SIRT6

General Information

Gene Name       : SIRT6
Gene ID             : ENSG00000077463.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SIRT6)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SIRT6ENSG00000077463.140.384.552.46ENCSR000AEF
HepG2SIRT6ENSG00000077463.1415.202.228.71ENCSR985KAT
K562SIRT6ENSG00000077463.1417.285.3511.32ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SIRT6 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SIRT6 RNA is bound by 6 proteins.  







eCLIP assay for SIRT6 is not avaliable on ENCORE database.





6 proteins are bound to SIRT6 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1941758494175934-3'-UTR,CDS,intron-Distal,intron-Proximal4.591935.27053HepG2PPIG
chr1941744284174543-3'-UTR,intron-Distal,intron-Proximal4.341724.78313HepG2UPF1
chr1941742304174320-3'-UTR,intron-Distal3.922395.24353K562UPF1
chr1941824704182560-5'-UTR,CDS,intron-Distal,intron-Proximal4.105653.58858HepG2NCBP2
chr1941808014180907-5'-UTR,CDS,intron-Distal,intron-Proximal4.988366.56499HepG2PPIG
chr1941807614180779-intron-Distal,intron-Proximal4.929354.65563K562AQR
chr1941794524179553-intron-Distal,intron-Proximal4.029849.74189HepG2PTBP1
chr1941792884179436-intron-Distal,intron-Proximal3.9437513.14139HepG2PTBP1
chr1941793394179528-intron-Distal,intron-Proximal4.226064.18579K562MATR3
chr1941794374179543-intron-Distal,intron-Proximal5.4311410.02898K562PTBP1
chr1941807314180761-intron-Distal,intron-Proximal5.123635.69951K562AQR
chr1941792954179437-intron-Distal,intron-Proximal4.6426317.05717K562PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SIRT6 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SIRT6 is not available on ENCORE database.

  • 95 RBPs can affect the levels of SIRT6.  








The Knockdown/knockout RNA-Seq assay for SIRT6 is not available on ENCORE database.





