EIF3K

General Information

Gene Name       : EIF3K
Gene ID             : ENSG00000178982.9
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: EIF3K)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878EIF3KENSG00000178982.9544.45631.05587.75ENCSR000AEF
HepG2EIF3KENSG00000178982.9381.95244.69313.32ENCSR985KAT
K562EIF3KENSG00000178982.91160.691228.651194.67ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
EIF3KA301-763A1BGHcLV41-33, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
EIF3KK562CRISPRBGKcLV46-31,BGKcLV46-32BGKcLV46-1,BGKcLV46-269.5,87.1ExperimentedENCORE2
EIF3KHepG2CRISPREIF3K-BGHcLV41-33,EIF3K-BGHcLV41-34NT-BGHcLV41-1,NT-BGHcLV41-268.1,80.0SubmittingENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
EIF3KProduct_ID: A301-763A
Lot_ID: 1
Source: Cell Signaling
Target Name: EIF3K-human		 EIF3K-HEPG2-CRISPR-A301-763A.png<br>Caption: Western blot following CRISPR against EIF3K in HepG2 whole cell lysate using EIF3K specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against EIF3K. EIF3K protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for EIF3K is not avaliable on ENCORE database.



Proteins bound to RNA
  • EIF3K RNA is bound by 23 proteins.  







eCLIP assay for EIF3K is not avaliable on ENCORE database.





23 proteins are bound to EIF3K RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr193912577939125875+3'-UTR,intron-Distal,intron-Proximal4.571407.65747HepG2EFTUD2
chr193912574439125796+3'-UTR,CDS,intron-Distal,intron-Proximal4.094226.18341HepG2PRPF8
chr193912577339125862+3'-UTR,intron-Distal,intron-Proximal6.0046821.71503K562EFTUD2
chr193912752939127565+3'-UTR,CDS4.5693319.51742K562YBX3
chr193912578439125837+3'-UTR,intron-Distal,intron-Proximal3.185975.13028HepG2RBM22
chr193912636839126442+3'-UTR,intron-Distal,polyA_site3.842753.45317HepG2HNRNPL
chr193912752839127571+3'-UTR,CDS,intron-Proximal4.6859212.05885K562PABPC4
chr193912578539125835+3'-UTR,intron-Distal,intron-Proximal4.885495.28751K562RBM22
chr193912753139127576+3'-UTR,CDS4.267496.71581HepG2SUB1
chr193912579639125856+3'-UTR,intron-Distal,intron-Proximal3.072515.00014HepG2PRPF8
chr193912576039125849+3'-UTR,CDS,intron-Distal,intron-Proximal5.6458210.04245K562AQR
chr193911105839111074+5'-UTR,CDS,intron-Distal3.6501313.76596K562YBX3
chr193911103339111058+5'-UTR,CDS,intron-Distal4.0578516.21695K562YBX3
chr193911479539114801+5'-UTR,CDS3.6005422.03290K562YBX3
chr193910983639109919+5'-UTR,CDS,intron-Proximal4.2656731.52934K562GEMIN5
chr193911475739114779+5'-UTR,CDS3.9256032.41390K562YBX3
chr193911480539114815+5'-UTR,CDS3.9360953.39386K562YBX3
chr193910983239109882+5'-UTR,intron-Proximal4.8888880.22708K562DDX3X
chr193911473439114757+5'-UTR,CDS4.3182535.89763K562YBX3
chr193911477939114793+5'-UTR,CDS3.6749529.25750K562YBX3
chr193911098139110997+5'-UTR,CDS,intron-Distal3.719436.31765K562LIN28B
