BRAF

General Information

Gene Name       : BRAF
Gene ID             : ENSG00000157764.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: BRAF)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878BRAFENSG00000157764.138.118.608.36ENCSR000AEF
HepG2BRAFENSG00000157764.135.716.025.87ENCSR985KAT
K562BRAFENSG00000157764.1317.4114.7616.09ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for BRAF is not avaliable on ENCORE database.



Proteins bound to RNA
  • BRAF RNA is bound by 29 proteins.  







eCLIP assay for BRAF is not avaliable on ENCORE database.





29 proteins are bound to BRAF RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr7140494141140494209-3'-UTR,CDS,intron-Distal3.328987.08969K562ZNF622
chr7140477830140477876-3'-UTR,CDS,intron-Distal,intron-Proximal3.962553.84295K562GRWD1
chr7140424976140425087-3'-UTR,intron-Distal4.2199116.80239HepG2QKI
chr7140507853140507920-3'-UTR,CDS,intron-Distal,intron-Proximal3.911575.02403K562SF3B4
chr7140481374140481411-3'-UTR,CDS,intron-Distal,intron-Proximal3.681656.81385HepG2BCLAF1
chr7140477810140477873-3'-UTR,CDS,intron-Distal3.685896.44455K562ZNF622
chr7140500145140500202-3'-UTR,CDS,intron-Distal,intron-Proximal3.122533.00343HepG2GRWD1
chr7140449197140449218-3'-UTR,CDS,intron-Distal3.533783.27569HepG2BCLAF1
chr7140481391140481428-3'-UTR,CDS,intron-Distal3.252114.61701K562ZNF622
chr7140425371140425474-3'-UTR,intron-Distal3.339746.00918K562FAM120A
chr7140424982140425079-3'-UTR,intron-Distal4.1844915.09533K562QKI
chr7140482913140482978-3'-UTR,CDS,intron-Distal,intron-Proximal3.904523.07225K562U2AF1
chr7140482819140482857-3'-UTR,CDS,intron-Distal,intron-Proximal5.124047.84234K562ZNF622
chr7140494121140494220-3'-UTR,CDS,intron-Distal3.228283.00343HepG2GRWD1
chr7140482898140482970-3'-UTR,CDS,intron-Distal,intron-Proximal3.283504.45024K562U2AF2
chr7140434529140434574-3'-UTR,CDS,intron-Distal,intron-Proximal3.917293.02097K562U2AF1
chr7140482903140482968-3'-UTR,CDS,intron-Distal,intron-Proximal4.353708.31636HepG2U2AF2
chr7140481434140481493-3'-UTR,CDS,intron-Distal3.855217.95479K562ZNF622
chr7140624455140624512-5'-UTR,CDS,intron-Distal,intron-Proximal4.161504.53890K562PCBP1
chr7140549909140549924-CDS,intron-Distal,intron-Proximal3.305325.39278K562ZNF622
chr7140534628140534673-CDS,intron-Distal,intron-Proximal3.720395.97823HepG2BCLAF1
chr7140624334140624388-CDS,intron-Distal4.011304.07395K562SRSF1
chr7140534454140534557-CDS,intron-Distal4.133067.94086K562U2AF1
chr7140534633140534674-CDS,intron-Distal,intron-Proximal3.442177.70405K562ZNF622
chr7140534455140534539-CDS,intron-Distal3.8296410.17690HepG2U2AF2
chr7140549910140549947-CDS,intron-Distal,intron-Proximal3.197495.00751HepG2BCLAF1
chr7140534446140534504-CDS,intron-Distal3.545763.24714K562IGF2BP1
chr7140534502140534558-CDS,intron-Distal4.288095.08762K562U2AF2
chr7140576870140576969-intron-Distal4.6006013.69723K562KHSRP
chr7140475662140475761-intron-Distal4.566968.08894HepG2QKI
chr7140530967140531032-intron-Distal4.129054.55118K562PPIL4
chr7140531408140531495-intron-Distal5.063949.89378K562SAFB2
chr7140517772140517852-intron-Distal3.975333.90026K562KHSRP
chr7140527200140527272-intron-Distal3.909713.85646K562PPIL4
chr7140623947140624026-intron-Distal3.520397.84057K562NONO
chr7140524353140524451-intron-Distal3.5747010.51274K562SAFB2
chr7140578314140578425-intron-Distal4.245034.30850HepG2QKI
chr7140500093140500151-intron-Distal,intron-Proximal4.347143.77503K562TIA1
chr7140455682140455772-intron-Distal3.610344.21358HepG2U2AF2
chr7140620500140620595-intron-Distal3.519573.62418K562PTBP1
chr7140525260140525316-intron-Distal4.605536.91685K562SAFB2
chr7140532191140532307-intron-Distal3.638226.14846K562QKI
chr7140533903140533975-intron-Distal3.6805811.99390K562KHSRP
chr7140624210140624311-intron-Distal4.579354.54675K562XRN2
chr7140521515140521627-intron-Distal4.676607.01496K562KHSRP
chr7140622677140622804-intron-Distal5.6762312.06807K562MATR3
chr7140534029140534143-intron-Distal4.277243.47043HepG2KHSRP
chr7140556767140556829-intron-Distal3.767293.06015K562MATR3
chr7140533975140534047-intron-Distal4.0477811.86374K562KHSRP
chr7140623253140623305-intron-Distal4.190816.90077HepG2PTBP1
chr7140596744140596839-intron-Distal3.166843.73266K562KHSRP
chr7140623068140623145-intron-Distal3.377824.52210K562KHSRP
chr7140523963140524035-intron-Distal4.634486.44643K562SAFB2
chr7140584178140584218-intron-Distal4.385674.94713K562HNRNPL
chr7140529654140529690-intron-Distal3.734283.19638K562SAFB2
chr7140622741140622815-intron-Distal3.605704.08528HepG2SUGP2
chr7140528410140528477-intron-Distal3.017714.91201K562SAFB2
chr7140624187140624278-intron-Distal3.892226.59396K562NONO
chr7140530962140531011-intron-Distal3.140923.87218K562SAFB2