95 RBPs can affect the gene expression of SIRT6 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SIRT6ENSG00000077463.10317.96080186.763700.767501.937201.48310HepG2AKAP1
SIRT6ENSG00000077463.10367.87230252.149000.544803.649602.88080HepG2AUH
SIRT6ENSG00000077463.10201.01340119.525600.749903.345602.69440HepG2BOP1
SIRT6ENSG00000077463.10311.68510201.917400.626204.649103.83020HepG2CKAP4
SIRT6ENSG00000077463.10143.4960057.603201.316705.068704.02900HepG2CNOT7
SIRT6ENSG00000077463.10260.04060183.482000.503002.436001.40300HepG2CPSF7
SIRT6ENSG00000077463.10108.8158061.752000.817202.780201.76040HepG2YBX3
SIRT6ENSG00000077463.10324.76390178.846500.860603.146702.48390HepG2DDX3X
SIRT6ENSG00000077463.10271.86190153.771900.822002.801802.18020HepG2DDX6
SIRT6ENSG00000077463.10160.0042060.109601.4123010.026208.87750HepG2DNAJC2
SIRT6ENSG00000077463.10292.90910197.348900.569603.113702.23040HepG2EWSR1
SIRT6ENSG00000077463.10102.7713053.333500.946202.745601.63750HepG2GRSF1
SIRT6ENSG00000077463.10122.4686048.761001.328505.487203.48560HepG2HNRNPA0
SIRT6ENSG00000077463.10117.7149047.610401.305805.360203.36800HepG2HNRNPAB
SIRT6ENSG00000077463.10145.6066068.079801.096702.117201.50130HepG2HNRNPC
SIRT6ENSG00000077463.10183.49170126.402500.537602.433201.75800HepG2HNRNPF
SIRT6ENSG00000077463.10206.09020120.046300.779603.983603.18640HepG2HNRNPL
SIRT6ENSG00000077463.10132.6196067.629000.971502.336401.77560HepG2HNRNPU
SIRT6ENSG00000077463.10196.86190124.471600.661303.387802.59360HepG2IGF2BP1
SIRT6ENSG00000077463.10117.4458069.079100.765602.629601.91320HepG2ILF2
SIRT6ENSG00000077463.10109.5843054.939700.996003.360602.02050HepG2KHDRBS1
SIRT6ENSG00000077463.10305.59170181.930200.748103.756102.78630HepG2LARP4
SIRT6ENSG00000077463.10141.1081060.144901.230205.299903.73670HepG2LARP7
SIRT6ENSG00000077463.10287.94800169.633900.763302.314901.73330HepG2NCBP2
SIRT6ENSG00000077463.10233.07470130.701200.834403.593802.72500HepG2NOL12
SIRT6ENSG00000077463.1099.4330040.045001.312004.100902.35610HepG2NOLC1
SIRT6ENSG00000077463.10204.6779082.794301.305702.660501.59000HepG2NONO
SIRT6ENSG00000077463.1054.59310105.24870-0.947002.723601.98010HepG2NSUN2
SIRT6ENSG00000077463.10124.3272052.665601.239104.379203.24720HepG2PABPC1
SIRT6ENSG00000077463.10151.9554060.318001.332908.101006.88900HepG2PPIL4
SIRT6ENSG00000077463.10218.42480150.257100.539602.544902.01630HepG2PTBP1
SIRT6ENSG00000077463.10177.23620124.782500.506202.084801.55690HepG2PUF60
SIRT6ENSG00000077463.10261.63530132.481800.981709.200008.25150HepG2PUM1
SIRT6ENSG00000077463.10418.11980241.998000.788806.800406.07330HepG2RBM22
SIRT6ENSG00000077463.10176.9014072.529201.286206.030404.56330HepG2RBM27
SIRT6ENSG00000077463.10142.6444058.897301.276004.709503.31690HepG2RCC2
SIRT6ENSG00000077463.10166.2599087.822500.920702.102701.55980HepG2RPS19
SIRT6ENSG00000077463.10167.6398066.883701.325506.201505.03060HepG2RPS2
SIRT6ENSG00000077463.10137.2629057.892201.245405.137404.04800HepG2RPS3A
SIRT6ENSG00000077463.10161.2837068.281801.239905.411003.89330HepG2RPS5
SIRT6ENSG00000077463.10144.3378060.220901.261004.148703.38750HepG2SAFB2
SIRT6ENSG00000077463.10114.3668054.514201.068903.668002.16670HepG2SART3
SIRT6ENSG00000077463.10372.89600213.553700.804104.177503.33950HepG2SF3A3
SIRT6ENSG00000077463.10263.40440156.437300.751604.677603.94000HepG2SF3B4
SIRT6ENSG00000077463.10175.26140119.687300.550101.908501.30750HepG2SLBP
SIRT6ENSG00000077463.10148.9569070.218201.084905.754504.88070HepG2SMN1
SIRT6ENSG00000077463.10174.1676083.482901.060802.182701.34280HepG2SMNDC1
SIRT6ENSG00000077463.1075.60100130.70120-0.789802.207901.51440HepG2SNRNP70
SIRT6ENSG00000077463.10557.05700273.310801.0272012.1898011.33670HepG2SRFBP1
SIRT6ENSG00000077463.1096.60690163.28660-0.757203.189302.69120HepG2SRSF1
SIRT6ENSG00000077463.10214.01190123.228100.796303.209202.54320HepG2SRSF5
SIRT6ENSG00000077463.10177.59480124.182000.516002.255501.62060HepG2SRSF7
SIRT6ENSG00000077463.10115.1889050.377001.193104.905103.39590HepG2STIP1
SIRT6ENSG00000077463.10205.77960140.124100.554303.003102.35980HepG2SUCLG1
SIRT6ENSG00000077463.10211.83300151.921200.479502.312301.44730HepG2SUPT6H
SIRT6ENSG00000077463.1044.93850146.76800-1.7075010.144009.17790HepG2TAF15
SIRT6ENSG00000077463.10183.7413066.304001.4704011.2054010.18270HepG2TRIM56
SIRT6ENSG00000077463.10272.51590192.425500.501902.239301.66840HepG2U2AF1
SIRT6ENSG00000077463.10213.1137082.932001.361503.482202.37170HepG2U2AF2
SIRT6ENSG00000077463.10287.54340129.091901.155307.192805.81870HepG2UBE2L3
SIRT6ENSG00000077463.10115.4422052.874401.126401.973501.33230HepG2UCHL5
SIRT6ENSG00000077463.10245.84650182.848200.427002.036601.50650HepG2UTP3
SIRT6ENSG00000077463.10134.5968051.857001.375906.504504.82960HepG2XPO5
SIRT6ENSG00000077463.10296.68060208.292200.510203.290202.70900HepG2ZNF622
SIRT6ENSG00000077463.10438.25760313.760000.482003.165502.46600K562AKAP8L
SIRT6ENSG00000077463.10940.43410404.226401.2181018.4918017.14090K562AQR
SIRT6ENSG00000077463.10243.09400161.754100.587602.796001.47800K562BCCIP
SIRT6ENSG00000077463.10315.05440156.334701.010908.727306.99130K562BCLAF1
SIRT6ENSG00000077463.10144.4580074.491900.955402.563401.33160K562CIRBP
SIRT6ENSG00000077463.10451.49130343.027600.396302.371701.35480K562CPEB4
SIRT6ENSG00000077463.10235.30610118.603200.988304.543903.13950K562CSTF2
SIRT6ENSG00000077463.10456.46550354.956600.362802.373801.76280K562DDX47
SIRT6ENSG00000077463.10280.93370122.307301.199605.444504.13750K562EFTUD2
SIRT6ENSG00000077463.10188.0045099.536300.917404.339501.87270K562EIF3H
SIRT6ENSG00000077463.10320.23570229.211800.482402.732101.47520K562EXOSC5
SIRT6ENSG00000077463.10311.40310199.723300.640703.777102.77670K562FIP1L1
SIRT6ENSG00000077463.10260.16050196.504500.404701.885001.36640K562FXR1
SIRT6ENSG00000077463.102.1910035.39080-4.013707.208705.95330K562G3BP2
SIRT6ENSG00000077463.10562.40580389.483500.529902.363701.66330K562GRSF1
SIRT6ENSG00000077463.10238.00590149.912600.666802.310501.75840K562HNRNPC
SIRT6ENSG00000077463.10191.3475069.529701.460405.120303.54490K562IGF2BP2
SIRT6ENSG00000077463.10132.8632070.710600.909803.997302.50690K562IGF2BP3
SIRT6ENSG00000077463.10195.4287073.046901.4196010.493008.79270K562MAGOH
SIRT6ENSG00000077463.10162.3461072.894701.155102.904701.95670K562MATR3
SIRT6ENSG00000077463.10267.25070147.755000.854904.162002.24040K562NUSAP1
SIRT6ENSG00000077463.10125.9466064.988800.954403.557902.45160K562PCBP2
SIRT6ENSG00000077463.10398.82810226.741100.814606.441405.09890K562PPIG
SIRT6ENSG00000077463.10300.07780119.022001.334008.041306.75680K562PRPF8
SIRT6ENSG00000077463.10246.77160134.439800.876102.999302.05200K562PSIP1
SIRT6ENSG00000077463.10209.3810070.971601.5607013.0887011.70090K562PTBP1
SIRT6ENSG00000077463.10392.32130575.09760-0.551805.083003.60460K562PUM1
SIRT6ENSG00000077463.10194.7315068.039001.5170011.215709.35310K562RBM22
SIRT6ENSG00000077463.10126.6859071.603500.823103.029201.88010K562NELFE
SIRT6ENSG00000077463.1074.3817036.811301.014702.963702.07770K562SF3B4
SIRT6ENSG00000077463.1029.1459065.67350-1.172002.993801.34040K562SND1
SIRT6ENSG00000077463.10214.21240116.389100.880004.222402.87810K562SRFBP1
SIRT6ENSG00000077463.10240.7809069.578701.7909015.9017014.21070K562SRSF1
SIRT6ENSG00000077463.10166.9775090.745200.879703.478402.27970K562SRSF4
SIRT6ENSG00000077463.10141.7286065.719101.108605.335603.79210K562SRSF5
SIRT6ENSG00000077463.108.5795034.74120-2.017703.309901.65830K562TAF15
SIRT6ENSG00000077463.10236.4106070.411901.7473015.1855013.26940K562TARDBP
SIRT6ENSG00000077463.10183.7627067.921901.435809.629707.98870K562TIA1
SIRT6ENSG00000077463.10170.5765066.666501.355307.763305.69590K562TRA2A
SIRT6ENSG00000077463.10282.47390137.504301.038503.421202.34770K562TRIM56
SIRT6ENSG00000077463.1012.1189035.43860-1.548102.668401.87880K562U2AF2
SIRT6ENSG00000077463.10270.90100368.26690-0.443003.104902.21000K562WDR43
SIRT6ENSG00000077463.10146.20100288.76540-0.981903.564401.66560K562YTHDC2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SIRT6 is not available on ENCORE database.





