TMEM66

General Information

Gene Name       : TMEM66
Gene ID             :
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM66)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM66 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM66 RNA is bound by 15 proteins.  







eCLIP assay for TMEM66 is not avaliable on ENCORE database.





15 proteins are bound to TMEM66 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr82992113629921249-3'-UTR,intron-Distal,intron-Proximal4.0168110.98347HepG2SUB1
chr82992355829923655-3'-UTR,CDS,intron-Distal,intron-Proximal3.457937.54912HepG2SND1
chr82992358629923656-3'-UTR,CDS,intron-Distal,intron-Proximal3.286766.32104K562SND1
chr82992715729927215-3'-UTR,CDS,intron-Distal,intron-Proximal3.214553.84724HepG2IGF2BP1
chr82992337429923454-3'-UTR,intron-Distal,intron-Proximal4.812597.04874K562EFTUD2
chr82992085129920991-3'-UTR,intron-Distal4.319934.55369K562LIN28B
chr82992748529927521-3'-UTR,CDS,intron-Distal,intron-Proximal3.902413.02397HepG2SND1
chr82993155529931573-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.480153.15824K562FTO
chr82992119029921248-3'-UTR,intron-Distal,intron-Proximal3.382764.39733HepG2FUBP3
chr82992733929927371-3'-UTR,CDS,intron-Distal,intron-Proximal4.168913.39506K562IGF2BP2
chr82992732429927374-3'-UTR,CDS,intron-Distal,intron-Proximal4.8268511.58757K562SND1
chr82992431129924363-3'-UTR,CDS,intron-Distal,intron-Proximal3.308223.45995K562IGF2BP2
chr82992055029920610-3'-UTR,intron-Distal,intron-Proximal4.033733.80512K562CSTF2T
chr82992720829927306-3'-UTR,CDS,intron-Distal,intron-Proximal3.080807.18734K562LIN28B
chr82992138629921447-3'-UTR,CDS,intron-Distal3.221994.66077K562U2AF2
chr82992748729927542-3'-UTR,CDS,intron-Distal,intron-Proximal4.6851910.17110K562SND1
chr82992140329921484-3'-UTR,CDS,intron-Distal3.2354911.52255K562SF3B4
chr82993139529931546-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.5471916.49413K562DDX3X
chr82992733129927372-3'-UTR,CDS,intron-Distal,intron-Proximal4.306097.36071HepG2SND1
chr82992716229927201-3'-UTR,CDS,intron-Distal3.641443.85049HepG2SND1
chr82993147729931544-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.4662010.05371K562YBX3
chr82992739729927456-3'-UTR,CDS,intron-Distal4.058206.47873K562SND1
chr82992063929920755-3'-UTR,intron-Distal,intron-Proximal4.874695.80303K562IGF2BP1
chr82994036129940407-5'-UTR,CDS,intron-Distal5.25042400.00000HepG2DDX3X
chr82994047329940481-5'-UTR,intron-Distal,intron-Proximal4.3765432.12493K562YBX3
chr82994036029940418-5'-UTR,CDS,intron-Distal3.243987.36580K562FTO
chr82994044729940464-5'-UTR,CDS,intron-Distal4.3648334.80535K562YBX3
chr82994048229940577-5'-UTR,intron-Distal,intron-Proximal5.62318400.00000HepG2DDX3X
chr82994042529940482-5'-UTR,CDS,intron-Distal,intron-Proximal5.6261181.07692HepG2DDX3X
chr82994049529940577-5'-UTR,intron-Distal,intron-Proximal4.1800411.81457K562DDX3X
chr82994043429940438-5'-UTR,CDS,intron-Distal4.2426926.32757K562YBX3
chr82994043829940447-5'-UTR,CDS,intron-Distal4.3309227.53010K562YBX3
chr82994044829940467-5'-UTR,CDS,intron-Distal,intron-Proximal3.333726.40930HepG2YBX3
chr82994037029940391-5'-UTR,CDS,intron-Distal3.972483.09880K562DROSHA
chr82994036129940421-5'-UTR,CDS,intron-Distal3.4086419.62115K562DDX3X
chr82994042129940495-5'-UTR,CDS,intron-Distal,intron-Proximal4.2595620.24705K562DDX3X
chr82994036329940411-5'-UTR,CDS,intron-Distal3.4492810.70078K562YBX3
chr82994048129940498-5'-UTR,intron-Distal,intron-Proximal3.557214.53005K562YBX3
chr82994049829940561-5'-UTR,intron-Distal,intron-Proximal4.812734.99413HepG2EIF3H
chr82994043329940448-5'-UTR,CDS,intron-Distal3.877277.36225HepG2YBX3
chr82994046429940473-5'-UTR,CDS,intron-Distal,intron-Proximal4.4592934.53331K562YBX3
chr82993149729931520-5'-UTR,CDS,intron-Distal,intron-Proximal4.0024814.25043HepG2DDX3X
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM66 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM66 is not available on ENCORE database.

