31050HepG2DKC1
ISCUENSG00000136003.11509.93390749.69040-0.556007.829306.80370HepG2DNAJC2
ISCUENSG00000136003.11470.89440791.55360-0.749306.892205.98500HepG2EIF2S1
ISCUENSG00000136003.111809.41300874.663601.0486014.6054013.15930HepG2EIF4A3
ISCUENSG00000136003.112114.699001585.748800.415206.918106.03950HepG2ETF1
ISCUENSG00000136003.11731.22430560.889500.382502.763601.97850HepG2FUBP3
ISCUENSG00000136003.111231.32730882.789800.480003.846403.04060HepG2FXR1
ISCUENSG00000136003.11593.31610763.64060-0.364102.394201.78960HepG2HNRNPA1
ISCUENSG00000136003.111241.63090849.400800.547605.612904.65240HepG2HNRNPC
ISCUENSG00000136003.111728.078201325.434000.382604.047403.18560HepG2IGF2BP1
ISCUENSG00000136003.111548.96710832.201300.8962012.2792010.96920HepG2IGF2BP2
ISCUENSG00000136003.111006.11110861.900500.223102.192201.53110HepG2ILF2
ISCUENSG00000136003.11970.14340801.154800.276002.873001.83950HepG2KIF1C
ISCUENSG00000136003.112229.080601476.605600.594104.934203.81430HepG2LARP4
ISCUENSG00000136003.111008.23590779.324100.371402.770901.55610HepG2LIN28B
ISCUENSG00000136003.111170.38790883.099300.406202.798002.13950HepG2MAGOH
ISCUENSG00000136003.111796.34220887.994601.0163013.7466012.41720HepG2MATR3
ISCUENSG00000136003.111269.37320908.873400.481903.659702.93520HepG2NCBP2
ISCUENSG00000136003.11999.999501286.09500-0.363003.845302.94590HepG2NOL12
ISCUENSG00000136003.111313.49520803.159800.709605.206603.81110HepG2PCBP2
ISCUENSG00000136003.111006.13310841.665100.257402.257101.75330HepG2PTBP1
ISCUENSG00000136003.111212.18370892.684000.441306.704505.81720HepG2PUS1
ISCUENSG00000136003.111677.847701325.398100.340104.083503.48570HepG2RBM22
ISCUENSG00000136003.111315.86070827.227900.669509.466708.27540HepG2RBM25
ISCUENSG00000136003.111138.10330872.438600.383404.663703.89270HepG2RECQL
ISCUENSG00000136003.112729.733401450.129400.9125017.4169015.99370HepG2RPLP0
ISCUENSG00000136003.111198.99440761.372500.655104.344903.16820HepG2RPS10
ISCUENSG00000136003.111186.95720679.288200.8051011.9831010.81090HepG2RPS19
ISCUENSG00000136003.111297.67810825.372300.652707.205305.95520HepG2RPS2
ISCUENSG00000136003.111362.15600977.522000.478602.978102.15010HepG2RPS3A
ISCUENSG00000136003.11829.94370574.561500.530503.226702.38700HepG2RRP9
ISCUENSG00000136003.111044.63580751.433300.475206.994406.03790HepG2SAFB2
ISCUENSG00000136003.111753.416901134.711200.627705.212504.26840HepG2SF3A3
ISCUENSG00000136003.11654.409001031.63970-0.656707.126006.03940HepG2SF3B1
ISCUENSG00000136003.111089.66980876.191600.314502.764702.17290HepG2SF3B4
