SIRT1

General Information

Gene Name       : SIRT1
Gene ID             : ENSG00000096717.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SIRT1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SIRT1ENSG00000096717.1111.329.1710.25ENCSR000AEF
HepG2SIRT1ENSG00000096717.116.5712.629.59ENCSR985KAT
K562SIRT1ENSG00000096717.1116.1117.3416.73ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SIRT1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SIRT1 RNA is bound by 15 proteins.  







eCLIP assay for SIRT1 is not avaliable on ENCORE database.





15 proteins are bound to SIRT1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr106967795269677997+3'-UTR4.8642710.49523K562PUM2
chr106967799769678049+3'-UTR3.9012715.23786K562PUM2
chr106964721269647311+5'-UTR,CDS,intron-Proximal3.103763.61570K562SRSF1
chr106965130469651439+5'-UTR,CDS,intron-Distal,intron-Proximal3.166144.48980K562PRPF8
chr106964710169647178+5'-UTR,CDS,intron-Proximal3.896566.18396K562KHSRP
chr106964712669647193+5'-UTR,CDS,intron-Proximal4.629717.56947K562SF3B4
chr106964492269645073+5'-UTR,intron-Distal,intron-Proximal4.620857.35715K562XRN2
chr106964446469644570+5'-UTR,CDS3.348754.06464K562MTPAP
chr106964713769647186+5'-UTR,CDS,intron-Proximal4.814044.82767HepG2SF3B4
chr106964474569644866+CDS3.585856.71596K562UCHL5
chr106964865769648774+CDS,intron-Distal3.916003.22245K562GRWD1
chr106964485269644902+CDS3.053363.84771K562ZNF622
chr106966901169669052+CDS,intron-Proximal3.302113.31745K562ZNF622
chr106964461969644726+CDS3.519985.02671K562PUM1
chr106967265269672737+CDS3.197543.34231K562RBM15
chr106966787469667975+CDS,intron-Proximal5.234826.75320K562AQR
chr106967218169672264+CDS,intron-Proximal3.541974.57435K562SF3B4
chr106964453869644627+CDS3.644366.84505K562ZNF622
chr106967272169672762+CDS4.220583.71613K562UCHL5
chr106966657769666644+CDS3.482364.06757K562UCHL5
chr106964480969644926+CDS,intron-Proximal3.939935.52342HepG2PPIG
chr106966918469669256+CDS,intron-Proximal4.091953.12843K562PRPF8
chr106967138669671436+intron-Distal4.277173.78681HepG2PCBP2
chr106964644569646588+intron-Distal3.623218.43196K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SIRT1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SIRT1 is not available on ENCORE database.

  • 78 RBPs can affect the levels of SIRT1.  








The Knockdown/knockout RNA-Seq assay for SIRT1 is not available on ENCORE database.





