PKN1

General Information

Gene Name       : PKN1
Gene ID             : ENSG00000123143.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PKN1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PKN1ENSG00000123143.1211.9030.9021.40ENCSR000AEF
HepG2PKN1ENSG00000123143.1255.9927.5541.77ENCSR985KAT
K562PKN1ENSG00000123143.1270.4752.1561.31ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PKN1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PKN1 RNA is bound by 22 proteins.  







eCLIP assay for PKN1 is not avaliable on ENCORE database.





22 proteins are bound to PKN1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr191455210314552174+3'-UTR,CDS3.020763.59114K562DHX30
chr191458239414582481+3'-UTR,CDS,intron-Proximal3.528069.43239K562METAP2
chr191458152014581612+3'-UTR,CDS,intron-Distal,intron-Proximal3.227634.82681K562EFTUD2
chr191455195914552025+3'-UTR,CDS3.805994.88678K562DHX30
chr191458243214582478+3'-UTR,CDS4.400767.37833K562PABPC4
chr191458239514582472+3'-UTR,CDS,intron-Proximal3.515999.74355K562FXR2
chr191455211514552192+3'-UTR,CDS4.4590610.84373K562METAP2
chr191455439314554431+3'-UTR,CDS3.401643.75245K562BUD13
chr191455437614554432+3'-UTR,CDS3.328675.98642K562DDX24
chr191455198114552063+3'-UTR,CDS5.0737714.27506K562FMR1
chr191455195414552094+3'-UTR,CDS,intron-Proximal4.9126217.39050HepG2DDX3X
chr191455428614554320+3'-UTR,CDS5.309627.12197K562FXR2
chr191458158414581654+3'-UTR,CDS,intron-Distal4.469889.03593K562LIN28B
chr191458239214582405+3'-UTR,CDS,intron-Proximal4.400215.05122K562DDX24
chr191458249714582531+3'-UTR,CDS4.635497.17614K562YBX3
chr191458166114581723+3'-UTR,CDS,intron-Distal,intron-Proximal3.419444.83230K562AQR
chr191454413714544207+5'-UTR,intron-Distal6.5666812.87189HepG2DDX3X
chr191454433614544399+5'-UTR,CDS,intron-Distal,intron-Proximal3.470445.34140HepG2PRPF8
chr191454426814544355+5'-UTR,CDS,intron-Distal,intron-Proximal4.6868811.73310HepG2DDX3X
chr191454420714544268+5'-UTR,intron-Distal4.1370210.43313HepG2DDX3X
chr191457838114578429+CDS3.087054.67166K562METAP2
chr191456890514568946+CDS4.218867.63320K562FMR1
chr191458056914580605+CDS,intron-Distal3.345895.65938K562FXR2
chr191456172514561812+CDS,intron-Distal3.1586613.52542K562METAP2
chr191456275914562816+CDS,intron-Distal4.6664710.20791K562FMR1
chr191457464114574685+CDS3.300094.70526K562DDX24
chr191458077514580800+CDS,intron-Distal3.002995.77001K562FXR2
chr191455735314557373+CDS4.127036.80577K562METAP2
chr191458097414581001+CDS,intron-Distal,intron-Proximal3.945574.53936K562METAP2
chr191457467714574772+CDS4.8699315.80569K562FMR1
chr191455729414557353+CDS4.9955120.35024K562METAP2
chr191457857414578600+CDS,intron-Distal3.315813.97871K562METAP2
chr191458074414580801+CDS,intron-Distal,intron-Proximal3.558769.11086K562METAP2
chr191455723614557272+CDS,intron-Proximal3.622198.72164K562METAP2
chr191456112914561179+CDS,intron-Distal,intron-Proximal3.289256.39070K562METAP2
chr191455723714557264+CDS,intron-Proximal3.223453.32039HepG2PPIG
chr191458073614580774+CDS,intron-Distal3.281587.37965K562YBX3
chr191458097414581005+CDS,intron-Distal,intron-Proximal3.485778.56897K562DDX24
chr191456905914569099+CDS4.402737.63320K562FMR1
chr191457465514574704+CDS4.692755.27053HepG2PPIG
chr191458074314580799+CDS,intron-Distal3.2880211.22158K562DDX24