ISCUENSG00000136003.111045.94320876.306400.255202.663102.02910HepG2SMN1
ISCUENSG00000136003.112183.688001496.998000.5446013.0391012.16600HepG2SRFBP1
ISCUENSG00000136003.111735.51660914.591200.9241027.5398026.38850HepG2SRSF1
ISCUENSG00000136003.111565.684101212.119200.369205.060704.25400HepG2SRSF5
ISCUENSG00000136003.111865.147001299.765500.5209010.868009.98140HepG2SSB
ISCUENSG00000136003.111167.86660749.732400.639304.884404.02440HepG2SUPV3L1
ISCUENSG00000136003.111507.22850822.172600.8743020.2446018.92590HepG2TAF15
ISCUENSG00000136003.11979.10510755.356000.374203.380602.46050HepG2TIA1
ISCUENSG00000136003.112365.59360819.926301.5285057.3535055.62790HepG2TIAL1
ISCUENSG00000136003.11977.702901269.46420-0.376802.259501.50820HepG2UBE2L3
ISCUENSG00000136003.11638.84950442.855800.528503.475802.62930HepG2UCHL5
ISCUENSG00000136003.111003.02080686.393400.547102.930401.89780HepG2UPF2
ISCUENSG00000136003.111197.51450852.366800.490402.864401.78850HepG2XRCC6
ISCUENSG00000136003.11991.35910738.030800.425602.499501.80770HepG2XRN2
ISCUENSG00000136003.111370.40630771.097100.8295016.9158015.49460HepG2ZC3H8
ISCUENSG00000136003.112237.023001662.260900.428304.902103.50550K562AKAP8
ISCUENSG00000136003.111863.263101573.985100.243301.909601.36270K562AKAP8L
ISCUENSG00000136003.112757.625201253.261901.1376026.1193024.51310K562AQR
ISCUENSG00000136003.112261.339101807.583600.323003.556802.19550K562CCDC124
ISCUENSG00000136003.11747.35200586.022200.350702.483401.49940K562DDX3X
ISCUENSG00000136003.111517.707901237.142000.294803.445802.72950K562DDX47
ISCUENSG00000136003.112058.577301693.548200.281503.553902.54390K562DKC1
ISCUENSG00000136003.11859.63000612.232600.489504.157203.15220K562EIF4A3
ISCUENSG00000136003.111042.74200827.839500.332902.275901.50640K562FIP1L1
ISCUENSG00000136003.11807.07190636.693400.342002.843002.23110K562FXR1
ISCUENSG00000136003.111093.94770680.892700.683906.411004.90640K562HNRNPM
ISCUENSG00000136003.111937.279501122.398500.7873011.8187010.20110K562HSPD1
ISCUENSG00000136003.112067.799201598.961700.370904.141302.74470K562MAK16
ISCUENSG00000136003.11811.79740611.372900.409003.383502.01470K562NCBP2
ISCUENSG00000136003.11861.50620577.496000.577005.050504.03820K562PRPF8
ISCUENSG00000136003.112458.328501881.161200.386004.831303.38990K562PUM1
ISCUENSG00000136003.112199.561601560.764800.494905.360904.63650K562PUS1
ISCUENSG00000136003.11906.07200671.954200.431204.168803.11380K562SF3B4
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for ISCU is not available on ENCORE database.





