PPM1A

General Information

Gene Name       : PPM1A
Gene ID             : ENSG00000100614.17
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PPM1A)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PPM1AENSG00000100614.1748.9037.9043.40ENCSR000AEF
HepG2PPM1AENSG00000100614.1716.2918.7017.49ENCSR985KAT
K562PPM1AENSG00000100614.1714.0510.2512.15ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PPM1A is not avaliable on ENCORE database.



Proteins bound to RNA
  • PPM1A RNA is bound by 17 proteins.  







eCLIP assay for PPM1A is not avaliable on ENCORE database.





17 proteins are bound to PPM1A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr146075234060752387+3'-UTR,CDS,intron-Proximal3.741776.76307K562LIN28B
chr146074997260750030+3'-UTR,CDS,intron-Distal4.277414.96063K562LIN28B
chr146075975760759811+3'-UTR4.6473712.53767K562LIN28B
chr146075652360756607+3'-UTR,CDS,intron-Proximal4.7561727.10211K562LIN28B
chr146076042260760508+3'-UTR3.240865.34980HepG2FUBP3
chr146075412460754226+3'-UTR,intron-Distal4.455465.44709K562KHSRP
chr146075237960752456+3'-UTR,CDS3.980335.36555HepG2BCLAF1
chr146076039260760480+3'-UTR4.865156.23114K562TARDBP
chr146075021860750257+3'-UTR,CDS,intron-Distal,intron-Proximal3.605095.61746K562LIN28B
chr146075652760756628+3'-UTR,CDS4.326388.59497HepG2LIN28B
chr146075404560754124+3'-UTR,intron-Distal3.101553.28806K562KHSRP
chr146075242960752460+3'-UTR,CDS,intron-Proximal3.812613.53569K562LIN28B
chr146075948560759533+3'-UTR3.843834.54968K562PUM2
chr146075919460759316+3'-UTR,CDS3.239354.29172K562YBX3
chr146074978660749859+3'-UTR,CDS,intron-Distal4.902275.68196HepG2BCLAF1
chr146075411260754239+3'-UTR,intron-Distal3.693684.03817HepG2KHSRP
chr146075947060759562+3'-UTR5.082785.78691HepG2FUBP3
chr146075974460759757+3'-UTR4.899207.88172K562LIN28B
chr146075938560759456+3'-UTR3.877746.29268K562PUM2
chr146071612860716193+5'-UTR,intron-Distal3.134133.39415HepG2DDX3X
chr146073179160731852+intron-Distal3.545984.33009HepG2SUGP2
chr146073310560733168+intron-Distal4.062503.54208HepG2SUGP2
chr146072328560723406+intron-Distal5.474637.94162K562QKI
chr146073108060731130+intron-Distal3.662155.78794HepG2SUGP2
chr146073784460737883+intron-Distal3.424426.72722HepG2SUGP2
chr146071661960716694+intron-Distal4.176329.16480HepG2PRPF4
chr146073780960737908+intron-Distal4.320743.98115K562MATR3
chr146074920260749303+intron-Distal,intron-Proximal4.035354.36528HepG2U2AF2
chr146073180460731850+intron-Distal4.159983.96879HepG2MATR3
chr146071662360716718+intron-Distal4.632064.84986K562GTF2F1
chr146073781260737885+intron-Distal3.393323.63322HepG2MATR3
chr146072330260723395+intron-Distal5.6950412.57135HepG2QKI
chr146071662260716694+intron-Distal3.1426110.46850HepG2NKRF
chr146073207860732155+intron-Distal3.704826.02877HepG2SUGP2
chr146071662460716685+intron-Distal4.218414.41148HepG2GTF2F1
chr146073089260730957+intron-Distal3.205364.46004HepG2SUGP2
chr146073169060731758+intron-Distal3.539484.36087HepG2MATR3
chr146071662060716689+intron-Distal4.390573.31384K562XRN2
chr146071661660716693+intron-Distal3.336606.13981HepG2CSTF2T
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PPM1A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PPM1A is not available on ENCORE database.

  • 71 RBPs can affect the levels of PPM1A.  








The Knockdown/knockout RNA-Seq assay for PPM1A is not available on ENCORE database.





