EXOSC3

General Information

Gene Name : EXOSC3
Gene ID : ENSG00000107371.12
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: EXOSC3)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	EXOSC3	ENSG00000107371.12	36.74	40.31	38.53	ENCSR000AEF
HepG2	EXOSC3	ENSG00000107371.12	47.13	57.80	52.47	ENCSR985KAT
K562	EXOSC3	ENSG00000107371.12	65.28	53.31	59.30	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

GeneName	Cell_Line	Method	Sample_reps	Control_reps	KD%	Status	Project
EXOSC3	K562	CRISPR	BGKcLV40-37,BGKcLV40-38	BGKcLV40-1,BGKcLV40-2	0.0,0.0	NotSatisfied	ENCORE2
EXOSC3	HepG2	CRISPR	BGHcLV41-57,BGHcLV41-58	BGHcLV41-1,BGHcLV41-2	0.0,0.0	NotSatisfied	ENCORE2
EXOSC3	HepG2	CRISPR	BGHcLV45-33,BGHcLV45-34	BGHcLV45-1,BGHcLV45-2	0.0,0.0	NotSatisfied	ENCORE2
EXOSC3	HepG2	CRISPR	BGHcLV45-35,BGHcLV45-36	BGHcLV45-1,BGHcLV45-2	0.0,0.0	NotSatisfied	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for EXOSC3 is not avaliable on ENCORE database.

Proteins bound to RNA

EXOSC3 RNA is bound by 11 proteins.

eCLIP assay for EXOSC3 is not avaliable on ENCORE database.

11 proteins are bound to EXOSC3 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr9	37779958	37780079	-	3'-UTR,intron-Distal	3.38262	4.51074	HepG2	HNRNPL
chr9	37780505	37780584	-	3'-UTR,5'-UTR,intron-Distal,intron-Proximal	4.80399	7.83850	HepG2	SUB1
chr9	37780851	37780902	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	4.56419	6.86842	HepG2	U2AF2
chr9	37780500	37780570	-	3'-UTR,5'-UTR,intron-Distal,intron-Proximal	3.31375	18.69899	K562	PABPC4
chr9	37779956	37780086	-	3'-UTR,intron-Distal	3.52291	5.45345	K562	HNRNPL
chr9	37785012	37785058	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.01997	4.24836	K562	DDX3X
chr9	37782031	37782120	-	CDS,intron-Distal	3.54267	6.01266	K562	LIN28B
chr9	37784777	37784888	-	CDS,intron-Distal,intron-Proximal	4.43565	4.14689	K562	FTO
chr9	37784851	37784899	-	CDS,intron-Distal	3.19692	5.44096	K562	DDX3X
chr9	37783882	37783931	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.78535	3.44979	HepG2	PRPF8
chr9	37784966	37785012	-	CDS,intron-Distal	3.78115	9.88402	K562	DDX3X
chr9	37784917	37784966	-	CDS,intron-Distal	3.01105	7.86233	K562	DDX3X
chr9	37784784	37785000	-	CDS,intron-Distal,intron-Proximal	3.02734	5.18108	K562	HNRNPM
chr9	37794264	37794340	-	intron-Distal	5.10267	6.97910	HepG2	PCBP2
chr9	37780901	37780944	-	intron-Distal,intron-Proximal	4.76817	3.55086	HepG2	RBM5
chr9	37783050	37783146	-	intron-Distal	3.46672	3.51804	HepG2	HNRNPL
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for EXOSC3 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for EXOSC3 is not available on ENCORE database.
77 RBPs can affect the levels of EXOSC3.

The Knockdown/knockout RNA-Seq assay for EXOSC3 is not available on ENCORE database.

