HEMK1

General Information

Gene Name       : HEMK1
Gene ID             : ENSG00000114735.9
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: HEMK1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878HEMK1ENSG00000114735.93.106.714.91ENCSR000AEF
HepG2HEMK1ENSG00000114735.95.655.615.63ENCSR985KAT
K562HEMK1ENSG00000114735.98.928.868.89ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for HEMK1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • HEMK1 RNA is bound by 11 proteins.  







eCLIP assay for HEMK1 is not avaliable on ENCORE database.





11 proteins are bound to HEMK1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr35061832750618403+3'-UTR3.827565.03283HepG2RBFOX2
chr35061755050617606+3'-UTR,CDS3.707237.55042HepG2PPIG
chr35061635550616416+3'-UTR,CDS,intron-Distal,intron-Proximal4.6348115.64024K562AQR
chr35061733450617366+3'-UTR,CDS4.834644.08604HepG2PPIG
chr35061631050616393+3'-UTR,CDS,intron-Distal,intron-Proximal4.192755.24452HepG2PPIG
chr35061634550616455+3'-UTR,CDS,intron-Distal,intron-Proximal4.891106.23323K562UCHL5
chr35061461250614665+3'-UTR,CDS,intron-Proximal4.895795.26064K562AQR
chr35061448050614538+3'-UTR,CDS,intron-Proximal4.191186.36347HepG2PPIG
chr35061776650617813+3'-UTR,CDS,intron-Proximal4.431236.25632HepG2SF3A3
chr35061764050617668+3'-UTR,CDS,intron-Proximal4.616745.52963HepG2PPIG
chr35061945850619536+3'-UTR3.399894.65237HepG2U2AF2
chr35061726550617310+3'-UTR,CDS,intron-Proximal4.265504.11693K562BUD13
chr35061755150617599+3'-UTR,CDS4.089063.01428K562UCHL5
chr35061775750617827+3'-UTR,CDS,intron-Proximal5.889209.16825K562SF3B4
chr35060953750609640+5'-UTR,CDS,intron-Distal,intron-Proximal4.296994.67299K562DDX24
chr35060954950609605+5'-UTR,CDS,intron-Distal3.529165.30777HepG2PPIG
chr35060697750607075+5'-UTR,intron-Distal,intron-Proximal3.709923.01994HepG2GTF2F1
chr35060960550609642+5'-UTR,CDS,intron-Distal,intron-Proximal4.200547.79455HepG2PPIG
chr35060850850608626+5'-UTR,CDS3.492396.13978HepG2PPIG
chr35061691650616972+intron-Distal4.221836.48405K562AQR
chr35061689950616982+intron-Distal4.428593.28989K562RBM15
chr35061688150616960+intron-Distal4.689487.47028K562DDX24
chr35061637650616446+intron-Distal,intron-Proximal4.428506.25151K562DDX24
chr35061722950617275+intron-Proximal3.203224.89507K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for HEMK1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for HEMK1 is not available on ENCORE database.

  • 91 RBPs can affect the levels of HEMK1.  








The Knockdown/knockout RNA-Seq assay for HEMK1 is not available on ENCORE database.





