PCSK4

General Information

Gene Name       : PCSK4
Gene ID             : ENSG00000115257.15
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PCSK4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PCSK4ENSG00000115257.150.000.040.02ENCSR000AEF
HepG2PCSK4ENSG00000115257.152.730.581.66ENCSR985KAT
K562PCSK4ENSG00000115257.151.560.571.06ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PCSK4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PCSK4 RNA is bound by 4 proteins.  







eCLIP assay for PCSK4 is not avaliable on ENCORE database.





4 proteins are bound to PCSK4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1914836871483814-3'-UTR,CDS,intron-Distal,intron-Proximal3.598684.06013K562PRPF8
chr1914872671487345-CDS,intron-Distal,intron-Proximal4.054525.07449K562DDX24
chr1914871441487201-CDS,intron-Distal,intron-Proximal4.041143.43980K562ZNF622
chr1914872161487275-CDS,intron-Distal,intron-Proximal3.248653.02345K562ZNF622
chr1914828211482895-intron-Distal,intron-Proximal4.429357.15298K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PCSK4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PCSK4 is not available on ENCORE database.

  • 86 RBPs can affect the levels of PCSK4.  








The Knockdown/knockout RNA-Seq assay for PCSK4 is not available on ENCORE database.





86 RBPs can affect the gene expression of PCSK4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PCSK4ENSG00000115257.1169.4613023.266001.577903.316502.29150HepG2BCCIP
PCSK4ENSG00000115257.1133.8751085.66810-1.338504.171803.45400HepG2BOP1
PCSK4ENSG00000115257.1132.9803073.97120-1.165403.007002.20470HepG2CALR
PCSK4ENSG00000115257.11194.21910105.508500.880203.654002.51860HepG2CCAR1
PCSK4ENSG00000115257.1191.0085036.383701.322604.432602.76300HepG2DDX52
PCSK4ENSG00000115257.11128.9428050.351301.356505.406904.56930HepG2DDX6
PCSK4ENSG00000115257.1154.9631013.573102.017605.692304.71390HepG2DNAJC21
PCSK4ENSG00000115257.1155.0025013.452702.031504.074403.31440HepG2DNAJC2
PCSK4ENSG00000115257.11102.2682043.405101.236303.597302.55460HepG2EEF2
PCSK4ENSG00000115257.11121.5933048.367401.329902.595202.02070HepG2EIF2S1
PCSK4ENSG00000115257.11157.43820102.486600.619202.139301.59710HepG2ETF1
PCSK4ENSG00000115257.1172.1089031.494801.195003.427502.10990HepG2FAM120A
PCSK4ENSG00000115257.11123.0276053.966101.188803.360802.60210HepG2FXR1
PCSK4ENSG00000115257.11210.0901089.144901.236706.757105.78360HepG2GPKOW
PCSK4ENSG00000115257.1167.2097037.177200.854202.147001.50880HepG2HNRNPF
PCSK4ENSG00000115257.11104.1248050.729001.037302.058901.45080HepG2HNRNPK
PCSK4ENSG00000115257.1145.7295015.141201.594503.544002.86630HepG2HNRNPU
PCSK4ENSG00000115257.1148.5722015.466301.650904.223603.33640HepG2ILF2
PCSK4ENSG00000115257.1162.7458021.111601.571403.444102.08900HepG2KHDRBS1
PCSK4ENSG00000115257.11228.54300111.517701.035105.435804.25780HepG2LARP4
PCSK4ENSG00000115257.11129.1876053.985201.258704.957004.08680HepG2MAGOH
PCSK4ENSG00000115257.11130.8905055.550201.236404.764903.94740HepG2NCBP2
PCSK4ENSG00000115257.1191.0451035.076301.376005.402004.34310HepG2NOL12
PCSK4ENSG00000115257.1158.9462012.066002.288403.152201.60330HepG2NOLC1
PCSK4ENSG00000115257.1168.6968021.019301.708403.600502.34270HepG2NONO
PCSK4ENSG00000115257.1171.5507020.227001.822605.170803.92740HepG2PABPC1
PCSK4ENSG00000115257.1189.9128049.438600.862802.298801.63610HepG2PABPC4
PCSK4ENSG00000115257.1161.5093029.136801.077902.502801.33800HepG2PKM
PCSK4ENSG00000115257.1174.6579013.504802.466702.447901.75010HepG2PPIL4
PCSK4ENSG00000115257.1189.4969053.901300.731401.966401.49100HepG2PTBP1
PCSK4ENSG00000115257.11145.2088033.485802.1164013.6263012.44050HepG2PUF60
PCSK4ENSG00000115257.1171.0506035.521701.000002.582601.93450HepG2PUM2
PCSK4ENSG00000115257.11122.9505059.981201.035404.040803.40960HepG2NELFE
PCSK4ENSG00000115257.11109.9013055.874900.975803.506202.82180HepG2RECQL
PCSK4ENSG00000115257.1184.6747034.285601.304204.054003.32440HepG2RPS19
PCSK4ENSG00000115257.1189.2381034.102601.387702.951202.12620HepG2RPS2
PCSK4ENSG00000115257.1173.3012022.244701.720305.078903.99570HepG2RPS3A
PCSK4ENSG00000115257.1167.3190013.484002.319708.231707.20910HepG2SAFB2
PCSK4ENSG00000115257.11158.6909039.048202.022805.929603.80710HepG2SF1
