PTPLB

General Information

Gene Name       : PTPLB
Gene ID             :
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PTPLB)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PTPLB is not avaliable on ENCORE database.



Proteins bound to RNA
  • PTPLB RNA is bound by 19 proteins.  







eCLIP assay for PTPLB is not avaliable on ENCORE database.





19 proteins are bound to PTPLB RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr3123210468123210503-3'-UTR,intron-Distal3.969533.68079HepG2FUBP3
chr3123210503123210554-3'-UTR,intron-Distal3.106373.97192HepG2FUBP3
chr3123212593123212695-3'-UTR,intron-Distal4.144976.36332HepG2UPF1
chr3123210590123210641-3'-UTR,intron-Distal3.408223.18141HepG2FUBP3
chr3123212938123213004-3'-UTR,intron-Distal4.919416.13324HepG2IGF2BP1
chr3123247227123247311-3'-UTR,CDS,intron-Distal,intron-Proximal3.893963.93645HepG2PPIG
chr3123210440123210468-3'-UTR,intron-Distal3.969533.68079HepG2FUBP3
chr3123211038123211115-3'-UTR,intron-Distal3.710066.10061HepG2IGF2BP1
chr3123210921123210992-3'-UTR,intron-Distal3.996503.31982HepG2IGF2BP1
chr3123210419123210555-3'-UTR,intron-Distal3.828817.34290HepG2DDX55
chr3123211052123211116-3'-UTR,intron-Distal3.934423.82009HepG2IGF2BP3
chr3123303895123303923-5'-UTR,intron-Distal3.663014.73375HepG2DDX3X
chr3123303779123303882-5'-UTR,CDS,intron-Distal4.588148.41080HepG2PRPF4
chr3123301112123301183-5'-UTR,CDS,intron-Distal,intron-Proximal3.249683.50639HepG2PPIG
chr3123303772123303880-5'-UTR,CDS,intron-Distal3.2513729.70925HepG2DDX3X
chr3123301018123301073-5'-UTR,CDS,intron-Distal,intron-Proximal5.354225.68502HepG2PRPF8
chr3123219427123219541-CDS,intron-Distal,intron-Proximal3.861188.59673HepG2SND1
chr3123303744123303868-CDS,intron-Distal3.5738816.19084HepG2RPS3
chr3123221466123221552-CDS,intron-Distal,intron-Proximal6.7073214.01388HepG2U2AF2
chr3123221465123221531-CDS,intron-Distal,intron-Proximal3.757904.95361HepG2SND1
chr3123221406123221427-CDS,intron-Distal,intron-Proximal4.194903.02397HepG2SND1
chr3123240015123240083-intron-Distal4.207583.16986HepG2QKI
chr3123283145123283258-intron-Distal4.219103.74583HepG2PTBP1
chr3123225282123225381-intron-Distal4.244153.95871HepG2ILF3
chr3123282776123282830-intron-Distal3.957213.63454HepG2SUGP2
chr3123230677123230762-intron-Distal4.511283.55640HepG2QKI
chr3123269135123269217-intron-Distal3.824388.23065HepG2PTBP1
chr3123303638123303695-intron-Distal4.083183.48722HepG2PRPF4
chr3123283180123283252-intron-Distal4.699755.72657HepG2MATR3
chr3123242271123242332-intron-Distal4.309688.76637HepG2QKI
chr3123221570123221617-intron-Distal,intron-Proximal5.016757.71578HepG2SF3B4
chr3123229117123229161-intron-Distal3.326863.12255HepG2XPO5
chr3123269363123269424-intron-Distal4.349554.40847HepG2PTBP1
chr3123269217123269304-intron-Distal3.966076.25656HepG2PTBP1
chr3123213981123214024-intron-Distal4.466593.79000HepG2U2AF2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PTPLB is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PTPLB is not available on ENCORE database.

  • 93 RBPs can affect the levels of PTPLB.  








The Knockdown/knockout RNA-Seq assay for PTPLB is not available on ENCORE database.