chr191458097414581084+CDS,intron-Distal,intron-Proximal3.504639.90087K562FXR2
chr191456172714561815+CDS,intron-Distal3.196006.70384HepG2PPIG
chr191456906214569104+CDS4.251159.41492K562FXR2
chr191456264614562748+CDS,intron-Distal4.3301115.08342K562FXR2
chr191458057014580610+CDS,intron-Distal3.762747.22239K562METAP2
chr191457840414578454+CDS,intron-Proximal4.020926.92541HepG2PPIG
chr191458056714580604+CDS,intron-Distal5.337918.02646K562FMR1
chr191455727414557371+CDS4.544277.17767HepG2YBX3
chr191456905214569091+CDS4.265486.28735K562DDX24
chr191456914114569186+CDS4.017866.72527K562FXR2
chr191458097614581073+CDS,intron-Distal,intron-Proximal3.516869.24219K562FMR1
chr191456172714561800+CDS,intron-Distal4.849133.98581K562PUM1
chr191457468914574773+CDS4.4405013.76917K562FXR2
chr191457842114578499+CDS,intron-Proximal3.344676.74268HepG2PRPF8
chr191458096714581002+CDS,intron-Distal,intron-Proximal3.381014.57435K562SF3B4
chr191457452514574546+CDS4.173683.49905HepG2PPIG
chr191456887914568940+CDS3.983545.81266K562FXR2
chr191455727114557348+CDS3.5704214.40828K562YBX3
chr191456178814561818+CDS,intron-Distal3.495674.60670K562FXR2
chr191456113114561169+CDS,intron-Distal4.384477.63320K562FMR1
chr191455440014554433+CDS3.400448.08605K562METAP2
chr191458015214580201+CDS,intron-Distal,intron-Proximal4.096485.81266K562FXR2
chr191457196414572122+intron-Distal5.9233411.94006HepG2PTBP1
chr191455473314554798+intron-Distal4.450315.63065K562HNRNPL
chr191457216014572281+intron-Distal5.6090117.07918K562PTBP1
chr191458051314580561+intron-Distal,intron-Proximal3.908234.69223K562SF3B4
chr191457175014571859+intron-Distal5.5561513.02909K562PTBP1
chr191455543114555561+intron-Distal3.9273210.31518K562HNRNPL
chr191457175614571815+intron-Distal4.225473.09122HepG2PTBP1
chr191455556114555631+intron-Distal5.057177.47311K562HNRNPL
chr191458009114580145+intron-Distal,intron-Proximal4.575184.26208K562SF3B4
chr191457171514571916+intron-Distal4.5590010.93364K562MATR3
chr191457181514571964+intron-Distal5.9788316.83057HepG2PTBP1
chr191456198214562156+intron-Distal,intron-Proximal3.653956.70242HepG2PCBP2
chr191457212614572246+intron-Distal4.528265.76788K562MATR3
chr191458092514580967+intron-Distal,intron-Proximal4.730164.40745K562SF3B4
chr191455491714555031+intron-Distal5.5596010.70386K562HNRNPL
chr191455475314554809+intron-Distal4.043583.19026HepG2HNRNPL
chr191455495414555027+intron-Distal4.1631319.71168K562AGGF1
chr191455550414555546+intron-Distal6.3525717.55005K562AGGF1
chr191455455714554612+intron-Distal3.614104.26070K562HNRNPL
chr191455503114555081+intron-Distal4.429405.41154K562HNRNPL
chr191456229114562368+intron-Distal4.215884.08723K562HNRNPK
chr191455492314554954+intron-Distal4.121437.03111K562AGGF1
chr191457200814572160+intron-Distal7.2377323.95693K562PTBP1
chr191457185914571907+intron-Distal5.354505.89856K562PTBP1
chr191457219114572277+intron-Distal4.764594.74221HepG2PTBP1
chr191457201114572126+intron-Distal4.481715.32928K562MATR3
chr191455737614557422+intron-Proximal4.064383.49003K562PRPF8
chr191455737314557445+intron-Proximal5.2035613.79863K562AQR
chr191457442714574475+intron-Proximal5.7301610.07464K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PKN1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PKN1 is not available on ENCORE database.

