SOS2

General Information

Gene Name       : SOS2
Gene ID             : ENSG00000100485.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SOS2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SOS2ENSG00000100485.1112.3210.0611.19ENCSR000AEF
HepG2SOS2ENSG00000100485.114.888.596.73ENCSR985KAT
K562SOS2ENSG00000100485.116.897.657.27ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SOS2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SOS2 RNA is bound by 10 proteins.  







eCLIP assay for SOS2 is not avaliable on ENCORE database.





10 proteins are bound to SOS2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr145058424850584325-3'-UTR,intron-Distal6.143997.94582K562PUM2
chr145066771650667779-3'-UTR,CDS,intron-Distal,intron-Proximal4.234653.53690K562ZNF622
chr145069812750698220-5'-UTR,intron-Distal,intron-Proximal3.706746.02805HepG2DDX3X
chr145069807350698109-5'-UTR,intron-Distal,intron-Proximal4.127463.41967HepG2DDX3X
chr145069798650698073-5'-UTR,CDS,intron-Distal,intron-Proximal4.795686.05264HepG2DDX3X
chr145064729150647357-CDS,intron-Distal4.130116.23296HepG2BCLAF1
chr145064118250641235-CDS,intron-Distal3.567343.68471HepG2BCLAF1
chr145066766950667729-CDS,intron-Distal,intron-Proximal4.591935.27053HepG2PPIG
chr145066766850667712-CDS,intron-Distal,intron-Proximal4.003984.51739HepG2BCLAF1
chr145058506750585115-CDS,intron-Distal4.474065.82129K562PUM2
chr145062618350626250-CDS,intron-Distal3.169114.26492HepG2BCLAF1
chr145061200850612051-CDS,intron-Distal,intron-Proximal4.650845.23259HepG2BCLAF1
chr145069533950695356-intron-Distal6.257456.80719K562WRN
chr145067591050676009-intron-Distal3.972203.37631K562HNRNPL
chr145069533550695339-intron-Distal6.257456.80719K562WRN
chr145062076850620868-intron-Distal3.981064.48652HepG2PTBP1
chr145059260350592658-intron-Distal4.072813.29248HepG2SUGP2
chr145059497550595033-intron-Distal4.978053.91475K562PTBP1
chr145059495550595048-intron-Distal3.635473.30286HepG2PTBP1
chr145059212950592190-intron-Distal4.138503.54208HepG2SUGP2
chr145059496450595032-intron-Distal3.820743.33944K562MATR3
chr145059495650595012-intron-Distal3.249703.35050HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SOS2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SOS2 is not available on ENCORE database.

  • 71 RBPs can affect the levels of SOS2.  








The Knockdown/knockout RNA-Seq assay for SOS2 is not available on ENCORE database.