93 RBPs can affect the gene expression of PTPLB :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PTPLBENSG00000206527.52224.966901791.892900.312202.347201.42650HepG2ADAR
PTPLBENSG00000206527.51822.879303299.24070-0.8559010.9977010.00610HepG2AKAP1
PTPLBENSG00000206527.52094.081402729.87440-0.382503.118802.28460HepG2ASCC1
PTPLBENSG00000206527.51730.613202254.35610-0.381402.137201.31730HepG2BCCIP
PTPLBENSG00000206527.51795.070802373.50410-0.403002.934102.22900HepG2CPSF6
PTPLBENSG00000206527.51422.225701837.53250-0.369604.853903.50850HepG2YBX3
PTPLBENSG00000206527.51743.759401392.759600.324202.878001.78150HepG2CSTF2
PTPLBENSG00000206527.51924.809001688.061900.189202.149101.40710HepG2DDX19B
PTPLBENSG00000206527.52085.400501540.403600.436902.943902.24660HepG2DDX21
PTPLBENSG00000206527.52391.742901506.078200.667208.323406.75550HepG2DDX24
PTPLBENSG00000206527.51228.689302216.40580-0.851109.636808.29680HepG2DDX55
PTPLBENSG00000206527.51797.665902714.77330-0.594705.593404.74210HepG2DDX6
PTPLBENSG00000206527.52870.149601746.224000.7168021.5835020.11610HepG2DKC1
PTPLBENSG00000206527.51513.794501804.40180-0.253402.609901.92230HepG2DNAJC21
PTPLBENSG00000206527.51325.676401788.34830-0.431907.171506.19090HepG2DNAJC2
PTPLBENSG00000206527.52091.822801476.708700.502305.094303.87860HepG2EEF2
PTPLBENSG00000206527.51937.011002609.92660-0.430203.770903.08550HepG2EIF2S1
PTPLBENSG00000206527.52134.817901453.778500.554204.870503.48390HepG2EIF3G
PTPLBENSG00000206527.52462.771801783.582300.465405.996404.76440HepG2EWSR1
PTPLBENSG00000206527.5791.459501071.33660-0.436804.448302.93510HepG2FAM120A
PTPLBENSG00000206527.51059.368301401.24250-0.403503.820502.90500HepG2FUBP3
PTPLBENSG00000206527.52166.659102909.96780-0.425503.827003.02360HepG2FXR1
PTPLBENSG00000206527.51632.785801067.400500.613106.552905.17500HepG2GEMIN5
PTPLBENSG00000206527.52304.650601655.032700.477604.408503.11460HepG2GNB2L1
PTPLBENSG00000206527.51199.294301821.68720-0.603108.219707.19180HepG2HNRNPA1
PTPLBENSG00000206527.51975.188902387.56750-0.273603.637502.59030HepG2HNRNPA2B1
PTPLBENSG00000206527.51477.271102026.25030-0.455904.923804.01890HepG2HNRNPC
PTPLBENSG00000206527.51787.162702154.88540-0.269903.525202.72350HepG2HNRNPF
PTPLBENSG00000206527.51574.875102366.66350-0.5876018.1489016.56550HepG2HNRNPL
PTPLBENSG00000206527.53576.736102567.735300.478005.176304.34360HepG2HNRNPLL
PTPLBENSG00000206527.51330.109902012.85690-0.5977014.1991012.91550HepG2HNRNPU
PTPLBENSG00000206527.51426.810202056.07350-0.527107.721406.56120HepG2ILF2
PTPLBENSG00000206527.5982.135201464.87220-0.576806.546404.10460HepG2CCAR2
PTPLBENSG00000206527.51236.481101668.48390-0.432308.510806.79910HepG2KIF1C
PTPLBENSG00000206527.53699.983102927.310600.337802.357101.77190HepG2MATR3
PTPLBENSG00000206527.5927.002501254.69890-0.436702.270001.31620HepG2METAP2
PTPLBENSG00000206527.52691.277901874.476200.521707.504806.23460HepG2MSI2
PTPLBENSG00000206527.51871.136202996.29410-0.679307.948506.90090HepG2NCBP2
PTPLBENSG00000206527.52162.624302576.18830-0.252502.711701.95630HepG2NOL12
PTPLBENSG00000206527.51858.705502276.71100-0.292702.264001.58610HepG2NSUN2
PTPLBENSG00000206527.51987.449401360.777500.546402.879601.97190HepG2PABPC1
PTPLBENSG00000206527.51247.831301992.43360-0.6751016.4989014.73660HepG2PARN
PTPLBENSG00000206527.51829.250902590.37820-0.5019011.4375010.33980HepG2PCBP1
PTPLBENSG00000206527.52895.734302066.649200.486502.992201.91290HepG2PCBP2
PTPLBENSG00000206527.51383.012001795.31450-0.376404.957503.99970HepG2PPIL4
PTPLBENSG00000206527.52185.697201710.291400.353803.096302.24580HepG2PRPF8
PTPLBENSG00000206527.51845.779602635.71630-0.5140011.4442010.48130HepG2PTBP1
PTPLBENSG00000206527.51932.289902610.42520-0.4340011.6416010.60100HepG2PUM1
PTPLBENSG00000206527.53161.276102608.558000.277202.831402.15350HepG2PUM2
PTPLBENSG00000206527.52382.386301859.080000.357706.532905.65770HepG2PUS1
PTPLBENSG00000206527.51820.096602854.73840-0.6493013.6948012.45700HepG2QKI
PTPLBENSG00000206527.51576.848902280.33190-0.532205.173004.04510HepG2RBM15
PTPLBENSG00000206527.51503.197202625.04450-0.8043021.8031020.62860HepG2RBM22
PTPLBENSG00000206527.53045.043802590.785800.233001.877301.31300HepG2RBM25