  • 101 RBPs can affect the levels of PKN1.  








The Knockdown/knockout RNA-Seq assay for PKN1 is not available on ENCORE database.





101 RBPs can affect the gene expression of PKN1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PKN1ENSG00000123143.81969.550501732.170800.185202.019701.48500HepG2ACO1
PKN1ENSG00000123143.8798.857301919.25400-1.264509.737608.32190HepG2ASCC1
PKN1ENSG00000123143.8644.22040923.31220-0.519302.791301.88970HepG2BCLAF1
PKN1ENSG00000123143.8595.900301002.71200-0.750805.140104.12860HepG2CALR
PKN1ENSG00000123143.81102.802901823.47460-0.725504.593403.61050HepG2CIRBP
PKN1ENSG00000123143.81963.225301731.771200.180902.070201.48290HepG2CKAP4
PKN1ENSG00000123143.81233.48010816.665700.594806.250304.71760HepG2YBX3
PKN1ENSG00000123143.82030.763401385.122600.5519010.926209.81470HepG2CELF1
PKN1ENSG00000123143.8606.30100956.43790-0.657607.817006.29510HepG2DDX24
PKN1ENSG00000123143.8415.51170917.97250-1.143603.774102.63890HepG2DDX59
PKN1ENSG00000123143.82432.079501909.392100.349001.932201.40760HepG2DDX6
PKN1ENSG00000123143.81340.708501657.21210-0.305803.747302.98190HepG2DKC1
PKN1ENSG00000123143.81132.39100801.834100.497904.165103.31740HepG2DNAJC21
PKN1ENSG00000123143.81006.15670794.856000.340004.261203.48490HepG2DNAJC2
PKN1ENSG00000123143.81361.231402027.22830-0.574603.241702.55100HepG2EIF4A3
PKN1ENSG00000123143.81077.937301469.32170-0.446903.544502.61570HepG2EIF4G1
PKN1ENSG00000123143.81130.714001592.49520-0.494105.250503.79290HepG2ESF1
PKN1ENSG00000123143.81872.548302513.76060-0.424808.655807.69340HepG2ETF1
PKN1ENSG00000123143.81206.218801755.78790-0.541606.895605.68960HepG2FUBP3
PKN1ENSG00000123143.81293.093101897.86560-0.553603.195302.48320HepG2G3BP1
PKN1ENSG00000123143.8576.14060809.51700-0.490602.760102.11430HepG2HNRNPA1
PKN1ENSG00000123143.81545.474101356.580000.188002.079501.48400HepG2HNRNPL
PKN1ENSG00000123143.81169.84540913.712800.356405.240904.25840HepG2ILF2
PKN1ENSG00000123143.81258.43290971.984200.372502.565401.47250HepG2LARP7
PKN1ENSG00000123143.81282.044502047.27310-0.675303.614802.86530HepG2MAGOH
PKN1ENSG00000123143.8999.826501502.21250-0.587307.713306.42730HepG2MSI2
PKN1ENSG00000123143.82138.701201476.755300.534203.274402.44710HepG2NOL12
PKN1ENSG00000123143.81575.56670960.092500.714503.452502.22140HepG2NONO
PKN1ENSG00000123143.81376.496801875.60460-0.446402.082401.44790HepG2PABPC4
PKN1ENSG00000123143.81101.49690885.375300.315003.073102.18430HepG2PARN
PKN1ENSG00000123143.81447.224602031.68510-0.489409.420308.40960HepG2PCBP1
PKN1ENSG00000123143.81177.29050797.831000.561203.157302.37520HepG2PPIL4
PKN1ENSG00000123143.8368.187601119.72290-1.6046017.1903015.53310HepG2PRPF4
PKN1ENSG00000123143.81693.848502067.39700-0.287503.562602.95890HepG2PTBP1
PKN1ENSG00000123143.82284.487801496.501800.6102019.5497018.26310HepG2PUM1
PKN1ENSG00000123143.81347.328801764.32490-0.389006.649405.76550HepG2PUS1
PKN1ENSG00000123143.81710.298502238.86830-0.388504.596503.82110HepG2QKI
PKN1ENSG00000123143.81481.222302101.03140-0.504308.320207.53440HepG2RBM22