71 RBPs can affect the gene expression of SOS2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SOS2ENSG00000100485.7564.21650706.99100-0.325402.191501.63720HepG2ACO1
SOS2ENSG00000100485.71117.01820860.019900.377104.372103.54410HepG2AUH
SOS2ENSG00000100485.7355.27730582.91750-0.714304.473703.28170HepG2BCCIP
SOS2ENSG00000100485.71007.45640745.940200.433504.138303.21940HepG2CALR
SOS2ENSG00000100485.7492.81630679.87640-0.464202.028201.37890HepG2CNOT7
SOS2ENSG00000100485.7672.43580526.571500.352702.212601.59920HepG2DDX21
SOS2ENSG00000100485.7665.59090515.584100.368302.524501.65520HepG2DDX24
SOS2ENSG00000100485.71337.025801043.133400.358002.349901.76850HepG2DDX3X
SOS2ENSG00000100485.71349.93630906.889600.573802.840601.85020HepG2DDX59
SOS2ENSG00000100485.7744.25110485.142800.617304.238202.85320HepG2AGO1
SOS2ENSG00000100485.7743.96580951.99490-0.355701.858801.33100HepG2EIF4A3
SOS2ENSG00000100485.71070.55980734.209200.544005.137304.04760HepG2EIF4G2
SOS2ENSG00000100485.71487.99690987.385400.5916010.773509.71270HepG2ETF1
SOS2ENSG00000100485.71232.94450942.245700.387802.674301.91680HepG2FIP1L1
SOS2ENSG00000100485.7601.96440960.44390-0.674006.331405.31030HepG2FXR1
SOS2ENSG00000100485.7658.78280890.99410-0.435602.782102.11500HepG2G3BP1
SOS2ENSG00000100485.7714.05620549.278000.378402.373701.77170HepG2HNRNPA1
SOS2ENSG00000100485.71108.67060863.940100.359702.426901.83170HepG2HNRNPLL
SOS2ENSG00000100485.7470.93630650.32810-0.465602.455601.55760HepG2HNRNPM
SOS2ENSG00000100485.7666.29820910.94260-0.451202.487001.54530HepG2KHSRP
SOS2ENSG00000100485.7653.598401043.55750-0.675004.761603.11250HepG2KRR1
SOS2ENSG00000100485.7604.89180966.16910-0.675603.812503.08150HepG2MATR3
SOS2ENSG00000100485.7931.23780762.940000.287502.109501.39830HepG2MSI2
SOS2ENSG00000100485.7565.33700770.33990-0.446404.067303.14260HepG2NOL12
SOS2ENSG00000100485.71013.35120621.378800.705504.052702.96470HepG2PABPC1
SOS2ENSG00000100485.7661.51980844.64330-0.352603.447102.78590HepG2PCBP1
SOS2ENSG00000100485.7568.98620689.74520-0.277702.103801.42150HepG2PRPF4
SOS2ENSG00000100485.7766.34630930.81260-0.280502.061201.51030HepG2QKI
SOS2ENSG00000100485.7952.71080647.935300.556102.588701.90590HepG2RAVER1
SOS2ENSG00000100485.71280.94830825.278300.6342010.311909.45380HepG2RBM22
SOS2ENSG00000100485.71027.72370844.772000.282701.950501.37640HepG2RBM25
SOS2ENSG00000100485.7806.97940956.49210-0.245201.887301.42140HepG2NELFE
SOS2ENSG00000100485.71024.90750749.622900.451203.829503.04590HepG2RPLP0
SOS2ENSG00000100485.7646.70540437.439200.563903.787202.88610HepG2RRP9
SOS2ENSG00000100485.7408.90590540.50390-0.402503.333302.63730HepG2SAFB2
SOS2ENSG00000100485.71177.05260855.129800.460904.055603.21610HepG2SF3B1
SOS2ENSG00000100485.71687.84580932.133400.8565025.2124024.09660HepG2SRFBP1
SOS2ENSG00000100485.7835.70560683.764100.289402.908902.19810HepG2SRSF7
SOS2ENSG00000100485.7964.57850759.844300.344103.740603.12060HepG2SRSF9
SOS2ENSG00000100485.7993.45750809.333500.295603.025902.49480HepG2SSB
SOS2ENSG00000100485.71061.25940605.476700.809506.037304.28030HepG2SUB1
SOS2ENSG00000100485.71091.41750842.075200.374102.758702.03510HepG2TARDBP
SOS2ENSG00000100485.71257.10060806.228100.640707.292306.27940HepG2U2AF1
SOS2ENSG00000100485.71068.52360893.540300.257902.499501.83000HepG2UPF1
SOS2ENSG00000100485.7639.84040862.67780-0.431104.759504.00850HepG2UTP3