chr7140526670140526698-intron-Distal3.884063.74251K562SAFB2
chr7140622731140622758-intron-Distal4.761573.42734K562PTBP1
chr7140622945140623000-intron-Distal4.126285.09669HepG2QKI
chr7140530432140530507-intron-Distal3.756486.58867K562SAFB2
chr7140532236140532320-intron-Distal3.356597.55922K562PTBP1
chr7140513635140513697-intron-Distal5.2275710.25043K562TARDBP
chr7140622969140623094-intron-Distal4.7895023.36503K562QKI
chr7140622948140623002-intron-Distal3.786526.25619HepG2SUGP2
chr7140562081140562166-intron-Distal4.944536.76922HepG2PTBP1
chr7140476611140476674-intron-Distal,intron-Proximal3.046343.46531K562KHSRP
chr7140509767140509849-intron-Distal4.5418010.58655HepG2QKI
chr7140487406140487472-intron-Distal,intron-Proximal3.180585.96041K562KHSRP
chr7140575893140575969-intron-Distal4.080363.42844K562KHSRP
chr7140534047140534146-intron-Distal3.9937612.49723K562KHSRP
chr7140532262140532359-intron-Distal3.724583.45805K562KHSRP
chr7140556646140556740-intron-Distal4.852937.02715K562MATR3
chr7140623949140624037-intron-Distal3.261064.67779HepG2SUGP2
chr7140623947140624024-intron-Distal3.077713.25653K562CSTF2T
chr7140529196140529254-intron-Distal3.467775.49916K562SAFB2
chr7140624216140624303-intron-Distal4.382433.35850HepG2TIAL1
chr7140621848140621899-intron-Distal4.251805.25174K562KHSRP
chr7140526769140526915-intron-Distal3.7358012.94586K562SAFB2
chr7140584177140584229-intron-Distal3.899635.16718K562AGGF1
chr7140527574140527621-intron-Distal4.085034.51328K562SAFB2
chr7140623000140623050-intron-Distal4.595254.17759HepG2QKI
chr7140622591140622671-intron-Distal4.981717.55950K562MATR3
chr7140623805140623877-intron-Distal4.325387.22321K562PTBP1
chr7140564051140564110-intron-Distal4.248554.75572K562MATR3
chr7140622480140622542-intron-Distal4.977537.90787HepG2SUGP2
chr7140530423140530509-intron-Distal3.287924.05044K562PPIL4
chr7140533928140534008-intron-Distal4.002263.75546HepG2KHSRP
chr7140622585140622664-intron-Distal3.746995.78896K562PTBP1
chr7140584218140584280-intron-Distal4.456355.60352K562HNRNPL
chr7140529484140529545-intron-Distal4.714957.76000K562SAFB2
chr7140624203140624301-intron-Distal3.513454.16791HepG2NKRF
chr7140576603140576722-intron-Distal5.155489.93832K562KHSRP
chr7140527493140527543-intron-Distal3.270633.86112K562SAFB2
chr7140576828140576856-intron-Distal3.860353.26999K562KHSRP
chr7140624058140624127-intron-Distal4.897066.67086K562NONO
chr7140507286140507363-intron-Distal4.693544.30178K562PTBP1
chr7140500454140500542-intron-Distal3.189043.68839K562KHSRP
chr7140562077140562166-intron-Distal4.631979.73442K562PTBP1
chr7140584212140584285-intron-Distal3.186643.77546HepG2HNRNPL
chr7140522735140522791-intron-Distal4.173723.84033K562SAFB2
chr7140529701140529768-intron-Distal4.697376.44435K562SAFB2
chr7140578347140578429-intron-Distal3.165433.76090HepG2U2AF2
chr7140623236140623292-intron-Distal3.254014.86332HepG2SUGP2
chr7140524345140524457-intron-Distal3.248755.80318K562PPIL4
chr7140532186140532302-intron-Distal3.975106.52138HepG2QKI
chr7140622645140622756-intron-Distal3.342994.89779HepG2PTBP1
chr7140531647140531767-intron-Distal3.213966.35363K562SAFB2
chr7140527454140527540-intron-Distal4.825316.81402HepG2HLTF
chr7140532247140532316-intron-Distal4.935105.75114HepG2PTBP1
chr7140530092140530147-intron-Distal4.138453.50894K562SAFB2
chr7140564320140564385-intron-Distal3.329283.45178K562MATR3
chr7140528340140528385-intron-Distal3.050643.26524K562SAFB2
chr7140623247140623310-intron-Distal4.854306.19517K562MATR3
chr7140578573140578656-intron-Distal3.095833.31830K562KHSRP
chr7140563965140564041-intron-Distal4.532545.26569K562MATR3
chr7140564307140564382-intron-Distal3.207253.59523HepG2SUGP2
chr7140522112140522226-intron-Distal3.388676.85960K562KHSRP
chr7140533691140533753-intron-Distal3.821983.10834HepG2CSTF2
chr7140623964140624036-intron-Distal4.674445.72657HepG2MATR3
chr7140524263140524307-intron-Distal4.013344.15306K562SAFB2
chr7140593983140594116-intron-Distal4.040863.41738HepG2PTBP1
chr7140511141140511263-intron-Distal3.240833.62729K562HNRNPK
chr7140500629140500673-intron-Distal3.793723.02234K562KHSRP
chr7140533850140533903-intron-Distal,intron-Proximal4.597746.07567K562KHSRP
chr7140622723140622807-intron-Distal3.864584.28254HepG2MATR3
chr7140594009140594115-intron-Distal4.555909.70238K562MATR3
chr7140624071140624138-intron-Distal3.724056.02877HepG2SUGP2
chr7140474850140474919-intron-Distal3.172843.12625HepG2QKI
chr7140454091140454161-intron-Distal,intron-Proximal4.062554.14103K562KHSRP
chr7140522042140522112-intron-Distal4.638857.17304K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for BRAF is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for BRAF is not available on ENCORE database.