  • 86 RBPs can affect the levels of TMEM66.  








The Knockdown/knockout RNA-Seq assay for TMEM66 is not available on ENCORE database.





86 RBPs can affect the gene expression of TMEM66 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM66ENSG00000133872.93625.183202996.712400.274604.906604.14060HepG2ACO1
TMEM66ENSG00000133872.93794.220203010.776600.333606.004204.91240HepG2AKAP8L
TMEM66ENSG00000133872.95278.062003923.235100.4279010.189909.01050HepG2AUH
TMEM66ENSG00000133872.92230.374201825.286100.289102.347101.79030HepG2BOP1
TMEM66ENSG00000133872.93757.630702273.188900.7250016.2860014.69070HepG2CALR
TMEM66ENSG00000133872.92206.960501675.744500.397203.698002.91510HepG2CPSF6
TMEM66ENSG00000133872.95928.100004085.699800.5369014.2320012.99620HepG2CELF1
TMEM66ENSG00000133872.93162.917102678.018400.240002.597001.47570HepG2DDX1
TMEM66ENSG00000133872.93483.771702522.636400.465606.673305.26050HepG2DDX24
TMEM66ENSG00000133872.97062.537405607.177200.332802.683002.06570HepG2DDX3X
TMEM66ENSG00000133872.92454.158501926.414700.349202.842701.72050HepG2EFTUD2
TMEM66ENSG00000133872.93185.834102373.926800.424302.904301.76650HepG2AGO1
TMEM66ENSG00000133872.94124.333805117.48740-0.311301.991701.44650HepG2EIF4A3
TMEM66ENSG00000133872.96556.148004981.952200.396002.522001.86400HepG2EIF4B
TMEM66ENSG00000133872.93742.205704334.09440-0.211802.841801.99620HepG2EIF4G1
TMEM66ENSG00000133872.95261.159504151.787000.341503.211102.33680HepG2EIF4G2
TMEM66ENSG00000133872.95423.266704504.234700.267804.399403.67250HepG2ETF1
TMEM66ENSG00000133872.93427.665905162.31580-0.590807.221306.13910HepG2FXR1
TMEM66ENSG00000133872.92574.210501899.675500.438303.677302.94830HepG2GPKOW
TMEM66ENSG00000133872.92836.306403873.49570-0.449602.767001.65430HepG2GRSF1
TMEM66ENSG00000133872.94922.277804037.418200.285804.833503.65240HepG2HNRNPA2B1
TMEM66ENSG00000133872.93647.672904848.39330-0.410504.404403.53920HepG2HNRNPK
TMEM66ENSG00000133872.93520.737804001.82100-0.184802.906902.21860HepG2HNRNPL
TMEM66ENSG00000133872.9905.418101812.88730-1.0016016.2515014.90120HepG2HNRNPLL
TMEM66ENSG00000133872.92523.909102929.37900-0.214902.638902.04630HepG2HNRNPU
TMEM66ENSG00000133872.93430.387404868.44780-0.505105.479104.55870HepG2IGF2BP2
TMEM66ENSG00000133872.94762.661403684.743700.370102.444501.66730HepG2LARP4
TMEM66ENSG00000133872.94134.515805193.18150-0.328902.277901.70180HepG2MATR3
TMEM66ENSG00000133872.93569.227905315.64410-0.574606.357705.41360HepG2NCBP2
TMEM66ENSG00000133872.93491.917104356.23100-0.319104.299903.34850HepG2NOL12
TMEM66ENSG00000133872.93730.794704734.54400-0.343702.659401.95080HepG2PABPC4
TMEM66ENSG00000133872.93573.060404661.02680-0.383508.612207.63940HepG2PCBP1
TMEM66ENSG00000133872.92717.352101962.017300.469804.744403.71910HepG2PRPF8
TMEM66ENSG00000133872.93116.846204742.67130-0.6056018.9402017.75070HepG2PTBP1
TMEM66ENSG00000133872.94854.248504414.320900.137001.996001.47600HepG2PUM1
TMEM66ENSG00000133872.97247.595104411.099200.7163018.8486017.19390HepG2PUM2
