DENND5B

General Information

Gene Name       : DENND5B
Gene ID             : ENSG00000170456.15
Essential Gene : No

Functions

Localization

Domains (AlphaFold: DENND5B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DENND5BENSG00000170456.1519.9017.4418.67ENCSR000AEF
HepG2DENND5BENSG00000170456.158.1712.9810.57ENCSR985KAT
K562DENND5BENSG00000170456.152.532.632.58ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for DENND5B is not avaliable on ENCORE database.



Proteins bound to RNA
  • DENND5B RNA is bound by 22 proteins.  







eCLIP assay for DENND5B is not avaliable on ENCORE database.





22 proteins are bound to DENND5B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr123174371831743826-5'-UTR,CDS,intron-Distal4.8422312.43527HepG2DDX3X
chr123174386531743985-5'-UTR,intron-Distal,intron-Proximal4.272225.65659HepG2DDX3X
chr123159570531595845-CDS,intron-Distal,intron-Proximal4.097814.01763HepG2GRWD1
chr123157652631576609-CDS,intron-Distal,intron-Proximal3.983074.01763HepG2GRWD1
chr123174361831743727-CDS,intron-Distal3.466193.99819HepG2SRSF1
chr123174358731743667-CDS,intron-Distal3.683716.74268HepG2PRPF8
chr123171484731714912-intron-Distal3.325853.10946HepG2SFPQ
chr123158505831585170-intron-Distal4.910986.42900HepG2PTBP1
chr123173235631732414-intron-Distal4.235317.41529HepG2QKI
chr123168999431690054-intron-Distal4.159255.95721HepG2MATR3
chr123170292931702977-intron-Distal3.192014.61488HepG2CSTF2
chr123174308031743131-intron-Distal4.002263.75546HepG2KHSRP
chr123173201131732137-intron-Distal4.454316.64835K562QKI
chr123169356031693613-intron-Distal4.385123.61897HepG2HNRNPC
chr123174342331743466-intron-Distal,intron-Proximal3.870743.20552HepG2KHSRP
chr123173259131732764-intron-Distal3.0307611.76800HepG2PTBP1
chr123168938131689458-intron-Distal3.207143.45713HepG2PTBP1
chr123168938431689509-intron-Distal3.498654.37446HepG2MATR3
chr123165923631659284-intron-Distal5.3672916.70354K562TROVE2
chr123174147431741533-intron-Distal4.166043.47043HepG2KHSRP
chr123173266231732711-intron-Distal5.4724810.24238HepG2PCBP2
chr123167333931673397-intron-Distal3.663294.33990HepG2QKI
chr123173200331732019-intron-Distal3.521608.45941HepG2QKI
chr123167958931679661-intron-Distal4.613524.17759HepG2QKI
chr123174275731742824-intron-Distal4.627466.18899HepG2KHSRP
chr123174260931742652-intron-Distal3.800835.22299HepG2SFPQ
chr123173205831732094-intron-Distal4.7737719.52445HepG2QKI
chr123168999331690057-intron-Distal4.401094.40847HepG2PTBP1
chr123173192331731958-intron-Distal5.128816.93116HepG2QKI
chr123174305531743146-intron-Distal3.495956.96992HepG2NKRF
chr123174276031742810-intron-Distal3.310163.40917HepG2XRN2
chr123171408731714186-intron-Distal3.377134.83226HepG2HNRNPM
chr123158423931584359-intron-Distal5.370358.94626HepG2QKI
chr123173262831732662-intron-Distal6.0523113.54105HepG2PCBP2
chr123173258231732628-intron-Distal5.3191512.87349HepG2PCBP2
chr123168545131685515-intron-Distal4.332859.35404HepG2QKI
chr123165103631651127-intron-Distal4.540733.97933HepG2DDX59
chr123168795031688011-intron-Distal3.890983.80060HepG2HNRNPC
chr123167829231678346-intron-Distal3.490484.51074HepG2HNRNPL
chr123174267431742723-intron-Distal4.936576.63341HepG2SFPQ
chr123174286431742912-intron-Distal4.6063711.58327HepG2HNRNPM
chr123158384531583950-intron-Distal3.799233.03357HepG2HNRNPC
chr123165065231650726-intron-Distal4.946446.17200HepG2PCBP2
chr123165064631650722-intron-Distal4.872215.41835HepG2DDX59
chr123165105331651102-intron-Distal3.695195.00478HepG2PCBP2
chr123174275731742860-intron-Distal3.262204.51194HepG2NKRF
chr123173375031733855-intron-Distal3.552498.53041HepG2ILF3
chr123164442231644505-intron-Distal5.8026410.55181HepG2PTBP1
chr123174325431743320-intron-Distal3.378093.48399HepG2CSTF2T
chr123168917131689211-intron-Distal4.379304.86548HepG2SUGP2
chr123174341631743461-intron-Distal,intron-Proximal3.721623.07287K562TIA1
chr123174287231742902-intron-Distal4.457364.57471HepG2SFPQ
chr123167902531679095-intron-Distal3.876195.81617HepG2QKI
chr123173201931732058-intron-Distal4.4648421.12182HepG2QKI
chr123172939331729435-intron-Distal3.853105.65979HepG2PTBP1
chr123172305731723132-intron-Distal3.754504.35223HepG2ILF3
chr123168952531689590-intron-Distal3.915526.01170HepG2MATR3
chr123171000031710094-intron-Distal5.236404.85866HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for DENND5B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for DENND5B is not available on ENCORE database.