chr193910991939109958+5'-UTR,CDS,intron-Proximal3.773223.57212K562GEMIN5
chr193911472239114734+5'-UTR,CDS3.8517919.63266K562YBX3
chr193910984439109934+5'-UTR,CDS,intron-Proximal3.688965.14244K562DROSHA
chr193911480139114805+5'-UTR,CDS4.1821152.87788K562YBX3
chr193910983339109897+5'-UTR,intron-Proximal5.442308.92434K562EIF3G
chr193910983639109926+5'-UTR,CDS,intron-Proximal4.873986.15796HepG2DDX3X
chr193910988239109966+5'-UTR,CDS,intron-Distal,intron-Proximal4.60551400.00000K562DDX3X
chr193911471639114722+5'-UTR,CDS,intron-Proximal3.319607.73042K562YBX3
chr193911671339116726+CDS4.236936.37184K562RBM15
chr193912565539125706+CDS,intron-Distal3.925964.43788HepG2SUB1
chr193911669339116744+CDS,intron-Proximal3.470994.71371HepG2GRWD1
chr193912565339125733+CDS,intron-Distal3.376013.80299HepG2GRWD1
chr193912313239123163+CDS,intron-Distal,intron-Proximal4.287883.11681HepG2EFTUD2
chr193912566639125751+CDS,intron-Distal4.7251115.88560K562APOBEC3C
chr193911668839116733+CDS3.3090011.78715K562RPS3
chr193912571539125742+CDS,intron-Distal3.548314.02386K562PABPC4
chr193912564239125717+CDS,intron-Distal4.6751810.11666K562LIN28B
chr193911482239114831+CDS3.6754746.29825K562YBX3
chr193912327939123349+CDS,intron-Distal,intron-Proximal3.354226.18341HepG2PRPF8
chr193912564639125715+CDS,intron-Distal4.2662658.85013K562PABPC4
chr193911668639116742+CDS3.100383.85861K562PUM1
chr193912563739125710+CDS,intron-Distal4.616304.66036K562PUM1
chr193912307339123131+CDS,intron-Distal3.983074.04622HepG2GRWD1
chr193912565139125737+CDS,intron-Distal4.862257.56262K562RPS3
chr193911669239116713+CDS3.606114.98411K562RBM15
chr193912329739123319+CDS,intron-Distal,intron-Proximal5.922498.17127K562RPS3
chr193912314039123250+CDS,intron-Distal,intron-Proximal4.2148220.25019K562EFTUD2
chr193912324139123287+CDS,intron-Distal4.035277.70120K562RPS3
chr193912317939123246+CDS,intron-Distal,intron-Proximal3.454797.00923K562SF3B4
chr193911669539116727+CDS3.333938.62245K562PABPC4
chr193911672339116784+CDS,intron-Proximal4.603889.10443HepG2PRPF8
chr193911672639116744+CDS,intron-Proximal3.756417.39702K562RBM15
chr193912565639125752+CDS,intron-Distal3.361416.04702K562ZNF800
chr193912564339125705+CDS,intron-Distal3.143543.27682HepG2LARP4
chr193911483139114839+CDS,intron-Proximal3.7772443.83215K562YBX3
chr193912318639123239+intron-Distal,intron-Proximal4.632764.32536HepG2SF3B4
chr193912333039123382+intron-Distal,intron-Proximal5.208594.13847K562AQR
chr193912318739123237+intron-Distal,intron-Proximal5.246656.41139HepG2EFTUD2
chr193912492039124969+intron-Distal3.538134.51399HepG2ILF3
chr193911676139116795+intron-Proximal3.533164.77019K562BUD13
chr193912747939127523+intron-Proximal5.298914.90235K562SF3B4
chr193911674339116793+intron-Proximal3.639489.30654K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for EIF3K is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for EIF3K is not available on ENCORE database.