  • 79 RBPs can affect the levels of BRAF.  








The Knockdown/knockout RNA-Seq assay for BRAF is not available on ENCORE database.





79 RBPs can affect the gene expression of BRAF :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
BRAFENSG00000157764.81472.245401072.851400.456503.128102.56700HepG2AKAP1
BRAFENSG00000157764.81314.50090887.689000.566305.194104.13600HepG2ASCC1
BRAFENSG00000157764.81424.294501150.871300.307403.500402.74480HepG2AUH
BRAFENSG00000157764.8963.52410791.005400.284501.803301.31090HepG2BOP1
BRAFENSG00000157764.81021.23850868.851100.233002.173801.50440HepG2DAZAP1
BRAFENSG00000157764.8565.65510750.09870-0.407204.203803.20020HepG2DDX19B
BRAFENSG00000157764.8909.13530682.157400.414303.492402.45850HepG2DDX24
BRAFENSG00000157764.81301.988501027.698800.341202.148801.59090HepG2DDX3X
BRAFENSG00000157764.81686.94220824.651801.032508.076206.45280HepG2DDX59
BRAFENSG00000157764.81177.12140858.747700.454903.813502.63320HepG2DDX5
BRAFENSG00000157764.81058.15630775.920000.447504.458003.63540HepG2DKC1
BRAFENSG00000157764.8515.13720639.24810-0.311402.690602.04630HepG2DNAJC2
BRAFENSG00000157764.81343.44370848.670200.662606.630205.73600HepG2EIF2S1
BRAFENSG00000157764.81249.83520857.155100.544008.657807.33140HepG2EIF4G1
BRAFENSG00000157764.81060.05370821.103300.368402.621001.82700HepG2EIF4G2
BRAFENSG00000157764.81605.74940727.411701.142304.102002.86490HepG2FTO
BRAFENSG00000157764.8893.27930553.757200.689805.819904.69680HepG2FUBP3
BRAFENSG00000157764.81109.71590823.256800.430702.930402.27350HepG2GPKOW
BRAFENSG00000157764.8866.23880723.615300.259401.952601.34330HepG2HNRNPF
BRAFENSG00000157764.81210.94830785.644800.624106.298905.39260HepG2HNRNPLL
BRAFENSG00000157764.8521.70860719.44030-0.463605.078204.27720HepG2HNRNPU
BRAFENSG00000157764.81115.55620892.276300.322101.956501.37980HepG2IGF2BP2
BRAFENSG00000157764.8640.94930904.52280-0.496903.150701.86130HepG2KHDRBS1
BRAFENSG00000157764.8931.29990696.589200.418802.982602.20620HepG2NSUN2
BRAFENSG00000157764.81308.02160867.697000.592005.443204.44080HepG2PABPC4
BRAFENSG00000157764.8667.87780881.06470-0.399704.243903.52050HepG2PCBP1
BRAFENSG00000157764.81237.33040781.564700.6627012.2505010.79370HepG2PRPF4
BRAFENSG00000157764.81110.77680873.025700.347404.557403.83660HepG2PUM1
BRAFENSG00000157764.81190.37940826.052700.527007.181506.26750HepG2PUS1
BRAFENSG00000157764.81575.31920970.933200.6981012.3819011.19890HepG2QKI
BRAFENSG00000157764.81325.949101041.899300.347703.550202.59030HepG2RBM15
BRAFENSG00000157764.8920.225801104.38080-0.263202.062301.59740HepG2RBM22
BRAFENSG00000157764.81949.67610881.196601.1456024.0585022.18610HepG2RBM25
BRAFENSG00000157764.81130.09550799.689400.498802.707601.77370HepG2RPS10
BRAFENSG00000157764.8694.87880441.741800.653505.015903.99130HepG2RRP9
BRAFENSG00000157764.8519.12770640.68760-0.303502.379001.77470HepG2SAFB2
BRAFENSG00000157764.81098.37300777.661000.498104.483803.60230HepG2SF3B1
BRAFENSG00000157764.81086.99170933.377600.219701.794601.30150HepG2SF3B4
BRAFENSG00000157764.81025.62910788.555400.379104.534903.67100HepG2SLBP
BRAFENSG00000157764.8524.59760829.64930-0.661303.978202.81200HepG2SMNDC1
BRAFENSG00000157764.81198.82630865.274200.470302.503201.76110HepG2SNRNP70
BRAFENSG00000157764.82064.776101247.373300.7270021.2442020.19690HepG2SRFBP1