TMEM66ENSG00000133872.93554.672205136.63840-0.5311011.5046010.35960HepG2QKI
TMEM66ENSG00000133872.95254.503203764.741000.4809010.858509.98010HepG2RBM22
TMEM66ENSG00000133872.93810.114904661.75080-0.291002.867902.18370HepG2RBM25
TMEM66ENSG00000133872.9736.748202239.80280-1.604107.365704.57610HepG2RBM39
TMEM66ENSG00000133872.93440.572505278.21900-0.6174020.5280019.31890HepG2NELFE
TMEM66ENSG00000133872.93153.468504915.79650-0.6405022.3642020.90410HepG2RECQL
TMEM66ENSG00000133872.93264.197504201.23680-0.364102.165801.45780HepG2RPS3A
TMEM66ENSG00000133872.9528.006601940.86790-1.8781042.8591040.52310HepG2RRP9
TMEM66ENSG00000133872.93165.155302608.720100.278805.002504.18070HepG2SAFB2
TMEM66ENSG00000133872.93838.383502818.371000.445503.243602.51230HepG2SF3A3
TMEM66ENSG00000133872.92234.072001794.451500.316002.626601.93910HepG2SF3B1
TMEM66ENSG00000133872.93129.983304937.90820-0.6577023.2804021.84790HepG2SF3B4
TMEM66ENSG00000133872.93825.952001996.623600.938209.459608.02340HepG2SNRNP70
TMEM66ENSG00000133872.94787.518804252.196900.171002.538802.05160HepG2SRFBP1
TMEM66ENSG00000133872.93837.401205154.03560-0.4256011.8800011.04650HepG2SRSF1
TMEM66ENSG00000133872.92553.601501930.690500.403302.686201.70080HepG2SRSF3
TMEM66ENSG00000133872.95225.776704105.809100.347907.242606.29460HepG2SRSF5
TMEM66ENSG00000133872.92638.395301959.391900.429205.037103.78730HepG2SUPT6H
TMEM66ENSG00000133872.94378.915102531.631000.7904011.2854010.07410HepG2SUPV3L1
TMEM66ENSG00000133872.92173.926001696.911400.357302.806001.80410HepG2TFIP11
TMEM66ENSG00000133872.91888.474102846.30260-0.5919011.3422010.45020HepG2TIAL1
TMEM66ENSG00000133872.93446.890904300.16540-0.319102.322401.56040HepG2UBE2L3
TMEM66ENSG00000133872.91044.466001495.56610-0.517904.563803.58650HepG2UCHL5
TMEM66ENSG00000133872.92810.995102499.463900.169401.987101.37870HepG2UPF1
TMEM66ENSG00000133872.92429.948301953.124300.315003.135002.42780HepG2ZC3H8
TMEM66ENSG00000133872.93963.972602748.932200.5280019.6734018.54250HepG2ZNF622
TMEM66ENSG00000133872.93781.550703165.178400.256603.560802.93090K562AGGF1
TMEM66ENSG00000133872.94571.747603478.253700.394304.761803.38770K562AKAP8
TMEM66ENSG00000133872.94449.280403293.561100.433805.639104.68920K562AKAP8L
TMEM66ENSG00000133872.94002.065603455.831900.211602.439001.58600K562ATP5C1
TMEM66ENSG00000133872.95278.374104343.537100.281102.661401.70500K562CELF1
TMEM66ENSG00000133872.91960.077202352.26190-0.263102.559201.92920K562DDX47
TMEM66ENSG00000133872.9628.60130929.38750-0.564102.956301.91350K562EIF3A
TMEM66ENSG00000133872.91381.988502014.28670-0.543506.461205.25980K562EIF3G
TMEM66ENSG00000133872.91654.782602198.03250-0.409603.045702.18640K562EIF4A3
TMEM66ENSG00000133872.92191.458901551.811700.497805.745004.49440K562FIP1L1
TMEM66ENSG00000133872.91649.290402285.85790-0.470908.322007.34250K562FXR1
TMEM66ENSG00000133872.93144.320302370.709900.407302.630701.94540K562G3BP2
TMEM66ENSG00000133872.91067.672601449.05620-0.440604.546803.80060K562HNRNPC