PKN1ENSG00000123143.81248.987602031.98250-0.7021010.600909.34120HepG2RBM25
PKN1ENSG00000123143.81898.888702300.74670-0.276903.464302.87360HepG2NELFE
PKN1ENSG00000123143.81730.375502142.95570-0.308504.161503.42610HepG2RECQL
PKN1ENSG00000123143.81261.020201030.157000.291602.119001.57390HepG2RPS19
PKN1ENSG00000123143.81479.077901103.459100.422602.586501.54960HepG2RPS5
PKN1ENSG00000123143.81668.78770796.586101.0668038.8871036.90200HepG2SAFB2
PKN1ENSG00000123143.81711.586702152.28100-0.330502.835902.23800HepG2SF3B4
PKN1ENSG00000123143.81745.150301351.752400.368406.578305.57030HepG2SLBP
PKN1ENSG00000123143.81586.25360928.920300.7719013.3627012.11270HepG2SMN1
PKN1ENSG00000123143.81457.32720895.728500.702103.513102.42010HepG2SMNDC1
PKN1ENSG00000123143.81125.345402246.57510-0.9974035.7812034.50720HepG2SRSF1
PKN1ENSG00000123143.81739.662101391.920700.321604.408803.65200HepG2SRSF5
PKN1ENSG00000123143.81560.630102060.32470-0.400707.184106.43290HepG2SSB
PKN1ENSG00000123143.81888.520901582.969600.254502.800802.17660HepG2SUCLG1
PKN1ENSG00000123143.8424.677501040.18310-1.292408.419707.34630HepG2SUPV3L1
PKN1ENSG00000123143.81239.861502019.47480-0.703808.945308.03070HepG2TAF15
PKN1ENSG00000123143.81048.714301628.13280-0.634602.850601.76940HepG2TBRG4
PKN1ENSG00000123143.81426.702601855.44660-0.379104.101503.09100HepG2TIA1
PKN1ENSG00000123143.81454.94160876.967700.730308.461207.56040HepG2TRIM56
PKN1ENSG00000123143.82178.855701457.853900.579603.088302.20480HepG2UBE2L3
PKN1ENSG00000123143.81097.42430614.369300.836809.037407.66370HepG2UCHL5
PKN1ENSG00000123143.8821.559801266.25830-0.624103.849303.16100HepG2UTP3
PKN1ENSG00000123143.8903.631901104.95430-0.290202.122101.52210HepG2ZC3H8
PKN1ENSG00000123143.81503.374402274.89530-0.597605.365103.66130K562AARS
PKN1ENSG00000123143.86367.288604120.365100.6278012.6310011.51390K562AGGF1
PKN1ENSG00000123143.86334.572004527.984600.484303.264002.17440K562AKAP8
PKN1ENSG00000123143.85800.457604287.506900.435905.547204.60560K562AKAP8L
PKN1ENSG00000123143.82397.716603809.73200-0.668009.696008.70200K562AQR
PKN1ENSG00000123143.86018.756104498.778500.419807.013605.46580K562ATP5C1
PKN1ENSG00000123143.82834.175802122.711600.416907.254205.67540K562BCLAF1
PKN1ENSG00000123143.81915.751001543.255000.311802.316401.36910K562CCAR1
PKN1ENSG00000123143.81429.54220998.205500.518006.322705.13830K562CPSF6
PKN1ENSG00000123143.82402.742701610.392900.577203.033101.92350K562CSTF2
PKN1ENSG00000123143.84177.320702990.180900.482203.336302.17920K562DDX3X
PKN1ENSG00000123143.83649.876803031.593200.267703.223501.78640K562DDX6
PKN1ENSG00000123143.83821.086803022.221100.338305.339104.38790K562EIF2S2
PKN1ENSG00000123143.81381.950701013.339600.447505.712204.58290K562EIF3G
PKN1ENSG00000123143.82269.455703123.91330-0.461005.551304.39220K562EIF4A3
PKN1ENSG00000123143.82786.114501668.063800.7400012.3633010.45510K562FIP1L1
PKN1ENSG00000123143.81054.608502162.00490-1.035706.417604.57360K562FKBP4
PKN1ENSG00000123143.8710.62620895.88540-0.334202.871101.50420K562FUS
