GCH1

General Information

Gene Name       : GCH1
Gene ID             : ENSG00000131979.18
Essential Gene : No

Functions

Localization

Domains (AlphaFold: GCH1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878GCH1ENSG00000131979.1828.0322.3725.20ENCSR000AEF
HepG2GCH1ENSG00000131979.1810.3917.2913.84ENCSR985KAT
K562GCH1ENSG00000131979.183.664.944.30ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for GCH1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • GCH1 RNA is bound by 2 proteins.  







eCLIP assay for GCH1 is not avaliable on ENCORE database.





2 proteins are bound to GCH1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr145536937855369507-5'-UTR,CDS,intron-Distal4.035793.70840HepG2EIF3D
chr145533204455332140-CDS,intron-Distal,intron-Proximal4.163953.82843HepG2PPIG
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for GCH1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for GCH1 is not available on ENCORE database.

  • 82 RBPs can affect the levels of GCH1.  








The Knockdown/knockout RNA-Seq assay for GCH1 is not available on ENCORE database.





82 RBPs can affect the gene expression of GCH1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
GCH1ENSG00000131979.14292.98050434.41860-0.568304.310403.58390HepG2ACO1
GCH1ENSG00000131979.14541.35380852.98140-0.655904.385203.73660HepG2AKAP1
GCH1ENSG00000131979.14513.05370705.80440-0.460202.650601.88180HepG2ASCC1
GCH1ENSG00000131979.14281.77190439.13340-0.640103.245902.23200HepG2BCCIP
GCH1ENSG00000131979.14557.42700340.711300.710104.771403.79290HepG2CALR
GCH1ENSG00000131979.14439.85070670.55180-0.608303.859002.95410HepG2CIRBP
GCH1ENSG00000131979.14602.72110434.301600.472704.891504.05460HepG2CKAP4
GCH1ENSG00000131979.14704.54240390.762800.850305.468504.38950HepG2CNOT7
GCH1ENSG00000131979.14205.63230300.73770-0.548402.610901.94070HepG2CPSF6
GCH1ENSG00000131979.14415.43100533.55220-0.361002.524101.90510HepG2CELF1
GCH1ENSG00000131979.14453.06580331.041100.452603.201401.95960HepG2DDX1
GCH1ENSG00000131979.14516.52930314.214900.717006.471905.07990HepG2DDX24
GCH1ENSG00000131979.141325.34910817.164500.697607.261706.29310HepG2DDX3X
GCH1ENSG00000131979.14616.94630366.232700.752305.882504.46510HepG2DDX5
GCH1ENSG00000131979.14363.73680701.78980-0.948107.585106.60770HepG2DDX6
GCH1ENSG00000131979.14744.36030415.615000.840709.300408.20510HepG2DKC1
GCH1ENSG00000131979.14448.25100324.600500.465503.381102.60880HepG2DNAJC21
GCH1ENSG00000131979.14490.86710674.81770-0.459202.054701.53500HepG2EIF2S1
GCH1ENSG00000131979.14820.41840565.990900.535506.287205.11560HepG2EIF4G1
GCH1ENSG00000131979.14516.29470367.593500.490003.455102.24100HepG2ESF1
GCH1ENSG00000131979.14183.99390287.23040-0.642603.331801.41730HepG2EXOSC9
GCH1ENSG00000131979.14516.67540301.263700.778102.403301.46330HepG2FTO
GCH1ENSG00000131979.14471.38930752.26740-0.674304.881203.97960HepG2FXR1
GCH1ENSG00000131979.14382.58900697.96930-0.867406.637505.62820HepG2G3BP1
GCH1ENSG00000131979.14211.49900378.90290-0.841204.582803.26630HepG2GNB2L1
GCH1ENSG00000131979.14699.43060340.895801.0367010.605809.40940HepG2GPKOW
GCH1ENSG00000131979.14462.06730327.710500.495602.965902.29890HepG2HNRNPA1
GCH1ENSG00000131979.14443.58220706.45140-0.671405.261604.32140HepG2HNRNPK
GCH1ENSG00000131979.14336.45890522.60720-0.635307.116006.08020HepG2HNRNPL
GCH1ENSG00000131979.14639.91500325.324400.9759010.032408.91870HepG2HNRNPLL
GCH1ENSG00000131979.14538.16600381.686400.495602.591901.40630HepG2HSPD1
GCH1ENSG00000131979.14492.18660366.021900.427202.760302.03720HepG2IGF2BP1
GCH1ENSG00000131979.14916.84090709.517100.369702.365501.73520HepG2IGF2BP2
GCH1ENSG00000131979.14277.94780369.88570-0.412302.832502.09240HepG2ILF2
GCH1ENSG00000131979.14240.92840371.09230-0.623202.994801.81420HepG2LARP7
GCH1ENSG00000131979.14557.26530756.78120-0.441502.482601.88170HepG2MATR3
GCH1ENSG00000131979.14447.07520568.88760-0.347602.350401.64860HepG2NOL12
GCH1ENSG00000131979.14464.28860288.472300.686504.696003.73060HepG2NSUN2
GCH1ENSG00000131979.14227.86730358.42200-0.653505.159704.05070HepG2PARN
