FIS1

General Information

Gene Name       : FIS1
Gene ID             : ENSG00000214253.8
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: FIS1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FIS1ENSG00000214253.832.8671.4652.16ENCSR000AEF
HepG2FIS1ENSG00000214253.8126.6663.8995.28ENCSR985KAT
K562FIS1ENSG00000214253.8113.50101.86107.68ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for FIS1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • FIS1 RNA is bound by 14 proteins.  







eCLIP assay for FIS1 is not avaliable on ENCORE database.





14 proteins are bound to FIS1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr7100882762100882834-3'-UTR,intron-Distal,intron-Proximal4.517688.42114HepG2XRN2
chr7100883003100883025-3'-UTR,CDS,intron-Distal,intron-Proximal3.808487.66579K562PABPC4
chr7100882929100882989-3'-UTR,CDS,intron-Distal,intron-Proximal3.774557.75202HepG2DDX55
chr7100882976100883003-3'-UTR,CDS,intron-Distal,intron-Proximal4.2425314.02882K562PABPC4
chr7100882922100883063-3'-UTR,CDS,intron-Distal,intron-Proximal3.4919416.19106HepG2PCBP2
chr7100882938100883049-3'-UTR,CDS,intron-Distal,intron-Proximal4.9293117.50368HepG2LARP4
chr7100883073100883183-3'-UTR,CDS,intron-Distal3.3033811.74139HepG2PPIG
chr7100882886100882973-3'-UTR,CDS,intron-Distal,intron-Proximal,polyA_site4.6288061.40195K562PUM2
chr7100883452100883504-3'-UTR,CDS,intron-Distal4.254379.18768K562PABPC4
chr7100883075100883174-3'-UTR,CDS,intron-Distal3.975038.53596HepG2LARP4
chr7100883450100883512-3'-UTR,CDS,intron-Distal4.6449410.78364HepG2PPIG
chr7100882931100882976-3'-UTR,CDS,intron-Distal,intron-Proximal5.1072762.66809K562PABPC4
chr7100888242100888344-5'-UTR,CDS,intron-Distal,intron-Proximal3.139025.91934K562DDX55
chr7100888262100888313-5'-UTR,CDS,intron-Distal5.0588730.90795K562DDX3X
chr7100888352100888362-5'-UTR,intron-Distal,intron-Proximal4.914365.47892K562DDX3X
chr7100888313100888352-5'-UTR,intron-Distal,intron-Proximal5.4691419.79992K562DDX3X
chr7100888288100888348-5'-UTR,intron-Distal,intron-Proximal4.502944.01285K562GEMIN5
chr7100888239100888294-5'-UTR,CDS,intron-Distal5.2076711.52455K562PABPC4
chr7100888248100888294-5'-UTR,CDS,intron-Distal4.229233.76880HepG2DDX3X
chr7100888240100888317-5'-UTR,CDS,intron-Distal3.425965.89531HepG2SUB1
chr7100887319100887368-CDS,intron-Distal3.8451110.44075K562DDX3X
chr7100884067100884132-CDS,intron-Distal,intron-Proximal4.656149.43475HepG2PRPF8
chr7100887366100887413-CDS,intron-Distal3.088453.97042HepG2LARP4
chr7100887286100887328-CDS,intron-Distal,intron-Proximal3.9943714.54489K562LIN28B
chr7100888242100888261-CDS,intron-Distal4.096993.72779HepG2LARP4
chr7100887404100887420-CDS,intron-Distal3.552945.97131K562DDX3X
chr7100888239100888262-CDS,intron-Distal4.0580814.94351K562DDX3X
chr7100884171100884187-CDS,intron-Distal3.147957.25123K562LIN28B
chr7100883763100883847-intron-Distal4.176724.35952HepG2PRPF4
chr7100883727100883839-intron-Distal4.753194.65580K562GTF2F1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for FIS1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for FIS1 is not available on ENCORE database.

  • 69 RBPs can affect the levels of FIS1.  








The Knockdown/knockout RNA-Seq assay for FIS1 is not available on ENCORE database.