37 RBPs can affect the splicing of ISCU :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEISCUENSG00000136003.11chr12+108960965108961044108959096108959207108962606108963160-0.133000.000000.00000excludedK562SF3B4
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.201000.000120.07261excludedHepG2NKRF
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.207000.000000.00000excludedHepG2RBM22
SEISCUENSG00000136003.11chr12+1089578351089579311089563811089565121089580541089581680.126000.003790.06080includedHepG2U2AF1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.111000.000260.05971excludedHepG2DKC1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.316000.000000.00000excludedHepG2TBRG4
SEISCUENSG00000136003.11chr12+1089578351089579311089563811089565121089580541089581680.212000.000000.00000includedK562AQR
SEISCUENSG00000136003.11chr12+1089614331089615331089609651089610441089626061089631440.141000.000000.00000includedK562AQR
SEISCUENSG00000136003.11chr12+108960965108961044108959096108959207108962606108963160-0.068000.000000.00010excludedK562AQR
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.107000.000000.00003excludedHepG2SRSF7
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.123000.001610.09490excludedHepG2DDX3X
SEISCUENSG00000136003.11chr12+1089578351089579311089563811089565121089580541089581680.189000.000000.00180includedK562MTPAP
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.139000.000460.03202excludedHepG2NCBP2
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.251000.000140.04299excludedHepG2EFTUD2
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.143000.000000.00043excludedHepG2SFPQ
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.438000.000000.00005excludedHepG2HNRNPA1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.107000.000430.07610excludedK562APOBEC3C
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.133000.000640.03048excludedHepG2MATR3
SEISCUENSG00000136003.11chr12+1089578351089579311089563811089565121089580541089581680.369000.000000.00002includedK562U2AF1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.109000.000000.00194excludedHepG2LARP4
SEISCUENSG00000136003.11chr12+1089578351089579311089563811089565121089580541089581680.157000.000560.04234includedK562HNRNPL
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.124000.000060.01649excludedHepG2HNRNPUL1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.116000.000010.00071excludedHepG2SF3A3
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.178000.000000.00001excludedHepG2SSB
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.170000.001550.08835excludedHepG2IGF2BP3
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.282000.000100.01170excludedHepG2TIAL1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.159000.000390.04216excludedHepG2SUPV3L1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.247000.000020.00216excludedHepG2PCBP1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.135000.000000.00155excludedK562EIF4G2
SEISCUENSG00000136003.11chr12+108960965108961044108959096108959207108962606108963160-0.061000.000090.02038excludedK562SRSF7
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.101000.001520.05174excludedK562HNRNPU
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.099000.000290.01045excludedK562AGGF1
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.258000.000140.04078excludedHepG2EIF3D
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.165000.000110.06667excludedK562AARS
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.407000.000000.00000excludedHepG2HNRNPU
SEISCUENSG00000136003.11chr12+108957835108957931108956381108956512108958054108958168-0.322000.000020.00162excludedHepG2HNRNPC
SEISCUENSG00000136003.11chr12+1089578351089579311089563811089565121089580541089581680.194000.000420.09916includedHepG2DROSHA
SEISCUENSG00000136003.11chr12+1089614331089615331089609651089610441089626061089631440.077000.000000.00001includedK562PTBP1
RIISCUENSG00000136003.11chr12+1089578351089581681089578351089579311089580541089581680.211000.001090.05996includedHepG2TBRG4
RIISCUENSG00000136003.11chr12+108957835108958168108957835108957931108958054108958168-0.217000.000460.01341excludedK562SRSF1
RIISCUENSG00000136003.11chr12+1089578351089581681089578351089579311089580541089581680.303000.000520.04245includedK562PHF6
RIISCUENSG00000136003.11chr12+1089578351089581681089578351089579311089580541089581680.284000.000710.09665includedHepG2DKC1
RIISCUENSG00000136003.11chr12+108957835108958168108957835108957931108958054108958168-0.251000.000080.02622excludedHepG2RBM15
RIISCUENSG00000136003.11chr12+1089578351089581681089578351089579311089580541089581680.282000.000070.00149includedHepG2QKI
RIISCUENSG00000136003.11chr12+1089578351089581681089578351089579311089580541089581680.483000.000000.00000includedHepG2HNRNPA1
RIISCUENSG00000136003.11chr12+108957835108958168108957835108957931108958054108958168-0.276000.000000.00001excludedHepG2U2AF1
RIISCUENSG00000136003.11chr12+1089578351089581681089578351089579311089580541089581680.251000.000090.00162includedHepG2RBM22
RIISCUENSG00000136003.11chr12+1089578351089581681089578351089579311089580541089581680.282000.000000.00078includedHepG2SSB
RIISCUENSG00000136003.11chr12+108957835108958168108957835108957931108958054108958168-0.200000.001710.03292excludedK562PTBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for ISCU is not avaliable on ENCORE database.