  • 89 RBPs can affect the levels of EIF3K.  








The Knockdown/knockout RNA-Seq assay for EIF3K is not available on ENCORE database.





89 RBPs can affect the gene expression of EIF3K :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
EIF3KENSG00000178982.52795.225902248.041900.314201.918901.46650HepG2AKAP1
EIF3KENSG00000178982.51308.14520987.806800.405103.426202.76770HepG2BOP1
EIF3KENSG00000178982.51227.70980985.863800.316403.123602.04080HepG2YBX3
EIF3KENSG00000178982.52589.279902058.825300.330602.696902.06080HepG2CELF1
EIF3KENSG00000178982.51431.223901778.24680-0.313202.045001.52620HepG2EIF2S1
EIF3KENSG00000178982.52070.370502458.31280-0.247803.557502.88910HepG2ETF1
EIF3KENSG00000178982.51381.251101839.34000-0.413203.087002.38620HepG2G3BP1
EIF3KENSG00000178982.51034.093401367.70850-0.403403.272902.16010HepG2GNB2L1
EIF3KENSG00000178982.5727.023801027.93810-0.499703.620102.89660HepG2GPKOW
EIF3KENSG00000178982.51347.929401660.24110-0.300603.941703.10140HepG2HNRNPF
EIF3KENSG00000178982.52312.436201862.825800.311802.455601.79540HepG2HNRNPK
EIF3KENSG00000178982.51630.869602016.10930-0.305902.546001.89770HepG2HNRNPL
EIF3KENSG00000178982.51321.247201079.907600.290903.236002.58400HepG2HNRNPU
EIF3KENSG00000178982.51439.320901869.59900-0.377302.826902.14590HepG2IGF2BP2
EIF3KENSG00000178982.51311.220001983.64710-0.597206.225305.25040HepG2MAGOH
EIF3KENSG00000178982.51597.641501994.70600-0.320201.970901.43400HepG2MATR3
EIF3KENSG00000178982.5688.599701000.56720-0.539102.999401.98580HepG2MTPAP
EIF3KENSG00000178982.5537.05700869.86020-0.695706.054704.97330HepG2NSUN2
EIF3KENSG00000178982.51229.621201818.06690-0.564205.437504.43600HepG2PABPC4
EIF3KENSG00000178982.51450.452801068.931500.440206.581805.35960HepG2PARN
EIF3KENSG00000178982.51563.520101956.90380-0.323804.655303.90230HepG2PCBP1
EIF3KENSG00000178982.51144.20990963.192400.248402.069001.42380HepG2PPIL4
EIF3KENSG00000178982.5758.635901067.66770-0.493003.397102.50970HepG2PRPF8
EIF3KENSG00000178982.51412.092201991.22240-0.495809.196808.31580HepG2PTBP1
EIF3KENSG00000178982.51670.973602095.23130-0.326402.358501.80180HepG2PUF60
EIF3KENSG00000178982.51464.718702156.54390-0.558109.592308.53010HepG2QKI
EIF3KENSG00000178982.51775.219702054.67470-0.210901.962701.50660HepG2RBM22
EIF3KENSG00000178982.51240.605901957.20190-0.6577010.435609.18540HepG2RBM25
EIF3KENSG00000178982.51512.731302216.03970-0.5508011.6699010.70660HepG2NELFE
EIF3KENSG00000178982.51413.951302063.93920-0.5457011.5245010.39590HepG2RECQL
EIF3KENSG00000178982.51131.949301490.38810-0.396903.565802.65950HepG2RPS2
EIF3KENSG00000178982.5704.565601056.17020-0.584004.184903.24140HepG2RRP9
EIF3KENSG00000178982.51181.13910961.709200.296403.384102.68430HepG2SAFB2
EIF3KENSG00000178982.5577.56530970.95640-0.749408.584607.40700HepG2SF3B1
EIF3KENSG00000178982.51331.354902073.12030-0.6389015.1994013.98090HepG2SF3B4
EIF3KENSG00000178982.51368.910001121.521600.287503.771503.04050HepG2SMN1
EIF3KENSG00000178982.52072.284402320.64430-0.163301.828101.39520HepG2SRFBP1
EIF3KENSG00000178982.51602.144902163.88840-0.433608.138507.42630HepG2SRSF1
EIF3KENSG00000178982.51625.641802068.87690-0.347802.219401.65190HepG2SRSF5
EIF3KENSG00000178982.51396.608001631.16290-0.224002.449201.79150HepG2SRSF7
EIF3KENSG00000178982.51153.405801760.43820-0.6100014.1664013.09270HepG2SRSF9
EIF3KENSG00000178982.51641.042402014.80730-0.296004.285303.67660HepG2SSB
EIF3KENSG00000178982.52028.133102352.76220-0.214202.144201.58370HepG2SUCLG1
EIF3KENSG00000178982.5897.216701377.51790-0.618504.876404.01700HepG2SUPV3L1
EIF3KENSG00000178982.51359.775701787.17850-0.394304.430503.37990HepG2TIA1
EIF3KENSG00000178982.51286.616001058.710700.281202.958502.37980HepG2TRIM56
EIF3KENSG00000178982.5575.701101165.20430-1.017208.402707.30710HepG2U2AF1
EIF3KENSG00000178982.5289.21980977.32910-1.756707.751406.01640HepG2U2AF2
EIF3KENSG00000178982.51708.828402166.99680-0.342702.040401.32730HepG2UBE2L3