69 RBPs can affect the gene expression of FIS1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FIS1ENSG00000214253.4775.70710476.827900.7019011.030709.98580HepG2ACO1
FIS1ENSG00000214253.41698.80560824.630901.0426013.4618012.38090HepG2AKAP1
FIS1ENSG00000214253.4831.26090648.221900.358702.112701.43150HepG2CIRBP
FIS1ENSG00000214253.4681.21260476.758600.514706.158605.23800HepG2CKAP4
FIS1ENSG00000214253.4745.78610321.178801.2153010.322608.87500HepG2CNOT7
FIS1ENSG00000214253.4553.10290394.717200.486602.593501.60980HepG2YBX3
FIS1ENSG00000214253.4928.42920671.133700.468102.701002.06450HepG2CELF1
FIS1ENSG00000214253.4696.26170441.013300.6587010.014208.61910HepG2DDX19B
FIS1ENSG00000214253.4736.12510510.550100.527802.828502.04730HepG2DDX55
FIS1ENSG00000214253.4144.85630461.30500-1.671106.185304.75340HepG2DDX59
FIS1ENSG00000214253.4984.86260678.683800.537103.771703.05980HepG2DDX6
FIS1ENSG00000214253.4621.40410456.204000.445802.077801.47840HepG2DKC1
FIS1ENSG00000214253.4621.64550387.549700.681607.918106.77700HepG2DNAJC21
FIS1ENSG00000214253.4702.03980528.652000.409103.088601.84840HepG2EIF2S2
FIS1ENSG00000214253.41020.89270720.734300.502203.403802.69600HepG2EIF4A3
FIS1ENSG00000214253.4732.48270406.977700.847703.419802.28620HepG2FTO
FIS1ENSG00000214253.4573.11870422.570600.439502.503701.54120HepG2GNB2L1
FIS1ENSG00000214253.4561.17460435.223800.366602.018501.41580HepG2HNRNPC
FIS1ENSG00000214253.4866.80490657.209900.399303.982803.18580HepG2HNRNPL
FIS1ENSG00000214253.4777.83970432.345200.8472014.7231013.41740HepG2HNRNPU
FIS1ENSG00000214253.4584.12400441.623600.403403.269202.47830HepG2ILF2
FIS1ENSG00000214253.41023.17500775.467200.399802.158501.43240HepG2LARP4
FIS1ENSG00000214253.4493.52610666.82070-0.434202.618001.91370HepG2PABPC4
FIS1ENSG00000214253.4803.41430633.300200.343202.786002.23710HepG2PTBP1
FIS1ENSG00000214253.4849.13220683.001600.314002.263301.71610HepG2PUF60
FIS1ENSG00000214253.41098.49310725.074600.5992012.4757011.40850HepG2PUM1
FIS1ENSG00000214253.4501.48160656.44270-0.388503.154902.50220HepG2RECQL
FIS1ENSG00000214253.4619.97130385.013100.687209.115808.05430HepG2SAFB2
FIS1ENSG00000214253.4591.53270393.996600.586204.164403.01630HepG2SERBP1
FIS1ENSG00000214253.4813.62530580.331200.487402.971102.27150HepG2SF3A3
FIS1ENSG00000214253.4712.78010434.857300.712804.951104.02920HepG2SF3B1
FIS1ENSG00000214253.4701.63820448.974500.644009.350708.28080HepG2SMN1
FIS1ENSG00000214253.4639.08160414.075200.626002.158401.32270HepG2SMNDC1
FIS1ENSG00000214253.41177.87590875.121200.428505.677105.03080HepG2SRFBP1
FIS1ENSG00000214253.4887.87700545.336500.703105.125503.32780HepG2SUGP2
FIS1ENSG00000214253.4731.15530508.205300.524702.841302.15670HepG2SUPV3L1
FIS1ENSG00000214253.4441.44110568.37940-0.364602.387201.60860HepG2TIA1
FIS1ENSG00000214253.4755.50330420.044400.8468011.8336010.92650HepG2TIAL1
FIS1ENSG00000214253.4575.73200423.863400.441704.128503.46760HepG2TRIM56
FIS1ENSG00000214253.4741.81970514.664900.527306.543905.54480HepG2UPF1
FIS1ENSG00000214253.4517.42670424.464500.285601.880001.31190HepG2ZC3H8
FIS1ENSG00000214253.4723.94900957.76180-0.403803.106201.84720K562AARS
FIS1ENSG00000214253.41790.655801309.619100.451207.903807.01430K562AGGF1
FIS1ENSG00000214253.41862.058401439.105200.371603.584502.43040K562AKAP8
FIS1ENSG00000214253.42069.263501362.725900.602508.364607.16650K562AKAP8L
FIS1ENSG00000214253.4429.28080593.40750-0.467102.767701.89390K562BOP1
FIS1ENSG00000214253.4984.58240789.408900.318602.847001.51300K562DDX6
FIS1ENSG00000214253.41072.36130855.230400.326303.464702.09660K562EIF2S1
FIS1ENSG00000214253.41071.26620745.825800.522305.011003.84500K562FIP1L1
FIS1ENSG00000214253.4578.15770909.85250-0.654205.861004.10700K562FKBP4
FIS1ENSG00000214253.4473.30750641.95710-0.439702.548501.72780K562FMR1
FIS1ENSG00000214253.4100.12290443.41510-2.1469013.7924011.95550K562G3BP2
FIS1ENSG00000214253.4683.349801047.96580-0.616907.019306.11000K562HNRNPC
FIS1ENSG00000214253.41015.24730613.451300.726706.317404.82680K562HNRNPM
FIS1ENSG00000214253.41480.536101011.183000.550005.748104.61620K562HSPD1
FIS1ENSG00000214253.41979.943201446.165400.453105.890204.58170K562KIF1C
FIS1ENSG00000214253.4790.430501014.84360-0.360502.719201.34620K562LARP7
FIS1ENSG00000214253.41679.509801384.358300.278702.367501.39860K562MAK16
FIS1ENSG00000214253.4440.91230588.07140-0.415502.264501.47330K562METAP2
FIS1ENSG00000214253.4843.811701090.20290-0.369604.353403.35890K562MTPAP
FIS1ENSG00000214253.41640.578701135.557200.530703.875502.78360K562NAA15
FIS1ENSG00000214253.4835.608801117.99600-0.420002.898502.04610K562PCBP3
FIS1ENSG00000214253.41261.87580846.658200.575604.587803.49350K562PPIG
FIS1ENSG00000214253.41887.230701351.394400.481705.263704.54580K562PUS1
FIS1ENSG00000214253.41870.513601316.776500.506303.438702.78980K562RBM15
FIS1ENSG00000214253.4571.41340420.372800.442803.085001.67460K562RBM25
FIS1ENSG00000214253.4410.40990572.87330-0.481202.680501.72110K562SF3B1
FIS1ENSG00000214253.4670.62710460.876400.541005.270004.06710K562SF3B4
FIS1ENSG00000214253.4979.11250712.518100.458403.848602.57260K562SRSF5
FIS1ENSG00000214253.41086.42760763.237600.509303.166002.40890K562TARDBP
FIS1ENSG00000214253.4994.05060736.265500.433002.798601.97580K562TIA1
FIS1ENSG00000214253.4681.63090903.74960-0.406902.662801.74610K562TIAL1
FIS1ENSG00000214253.4998.02510722.826300.465302.668201.59880K562TRA2A
FIS1ENSG00000214253.4305.79640443.74700-0.537204.026803.05810K562U2AF2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for FIS1 is not available on ENCORE database.