91 RBPs can affect the gene expression of HEMK1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
HEMK1ENSG00000114735.5373.17850483.94310-0.375002.810302.19890HepG2ACO1
HEMK1ENSG00000114735.5336.57120505.42560-0.586603.234402.66500HepG2AKAP1
HEMK1ENSG00000114735.5395.78910575.63090-0.540405.480804.57080HepG2AUH
HEMK1ENSG00000114735.5425.36360293.033200.537502.639301.75940HepG2BCLAF1
HEMK1ENSG00000114735.5808.84910245.305801.7212031.4874029.51250HepG2CPSF6
HEMK1ENSG00000114735.5692.70390541.549200.355003.876603.02310HepG2DAZAP1
HEMK1ENSG00000114735.5876.51120354.251301.3069013.6399012.27190HepG2DDX21
HEMK1ENSG00000114735.5207.06440484.13580-1.2253012.1432010.91920HepG2DDX3X
HEMK1ENSG00000114735.5553.24040363.744500.604904.590903.30420HepG2DDX5
HEMK1ENSG00000114735.5289.50880415.93840-0.522802.603602.00410HepG2DDX6
HEMK1ENSG00000114735.5485.11890285.204300.766204.943803.65110HepG2DHX30
HEMK1ENSG00000114735.5632.10640463.000100.449104.034603.24630HepG2DKC1
HEMK1ENSG00000114735.5416.14530295.722300.492702.968402.24500HepG2DNAJC21
HEMK1ENSG00000114735.5419.25530293.026800.516703.376002.66880HepG2DNAJC2
HEMK1ENSG00000114735.5448.44530316.830200.501102.649301.74470HepG2EEF2
HEMK1ENSG00000114735.5599.34570399.796400.584003.936403.23680HepG2EIF2S1
HEMK1ENSG00000114735.5972.09640441.795201.1376014.0832012.66580HepG2EIF4A3
HEMK1ENSG00000114735.5965.86440660.944200.547206.883206.00610HepG2ETF1
HEMK1ENSG00000114735.5328.50600472.89090-0.525603.782402.80500HepG2EWSR1
HEMK1ENSG00000114735.5438.24670245.711700.834702.986001.92970HepG2FTO
HEMK1ENSG00000114735.5492.11380312.658500.654305.147504.08550HepG2FUBP3
HEMK1ENSG00000114735.5641.25360413.533700.632804.616603.76620HepG2G3BP1
HEMK1ENSG00000114735.5615.24020439.074600.486603.056202.12060HepG2G3BP2
HEMK1ENSG00000114735.5382.24610278.092300.458802.096901.53510HepG2GPKOW
HEMK1ENSG00000114735.5689.75150298.554501.2080016.8087015.43770HepG2HNRNPA1
HEMK1ENSG00000114735.5548.76350332.058700.724605.919204.93370HepG2HNRNPC
HEMK1ENSG00000114735.5492.75240320.655900.619705.802704.81350HepG2HNRNPF
HEMK1ENSG00000114735.5708.20060493.272300.521706.978005.95230HepG2HNRNPL
HEMK1ENSG00000114735.5501.18370265.386900.917107.982806.97450HepG2HNRNPLL
HEMK1ENSG00000114735.5440.93730329.865400.418602.048601.51770HepG2HNRNPU
HEMK1ENSG00000114735.5487.16410315.751400.625505.029904.08150HepG2IGF2BP1
HEMK1ENSG00000114735.5672.34880422.811300.669104.362303.07530HepG2KHSRP
HEMK1ENSG00000114735.5746.23770445.989800.742506.501105.50620HepG2MAGOH
HEMK1ENSG00000114735.5251.02310448.47280-0.837205.713404.83270HepG2MATR3
HEMK1ENSG00000114735.5588.06940384.427900.613204.417003.40980HepG2MSI2
HEMK1ENSG00000114735.5474.21640270.618300.809204.424703.17940HepG2MTPAP
HEMK1ENSG00000114735.5357.79630235.302400.604503.295902.47950HepG2NSUN2
HEMK1ENSG00000114735.5128.38780280.62890-1.128205.973604.63270HepG2PABPC1
HEMK1ENSG00000114735.5397.74750294.218500.434902.145901.48860HepG2PPIL4
HEMK1ENSG00000114735.5162.47130255.75880-0.654603.026802.18500HepG2PRPF8
HEMK1ENSG00000114735.5701.84770419.814100.741308.721407.70730HepG2QKI
HEMK1ENSG00000114735.598.88930331.89760-1.7469011.6779010.30430HepG2RAVER1
HEMK1ENSG00000114735.5463.61090345.471400.424202.177701.56260HepG2RPLP0
HEMK1ENSG00000114735.5479.20910308.259000.636403.532402.62790HepG2RPS3A
HEMK1ENSG00000114735.5313.29230465.91800-0.572603.836402.55650HepG2RPS5
HEMK1ENSG00000114735.5114.19900252.99400-1.147606.863705.68710HepG2RRP9
HEMK1ENSG00000114735.5161.79630596.75520-1.8830024.9981022.91730HepG2SF3A3
HEMK1ENSG00000114735.5650.88070491.637100.404702.544701.86830HepG2SLBP
HEMK1ENSG00000114735.5145.34000282.62570-0.959504.839303.48390HepG2SRSF3
HEMK1ENSG00000114735.5434.63560315.044500.464202.072901.46090HepG2SRSF7
HEMK1ENSG00000114735.5928.26260541.682700.7770014.0757013.09910HepG2SSB
HEMK1ENSG00000114735.5532.17150317.247800.746204.771103.18870HepG2STAU1
HEMK1ENSG00000114735.5161.52550268.12500-0.731103.811702.50100HepG2STIP1
HEMK1ENSG00000114735.5504.52640330.091100.612003.256802.52980HepG2SUPV3L1
HEMK1ENSG00000114735.5475.51710378.662600.328501.959001.47310HepG2TAF15
HEMK1ENSG00000114735.5349.04530258.619300.432502.028201.39550HepG2TARDBP
HEMK1ENSG00000114735.5514.17650320.630700.681304.767904.14810HepG2TIAL1
HEMK1ENSG00000114735.5203.19510406.40980-1.000108.802707.67680HepG2U2AF1
HEMK1ENSG00000114735.5487.26620302.228100.689003.401302.28200HepG2UPF2