BRAFENSG00000157764.81340.44940974.255400.460206.752806.09300HepG2SRSF1
BRAFENSG00000157764.8965.00230710.943200.440705.062504.16590HepG2SRSF7
BRAFENSG00000157764.81034.44250792.618400.384104.718204.03370HepG2SRSF9
BRAFENSG00000157764.81304.635301083.042900.268503.019902.48920HepG2SSB
BRAFENSG00000157764.8662.81410923.48590-0.478506.479905.59840HepG2SUCLG1
BRAFENSG00000157764.8931.32180576.135900.692806.001805.06300HepG2SUPV3L1
BRAFENSG00000157764.81123.41940875.730000.359203.650903.02170HepG2TAF15
BRAFENSG00000157764.8979.78450765.632200.355702.486801.79370HepG2TARDBP
BRAFENSG00000157764.81252.03670815.347500.618706.064505.15110HepG2U2AF1
BRAFENSG00000157764.81166.878801005.975000.214001.928101.32780HepG2UPF1
BRAFENSG00000157764.8807.39190971.23080-0.266502.203401.65570HepG2UTP3
BRAFENSG00000157764.81196.68620800.552300.579903.538502.08970HepG2XRCC5
BRAFENSG00000157764.81192.77740771.318000.6288012.5319011.27290HepG2ZC3H8
BRAFENSG00000157764.8956.934101106.38130-0.209402.015001.52860HepG2ZNF622
BRAFENSG00000157764.81178.49910813.359400.534903.504002.03870HepG2ZRANB2
BRAFENSG00000157764.83676.233002356.492300.641509.713008.71840K562AQR
BRAFENSG00000157764.82206.874401785.804400.305302.939302.13100K562CPSF6
BRAFENSG00000157764.84321.266403525.613000.293503.660702.53450K562CELF1
BRAFENSG00000157764.83223.486902525.177200.352106.153305.23510K562DDX47
BRAFENSG00000157764.81239.100801622.28920-0.388704.882202.97670K562DDX6
BRAFENSG00000157764.81465.211901757.57060-0.262502.940501.68580K562EIF2S1
BRAFENSG00000157764.81424.815201079.249200.400602.951801.77930K562FKBP4
BRAFENSG00000157764.81389.733201738.50680-0.323003.829103.13470K562FXR1
BRAFENSG00000157764.81502.528901982.55700-0.400004.158103.23490K562GRSF1
BRAFENSG00000157764.81854.981001473.100000.332403.216602.05670K562HNRNPA1
BRAFENSG00000157764.83007.771601906.937800.657302.899501.64730K562HNRNPA2B1
BRAFENSG00000157764.81081.226501547.30140-0.517104.346903.16400K562HNRNPM
BRAFENSG00000157764.82095.765702550.34120-0.283202.201501.49010K562HSPD1
BRAFENSG00000157764.82743.633601667.505000.718303.294402.18620K562PABPN1
BRAFENSG00000157764.81695.867902135.51990-0.332602.653601.85440K562PPIG
BRAFENSG00000157764.81405.117802015.35790-0.520307.271306.23260K562PTBP1
BRAFENSG00000157764.83862.128802837.710300.444604.792904.10330K562PUS1
BRAFENSG00000157764.81560.948601988.06540-0.348902.586501.62040K562RPS3
BRAFENSG00000157764.82050.228501621.751800.338102.190101.33530K562SF3B1
BRAFENSG00000157764.82842.156401751.464700.698302.957601.67400K562SNRNP200
BRAFENSG00000157764.82200.104701930.836500.188202.323601.45750K562SRPK2
BRAFENSG00000157764.82863.425602257.339400.343002.754001.50790K562STAU1
BRAFENSG00000157764.81479.655901111.814200.412203.189702.09660K562SUPV3L1
BRAFENSG00000157764.81559.624901999.60060-0.358502.935202.20670K562TARDBP
BRAFENSG00000157764.81602.096001928.82060-0.267802.362001.61280K562TIA1
BRAFENSG00000157764.82268.036201731.931500.389002.865601.75130K562U2AF1
BRAFENSG00000157764.82490.145401788.600900.477307.074005.79800K562U2AF2
BRAFENSG00000157764.83502.640002060.853300.765103.546901.65650K562YTHDC2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for BRAF is not available on ENCORE database.