77 RBPs can affect the gene expression of EXOSC3 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
EXOSC3	ENSG00000107371.8	327.19960	428.78100	-0.39010	2.60630	1.85860	HepG2	AKAP8L
EXOSC3	ENSG00000107371.8	440.81770	640.54870	-0.53910	5.68370	4.75940	HepG2	AUH
EXOSC3	ENSG00000107371.8	228.63680	354.99290	-0.63470	3.06630	2.11830	HepG2	BCLAF1
EXOSC3	ENSG00000107371.8	197.56900	370.51050	-0.90720	7.93840	6.72810	HepG2	CALR
EXOSC3	ENSG00000107371.8	302.36190	426.68750	-0.49690	4.13000	3.34870	HepG2	CKAP4
EXOSC3	ENSG00000107371.8	235.02550	363.79820	-0.63030	3.54660	2.77840	HepG2	CPSF6
EXOSC3	ENSG00000107371.8	277.94880	401.65410	-0.53110	2.30590	1.59390	HepG2	DDX55
EXOSC3	ENSG00000107371.8	235.87600	337.76230	-0.51800	2.39290	1.83980	HepG2	EIF2S1
EXOSC3	ENSG00000107371.8	209.75450	373.29050	-0.83160	5.39880	4.50780	HepG2	EIF4A3
EXOSC3	ENSG00000107371.8	330.50820	533.82220	-0.69170	5.77000	4.61260	HepG2	EIF4G2
EXOSC3	ENSG00000107371.8	550.17340	735.44660	-0.41870	4.46650	3.73600	HepG2	ETF1
EXOSC3	ENSG00000107371.8	206.91330	364.40920	-0.81650	2.63600	1.64530	HepG2	FTO
EXOSC3	ENSG00000107371.8	178.14860	249.52350	-0.48610	2.16930	1.46570	HepG2	FUBP3
EXOSC3	ENSG00000107371.8	237.98670	349.35520	-0.55380	2.76450	2.09950	HepG2	G3BP1
EXOSC3	ENSG00000107371.8	258.89760	412.41020	-0.67170	3.89490	3.14620	HepG2	GPKOW
EXOSC3	ENSG00000107371.8	168.93410	331.38620	-0.97210	6.95610	5.89790	HepG2	HNRNPC
EXOSC3	ENSG00000107371.8	264.98540	399.35040	-0.59170	3.88600	3.04980	HepG2	HNRNPF
EXOSC3	ENSG00000107371.8	405.89290	514.60860	-0.34240	2.80770	2.12950	HepG2	HNRNPL
EXOSC3	ENSG00000107371.8	183.11350	393.56910	-1.10390	9.11460	8.04550	HepG2	HNRNPLL
EXOSC3	ENSG00000107371.8	286.76860	393.24540	-0.45550	2.74080	2.02060	HepG2	IGF2BP1
EXOSC3	ENSG00000107371.8	284.35110	390.12320	-0.45630	3.40670	2.27500	HepG2	KIF1C
EXOSC3	ENSG00000107371.8	614.22670	378.81460	0.69720	4.93190	4.11010	HepG2	MATR3
EXOSC3	ENSG00000107371.8	265.53460	401.35310	-0.59600	2.38290	1.49040	HepG2	MTPAP
EXOSC3	ENSG00000107371.8	247.99550	348.96230	-0.49280	2.23800	1.56280	HepG2	NSUN2
EXOSC3	ENSG00000107371.8	415.63640	534.69720	-0.36340	2.23270	1.68860	HepG2	PUF60
EXOSC3	ENSG00000107371.8	405.72650	567.58070	-0.48430	5.26030	4.49620	HepG2	PUM1
EXOSC3	ENSG00000107371.8	319.07620	434.68110	-0.44610	3.41850	2.75180	HepG2	PUS1
EXOSC3	ENSG00000107371.8	166.33930	535.36570	-1.68640	6.76040	4.08700	HepG2	RBM39
EXOSC3	ENSG00000107371.8	408.88100	293.90100	0.47630	2.39670	1.41070	HepG2	RCC2
EXOSC3	ENSG00000107371.8	209.09020	306.55520	-0.55200	2.24430	1.52880	HepG2	RRP9
EXOSC3	ENSG00000107371.8	221.03500	293.17200	-0.40750	2.19650	1.61100	HepG2	SAFB2
EXOSC3	ENSG00000107371.8	402.79310	512.64200	-0.34790	2.70870	2.01300	HepG2	SLBP