  • 76 RBPs can affect the levels of DENND5B.  








The Knockdown/knockout RNA-Seq assay for DENND5B is not available on ENCORE database.





76 RBPs can affect the gene expression of DENND5B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
DENND5BENSG00000170456.101412.036401015.802700.475103.895302.79150HepG2ABCF1
DENND5BENSG00000170456.10291.53640824.96890-1.5007019.7552017.14370HepG2BCCIP
DENND5BENSG00000170456.101723.33380773.728101.1552023.6181022.14070HepG2BOP1
DENND5BENSG00000170456.101629.881601263.945700.366702.748401.97830HepG2CIRBP
DENND5BENSG00000170456.10800.94740509.626500.652206.423704.88520HepG2CSTF2
DENND5BENSG00000170456.10720.30410985.34410-0.452005.628004.77250HepG2CELF1
DENND5BENSG00000170456.10796.40510964.60050-0.276402.889402.03840HepG2DDX19B
DENND5BENSG00000170456.101284.07760851.353500.592804.999604.11590HepG2DDX21
DENND5BENSG00000170456.101379.66260832.330800.7290010.097908.40400HepG2DDX24
DENND5BENSG00000170456.101162.08630806.606600.526702.374701.46930HepG2DDX59
DENND5BENSG00000170456.101393.78670875.350200.671007.845706.23370HepG2DDX5
DENND5BENSG00000170456.101669.79370997.832000.7427017.6544016.27810HepG2DKC1
DENND5BENSG00000170456.10549.94040760.83410-0.468304.792003.88880HepG2DNAJC21
DENND5BENSG00000170456.10549.39160754.05890-0.456805.706504.81800HepG2DNAJC2
DENND5BENSG00000170456.101130.58420793.108600.511402.540101.65370HepG2EEF2
DENND5BENSG00000170456.10781.460001271.94630-0.702807.332706.40190HepG2EIF2S1
DENND5BENSG00000170456.101162.71050803.442800.533104.621803.26890HepG2EIF3G
DENND5BENSG00000170456.101798.654401405.730300.355502.329801.74130HepG2EIF4A3
DENND5BENSG00000170456.10880.157001368.52280-0.636804.519103.65060HepG2EIF4B
DENND5BENSG00000170456.101560.872701045.272600.5784010.043508.64180HepG2EIF4G1
DENND5BENSG00000170456.101219.21110880.100600.470104.441603.08700HepG2ESF1
DENND5BENSG00000170456.102370.966301627.148300.5430012.5391011.41050HepG2ETF1
DENND5BENSG00000170456.101023.04300675.139700.599505.157803.46880HepG2FKBP4
DENND5BENSG00000170456.10965.92870706.401600.451304.043003.10060HepG2FUBP3
DENND5BENSG00000170456.10988.446901418.08050-0.520704.592603.71750HepG2FXR1
DENND5BENSG00000170456.101679.827901315.605200.352502.368201.74970HepG2G3BP1
DENND5BENSG00000170456.102106.353201396.516900.592806.576605.19610HepG2G3BP2
DENND5BENSG00000170456.101334.59870805.116200.729007.374106.35940HepG2GPKOW
DENND5BENSG00000170456.101174.22430973.781700.269902.224401.37740HepG2HNRNPA2B1
DENND5BENSG00000170456.101014.563801331.87170-0.392603.064002.33070HepG2HNRNPK
DENND5BENSG00000170456.10640.87950965.34210-0.591009.759108.56950HepG2HNRNPL
DENND5BENSG00000170456.101537.16750768.343101.0004015.4034014.08290HepG2HNRNPLL
DENND5BENSG00000170456.10417.88790848.72820-1.0222021.5187019.93880HepG2HNRNPU
DENND5BENSG00000170456.101899.699701337.329300.506304.748303.88480HepG2IGF2BP2
DENND5BENSG00000170456.10503.97420930.28880-0.8843010.678308.43720HepG2LIN28B
DENND5BENSG00000170456.101147.16830830.413700.466104.798903.75410HepG2MSI2
DENND5BENSG00000170456.101141.91240681.330400.744908.516107.25560HepG2NSUN2
DENND5BENSG00000170456.101859.025101300.540800.515304.309103.42120HepG2PABPC4
DENND5BENSG00000170456.10617.61570840.11920-0.443904.920103.83110HepG2PARN
DENND5BENSG00000170456.10720.635701253.71930-0.7989017.8825016.55590HepG2PCBP1
DENND5BENSG00000170456.101175.22730781.260400.589009.702108.38470HepG2PRPF4
DENND5BENSG00000170456.101383.523001064.659300.377905.549804.77070HepG2PUM1
DENND5BENSG00000170456.10831.767101063.92000-0.355103.398002.65680HepG2PUM2