PKN1ENSG00000123143.81871.054203248.72330-0.7960024.7315023.04240K562FXR1
PKN1ENSG00000123143.8127.31200845.61400-2.7316023.2600020.59250K562G3BP2
PKN1ENSG00000123143.81358.99930953.008000.511902.642201.86410K562GPKOW
PKN1ENSG00000123143.82066.685102487.81570-0.267602.433201.86940K562HNRNPC
PKN1ENSG00000123143.85219.150704258.534900.293404.026102.93990K562HNRNPU
PKN1ENSG00000123143.83553.545602261.338200.6520010.005408.52130K562HSPD1
PKN1ENSG00000123143.83220.698201802.347600.837403.463102.26820K562IGF2BP2
PKN1ENSG00000123143.82413.873301832.943000.397104.071002.56250K562IGF2BP3
PKN1ENSG00000123143.85363.487204549.835200.237302.511601.72850K562KIF1C
PKN1ENSG00000123143.81728.802902410.93550-0.479804.275202.49640K562LARP7
PKN1ENSG00000123143.85220.104704355.540000.261102.459201.46540K562MAK16
PKN1ENSG00000123143.85988.711605097.003900.232502.434301.58910K562MBNL1
PKN1ENSG00000123143.81187.42750930.255900.352002.848401.95770K562METAP2
PKN1ENSG00000123143.83300.625803765.54020-0.190102.423801.66570K562MTPAP
PKN1ENSG00000123143.84936.901104183.748800.238705.904604.87170K562NSUN2
PKN1ENSG00000123143.83091.334401893.790300.7069010.966009.01360K562PPIG
PKN1ENSG00000123143.85588.767704251.456900.394504.195103.54750K562PUS1
PKN1ENSG00000123143.85314.253904142.879500.359103.176002.54810K562RBM15
PKN1ENSG00000123143.81497.612702002.22560-0.418903.838702.11790K562SDAD1
PKN1ENSG00000123143.8634.61660930.49610-0.552103.651701.76240K562SND1
PKN1ENSG00000123143.83458.945004229.69790-0.290206.213004.87720K562SRPK2
PKN1ENSG00000123143.82166.935701558.963500.475005.914904.27320K562SRSF4
PKN1ENSG00000123143.82768.271401703.553100.7003010.740308.52180K562SRSF5
PKN1ENSG00000123143.81441.841302180.05350-0.596505.603304.42700K562SYNCRIP
PKN1ENSG00000123143.8417.77880830.02230-0.990402.759401.30300K562TAF15
PKN1ENSG00000123143.83178.214901760.635500.8520011.244409.47330K562TIA1
PKN1ENSG00000123143.82851.832001728.116000.722605.891604.15580K562TRA2A
PKN1ENSG00000123143.82465.270001950.503600.337802.694601.33660K562TRIP6
PKN1ENSG00000123143.8372.48600846.09470-1.1836015.2407013.32880K562U2AF2
PKN1ENSG00000123143.82938.438503947.32520-0.4258011.204809.63200K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PKN1 is not available on ENCORE database.





3 RBPs can affect the splicing of PKN1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPKN1ENSG00000123143.8chr19+1456089914561026145572371455737314561129145612730.155000.000010.00050includedK562TARDBP
A3SSPKN1ENSG00000123143.8chr19+1457484514574965145748711457496514574686145747810.066000.000010.00183longerHepG2RBM22
RIPKN1ENSG00000123143.8chr19+1457837614578605145783761457845314578529145786050.085000.001090.01698includedK562U2AF2
RIPKN1ENSG00000123143.8chr19+1458138614581663145813861458149414581582145816630.071000.000000.00000includedHepG2RBM22
RIPKN1ENSG00000123143.8chr19+1457837614578605145783761457845314578529145786050.074000.000150.00924includedK562TARDBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PKN1 is not avaliable on ENCORE database.