EXOSC3	ENSG00000107371.8	236.29650	526.07670	-1.15470	4.04080	2.38470	HepG2	SNRNP200
EXOSC3	ENSG00000107371.8	492.95650	694.27130	-0.49400	5.20310	4.57580	HepG2	SRFBP1
EXOSC3	ENSG00000107371.8	274.92990	392.35110	-0.51310	3.95240	3.14260	HepG2	SRSF7
EXOSC3	ENSG00000107371.8	492.33380	600.40020	-0.28630	2.15830	1.59640	HepG2	SUCLG1
EXOSC3	ENSG00000107371.8	189.33330	399.85530	-1.07860	7.61090	6.58100	HepG2	SUPV3L1
EXOSC3	ENSG00000107371.8	245.06830	383.56410	-0.64630	3.93750	3.09090	HepG2	TARDBP
EXOSC3	ENSG00000107371.8	140.48410	319.92720	-1.18730	11.64120	10.74140	HepG2	TIAL1
EXOSC3	ENSG00000107371.8	187.86920	322.73190	-0.78060	6.81040	5.99370	HepG2	TRIM56
EXOSC3	ENSG00000107371.8	260.21950	612.44730	-1.23490	3.98060	2.78480	HepG2	U2AF2
EXOSC3	ENSG00000107371.8	188.31230	249.78540	-0.40760	1.96320	1.38210	HepG2	ZC3H8
EXOSC3	ENSG00000107371.8	1044.70450	739.20480	0.49890	4.63750	3.06750	K562	AARS
EXOSC3	ENSG00000107371.8	878.16550	717.54500	0.29130	2.39120	1.85700	K562	AGGF1
EXOSC3	ENSG00000107371.8	562.05400	822.32570	-0.54900	4.42670	3.31490	K562	BOP1
EXOSC3	ENSG00000107371.8	898.26850	1587.21850	-0.82130	2.35470	1.38880	K562	CNOT7
EXOSC3	ENSG00000107371.8	491.59300	874.39060	-0.83080	11.35300	9.74900	K562	CPSF6
EXOSC3	ENSG00000107371.8	437.29240	567.84940	-0.37690	2.44540	1.46840	K562	DDX3X
EXOSC3	ENSG00000107371.8	2016.48980	1522.29030	0.40550	6.66000	5.71290	K562	DDX47
EXOSC3	ENSG00000107371.8	501.89980	739.63600	-0.55940	4.20190	3.05890	K562	EFTUD2
EXOSC3	ENSG00000107371.8	1054.19850	1432.65830	-0.44250	4.09990	3.25010	K562	EIF2S2
EXOSC3	ENSG00000107371.8	358.06630	593.26070	-0.72840	7.01270	5.71250	K562	EIF4A3
EXOSC3	ENSG00000107371.8	1723.40110	2109.44470	-0.29160	2.35400	1.48250	K562	EIF4G2
EXOSC3	ENSG00000107371.8	870.75360	1202.09720	-0.46520	4.18180	3.12610	K562	FIP1L1
EXOSC3	ENSG00000107371.8	505.72810	889.62810	-0.81480	9.30510	7.68610	K562	FMR1
EXOSC3	ENSG00000107371.8	402.86250	754.02120	-0.90430	9.78800	7.95890	K562	FTO
EXOSC3	ENSG00000107371.8	1169.90440	616.96580	0.92300	19.57920	18.08190	K562	FXR1
EXOSC3	ENSG00000107371.8	491.11580	834.84590	-0.76540	8.75210	7.33320	K562	GPKOW
EXOSC3	ENSG00000107371.8	340.17660	808.85310	-1.24960	20.44110	18.89770	K562	HNRNPC
EXOSC3	ENSG00000107371.8	492.42990	722.30040	-0.55270	4.78530	3.23550	K562	HNRNPF
EXOSC3	ENSG00000107371.8	949.82610	707.65390	0.42450	2.91500	1.64660	K562	HNRNPK
EXOSC3	ENSG00000107371.8	1353.32370	988.67700	0.45280	3.32770	2.29920	K562	HNRNPM
EXOSC3	ENSG00000107371.8	454.48830	712.80710	-0.64930	4.23100	3.05290	K562	KRR1
EXOSC3	ENSG00000107371.8	572.79130	783.25100	-0.45150	3.43630	1.84740	K562	LARP7