71 RBPs can affect the gene expression of PPM1A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PPM1AENSG00000100614.13884.703401043.47200-0.238102.190601.63640HepG2ACO1
PPM1AENSG00000100614.13848.240001760.57000-1.0535014.0469012.94520HepG2AKAP1
PPM1AENSG00000100614.131170.86670920.089500.347602.591302.00960HepG2BOP1
PPM1AENSG00000100614.131202.68010993.955200.274902.061101.38910HepG2CALR
PPM1AENSG00000100614.131070.821301383.98290-0.370102.641501.88460HepG2CIRBP
PPM1AENSG00000100614.13837.162201043.31730-0.317603.708902.95970HepG2CKAP4
PPM1AENSG00000100614.131011.844201534.71910-0.601003.639902.75710HepG2CNOT7
PPM1AENSG00000100614.13663.37100965.09520-0.540908.852007.51420HepG2DDX19B
PPM1AENSG00000100614.13678.27980819.14320-0.272202.034501.42190HepG2DNAJC21
PPM1AENSG00000100614.13625.49580811.94850-0.376404.325403.54290HepG2DNAJC2
PPM1AENSG00000100614.13697.281001392.68600-0.9981013.9624012.69800HepG2EIF2S1
PPM1AENSG00000100614.13971.977201552.90810-0.676007.583506.48110HepG2FXR1
PPM1AENSG00000100614.131019.011001440.51910-0.499404.004403.21210HepG2G3BP1
PPM1AENSG00000100614.13986.307101420.62580-0.526403.233802.02220HepG2GRSF1
PPM1AENSG00000100614.131105.024001458.72830-0.400603.286102.52640HepG2HNRNPK
PPM1AENSG00000100614.13919.438401177.50200-0.356904.838803.96570HepG2HNRNPL
PPM1AENSG00000100614.131313.02050913.773100.522904.742103.94020HepG2HNRNPLL
PPM1AENSG00000100614.13595.65200789.75480-0.406903.247502.22450HepG2HNRNPM
PPM1AENSG00000100614.13705.74800913.80500-0.372704.119603.39150HepG2HNRNPU
PPM1AENSG00000100614.131178.315601464.24520-0.313402.034001.44590HepG2IGF2BP2
PPM1AENSG00000100614.13728.72010933.41940-0.357204.466103.55310HepG2ILF2
PPM1AENSG00000100614.13951.718501472.80100-0.630004.931703.55720HepG2KHSRP
PPM1AENSG00000100614.13782.83500953.90910-0.285102.982301.92810HepG2KIF1C
PPM1AENSG00000100614.131207.008501553.45050-0.364002.515701.88810HepG2MAGOH
PPM1AENSG00000100614.131067.646101562.13550-0.549104.538403.74810HepG2MATR3
PPM1AENSG00000100614.131136.246501394.03100-0.295002.283601.72180HepG2PCBP1
PPM1AENSG00000100614.13881.301101418.46640-0.6866013.6434012.61030HepG2PTBP1
PPM1AENSG00000100614.131116.983701298.84540-0.217602.444401.87990HepG2PUM1
PPM1AENSG00000100614.13653.877501062.85440-0.7009013.7681012.57310HepG2PUS1
PPM1AENSG00000100614.131556.50060919.900300.758704.848703.93020HepG2RAVER1
PPM1AENSG00000100614.131822.354401394.245100.386203.960403.16450HepG2RBM25
PPM1AENSG00000100614.131236.538101578.62710-0.352404.581403.91730HepG2NELFE
PPM1AENSG00000100614.131025.503201470.25800-0.519708.852007.84310HepG2RECQL
PPM1AENSG00000100614.131197.52330848.451300.497105.109104.21870HepG2RPLP0
PPM1AENSG00000100614.131093.141501540.69230-0.495103.227502.36550HepG2RPS3A
PPM1AENSG00000100614.131167.29570904.450300.368002.675301.98170HepG2SF3B1
PPM1AENSG00000100614.13706.57210948.98780-0.425605.912305.02710HepG2SMN1
PPM1AENSG00000100614.131329.49850973.204800.450002.756601.75750HepG2SRSF3
PPM1AENSG00000100614.131434.592901254.068600.193901.794701.33280HepG2SRSF9
PPM1AENSG00000100614.131277.79530859.647100.571703.592902.21120HepG2SUB1
PPM1AENSG00000100614.131143.068201373.91760-0.265403.170202.51340HepG2SUCLG1
PPM1AENSG00000100614.131130.15740731.259600.628005.572004.66420HepG2SUPV3L1
PPM1AENSG00000100614.13573.27610895.87290-0.6441010.342109.35660HepG2TRIM56
PPM1AENSG00000100614.131387.33910979.187400.502604.408103.62370HepG2U2AF1
PPM1AENSG00000100614.13870.267601115.58050-0.358303.926202.69980HepG2UTP18
PPM1AENSG00000100614.13862.104801047.85920-0.281502.688802.09840HepG2UTP3
PPM1AENSG00000100614.13544.34000719.84370-0.403202.023401.39470HepG2XRN2
PPM1AENSG00000100614.13987.52750750.009200.396804.985804.12880HepG2ZC3H8
PPM1AENSG00000100614.131791.976501177.579400.6056013.5475012.39440K562AGGF1
PPM1AENSG00000100614.131841.189501225.346000.587307.927706.76820K562AKAP8L
PPM1AENSG00000100614.131765.516001334.815900.403303.625002.97110K562AQR
PPM1AENSG00000100614.131527.748001285.723000.248702.511401.64380K562ATP5C1
PPM1AENSG00000100614.131050.834801297.29830-0.304003.214202.01580K562CPEB4
PPM1AENSG00000100614.132515.070101944.232700.371304.899803.59280K562CELF1
PPM1AENSG00000100614.13667.19990831.47810-0.317602.431601.68330K562EIF3G
PPM1AENSG00000100614.13723.41150924.20070-0.353402.534401.74920K562EIF4A3
PPM1AENSG00000100614.131875.301901581.376100.245802.793601.85140K562EIF4G2
PPM1AENSG00000100614.13765.62190961.13210-0.328102.920602.30130K562FXR1
PPM1AENSG00000100614.13787.004701115.25130-0.502904.943403.93520K562GRSF1
PPM1AENSG00000100614.131739.026601001.371100.796203.903402.37260K562HNRNPA2B1
PPM1AENSG00000100614.13896.101401213.19110-0.437104.274102.93140K562HNRNPL
PPM1AENSG00000100614.131915.859801300.323900.559003.977302.96600K562KIF1C
PPM1AENSG00000100614.13902.682301170.08650-0.374303.375202.44080K562MAGOH
PPM1AENSG00000100614.131754.249701456.701600.268002.275801.46420K562MBNL1
PPM1AENSG00000100614.13675.11640906.90280-0.425804.894803.84250K562MTPAP
PPM1AENSG00000100614.131939.108501021.048900.925204.555703.33450K562NAA15
PPM1AENSG00000100614.13814.001701043.89410-0.358902.533401.75330K562PPIG
PPM1AENSG00000100614.13618.232301136.78390-0.8787015.1035013.61870K562PTBP1
PPM1AENSG00000100614.132365.781501215.055300.9612017.7088016.37430K562PUS1
PPM1AENSG00000100614.131953.650101184.014000.7224011.6833010.47490K562RBM15
PPM1AENSG00000100614.13834.287701090.24750-0.386003.067602.17780K562RBM22
PPM1AENSG00000100614.13393.11790539.13100-0.455703.120502.06020K562RCC2
PPM1AENSG00000100614.13688.00300975.17220-0.503204.630202.32090K562RECQL
PPM1AENSG00000100614.13680.37370981.71940-0.529004.028002.79020K562RPS3
PPM1AENSG00000100614.13896.379501114.38470-0.314102.406401.73920K562SRSF1
PPM1AENSG00000100614.13703.49850947.81240-0.430103.578802.35910K562SRSF4
PPM1AENSG00000100614.13793.361401127.92180-0.507604.544103.63280K562TARDBP
PPM1AENSG00000100614.131213.72730961.664000.335703.006802.16910K562U2AF2
PPM1AENSG00000100614.13888.542601068.43070-0.266002.486601.80380K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PPM1A is not available on ENCORE database.