78 RBPs can affect the gene expression of SIRT1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SIRT1ENSG00000096717.7451.04480567.69580-0.331802.558201.96970HepG2ACO1
SIRT1ENSG00000096717.7517.02780844.95460-0.708605.461904.74410HepG2AKAP1
SIRT1ENSG00000096717.7341.04980570.42900-0.742109.225207.92530HepG2AKAP8L
SIRT1ENSG00000096717.7275.85180504.15020-0.870006.117204.69900HepG2BCCIP
SIRT1ENSG00000096717.7297.41740438.07750-0.558702.895901.97420HepG2BCLAF1
SIRT1ENSG00000096717.7276.26350463.26340-0.745805.794804.96740HepG2BOP1
SIRT1ENSG00000096717.7485.80610757.33060-0.640504.255603.03350HepG2CCAR1
SIRT1ENSG00000096717.7511.39900664.23380-0.377202.079601.40290HepG2CIRBP
SIRT1ENSG00000096717.7357.17850567.65180-0.668408.410807.37400HepG2CKAP4
SIRT1ENSG00000096717.7457.02990712.26270-0.640103.466602.60420HepG2CNOT7
SIRT1ENSG00000096717.7349.64070525.07380-0.586606.691405.48370HepG2DDX19B
SIRT1ENSG00000096717.7277.60760463.80470-0.740503.774202.30220HepG2DDX27
SIRT1ENSG00000096717.7572.43300758.92180-0.406802.936401.60200HepG2DDX47
SIRT1ENSG00000096717.7282.91410495.67900-0.809005.383904.34920HepG2DDX55
SIRT1ENSG00000096717.7313.60030445.03100-0.505003.843503.02560HepG2DNAJC21
SIRT1ENSG00000096717.7242.99190441.13530-0.8603010.869309.67350HepG2DNAJC2
SIRT1ENSG00000096717.7317.68590668.44310-1.0732011.5908010.42860HepG2EIF2S1
SIRT1ENSG00000096717.7368.52250738.75910-1.0034010.071708.86900HepG2EIF4A3
SIRT1ENSG00000096717.7645.08880894.47620-0.471505.436904.64250HepG2ETF1
SIRT1ENSG00000096717.7392.32930554.81070-0.499903.732202.76300HepG2EWSR1
SIRT1ENSG00000096717.7518.04600745.22290-0.524603.771702.97380HepG2FXR1
SIRT1ENSG00000096717.7458.07470691.38460-0.593904.236503.42130HepG2G3BP1
SIRT1ENSG00000096717.7299.91240482.15720-0.685004.351203.56050HepG2GPKOW
SIRT1ENSG00000096717.7331.46070449.29490-0.438802.437001.82820HepG2HNRNPA1
SIRT1ENSG00000096717.7261.84280499.76880-0.932608.557807.39100HepG2HNRNPC
SIRT1ENSG00000096717.7400.24650634.91220-0.665709.381208.21070HepG2HNRNPL
SIRT1ENSG00000096717.7293.70840460.12860-0.647704.122403.36980HepG2HNRNPLL
SIRT1ENSG00000096717.7394.14400496.46380-0.333002.273901.71910HepG2HNRNPU
SIRT1ENSG00000096717.7502.85620702.80610-0.483003.217302.49510HepG2IGF2BP2
SIRT1ENSG00000096717.7317.02170507.11940-0.677708.404307.19420HepG2ILF2
SIRT1ENSG00000096717.7436.98780799.49490-0.871507.536906.15350HepG2LARP4
SIRT1ENSG00000096717.7597.85430767.35930-0.360101.928601.39440HepG2NCBP2
SIRT1ENSG00000096717.7481.88150683.47720-0.504203.332302.54420HepG2PABPC4
SIRT1ENSG00000096717.7432.71380641.43220-0.567906.301305.44260HepG2PCBP1
SIRT1ENSG00000096717.7314.57400442.80410-0.493303.724502.88180HepG2PPIL4
SIRT1ENSG00000096717.7270.92920382.40640-0.497202.307601.56700HepG2PRPF8
SIRT1ENSG00000096717.7485.08690652.67700-0.428103.991703.36130HepG2PTBP1
SIRT1ENSG00000096717.7485.63510659.67180-0.441903.431302.77720HepG2PUF60
SIRT1ENSG00000096717.7560.32200699.74330-0.320602.379301.75650HepG2PUM2
SIRT1ENSG00000096717.7390.91940578.24660-0.564806.209505.35270HepG2PUS1
SIRT1ENSG00000096717.7222.54970357.13000-0.682304.627403.85420HepG2RPS19
SIRT1ENSG00000096717.7434.31960714.72620-0.718604.358003.35350HepG2RPS3A
SIRT1ENSG00000096717.7300.03500442.11630-0.559304.922704.10460HepG2SAFB2
SIRT1ENSG00000096717.7232.34940358.47600-0.625603.550602.48240HepG2SERBP1
SIRT1ENSG00000096717.7846.24310566.754500.578203.675602.89530HepG2SF3A3
SIRT1ENSG00000096717.7539.30870679.52860-0.333402.540301.96970HepG2SF3B4
SIRT1ENSG00000096717.7402.18620515.57110-0.358302.754502.11140HepG2SMN1
SIRT1ENSG00000096717.7819.20200506.766800.692804.257303.28110HepG2SNRNP70
SIRT1ENSG00000096717.71405.78160844.433500.7352017.0870016.12000HepG2SRFBP1
SIRT1ENSG00000096717.7708.96470490.018400.532803.069802.00730HepG2SRSF3