EXOSC3	ENSG00000107371.8	601.28210	820.34750	-0.44820	3.16100	1.57450	K562	LIN28B
EXOSC3	ENSG00000107371.8	546.37340	814.89510	-0.57670	3.97770	2.91500	K562	METAP2
EXOSC3	ENSG00000107371.8	938.90500	1111.95280	-0.24400	2.17960	1.45720	K562	MTPAP
EXOSC3	ENSG00000107371.8	415.22770	592.40880	-0.51270	4.18610	2.65850	K562	NCBP2
EXOSC3	ENSG00000107371.8	880.83940	1235.46460	-0.48810	8.98780	7.74740	K562	NSUN2
EXOSC3	ENSG00000107371.8	538.96450	796.38330	-0.56330	4.20070	2.26580	K562	NUSAP1
EXOSC3	ENSG00000107371.8	491.63940	675.13440	-0.45760	2.89050	2.04000	K562	PCBP3
EXOSC3	ENSG00000107371.8	600.42400	789.68680	-0.39530	3.12990	1.59570	K562	PHF6
EXOSC3	ENSG00000107371.8	394.33350	517.83090	-0.39310	2.47620	1.72080	K562	POLR2G
EXOSC3	ENSG00000107371.8	385.70090	725.21970	-0.91090	10.86910	8.81810	K562	PSIP1
EXOSC3	ENSG00000107371.8	996.63300	723.34900	0.46230	4.67380	3.83300	K562	PTBP1
EXOSC3	ENSG00000107371.8	1864.06160	2398.70040	-0.36380	4.53960	3.30070	K562	PUM2
EXOSC3	ENSG00000107371.8	929.42710	740.50080	0.32770	1.82110	1.36210	K562	PUS1
EXOSC3	ENSG00000107371.8	414.51140	550.37390	-0.40900	2.68890	1.37910	K562	RBM25
EXOSC3	ENSG00000107371.8	430.20280	1171.47990	-1.44520	3.17470	1.49680	K562	RBM39
EXOSC3	ENSG00000107371.8	457.58390	661.66040	-0.53210	4.58870	3.30950	K562	RCC2
EXOSC3	ENSG00000107371.8	1005.55750	1219.11030	-0.27780	2.40850	1.64340	K562	SF3A3
EXOSC3	ENSG00000107371.8	430.07830	999.82860	-1.21710	2.62340	1.43930	K562	SNRNP200
EXOSC3	ENSG00000107371.8	404.53130	627.23730	-0.63280	4.78120	3.32170	K562	SRFBP1
EXOSC3	ENSG00000107371.8	518.93430	669.58810	-0.36770	2.31210	1.36750	K562	SRSF5
EXOSC3	ENSG00000107371.8	661.04550	855.93440	-0.37280	3.27780	1.99570	K562	SRSF7
EXOSC3	ENSG00000107371.8	523.36410	666.93910	-0.34970	2.77150	1.49550	K562	SSB
EXOSC3	ENSG00000107371.8	419.01110	696.97690	-0.73410	5.96350	4.42840	K562	SUPV3L1
EXOSC3	ENSG00000107371.8	856.78460	519.42580	0.72190	7.12880	5.79370	K562	SYNCRIP
EXOSC3	ENSG00000107371.8	556.18890	692.30200	-0.31580	2.02400	1.33090	K562	TIA1
EXOSC3	ENSG00000107371.8	362.65660	697.54110	-0.94370	9.76090	7.90780	K562	TIAL1
EXOSC3	ENSG00000107371.8	355.17690	741.03760	-1.06100	13.63960	11.18250	K562	TRIM56
EXOSC3	ENSG00000107371.8	1964.65910	2594.69840	-0.40130	4.27210	2.52960	K562	UBE2L3
EXOSC3	ENSG00000107371.8	466.27510	737.61200	-0.66170	5.63170	4.12880	K562	UCHL5
EXOSC3	ENSG00000107371.8	948.78230	1309.99050	-0.46540	7.31270	6.21040	K562	UPF1
EXOSC3	ENSG00000107371.8	793.11050	1120.91560	-0.49910	5.32770	4.09190	K562	WDR3
EXOSC3	ENSG00000107371.8	1316.65080	1927.17570	-0.54960	2.52250	1.70620	K562	ZC3H8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for EXOSC3 is not available on ENCORE database.