13 RBPs can affect the splicing of PPM1A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPPM1AENSG00000100614.13chr14+6074372260743809607163776071639560749401607502550.514000.000040.00134includedK562SRSF1
SEPPM1AENSG00000100614.13chr14+6074372260743809607163776071639560749401607502550.173000.000460.01059includedHepG2U2AF1
SEPPM1AENSG00000100614.13chr14+607565236075663260752341607524596075811460758172-0.119000.000000.00028excludedK562AKAP8L
SEPPM1AENSG00000100614.13chr14+607350106073515360717148607171996074940160749984-0.369000.000060.01094excludedHepG2DDX59
SEPPM1AENSG00000100614.13chr14+607565236075663260752341607524596075811460758172-0.196000.000000.00000excludedK562PUS1
SEPPM1AENSG00000100614.13chr14+607350106073515360717148607171996074940160749984-0.369000.001380.07487excludedHepG2FTO
SEPPM1AENSG00000100614.13chr14+6074372260743809607163776071639560749401607502550.580000.000000.00026includedHepG2MATR3
SEPPM1AENSG00000100614.13chr14+6074372260743809607163776071639560749401607502550.665000.000000.00001includedHepG2SRSF1
SEPPM1AENSG00000100614.13chr14+6071709760717199607161586071639560749401607502550.357000.000340.03085includedHepG2IGF2BP3
SEPPM1AENSG00000100614.13chr14+607565236075663260752341607524596075811460758172-0.147000.000000.00007excludedK562UTP18
SEPPM1AENSG00000100614.13chr14+607565236075663260752341607524596075811460758172-0.127000.000000.00010excludedK562RBM15
SEPPM1AENSG00000100614.13chr14+607565236075663260752341607524596075811460758172-0.104000.000020.00122excludedK562AGGF1
SEPPM1AENSG00000100614.13chr14+6074372260743809607163776071639560749401607502550.197000.004160.06022includedK562HNRNPC
A3SSPPM1AENSG00000100614.13chr14+6075808460758172607581146075817260756523607566320.153000.000000.00001longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PPM1A is not avaliable on ENCORE database.