DENND5BENSG00000170456.101743.425501062.318200.7146019.0977017.74000HepG2PUS1
DENND5BENSG00000170456.102393.878301381.673500.7928018.1739016.76820HepG2QKI
DENND5BENSG00000170456.101497.81250978.277000.614403.382102.60440HepG2RAVER1
DENND5BENSG00000170456.101618.689801253.917500.368302.998202.30020HepG2RBM25
DENND5BENSG00000170456.101529.43170960.737200.670704.693603.47660HepG2RPS10
DENND5BENSG00000170456.10441.93310626.47490-0.503403.999503.27440HepG2RPS19
DENND5BENSG00000170456.101275.29910853.320800.579604.030503.06390HepG2RPS3A
DENND5BENSG00000170456.10567.67770755.84110-0.413004.423803.64260HepG2SAFB2
DENND5BENSG00000170456.101226.90020760.470300.690008.061706.91630HepG2SF3B1
DENND5BENSG00000170456.101144.477101328.21230-0.214801.996201.48070HepG2SF3B4
DENND5BENSG00000170456.101501.09610961.586900.6424014.6453013.25870HepG2SLBP
DENND5BENSG00000170456.10432.25350996.79900-1.2054013.7940011.61950HepG2SMNDC1
DENND5BENSG00000170456.101349.92090846.170100.673804.468803.46540HepG2SNRNP70
DENND5BENSG00000170456.102054.391701386.329700.5673012.3135011.46840HepG2SRSF1
DENND5BENSG00000170456.101411.77520990.235200.511607.976006.98470HepG2SRSF5
DENND5BENSG00000170456.101433.984101127.821700.346404.554703.87930HepG2SRSF9
DENND5BENSG00000170456.102867.011301333.748601.1040051.7306050.19690HepG2SSB
DENND5BENSG00000170456.101291.92280914.189100.498902.725101.53250HepG2SUB1
DENND5BENSG00000170456.101474.367501126.233600.388505.470804.65060HepG2SUCLG1
DENND5BENSG00000170456.10861.87040692.839900.314802.390501.51180HepG2SUPT6H
DENND5BENSG00000170456.101421.66720807.463800.816009.165808.05370HepG2SUPV3L1
DENND5BENSG00000170456.101275.87610749.069200.768208.615807.43650HepG2TARDBP
DENND5BENSG00000170456.10792.816301144.99870-0.530306.362205.09960HepG2TIA1
DENND5BENSG00000170456.101009.04620824.768800.290802.202701.74630HepG2TIAL1
DENND5BENSG00000170456.10543.29660832.06560-0.615009.047808.11870HepG2TRIM56
DENND5BENSG00000170456.101552.35080979.780500.663809.345207.55840HepG2TUFM
DENND5BENSG00000170456.10267.26400477.01310-0.835806.782505.58120HepG2UCHL5
DENND5BENSG00000170456.101444.621401173.495900.299803.743502.95060HepG2UPF1
DENND5BENSG00000170456.101045.77920770.990100.439706.275005.33020HepG2ZC3H8
DENND5BENSG00000170456.10118.7196069.199400.778602.681101.87280K562EIF4A3
DENND5BENSG00000170456.10121.0424071.964400.750102.576201.98790K562FXR1
DENND5BENSG00000170456.10157.10470101.832800.625402.008901.35900K562GRSF1
DENND5BENSG00000170456.10224.7062098.955301.183106.776805.47310K562PCBP3
DENND5BENSG00000170456.10161.3252075.903101.087605.530004.39890K562POLR2G
DENND5BENSG00000170456.10329.91840160.872801.036108.324006.90390K562PUF60
DENND5BENSG00000170456.1055.95680114.90550-1.038103.607502.99890K562PUS1
DENND5BENSG00000170456.10105.6019059.014600.839402.313801.56960K562RPS19
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for DENND5B is not available on ENCORE database.





2 RBPs can affect the splicing of DENND5B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
MXEDENND5BENSG00000170456.10chr12-3159570831595859316005323160070331586088315861823160487331605410-0.176000.000840.013882includedHepG2SFPQ
MXEDENND5BENSG00000170456.10chr12-3159570831595859316004713160070331586088315861823160487331605410-0.180000.000620.010752includedHepG2SFPQ
MXEDENND5BENSG00000170456.10chr12-3160487331605410316131273161331531600471316007033163252231633189-0.200000.002110.076932includedHepG2DROSHA

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for DENND5B is not avaliable on ENCORE database.