16 RBPs can affect the splicing of EXOSC3 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.14600	0.00000	0.00000	excluded	K562	SRSF1
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.14500	0.00000	0.00003	excluded	K562	SF3B4
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.26600	0.00000	0.00000	excluded	K562	PRPF8
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.23000	0.00001	0.00022	excluded	HepG2	U2AF1
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.25200	0.00000	0.00098	excluded	HepG2	PRPF8
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.15300	0.00024	0.02706	excluded	K562	XRCC6
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.12200	0.00070	0.02004	excluded	HepG2	HNRNPK
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.17000	0.00051	0.00796	excluded	HepG2	U2AF2
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.13900	0.00000	0.00000	excluded	K562	AQR
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.08100	0.00066	0.02790	excluded	K562	FXR1
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.14700	0.00139	0.06600	excluded	HepG2	PTBP1
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.22500	0.00000	0.00000	excluded	K562	EFTUD2
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.06900	0.00518	0.08352	excluded	K562	U2AF1
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.15900	0.00034	0.04479	excluded	HepG2	PCBP2
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	0.10900	0.00000	0.00003	included	K562	HNRNPM
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.24700	0.00000	0.00000	excluded	HepG2	SRSF1
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.08900	0.00010	0.00600	excluded	K562	TARDBP
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.14000	0.00000	0.00000	excluded	K562	HNRNPU
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.06500	0.00080	0.03750	excluded	K562	HNRNPK
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.21800	0.00016	0.01043	excluded	HepG2	HNRNPU
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.10300	0.00016	0.03455	excluded	K562	EIF3G
SE	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782134	37780687	37780877	37783910	37784060	-0.13100	0.00000	0.00000	excluded	K562	PTBP1
A3SS	EXOSC3	ENSG00000107371.8	chr9	-	37781982	37782175	37781982	37782134	37783910	37784132	0.05900	0.00000	0.00000	longer	K562	AQR
A3SS	EXOSC3	ENSG00000107371.8	chr9	-	37783910	37784120	37783910	37784060	37784717	37785061	0.08200	0.00000	0.00000	longer	K562	AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

EXOSC3

General Information

Functions

Localization

Domains (AlphaFold: EXOSC3)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for EXOSC3 is not avaliable on ENCORE database.

11 proteins are bound to EXOSC3 RNA:

eCLIP assay for EXOSC3 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for EXOSC3 is not available on ENCORE database.

77 RBPs can affect the gene expression of EXOSC3 :

The Knockdown/knockout RNA-Seq assay for EXOSC3 is not available on ENCORE database.

16 RBPs can affect the splicing of EXOSC3 :

The Knockdown/knockout RNA-Seq assay for EXOSC3 is not avaliable on ENCORE database.