PCSK4ENSG00000115257.1199.27340166.33660-0.744602.936002.24010HepG2SF3A3
PCSK4ENSG00000115257.11110.0820032.113301.777209.421208.24890HepG2SLBP
PCSK4ENSG00000115257.1192.7226034.972901.406603.035701.64680HepG2SNRNP200
PCSK4ENSG00000115257.1134.2217090.61190-1.404803.885602.67730HepG2SRSF3
PCSK4ENSG00000115257.1160.0827033.065600.861501.953901.41640HepG2SRSF5
PCSK4ENSG00000115257.11129.7951083.972600.628102.062401.60320HepG2SSB
PCSK4ENSG00000115257.1158.1231019.362501.585704.441203.01310HepG2STIP1
PCSK4ENSG00000115257.11100.0557037.601901.411806.155005.29510HepG2SUCLG1
PCSK4ENSG00000115257.1184.3676014.713202.5195010.497609.63280HepG2TIAL1
PCSK4ENSG00000115257.1173.0336014.844002.298608.911407.98910HepG2TRIM56
PCSK4ENSG00000115257.1148.75370103.19760-1.081803.244702.56920HepG2U2AF1
PCSK4ENSG00000115257.11133.9736040.581401.723004.058302.85080HepG2U2AF2
PCSK4ENSG00000115257.11148.6460034.635202.101509.865708.24690HepG2UBE2L3
PCSK4ENSG00000115257.1136.3113013.448901.432802.326501.62910HepG2UCHL5
PCSK4ENSG00000115257.11214.38090147.515100.539202.723102.02840HepG2UPF1
PCSK4ENSG00000115257.1156.8164020.841501.446702.272401.37000HepG2UPF2
PCSK4ENSG00000115257.1148.94960142.42010-1.540808.446007.49140HepG2UTP3
PCSK4ENSG00000115257.1164.5278019.926601.695104.969503.48570HepG2XPO5
PCSK4ENSG00000115257.1194.3952022.415402.074106.446505.35460HepG2XRN2
PCSK4ENSG00000115257.11117.32310162.23840-0.467601.791601.32560HepG2ZNF622
PCSK4ENSG00000115257.11433.44710260.029200.737103.105602.04990K562AKAP8
PCSK4ENSG00000115257.11401.85860246.213000.706704.788603.92180K562AKAP8L
PCSK4ENSG00000115257.1153.69340133.62280-1.315303.005002.39800K562AQR
PCSK4ENSG00000115257.11338.42240258.349500.389402.342901.50890K562ATP5C1
PCSK4ENSG00000115257.1199.8192033.338801.582004.689103.42190K562BCLAF1
PCSK4ENSG00000115257.11180.8618074.290401.283504.832003.35240K562CCAR1
PCSK4ENSG00000115257.11448.05580282.743000.664105.939004.17900K562CCDC124
PCSK4ENSG00000115257.1184.3131025.292401.737005.969604.33670K562CSTF2
PCSK4ENSG00000115257.11121.42280221.25850-0.865702.452901.53610K562CELF1
PCSK4ENSG00000115257.11421.94170277.612000.603903.765402.05010K562DDX19B
PCSK4ENSG00000115257.11165.65950106.440400.638102.561401.39840K562DDX21
PCSK4ENSG00000115257.11158.4641083.183000.929704.301102.58370K562DHX30
PCSK4ENSG00000115257.1198.0822056.605300.793002.157001.50860K562EIF2S2
PCSK4ENSG00000115257.11108.0112061.936200.802202.660401.42020K562EXOSC5
PCSK4ENSG00000115257.1126.75840113.78990-2.0883011.079909.95430K562FXR1
PCSK4ENSG00000115257.1156.83690163.70830-1.526204.560403.16870K562HNRNPL
PCSK4ENSG00000115257.1185.3305038.086901.163704.098402.58510K562IGF2BP3
PCSK4ENSG00000115257.1160.28290141.62300-1.232204.180402.41670K562ILF2
PCSK4ENSG00000115257.11367.56010250.118700.555303.867202.52700K562MAK16
PCSK4ENSG00000115257.11157.6517072.711101.116404.810202.70490K562NUSAP1
PCSK4ENSG00000115257.11239.24800119.166801.005402.894601.30600K562PKM
PCSK4ENSG00000115257.11169.91080244.12720-0.522901.868801.40520K562PUS1
PCSK4ENSG00000115257.11190.1353079.279401.261904.883302.29030K562RBFOX2
PCSK4ENSG00000115257.11120.72920209.18990-0.793004.415203.40290K562SF3A3
PCSK4ENSG00000115257.11292.81150167.800200.803102.783001.47870K562SFPQ
PCSK4ENSG00000115257.11122.7802051.844801.243704.514803.11450K562SRSF4
PCSK4ENSG00000115257.11107.8618035.394001.607507.437605.61280K562SRSF5
PCSK4ENSG00000115257.1123.0724060.61410-1.393503.607702.67050K562SYNCRIP
PCSK4ENSG00000115257.1180.8007037.887901.092502.232201.59220K562TARDBP
PCSK4ENSG00000115257.11125.5869036.552001.780609.387507.76390K562TIA1
PCSK4ENSG00000115257.1179.7555035.911901.151003.213102.02210K562TRA2A
PCSK4ENSG00000115257.11121.42330200.00200-0.720004.023503.01640K562WDR43
PCSK4ENSG00000115257.1143.14940110.92120-1.362103.209801.48320K562XRCC6
PCSK4ENSG00000115257.1175.8284029.585901.357702.600501.44130K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PCSK4 is not available on ENCORE database.





1 RBPs can affect the splicing of PCSK4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPCSK4ENSG00000115257.11chr19-1487601148769014871391487312148778314878600.605000.000050.01711includedK562NPM1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PCSK4 is not avaliable on ENCORE database.