PTPLBENSG00000206527.51553.624801955.36710-0.331802.670201.69460HepG2RBM27
PTPLBENSG00000206527.53564.558902933.374300.281104.078903.44490HepG2NELFE
PTPLBENSG00000206527.52418.201402731.90330-0.176002.002701.46670HepG2RECQL
PTPLBENSG00000206527.51047.671501792.56160-0.7748023.0434021.42920HepG2SAFB2
PTPLBENSG00000206527.54116.718602475.787700.733506.684405.60660HepG2SF3A3
PTPLBENSG00000206527.51246.547502744.28290-1.1385047.2265045.37000HepG2SF3B4
PTPLBENSG00000206527.51004.156902090.46930-1.0578038.8715036.96140HepG2SMN1
PTPLBENSG00000206527.51441.922302033.32510-0.495803.346302.28170HepG2SMNDC1
PTPLBENSG00000206527.51281.544901940.67620-0.598704.758302.62950HepG2SND1
PTPLBENSG00000206527.55640.002502864.371100.9774052.6791051.19010HepG2SRSF1
PTPLBENSG00000206527.52851.010302427.969200.231602.797502.16790HepG2SRSF5
PTPLBENSG00000206527.52044.813002330.26150-0.188502.290401.77820HepG2SRSF9
PTPLBENSG00000206527.54965.919502574.305500.9478048.6357047.13630HepG2SSB
PTPLBENSG00000206527.52219.544202761.33520-0.315106.227805.36280HepG2SUCLG1
PTPLBENSG00000206527.51199.888301851.12150-0.625505.013403.23000HepG2SUGP2
PTPLBENSG00000206527.51081.448101563.92590-0.532206.314704.93040HepG2SUPT6H
PTPLBENSG00000206527.52654.392702206.546700.266501.922501.34410HepG2SUPV3L1
PTPLBENSG00000206527.52234.097002574.42490-0.204602.083101.58400HepG2TAF15
PTPLBENSG00000206527.51930.227302502.46400-0.374603.445002.64640HepG2TARDBP
PTPLBENSG00000206527.52973.861001795.571800.727803.714002.48680HepG2TBRG4
PTPLBENSG00000206527.51069.083901479.06170-0.468303.331702.24530HepG2TFIP11
PTPLBENSG00000206527.51655.049902365.74050-0.515407.752906.36970HepG2TIA1
PTPLBENSG00000206527.51150.794901973.34100-0.7780022.6681021.25750HepG2TRIM56
PTPLBENSG00000206527.5813.228601303.57680-0.680705.746304.64260HepG2UCHL5
PTPLBENSG00000206527.52615.906402256.814900.212902.328801.35420HepG2UTP18
PTPLBENSG00000206527.52637.758702119.809000.315305.320704.53500HepG2UTP3
PTPLBENSG00000206527.51596.160102172.09880-0.444503.315302.52650HepG2XRN2
PTPLBENSG00000206527.52161.890801722.253000.327905.611304.70670HepG2ZC3H8
PTPLBENSG00000206527.53477.821502414.789300.5262010.432109.54070HepG2ZNF622
PTPLBENSG00000206527.5421.76630273.706500.623703.798303.13200K562AQR
PTPLBENSG00000206527.599.41040156.78020-0.657302.196201.42560K562BOP1
PTPLBENSG00000206527.5133.96280202.50780-0.596102.555301.32560K562CIRBP
PTPLBENSG00000206527.5350.44630266.367400.395702.264101.66570K562DDX47
PTPLBENSG00000206527.589.39330143.76390-0.685502.435201.58100K562FTO
PTPLBENSG00000206527.5105.22550159.16040-0.597002.083901.39110K562GPKOW
PTPLBENSG00000206527.5341.10740154.755001.140103.649202.18300K562HNRNPA2B1
PTPLBENSG00000206527.5199.61040140.764600.503801.847601.34850K562HNRNPC
PTPLBENSG00000206527.5103.47850198.18440-0.937505.596404.22230K562MATR3
PTPLBENSG00000206527.5136.15700199.10160-0.548202.486201.77470K562NSUN2
PTPLBENSG00000206527.5230.03190134.872400.770103.810202.93140K562PRPF8
PTPLBENSG00000206527.5398.79650285.562100.481702.641002.10700K562PUS1
PTPLBENSG00000206527.5379.06480278.223000.446102.598402.02140K562RBM15
PTPLBENSG00000206527.5118.25830185.03350-0.645802.844401.99110K562RBM22
PTPLBENSG00000206527.5198.63670137.433600.531302.003101.31370K562RPS19
PTPLBENSG00000206527.5292.93800142.079501.043802.614901.43290K562SNRNP200
PTPLBENSG00000206527.5188.71730122.006200.629202.000001.30230K562SYNCRIP
PTPLBENSG00000206527.5140.93410211.11230-0.583002.808802.08540K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PTPLB is not available on ENCORE database.





3 RBPs can affect the splicing of PTPLB :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPTPLBENSG00000206527.5chr3-1232323931232325701232214061232215281232472321232473210.051000.001170.06725includedHepG2RBM22
SEPTPLBENSG00000206527.5chr3-123218346123218487123210400123213817123219361123219540-0.224000.001710.09314excludedK562HNRNPUL1
SEPTPLBENSG00000206527.5chr3-1232183461232184871232104001232138171232193611232195400.072000.000000.00004includedHepG2SF3B4

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PTPLB is not avaliable on ENCORE database.