TMEM66ENSG00000133872.93149.628902103.885100.582007.741306.42900K562HSPD1
TMEM66ENSG00000133872.94638.385503495.118100.408205.440804.19950K562KIF1C
TMEM66ENSG00000133872.92068.325502827.05290-0.450805.655004.44270K562MAGOH
TMEM66ENSG00000133872.94051.052303345.828700.275802.784301.70510K562MAK16
TMEM66ENSG00000133872.94578.746503915.439300.225702.194701.40100K562MBNL1
TMEM66ENSG00000133872.93713.083802744.454600.436003.214502.24930K562NAA15
TMEM66ENSG00000133872.91913.800302515.46620-0.394404.223903.00880K562PCBP2
TMEM66ENSG00000133872.92265.163801761.656500.362603.164402.27840K562PPIG
TMEM66ENSG00000133872.91732.483902746.62250-0.6648012.2349010.88890K562PTBP1
TMEM66ENSG00000133872.95010.428703853.292400.378703.687002.74740K562PUF60
TMEM66ENSG00000133872.94450.606503265.955400.446404.367603.70800K562PUS1
TMEM66ENSG00000133872.94131.183203182.474400.376306.343505.47150K562RBM15
TMEM66ENSG00000133872.91612.235302633.94970-0.7082011.124709.26990K562RBM22
TMEM66ENSG00000133872.92205.142602771.74840-0.329902.667801.59620K562NELFE
TMEM66ENSG00000133872.91388.773101941.94770-0.483704.366503.07030K562RPS3
TMEM66ENSG00000133872.9942.155601454.79610-0.626804.713702.96990K562RRP9
TMEM66ENSG00000133872.9925.474301210.74220-0.387603.334602.14500K562SAFB
TMEM66ENSG00000133872.91901.947902464.73930-0.374004.700203.57470K562SF3B4
TMEM66ENSG00000133872.9802.739101123.79460-0.485404.440203.05580K562SRFBP1
TMEM66ENSG00000133872.92152.695602725.15530-0.340202.854802.13650K562TARDBP
TMEM66ENSG00000133872.92429.584502042.937200.250003.519202.71620K562UPF1
TMEM66ENSG00000133872.92137.014101748.073400.289702.600401.74930K562WDR3
TMEM66ENSG00000133872.94283.315803577.931500.259502.250101.48420K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM66 is not available on ENCORE database.





8 RBPs can affect the splicing of TMEM66 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM66ENSG00000133872.9chr8-299313922993156729927157299275752994036229940640-0.085000.000400.09884excludedK562IGF2BP2
SETMEM66ENSG00000133872.9chr8-299313922993156729927157299275752994036229940640-0.092000.000170.07683excludedK562TIA1
SETMEM66ENSG00000133872.9chr8-299313922993157129927157299275752994036229940723-0.076000.001080.02194excludedHepG2U2AF1
SETMEM66ENSG00000133872.9chr8-2993139229931571299271572992757529940362299407230.057000.000580.04882includedHepG2TBRG4
SETMEM66ENSG00000133872.9chr8-2993139229931571299271572992757529940362299407230.079000.000220.00335includedK562AQR
SETMEM66ENSG00000133872.9chr8-299313922993157129927157299275752994036229940723-0.058000.001500.07504excludedHepG2NCBP2
SETMEM66ENSG00000133872.9chr8-299313922993157129927157299275752994036229940723-0.054000.000160.02372excludedHepG2LARP4
SETMEM66ENSG00000133872.9chr8-299313922993157129927157299275752994036229940723-0.101000.005770.07766excludedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM66 is not avaliable on ENCORE database.