HEMK1ENSG00000114735.5261.31960510.95100-0.9674012.1765011.05660HepG2UTP3
HEMK1ENSG00000114735.5456.97850324.938900.491902.356101.68240HepG2XRN2
HEMK1ENSG00000114735.5374.20920582.05220-0.637308.088107.28050HepG2ZNF622
HEMK1ENSG00000114735.5545.77870776.70990-0.509103.277402.66920K562AGGF1
HEMK1ENSG00000114735.5536.69820808.17260-0.590604.423403.59080K562AKAP8L
HEMK1ENSG00000114735.5494.31520768.16170-0.636005.393704.62140K562AQR
HEMK1ENSG00000114735.5442.51110284.197500.638704.106003.04120K562BOP1
HEMK1ENSG00000114735.5551.59750911.29110-0.724306.078503.87620K562DDX19B
HEMK1ENSG00000114735.5735.54700549.537700.420504.134003.35880K562DDX47
HEMK1ENSG00000114735.5589.21530869.83500-0.561904.038702.95380K562DKC1
HEMK1ENSG00000114735.5480.10270341.708900.490503.885002.42840K562EIF2S1
HEMK1ENSG00000114735.5729.67260556.688600.390303.342902.56430K562EIF2S2
HEMK1ENSG00000114735.5301.00390416.80740-0.469602.330801.39030K562EIF3D
HEMK1ENSG00000114735.5515.39230325.041000.664905.413004.26660K562EIF4A3
HEMK1ENSG00000114735.5382.15440260.619100.552103.117102.14110K562FTO
HEMK1ENSG00000114735.5106.50950227.82990-1.097004.895303.89350K562G3BP2
HEMK1ENSG00000114735.5471.16450288.494500.707605.534404.41550K562GPKOW
HEMK1ENSG00000114735.5949.19680741.774100.355602.463501.74840K562GRSF1
HEMK1ENSG00000114735.5684.20640510.236900.423203.341702.16030K562HNRNPA1
HEMK1ENSG00000114735.5813.16560361.317601.1702018.3343016.88020K562HNRNPC
HEMK1ENSG00000114735.5794.09590496.604600.677107.558605.72860K562HNRNPL
HEMK1ENSG00000114735.5785.04760565.048800.474304.799203.61420K562HNRNPU
HEMK1ENSG00000114735.5535.35460857.77560-0.680104.582603.47790K562KIF1C
HEMK1ENSG00000114735.5608.36100821.01920-0.432502.294401.34470K562MAK16
HEMK1ENSG00000114735.5562.29720960.91110-0.773104.790603.53160K562MBNL1
HEMK1ENSG00000114735.5438.94510281.606000.640304.621903.46840K562METAP2
HEMK1ENSG00000114735.5711.05000437.667200.700009.613408.20050K562MTPAP
HEMK1ENSG00000114735.5353.19490673.52010-0.931307.180405.50770K562NAA15
HEMK1ENSG00000114735.5487.55040352.771900.466702.942601.46680K562PHF6
HEMK1ENSG00000114735.5227.87860378.90310-0.733604.780903.79910K562PRPF8
HEMK1ENSG00000114735.5463.31900323.964100.516103.305502.30470K562PSIP1
HEMK1ENSG00000114735.5677.06670919.56330-0.441703.023702.17040K562PUF60
HEMK1ENSG00000114735.5732.44070978.08960-0.417302.605101.57140K562PUM1
HEMK1ENSG00000114735.5495.46680801.69470-0.694305.205304.49050K562PUS1
HEMK1ENSG00000114735.5124.33700217.38540-0.806002.723301.32200K562RAVER1
HEMK1ENSG00000114735.5505.71050780.95730-0.626904.182403.46940K562RBM15
HEMK1ENSG00000114735.5440.50730295.599200.575404.181402.95930K562RCC2
HEMK1ENSG00000114735.5464.69730344.780700.430502.554701.51670K562SAFB
HEMK1ENSG00000114735.5169.74010236.93980-0.481202.237501.47040K562SF3B4
HEMK1ENSG00000114735.5267.10700434.74940-0.702802.455301.32670K562SNRNP200
HEMK1ENSG00000114735.5197.36700358.02090-0.859202.572901.88750K562SRSF1
HEMK1ENSG00000114735.5432.44670311.596300.472702.496901.61290K562TIAL1
HEMK1ENSG00000114735.5130.95880220.88260-0.754202.986101.84400K562U2AF1
HEMK1ENSG00000114735.5134.57920228.11010-0.761304.367203.36270K562U2AF2
HEMK1ENSG00000114735.51040.92680515.628001.0134023.8223021.96960K562UPF1
HEMK1ENSG00000114735.5541.77180812.62330-0.584902.558301.33430K562UTP18
HEMK1ENSG00000114735.5619.14510441.207500.488703.944402.89290K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for HEMK1 is not available on ENCORE database.





6 RBPs can affect the splicing of HEMK1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEHEMK1ENSG00000114735.5chr3+506162515061635750614939506150045061727450617660-0.342000.005180.06390excludedK562PUS1
SEHEMK1ENSG00000114735.5chr3+5061696650617171506162515061635750617274506173700.179000.000570.07468includedK562LARP4
SEHEMK1ENSG00000114735.5chr3+5061693550617171506162515061635750617274506173700.200000.000160.01845includedK562HNRNPUL1
A5SSHEMK1ENSG00000114735.5chr3+506083615060876350608361506087255060914050609232-0.214000.000520.05812shorterK562EFTUD2
RIHEMK1ENSG00000114735.5chr3+506172745061766050617274506173705061754650617660-0.126000.000070.00936excludedK562EIF4G2
RIHEMK1ENSG00000114735.5chr3+5061727450617660506172745061737050617546506176600.160000.005490.05893includedHepG2PCBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for HEMK1 is not avaliable on ENCORE database.