4 RBPs can affect the splicing of SIRT6 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESIRT6ENSG00000077463.10chr19-418077841809064179100417928341824704182544-0.216000.004820.07370excludedHepG2U2AF1
A3SSSIRT6ENSG00000077463.10chr19-4175838417604941758384175934417707541771910.261000.000000.00000longerK562AQR
A3SSSIRT6ENSG00000077463.10chr19-4177075417719141770754177135417910041792830.182000.000150.00129longerK562AQR
RISIRT6ENSG00000077463.10chr19-4175024417593441750244175148417567641759340.166000.005450.04927includedHepG2U2AF1
RISIRT6ENSG00000077463.10chr19-417502441759344175024417514841756764175934-0.131000.000040.00849excludedK562TROVE2
RISIRT6ENSG00000077463.10chr19-4175024417575741750244175108417567641757570.675000.007690.07031includedHepG2NCBP2
RISIRT6ENSG00000077463.10chr19-4175024417593441750244175148417567641759340.445000.000000.00000includedK562AQR
RISIRT6ENSG00000077463.10chr19-4175676417593441756764175757417583841759340.352000.000000.00000includedK562AQR
MXESIRT6ENSG00000077463.10chr19-417707541771914180778418090641758384175934418247041826010.135000.013690.081401includedK562AQR
MXESIRT6ENSG00000077463.10chr19-417707541771784180778418090641758384175934418247041826010.133000.015650.090611includedK562AQR
MXESIRT6ENSG00000077463.10chr19-41750244175148417567641757574174632417494341758384175934-0.201000.002550.020372includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SIRT6 is not avaliable on ENCORE database.