EIF3KENSG00000178982.51290.051001094.139200.237502.204001.65600HepG2UTP3
EIF3KENSG00000178982.5962.646301316.11900-0.451207.508006.48980HepG2ZC3H8
EIF3KENSG00000178982.51443.115501246.392500.211302.379901.86170HepG2ZNF622
EIF3KENSG00000178982.59148.000606194.360800.5624020.2865018.86650K562AGGF1
EIF3KENSG00000178982.59864.412606445.492100.6138010.744709.34460K562AKAP8L
EIF3KENSG00000178982.55572.797808806.45590-0.6602010.876009.82490K562AQR
EIF3KENSG00000178982.55267.117106104.02630-0.212703.378302.31270K562BCLAF1
EIF3KENSG00000178982.52377.528702989.83430-0.330602.733201.86550K562BOP1
EIF3KENSG00000178982.52306.885303237.75830-0.489005.708204.05250K562CCAR1
EIF3KENSG00000178982.52547.647503179.13910-0.319503.467002.58690K562CPSF6
EIF3KENSG00000178982.53828.412004630.81270-0.274503.536602.32030K562CSTF2
EIF3KENSG00000178982.55490.886004565.470400.266202.777701.73470K562DDX3X
EIF3KENSG00000178982.52790.266703624.58170-0.377403.319101.85070K562DHX30
EIF3KENSG00000178982.58530.169806935.943300.298404.981503.75390K562DKC1
EIF3KENSG00000178982.53481.133305194.71410-0.577508.064806.43810K562EFTUD2
EIF3KENSG00000178982.55773.320807296.80140-0.337906.212305.19820K562EIF2S2
EIF3KENSG00000178982.54538.989003220.667600.494904.104303.14400K562EIF3G
EIF3KENSG00000178982.55665.019704769.812300.248002.118501.39590K562EIF4A3
EIF3KENSG00000178982.55587.788904023.967400.473603.403302.45490K562FIP1L1
EIF3KENSG00000178982.52640.757803234.52930-0.292602.318501.53360K562FMR1
EIF3KENSG00000178982.52223.034802741.48190-0.302402.117601.32310K562FTO
EIF3KENSG00000178982.51014.563103370.83760-1.7322013.4904011.67440K562G3BP2
EIF3KENSG00000178982.53182.225104838.28750-0.6045011.1374010.00790K562HNRNPC
EIF3KENSG00000178982.55085.811503310.267000.619404.718903.47220K562HNRNPM
EIF3KENSG00000178982.57063.784008075.90270-0.193202.099401.32310K562HNRNPU
EIF3KENSG00000178982.57275.513105454.949300.415402.051501.36240K562HSPD1
EIF3KENSG00000178982.53502.763005183.32950-0.565403.196101.65560K562ILF2
EIF3KENSG00000178982.52366.557503269.19400-0.466104.728802.79220K562KHDRBS1
EIF3KENSG00000178982.58354.928006840.351900.288503.256102.35440K562KIF1C
EIF3KENSG00000178982.58022.840606547.840100.293002.818401.73140K562MAK16
EIF3KENSG00000178982.59153.975807662.911600.256402.497801.64180K562MBNL1
EIF3KENSG00000178982.54517.828305891.18510-0.382909.656408.24210K562MTPAP
EIF3KENSG00000178982.57228.184905371.139600.428303.146502.19550K562NAA15
EIF3KENSG00000178982.55130.502306545.51330-0.3514013.2576011.79460K562NSUN2
EIF3KENSG00000178982.56956.987004896.580400.506602.202001.33950K562PABPN1
EIF3KENSG00000178982.53203.199904479.91400-0.484002.779901.79750K562PCBP2
EIF3KENSG00000178982.55123.003907358.38920-0.522405.712304.51120K562PCBP3
EIF3KENSG00000178982.54267.557805644.18030-0.403405.856304.69460K562POLR2G
EIF3KENSG00000178982.57343.830004568.714700.684604.075503.05560K562PPIG
EIF3KENSG00000178982.53627.188105055.06660-0.478905.710404.63220K562PRPF8
EIF3KENSG00000178982.59644.2995011346.26250-0.234502.476101.70590K562PUF60
EIF3KENSG00000178982.510074.293706392.310800.6562011.3660010.31320K562PUS1
EIF3KENSG00000178982.58873.622306228.218500.5106011.8457010.62410K562RBM15
EIF3KENSG00000178982.51861.266802886.48550-0.633006.882705.30360K562SF3B1
EIF3KENSG00000178982.52326.300102957.40970-0.346303.660901.76980K562SND1
EIF3KENSG00000178982.55309.678306617.33300-0.317608.453506.91410K562SRPK2
EIF3KENSG00000178982.53472.819804893.80430-0.494804.962903.56780K562SUPV3L1
EIF3KENSG00000178982.53297.616004433.12140-0.426905.087303.71160K562TRIM56
EIF3KENSG00000178982.52086.034303264.61210-0.646102.323301.33280K562U2AF1
EIF3KENSG00000178982.51374.281603372.55790-1.2952014.1281012.29630K562U2AF2
EIF3KENSG00000178982.55569.518906940.35620-0.317506.842905.76910K562UPF1
EIF3KENSG00000178982.57843.826009920.61670-0.338903.719702.69120K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for EIF3K is not available on ENCORE database.