SIRT1ENSG00000096717.7873.09400733.198200.251802.156701.68960HepG2SSB
SIRT1ENSG00000096717.7337.02780493.44950-0.550002.917802.22580HepG2SUPV3L1
SIRT1ENSG00000096717.7316.00220482.36490-0.610205.173204.53340HepG2TIAL1
SIRT1ENSG00000096717.7337.69300486.72250-0.527404.985104.27270HepG2TRIM56
SIRT1ENSG00000096717.7349.19070502.62470-0.525504.877203.99140HepG2UPF1
SIRT1ENSG00000096717.7271.64340451.87170-0.734203.566102.41680HepG2UPF2
SIRT1ENSG00000096717.7443.08920640.15460-0.530802.975101.83120HepG2XPO5
SIRT1ENSG00000096717.7277.62570485.74670-0.807105.774804.73890HepG2XRN2
SIRT1ENSG00000096717.71549.559701103.278600.490008.296707.38630K562AGGF1
SIRT1ENSG00000096717.73711.646501357.004601.4515043.4998041.42030K562AQR
SIRT1ENSG00000096717.7838.931401179.03060-0.491006.286804.58280K562CPEB4
SIRT1ENSG00000096717.7518.72550686.09760-0.403403.730802.17190K562DDX27
SIRT1ENSG00000096717.71531.105201219.884500.327704.091703.32040K562DDX47
SIRT1ENSG00000096717.71562.241001235.328100.338604.049102.96200K562DKC1
SIRT1ENSG00000096717.71870.273901594.375000.230202.533601.62950K562EIF4G2
SIRT1ENSG00000096717.71017.31990790.657800.363503.710103.02460K562FXR1
SIRT1ENSG00000096717.71379.71750851.584400.696105.113504.08530K562G3BP2
SIRT1ENSG00000096717.7730.206001102.47710-0.594406.969905.21780K562HNRNPL
SIRT1ENSG00000096717.7408.39400606.11550-0.569603.175502.16740K562KRR1
SIRT1ENSG00000096717.72324.459601743.937200.414404.212902.34760K562NOL12
SIRT1ENSG00000096717.7479.93140715.17720-0.575503.544401.90080K562PHF6
SIRT1ENSG00000096717.7729.46590563.909300.371302.096801.39960K562POLR2G
SIRT1ENSG00000096717.7874.041001136.83800-0.379302.355901.60020K562PPIG
SIRT1ENSG00000096717.71029.49070622.781600.725007.814506.54830K562PRPF8
SIRT1ENSG00000096717.7412.08660656.86010-0.672604.133102.99760K562PSIP1
SIRT1ENSG00000096717.72562.512701739.597500.558707.131605.81680K562PUF60
SIRT1ENSG00000096717.72313.514801850.235400.322303.601302.37450K562PUM1
SIRT1ENSG00000096717.71558.900901138.495300.453303.805803.18290K562PUS1
SIRT1ENSG00000096717.71374.600201109.308500.309303.054302.43660K562RBM15
SIRT1ENSG00000096717.7812.25680634.398200.356402.006601.31670K562RPS19
SIRT1ENSG00000096717.7591.59080801.68520-0.438402.735401.73730K562RPS3
SIRT1ENSG00000096717.7379.88440567.93560-0.580203.786702.53150K562SRFBP1
SIRT1ENSG00000096717.7570.69770774.02490-0.439703.359302.18520K562SRSF4
SIRT1ENSG00000096717.7945.55890750.819200.332603.016301.67080K562SSB
SIRT1ENSG00000096717.7842.63430565.574900.575106.372505.11910K562SYNCRIP
SIRT1ENSG00000096717.7495.68350670.97900-0.436802.482001.59460K562TRIM56
SIRT1ENSG00000096717.7863.378301078.17810-0.320503.387701.97320K562TROVE2
SIRT1ENSG00000096717.71090.76360825.575500.401802.587501.53400K562U2AF1
SIRT1ENSG00000096717.71076.53970852.602700.336402.934102.10680K562U2AF2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SIRT1 is not available on ENCORE database.





5 RBPs can affect the splicing of SIRT1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESIRT1ENSG00000096717.7chr10+6966591969666044696512416965131269666546696666940.277000.001110.02252includedHepG2U2AF1
SESIRT1ENSG00000096717.7chr10+696511596965131269648639696488816966654669666694-0.106000.000930.01146excludedK562AQR
SESIRT1ENSG00000096717.7chr10+6966591969666044696512416965131269666546696666940.099000.000220.02025includedHepG2HNRNPL
SESIRT1ENSG00000096717.7chr10+6966591969666044696512416965131269666546696666940.474000.000000.00000includedK562HNRNPC
A3SSSIRT1ENSG00000096717.7chr10+6966777869667882696678026966788269666546696666940.130000.000010.00010longerK562AQR
MXESIRT1ENSG00000096717.7chr10+69648639696488816965115969651312696471746964729169666546696666940.201000.014690.073651includedHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SIRT1 is not avaliable on ENCORE database.