GCH1ENSG00000131979.14360.01040655.28830-0.8641013.2325012.06150HepG2PCBP1
GCH1ENSG00000131979.14366.47900274.831800.415102.675601.91290HepG2PRPF4
GCH1ENSG00000131979.14596.24200333.124500.839707.445506.19640HepG2PRPF8
GCH1ENSG00000131979.14403.86240666.74410-0.723304.731404.05830HepG2PTBP1
GCH1ENSG00000131979.14930.39510543.050500.776708.301407.34290HepG2PUF60
GCH1ENSG00000131979.14330.98380480.61310-0.538104.313603.27160HepG2RBM15
GCH1ENSG00000131979.14747.96330599.166300.319902.055601.59120HepG2RBM22
GCH1ENSG00000131979.14168.83810447.45600-1.406109.672307.79860HepG2RBM27
GCH1ENSG00000131979.14621.14470742.05230-0.256601.863001.39990HepG2NELFE
GCH1ENSG00000131979.14603.75460371.317500.701204.119402.97190HepG2RPS10
GCH1ENSG00000131979.14172.36200249.86500-0.535702.450601.86820HepG2RPS19
GCH1ENSG00000131979.14551.21380392.193400.490902.439101.68610HepG2RPS3A
GCH1ENSG00000131979.14133.92780329.53560-1.299009.382708.05760HepG2RRP9
GCH1ENSG00000131979.14245.76020322.47410-0.391902.209801.62290HepG2SAFB2
GCH1ENSG00000131979.14516.92030321.999000.682805.179904.23660HepG2SF3B1
GCH1ENSG00000131979.14431.21470694.23160-0.687008.877307.90970HepG2SF3B4
GCH1ENSG00000131979.14485.64230365.199600.411102.923802.21140HepG2SRSF7
GCH1ENSG00000131979.14382.32340589.47870-0.624603.879303.24830HepG2SRSF9
GCH1ENSG00000131979.141441.36230587.636901.2943046.8706045.38970HepG2SSB
GCH1ENSG00000131979.14391.77340609.78720-0.638307.564606.61970HepG2SUCLG1
GCH1ENSG00000131979.14684.25840429.817000.670705.077104.20530HepG2SUPV3L1
GCH1ENSG00000131979.14615.92240351.836100.807709.539708.70860HepG2TIAL1
GCH1ENSG00000131979.14142.26350355.00780-1.3193016.8135015.58120HepG2TRIM56
GCH1ENSG00000131979.14688.33820366.558000.909009.892008.69060HepG2U2AF1
GCH1ENSG00000131979.14420.22580271.201600.631705.953805.02770HepG2ZC3H8
GCH1ENSG00000131979.14783.39170587.649700.414704.920404.24370HepG2ZNF622
GCH1ENSG00000131979.14376.84730264.234300.512103.114402.42060K562AKAP8L
GCH1ENSG00000131979.14239.14070360.49460-0.592103.181702.56050K562AQR
GCH1ENSG00000131979.14366.13410277.251200.401102.447101.59220K562ATP5C1
GCH1ENSG00000131979.14196.72420279.64790-0.507402.565301.50010K562CPEB4
GCH1ENSG00000131979.14148.92130289.36040-0.958308.258807.21220K562DDX47
GCH1ENSG00000131979.14396.27440284.315800.478903.423002.43500K562DKC1
GCH1ENSG00000131979.1478.09840141.96770-0.862203.174602.19200K562EFTUD2
GCH1ENSG00000131979.14127.98270187.56670-0.551502.366901.62810K562EIF3G
GCH1ENSG00000131979.14104.80830223.95100-1.095405.878904.69060K562EIF4A3
GCH1ENSG00000131979.14111.33430191.05090-0.779102.380301.82040K562HNRNPC
GCH1ENSG00000131979.14185.12800261.50490-0.498302.385901.41170K562HNRNPL
GCH1ENSG00000131979.14357.09690220.182800.697503.575702.54200K562NAA15
GCH1ENSG00000131979.14142.45920230.28820-0.692902.619001.42690K562PABPC1
GCH1ENSG00000131979.14110.06950171.27870-0.637902.147801.36010K562PSIP1
GCH1ENSG00000131979.14366.64560255.323100.522003.429702.78130K562RBM15
GCH1ENSG00000131979.14136.82480224.96160-0.717303.660602.38250K562NELFE
GCH1ENSG00000131979.14149.10630235.50380-0.659403.690402.69860K562SF3B4
GCH1ENSG00000131979.1479.97040148.06420-0.888703.333802.18210K562SRFBP1
GCH1ENSG00000131979.14149.13540221.21910-0.568902.497801.82290K562TARDBP
GCH1ENSG00000131979.1495.97930164.75220-0.779502.539901.64670K562TIAL1
GCH1ENSG00000131979.1485.90920174.92860-1.025903.059902.05510K562TRIM56
GCH1ENSG00000131979.14151.95280229.20970-0.593003.209602.43870K562UPF1
GCH1ENSG00000131979.14147.14150203.95000-0.471002.117801.37000K562WDR43
GCH1ENSG00000131979.14308.46750426.98200-0.469102.619101.36900K562WRN
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for GCH1 is not available on ENCORE database.





1 RBPs can affect the splicing of GCH1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSGCH1ENSG00000131979.14chr14-5531248555312651553124855531257055313816553138480.197000.011790.06084longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for GCH1 is not avaliable on ENCORE database.