21 RBPs can affect the splicing of EIF3K :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEEIF3KENSG00000178982.5chr19+391230363912313639116674391167423912563239125758-0.167000.010930.08718excludedK562AQR
SEEIF3KENSG00000178982.5chr19+391109763911107539109825391099673911471639114837-0.064000.000000.00000excludedK562SDAD1
SEEIF3KENSG00000178982.5chr19+391232403912331839123069391231363912563239125742-0.071000.000000.00027excludedHepG2PCBP2
SEEIF3KENSG00000178982.5chr19+391232403912331839123069391231363912563239125742-0.062000.000030.00184excludedHepG2SF3A3
SEEIF3KENSG00000178982.5chr19+391232403912331839123069391231363912563239125742-0.061000.000560.02566excludedK562SF3B1
SEEIF3KENSG00000178982.5chr19+391109763911107539109850391099673911471639114837-0.051000.000000.00005excludedK562SAFB
SEEIF3KENSG00000178982.5chr19+3912306939123136391166673911674239125632391257580.054000.000020.00907includedK562NPM1
A3SSEIF3KENSG00000178982.5chr19+3911471639114831391147443911483139109835391099670.163000.000020.02888longerK562SAFB
A3SSEIF3KENSG00000178982.5chr19+391147163911483739114744391148373910983539109967-0.249000.000400.08311shorterK562TARDBP
A5SSEIF3KENSG00000178982.5chr19+391097343910994239109734391098633911097639111075-0.195000.000040.02536shorterK562CPSF6
A5SSEIF3KENSG00000178982.5chr19+391097343910994239109734391098633911097639111075-0.242000.000000.00000shorterK562RBM22
A5SSEIF3KENSG00000178982.5chr19+391097343910994239109734391098633911097639111075-0.083000.000320.01473shorterK562PUS1
A5SSEIF3KENSG00000178982.5chr19+391097343910994239109734391098633911097639111075-0.100000.000000.00010shorterK562AQR
A5SSEIF3KENSG00000178982.5chr19+391097343910994239109734391098633911097639111075-0.128000.000030.00817shorterK562SUPV3L1
A5SSEIF3KENSG00000178982.5chr19+3910983539109957391098353910994239110976391110750.054000.000850.08163longerHepG2SRSF9
A5SSEIF3KENSG00000178982.5chr19+3911666739116902391166673911674239123069391231360.201000.000000.00001longerHepG2U2AF2
A5SSEIF3KENSG00000178982.5chr19+391098353910996739109835391099573911097639111075-0.052000.001040.04109shorterHepG2U2AF2
A5SSEIF3KENSG00000178982.5chr19+391098353910996739109835391099573911097639111075-0.082000.000000.00000shorterK562HNRNPC
A5SSEIF3KENSG00000178982.5chr19+391098353910995739109835391099423911097639111075-0.101000.000010.00625shorterHepG2SRSF7
A5SSEIF3KENSG00000178982.5chr19+391097343910994239109734391098633911097639111075-0.088000.000240.02786shorterK562UTP18
A5SSEIF3KENSG00000178982.5chr19+391097343910994239109734391098633911097639111075-0.163000.000290.06186shorterK562SF3B1
A5SSEIF3KENSG00000178982.5chr19+391098353910996739109835391099573911097639111075-0.074000.000040.01075shorterHepG2FTO
MXEEIF3KENSG00000178982.5chr19+39123069391231363912563239125758391166673911674239127528391275950.119000.000000.000311includedK562UCHL5
MXEEIF3KENSG00000178982.5chr19+39123069391231363912563239125758391166673911674239127528391275950.117000.000000.000311includedK562XRN2
MXEEIF3KENSG00000178982.5chr19+39123240391233183912563239125758391230693912313639127528391275930.099000.000000.000481includedK562XRN2
MXEEIF3KENSG00000178982.5chr19+39123069391231363912563239125758391166673911674239127528391275930.089000.000880.022151includedK562SUPV3L1
MXEEIF3KENSG00000178982.5chr19+39123069391231363912563239125758391166673911674239127528391275950.124000.000000.000351includedK562SERBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for EIF3K is not avaliable on ENCORE database.