4 RBPs can affect the splicing of BRAF :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEBRAFENSG00000157764.8chr7-140434416140434570140419126140426316140439611140439746-0.301000.000770.01137excludedHepG2U2AF2
SEBRAFENSG00000157764.8chr7-1405080361405081421405077591405078621405086911405088780.066000.004620.04358includedK562AQR
SEBRAFENSG00000157764.8chr7-140434416140434570140419126140426316140439611140439746-0.215000.000810.01023excludedK562AQR
SEBRAFENSG00000157764.8chr7-140487347140487384140482820140482957140494107140494267-0.076000.000920.01137excludedK562AQR
SEBRAFENSG00000157764.8chr7-140434416140434570140419126140426316140439611140439746-0.258000.001620.07285excludedK562EFTUD2
SEBRAFENSG00000157764.8chr7-140549910140550012140533860140534672140624365140624509-0.056000.001910.04572excludedK562AGGF1
A3SSBRAFENSG00000157764.8chr7-1404539861404541411404539861404540331404767111404768880.101000.000000.00000longerK562AQR
A3SSBRAFENSG00000157764.8chr7-1405012111405014091405012111405013601405077591405079830.088000.000010.00012longerK562AQR
A3SSBRAFENSG00000157764.8chr7-1405001611405003271405001611405002811405012111405013600.137000.000010.00008longerK562AQR
A3SSBRAFENSG00000157764.8chr7-1404490861404492451404490861404492181404530741404531930.152000.000140.00122longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for BRAF is not avaliable on ENCORE database.