21 RBPs can affect the splicing of FIS1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100888240100888366-0.107000.001040.03872excludedK562PRPF8
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100895175100895572-0.064000.000110.06800excludedK562UTP3
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008882401008883660.073000.000090.00188includedHepG2U2AF2
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008951751008955720.073000.000160.08283includedHepG2SUGP2
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100895175100895572-0.417000.000000.00000excludedK562AQR
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100888240100888366-0.106000.000000.00051excludedK562FXR1
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008882401008883660.071000.000120.06728includedHepG2FAM120A
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008951751008955720.059000.000400.03036includedHepG2FTO
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100895175100895572-0.109000.000670.02242excludedHepG2SF3A3
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008882401008883660.072000.000200.04892includedK562FXR2
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008951751008955720.053000.000130.01630includedK562HNRNPUL1
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008951751008955720.086000.000000.00164includedK562EIF4G2
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100888240100888366-0.098000.000000.00029excludedK562TARDBP
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100888240100888366-0.092000.000070.00450excludedK562HNRNPU
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100888240100888366-0.067000.000290.03813excludedK562CPSF6
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100895175100895572-0.085000.001940.06683excludedK562SF3B1
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008882401008883660.061000.000180.03244includedK562ZC3H8
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100888240100888366-0.099000.000130.03485excludedK562SAFB
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100888240100888366-0.118000.000000.00002excludedK562PTBP1
SEFIS1ENSG00000214253.4chr7-1008872871008874201008841101008841871008951751008955720.054000.000180.04064includedK562NPM1
SEFIS1ENSG00000214253.4chr7-100887287100887420100884110100884187100888240100888366-0.059000.003090.04771excludedK562HNRNPC
A3SSFIS1ENSG00000214253.4chr7-1008841051008842891008841051008841871008882401008883560.217000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for FIS1 is not avaliable on ENCORE database.