SOS2ENSG00000100485.7905.75050636.929300.507902.579701.36700HepG2XRCC5
SOS2ENSG00000100485.7353.58890561.64410-0.667604.334803.43270HepG2XRN2
SOS2ENSG00000100485.7915.28610680.711700.427105.320004.43860HepG2ZC3H8
SOS2ENSG00000100485.71381.15610982.723000.490909.690608.82370HepG2ZNF622
SOS2ENSG00000100485.7799.447501155.59830-0.531607.965507.07240K562AGGF1
SOS2ENSG00000100485.71019.724601269.76290-0.316402.454201.53720K562AKAP8
SOS2ENSG00000100485.7797.989601202.43640-0.591506.712205.66140K562AKAP8L
SOS2ENSG00000100485.71005.577701261.61510-0.327203.327802.31890K562ATP5C1
SOS2ENSG00000100485.7952.61960696.543100.451603.340702.38060K562BOP1
SOS2ENSG00000100485.71021.410201294.00800-0.341303.817502.76630K562DKC1
SOS2ENSG00000100485.7868.08270611.564700.505205.851304.86420K562EIF2S2
SOS2ENSG00000100485.7424.79980575.12270-0.437103.467902.58220K562EIF3G
SOS2ENSG00000100485.71021.64710753.553200.439003.415102.46160K562FMR1
SOS2ENSG00000100485.7864.94000638.690200.437402.926701.98570K562FTO
SOS2ENSG00000100485.7455.32360558.33710-0.294201.852501.33740K562FXR1
SOS2ENSG00000100485.7870.22550623.569800.480702.817302.10200K562G3BP2
SOS2ENSG00000100485.7569.17300815.01650-0.518004.431003.47830K562GRSF1
SOS2ENSG00000100485.7814.36550537.594600.599105.988905.14390K562HNRNPC
SOS2ENSG00000100485.71312.01620944.217200.474504.213303.23760K562HSPD1
SOS2ENSG00000100485.7558.98640764.53520-0.451803.672402.69620K562MAGOH
SOS2ENSG00000100485.7589.52390763.00080-0.372102.838301.90300K562MATR3
SOS2ENSG00000100485.7950.850801429.59310-0.588308.386006.62290K562MBNL1
SOS2ENSG00000100485.7590.44090953.32730-0.691202.956201.92270K562PABPN1
SOS2ENSG00000100485.7588.09330790.52520-0.426803.185202.29600K562PPIG
SOS2ENSG00000100485.7535.94520742.78570-0.470904.216403.41280K562PTBP1
SOS2ENSG00000100485.7962.718701192.60140-0.308902.281101.77840K562PUS1
SOS2ENSG00000100485.7786.242101161.91560-0.563507.654706.69850K562RBM15
SOS2ENSG00000100485.7501.33980712.30240-0.506704.131303.08200K562RBM22
SOS2ENSG00000100485.7554.76890749.57040-0.434202.992401.85120K562NELFE
SOS2ENSG00000100485.7567.85560728.16540-0.358701.911201.31070K562SRSF1
SOS2ENSG00000100485.7525.79160736.97730-0.487103.666702.84800K562TARDBP
SOS2ENSG00000100485.7985.69260810.126100.282902.594201.89830K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SOS2 is not available on ENCORE database.





3 RBPs can affect the splicing of SOS2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESOS2ENSG00000100485.7chr14-505869925058710250583846505855715059667850596720-0.142000.000080.00158excludedHepG2U2AF2
SESOS2ENSG00000100485.7chr14-505869925058710250583846505855715059667850596720-0.092000.001390.02230excludedK562PUS1
A3SSSOS2ENSG00000100485.7chr14-5061219450612344506121945061231450616725506169480.210000.004970.02871longerK562AQR
A3SSSOS2ENSG00000100485.7chr14-5064728950647449506472895064740050649180506493240.064000.017100.08356longerK562AQR
MXESOS2ENSG00000100485.7chr14-50611887506120505061219450612344506066595060677750616725506169480.174000.007240.048801includedK562AQR
MXESOS2ENSG00000100485.7chr14-5062528250625364506261485062680450623716506238395062819950628327-0.214000.000120.001322includedHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SOS2 is not avaliable on ENCORE database.